Citations for
1DUOX1, DUOX2, DUOXA1, DUOXA2
The Dual Oxidase Duox2 stabilized with DuoxA2 in an enzymatic complex at the surface of the cell produces extracellular H2O2 able to induce DNA damage in an inducible cellular model.
Poncelet L, Dumont JE, Miot F, De Deken X.
Exp Cell Res 384(1):111620. doi: 10.1016/j.yexcr.2019.111620. Epub 2019 Sep 9. 2019
2DUOX1, DUOXA1, HTDI3
Identification of Two Missense Mutations in DUOX1 (p.R1307Q) and DUOXA1 (p.R56W) That Can Cause Congenital Hypothyroidism Through Impairing H2O2 Generation.
Liu S, Han W, Zang Y, Zang H, Wang F, Jiang P, Wei H, Liu X, Wang Y, Ma X, Ge Y.
Front Endocrinol (Lausanne) 10:526. doi: 10.3389/fendo.2019.00526. eCollection 2019. 2019
3DUOX1, iL4
Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.
Sugamata R, Donko A, Murakami Y, Boudreau HE, Qi CF, Kwon J, Leto TL.
J Immunol 202(2):428-440. doi: 10.4049/jimmunol.1601395. Epub 2018 Dec 17. 2019
4DUOX1, DUOX2, DUOXA1, DUOXA2
Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.
Louzada RA, Corre R, Ameziane-El-Hassani R, Hecht F, Cazarin J, Buffet C, Carvalho DP, Dupuy C.
Thyroid 28(8):1052-1062. doi: 10.1089/thy.2017.0596. Epub 2018 Jul 24. 2018
5DUOX1
DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress.
Fortunato RS, Gomes LR, Munford V, Pessoa CF, Quinet A, Hecht F, Kajitani GS, Milito CB, Carvalho DP, Menck CFM.
Oxid Med Cell Longev 2018:3570526. doi: 10.1155/2018/3570526. eCollection 2018. 2018
6DUOX1, IL13
Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation.
Dickinson JD, Sweeter JM, Warren KJ, Ahmad IM, De Deken X, Zimmerman MC, Brody SL.
Redox Biol 14:272-284. doi: 10.1016/j.redox.2017.09.013. Epub 2017 Sep 22. 2018
7DUOX1, DUOX2, NOX4, PDGFA
Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.
Tyurin-Kuzmin PA, Zhdanovskaya ND, Sukhova AA, Sagaradze GD, Albert EA, Ageeva LV, Sharonov GV, Vorotnikov AV, Tkachuk VA.
PLoS One 11(4):e0154157. doi: 10.1371/journal.pone.0154157. eCollection 2016. 2016
8CYBB, DUOX1
The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling.
Heppner DE, Hristova M, Dustin CM, Danyal K, Habibovic A, van der Vliet A.
J Biol Chem 291(44):23282-23293. Epub 2016 Sep 20. 2016
9DUOX1
Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1.
Sirokmány G, Pató A, Zana M, Donkó Á, Bíró A, Nagy P, Geiszt M.
Free Radic Biol Med 97:204-211. doi: 10.1016/j.freeradbiomed.2016.05.028. Epub 2016 Jun 1. 2016
10DUOX1
Dual oxidase 1: A predictive tool for the prognosis of hepatocellular carcinoma patients.
Chen S, Ling Q, Yu K, Huang C, Li N, Zheng J, Bao S, Cheng Q, Zhu M, Chen M.
Oncol Rep 35(6):3198-208. doi: 10.3892/or.2016.4745. Epub 2016 Apr 14. 2016
11DUOX1
NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation.
Ameziane-El-Hassani R, Talbot M, de Souza Dos Santos MC, Al Ghuzlan A, Hartl D, Bidart JM, De Deken X, Miot F, Diallo I, de Vathaire F, Schlumberger M, Dupuy C.
Proc Natl Acad Sci U S A 112(16):5051-6. doi: 10.1073/pnas.1420707112. Epub 2015 Apr 6. 2015
12DUOX1, GPRC6A
Testosterone stimulates Duox1 activity through GPRC6A in skin keratinocytes.
Ko E, Choi H, Kim B, Kim M, Park KN, Bae IH, Sung YK, Lee TR, Shin DW, Bae YS.
J Biol Chem 289(42):28835-45. doi: 10.1074/jbc.M114.583450. Epub 2014 Aug 27. 2014
13DUOX1
Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells.
Hristova M, Veith C, Habibovic A, Lam YW, Deng B, Geiszt M, Janssen-Heininger YM, van der Vliet A.
Redox Biol 2:436-46. doi: 10.1016/j.redox.2013.12.030. eCollection 2014. 2014
14DUOX1, DUOX2
Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.
De Deken X, Corvilain B, Dumont JE, Miot F.
Antioxid Redox Signal 20(17):2776-93. doi: 10.1089/ars.2013.5602. Epub 2013 Oct 25. Review. 2014
15DUOX1, DUOX2, DUOXA1, DUOXA2, IL13, IL4
Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.
Raad H, Eskalli Z, Corvilain B, Miot F, De Deken X.
Free Radic Biol Med 56:216-25. doi: 10.1016/j.freeradbiomed.2012.09.003. Epub 2012 Sep 23. 2013
16DUOX1, DUOX2, DUOXA1
Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.
Meitzler JL, Hinde S, Bánfi B, Nauseef WM, Ortiz de Montellano PR.
J Biol Chem 288(10):7147-57. doi: 10.1074/jbc.M112.414797. Epub 2013 Jan 28. 2013
17DUOX1, IL13, IL4
Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes.
Hirakawa S, Saito R, Ohara H, Okuyama R, Aiba S.
J Immunol 186(8):4762-70. doi: 10.4049/jimmunol.1000791. Epub 2011 Mar 16. 2011
18DUOX1, DUOX2, TPO
Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membrane.
Fortunato RS, Lima de Souza EC, Ameziane-el Hassani R, Boufraqech M, Weyemi U, Talbot M, Lagente-Chevallier O, de Carvalho DP, Bidart JM, Schlumberger M, Dupuy C.
J Clin Endocrinol Metab 95(12):5403-11. Epub 2010 Sep 8. 2010
19DUOX1, DUOX2, TPO
Association of duoxes with thyroid peroxidase and its regulation in thyrocytes.
Song Y, Ruf J, Lothaire P, Dequanter D, Andry G, Willemse E, Dumont JE, Van Sande J, De Deken X.
J Clin Endocrinol Metab 95(1):375-82. Epub 2009 Dec 1. 2010
20DUOX1
ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli.
Boots AW, Hristova M, Kasahara DI, Haenen GR, Bast A, van der Vliet A.
J Biol Chem 284(26):17858-67. Epub 2009 Apr 21. 2009
21DUOX1
Caenorhabditis elegans and human dual oxidase 1 (DUOX1) "peroxidase" domains: insights into heme binding and catalytic activity.
Meitzler JL, Ortiz de Montellano PR.
J Biol Chem 284(28):18634-43. Epub 2009 May 21.PMID: 19460756 2009
22DUOX1, DUOX2
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, Knaus UG.
J Cell Sci 122(Pt 8):1238-47.PMID: 19339556 2009
23DUOX1, DUOX2
Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.
Rigutto S, Hoste C, Grasberger H, Milenkovic M, Communi D, Dumont JE, Corvilain B, Miot F, De Deken X.
J Biol Chem 284(11):6725-34. Epub 2009 Jan 14.PMID: 19144650 2009
24DUOX1, DUOX2, DUOXA1, DUOXA2
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, Knaus UG.
J Cell Sci 122(Pt 8):1238-47. doi: 10.1242/jcs.044123. 2009
25DUOX1, DUOX2
Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.
Luxen S, Belinsky SA, Knaus UG.
Cancer Res 68(4):1037-45.PMID: 18281478 2008
26DUOX1
Developmental regulation of DUOX1 expression and function in human fetal lung epithelial cells.
Fischer H, Gonzales LK, Kolla V, Schwarzer C, Miot F, Illek B, Ballard PL.
Am J Physiol Lung Cell Mol Physiol 292(6):L1506-14. Epub 2007 Mar 2. 2007
27DUOX1
Developmental regulation of DUOX1 expression and function in human fetal lung epithelial cells.
Fischer H, Gonzales LK, Kolla V, Schwarzer C, Miot F, Illek B, Ballard PL.
Am J Physiol Lung Cell Mol Physiol 292(6):L1506-14. Epub 2007 Mar 2.PMID: 17337509 2007
28DUOX1, DUOX2, DUOXA1, DUOXA2
Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.
Grasberger H, Refetoff S.
J Biol Chem 281(27):18269-72. Epub 2006 May 1. 2006
29DUOX1,DUOX2
Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium.
Harper RW, Xu C, McManus M, Heidersbach A, Eiserich JP.
FEBS Lett 580(22):5150-4. Epub 2006 Sep 1. 2006
30MUC5AC, DUOX1
Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells.
Shao MX, Nadel JA.
Proc Natl Acad Sci U S A 102(3):767-72. Epub 2005 Jan 07. 2005
31DUOX1, DUOX2
Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.
Harper RW, Xu C, Eiserich JP, Chen Y, Kao CY, Thai P, Setiadi H, Wu R.
FEBS Lett 579(21):4911-7. 2005
32DUOX1, TXNDC11
Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.
Wang D, De Deken X, Milenkovic M, Song Y, Pirson I, Dumont JE, Miot F.
J Biol Chem 280(4):3096-103. Epub 2004 Nov 22. 2005
33DUOX1, DUOX2
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F.
J Biol Chem 275(30):23227-33. 2000