Citations for
1DUOXA2
Defects in protein folding in congenital hypothyroidism.
Targovnik HM, Scheps KG, Rivolta CM.
Mol Cell Endocrinol 501:110638. doi: 10.1016/j.mce.2019.110638. Epub 2019 Nov 18. Review. 2020
2DUOX1, DUOX2, DUOXA1, DUOXA2
The Dual Oxidase Duox2 stabilized with DuoxA2 in an enzymatic complex at the surface of the cell produces extracellular H2O2 able to induce DNA damage in an inducible cellular model.
Poncelet L, Dumont JE, Miot F, De Deken X.
Exp Cell Res 384(1):111620. doi: 10.1016/j.yexcr.2019.111620. Epub 2019 Sep 9. 2019
3DUOX2, DUOXA2, HTDI1
DUOX Defects and Their Roles in Congenital Hypothyroidism.
De Deken X, Miot F.
Methods Mol Biol 1982:667-693. doi: 10.1007/978-1-4939-9424-3_37. Review. 2019
4DUOX2, DUOXA2, HTDI1, HTDI2
DUOX2/DUOXA2 Mutations Frequently Cause Congenital Hypothyroidism that Evades Detection on Newborn Screening in the United Kingdom.
Peters C, Nicholas AK, Schoenmakers E, Lyons G, Langham S, Serra EG, Sebire NJ, Muzza M, Fugazzola L, Schoenmakers N.
Thyroid 29(6):790-801. doi: 10.1089/thy.2018.0587. 2019
5DUOX2, DUOXA2, HTDI1, HTDI2
Mutational Spectrum Analysis of Seven Genes Associated with Thyroid Dyshormonogenesis.
Chen X, Kong X, Zhu J, Zhang T, Li Y, Ding G, Wang H.
Int J Endocrinol 2018:8986475. doi: 10.1155/2018/8986475. eCollection 2018. 2018
6DUOXA2, HTDI2
Fetal Goitrous Hypothyroidism and Polyhydramnios in a Patient with Compound Heterozygous DUOXA2 Mutations.
Tanase-Nakao K, Miyata I, Terauchi A, Saito M, Wada S, Hasegawa T, Narumi S.
Horm Res Paediatr 90(2):132-137. doi: 10.1159/000491104. Epub 2018 Aug 15. 2018
7DUOX1, DUOX2, DUOXA1, DUOXA2
Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.
Louzada RA, Corre R, Ameziane-El-Hassani R, Hecht F, Cazarin J, Buffet C, Carvalho DP, Dupuy C.
Thyroid 28(8):1052-1062. doi: 10.1089/thy.2017.0596. Epub 2018 Jul 24. 2018
8DUOX2, DUOXA2, HTDI1, HTDI2
Heterozygous Mutations of the DUOXA2 and DUOX2 Genes in Dizygotic Twins with Congenital Hypothyroidism.
Yang LX, Ma SG, Qiu YL, Zheng X.
Clin Lab 62(5):849-54. 2016
9DUOX2, DUOXA2
When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.
Carré A, Louzada RA, Fortunato RS, Ameziane-El-Hassani R, Morand S, Ogryzko V, de Carvalho DP, Grasberger H, Leto TL, Dupuy C.
Antioxid Redox Signal 23(9):724-33. doi: 10.1089/ars.2015.6265. Epub 2015 Apr 20. 2015
10DUOXA2, HTDI2
A novel missense mutation (I26M) in DUOXA2 causing congenital goiter hypothyroidism impairs NADPH oxidase activity but not protein expression.
Liu S, Liu L, Niu X, Lu D, Xia H, Yan S.
J Clin Endocrinol Metab 100(4):1225-9. doi: 10.1210/jc.2014-3964. Epub 2015 Feb 12. 2015
11DUOX2, DUOXA2
DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.
MacFie TS, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, Suraweera N, Poehlmann A, Szary J, Feakins R, Jeffery R, Harper RW, Jubb AM, Lindsay JO, Silver A.
Inflamm Bowel Dis 20(3):514-24. doi: 10.1097/01.MIB.0000442012.45038.0e. Erratum in: Inflamm Bowel Dis. 2014 Apr;20(4):775. 2014
12DUOXA2, HTDI2
A novel dual oxidase maturation factor 2 gene mutation for congenital hypothyroidism.
Yi RH, Zhu WB, Yang LY, Lan L, Chen Y, Zhou JF, Wang J, Su YQ.
Int J Mol Med 31(2):467-70. doi: 10.3892/ijmm.2012.1223. Epub 2012 Dec 24. 2013
13DUOX1, DUOX2, DUOXA1, DUOXA2, IL13, IL4
Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.
Raad H, Eskalli Z, Corvilain B, Miot F, De Deken X.
Free Radic Biol Med 56:216-25. doi: 10.1016/j.freeradbiomed.2012.09.003. Epub 2012 Sep 23. 2013
14DUOX2, DUOXA2
Dual oxidase 2 bidirectional promoter polymorphisms confer differential immune responses in airway epithelia.
Xu C, Linderholm A, Grasberger H, Harper RW.
Am J Respir Cell Mol Biol 47(4):484-90. doi: 10.1165/rcmb.2012-0037OC. Epub 2012 May 16. 2012
15DUOX1, DUOX2, DUOXA1, DUOXA2
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, Knaus UG.
J Cell Sci 122(Pt 8):1238-47. doi: 10.1242/jcs.044123. 2009
16DUOXA2, HTDI2
Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism.
Zamproni I, Grasberger H, Cortinovis F, Vigone MC, Chiumello G, Mora S, Onigata K, Fugazzola L, Refetoff S, Persani L, Weber G.
J Clin Endocrinol Metab 93(2):605-10. Epub 2007 Nov 27. 2008
17DUOXA2,DUOX2
Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.
Grasberger H, De Deken X, Miot F, Pohlenz J, Refetoff S.
Mol Endocrinol 21(6):1408-21. Epub 2007 Mar 20. 2007
18DUOX1, DUOX2, DUOXA1, DUOXA2
Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.
Grasberger H, Refetoff S.
J Biol Chem 281(27):18269-72. Epub 2006 May 1. 2006