1 | DUOXA2
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| Defects in protein folding in congenital hypothyroidism.
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| Targovnik HM, Scheps KG, Rivolta CM.
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| Mol Cell Endocrinol 501:110638. doi: 10.1016/j.mce.2019.110638. Epub 2019 Nov 18. Review.
2020
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2 | DUOX1, DUOX2, DUOXA1, DUOXA2
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| The Dual Oxidase Duox2 stabilized with DuoxA2 in an enzymatic complex at the surface of the cell produces extracellular H2O2 able to induce DNA damage in an inducible cellular model.
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| Poncelet L, Dumont JE, Miot F, De Deken X.
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| Exp Cell Res 384(1):111620. doi: 10.1016/j.yexcr.2019.111620. Epub 2019 Sep 9.
2019
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3 | DUOX2, DUOXA2, HTDI1
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| DUOX Defects and Their Roles in Congenital Hypothyroidism.
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| De Deken X, Miot F.
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| Methods Mol Biol 1982:667-693. doi: 10.1007/978-1-4939-9424-3_37. Review.
2019
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4 | DUOX2, DUOXA2, HTDI1, HTDI2
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| DUOX2/DUOXA2 Mutations Frequently Cause Congenital Hypothyroidism that Evades Detection on Newborn Screening in the United Kingdom.
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| Peters C, Nicholas AK, Schoenmakers E, Lyons G, Langham S, Serra EG, Sebire NJ, Muzza M, Fugazzola L, Schoenmakers N.
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| Thyroid 29(6):790-801. doi: 10.1089/thy.2018.0587.
2019
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5 | DUOX2, DUOXA2, HTDI1, HTDI2
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| Mutational Spectrum Analysis of Seven Genes Associated with Thyroid Dyshormonogenesis.
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| Chen X, Kong X, Zhu J, Zhang T, Li Y, Ding G, Wang H.
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| Int J Endocrinol 2018:8986475. doi: 10.1155/2018/8986475. eCollection 2018.
2018
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6 | DUOXA2, HTDI2
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| Fetal Goitrous Hypothyroidism and Polyhydramnios in a Patient with Compound Heterozygous DUOXA2 Mutations.
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| Tanase-Nakao K, Miyata I, Terauchi A, Saito M, Wada S, Hasegawa T, Narumi S.
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| Horm Res Paediatr 90(2):132-137. doi: 10.1159/000491104. Epub 2018 Aug 15.
2018
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7 | DUOX1, DUOX2, DUOXA1, DUOXA2
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| Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.
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| Louzada RA, Corre R, Ameziane-El-Hassani R, Hecht F, Cazarin J, Buffet C, Carvalho DP, Dupuy C.
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| Thyroid 28(8):1052-1062. doi: 10.1089/thy.2017.0596. Epub 2018 Jul 24.
2018
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8 | DUOX2, DUOXA2, HTDI1, HTDI2
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| Heterozygous Mutations of the DUOXA2 and DUOX2 Genes in Dizygotic Twins with Congenital Hypothyroidism.
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| Yang LX, Ma SG, Qiu YL, Zheng X.
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| Clin Lab 62(5):849-54.
2016
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9 | DUOX2, DUOXA2
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| When an Intramolecular Disulfide Bridge Governs the Interaction of DUOX2 with Its Partner DUOXA2.
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| Carré A, Louzada RA, Fortunato RS, Ameziane-El-Hassani R, Morand S, Ogryzko V, de Carvalho DP, Grasberger H, Leto TL, Dupuy C.
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| Antioxid Redox Signal 23(9):724-33. doi: 10.1089/ars.2015.6265. Epub 2015 Apr 20.
2015
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10 | DUOXA2, HTDI2
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| A novel missense mutation (I26M) in DUOXA2 causing congenital goiter hypothyroidism impairs NADPH oxidase activity but not protein expression.
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| Liu S, Liu L, Niu X, Lu D, Xia H, Yan S.
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| J Clin Endocrinol Metab 100(4):1225-9. doi: 10.1210/jc.2014-3964. Epub 2015 Feb 12.
2015
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11 | DUOX2, DUOXA2
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| DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.
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| MacFie TS, Poulsom R, Parker A, Warnes G, Boitsova T, Nijhuis A, Suraweera N, Poehlmann A, Szary J, Feakins R, Jeffery R, Harper RW, Jubb AM, Lindsay JO, Silver A.
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| Inflamm Bowel Dis 20(3):514-24. doi: 10.1097/01.MIB.0000442012.45038.0e. Erratum in: Inflamm Bowel Dis. 2014 Apr;20(4):775.
2014
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12 | DUOXA2, HTDI2
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| A novel dual oxidase maturation factor 2 gene mutation for congenital hypothyroidism.
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| Yi RH, Zhu WB, Yang LY, Lan L, Chen Y, Zhou JF, Wang J, Su YQ.
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| Int J Mol Med 31(2):467-70. doi: 10.3892/ijmm.2012.1223. Epub 2012 Dec 24.
2013
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13 | DUOX1, DUOX2, DUOXA1, DUOXA2, IL13, IL4
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| Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.
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| Raad H, Eskalli Z, Corvilain B, Miot F, De Deken X.
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| Free Radic Biol Med 56:216-25. doi: 10.1016/j.freeradbiomed.2012.09.003. Epub 2012 Sep 23.
2013
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14 | DUOX2, DUOXA2
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| Dual oxidase 2 bidirectional promoter polymorphisms confer differential immune responses in airway epithelia.
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| Xu C, Linderholm A, Grasberger H, Harper RW.
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| Am J Respir Cell Mol Biol 47(4):484-90. doi: 10.1165/rcmb.2012-0037OC. Epub 2012 May 16.
2012
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15 | DUOX1, DUOX2, DUOXA1, DUOXA2
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| Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
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| Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, Knaus UG.
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| J Cell Sci 122(Pt 8):1238-47. doi: 10.1242/jcs.044123.
2009
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16 | DUOXA2, HTDI2
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| Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism.
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| Zamproni I, Grasberger H, Cortinovis F, Vigone MC, Chiumello G, Mora S, Onigata K, Fugazzola L, Refetoff S, Persani L, Weber G.
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| J Clin Endocrinol Metab 93(2):605-10. Epub 2007 Nov 27. 2008
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17 | DUOXA2,DUOX2
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| Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.
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| Grasberger H, De Deken X, Miot F, Pohlenz J, Refetoff S.
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| Mol Endocrinol 21(6):1408-21. Epub 2007 Mar 20. 2007
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18 | DUOX1, DUOX2, DUOXA1, DUOXA2
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| Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.
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| Grasberger H, Refetoff S.
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| J Biol Chem 281(27):18269-72. Epub 2006 May 1. 2006
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