| 1 | DUOX1, DUOX2, DUOXA1, DUOXA2
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| The Dual Oxidase Duox2 stabilized with DuoxA2 in an enzymatic complex at the surface of the cell produces extracellular H2O2 able to induce DNA damage in an inducible cellular model.
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| Poncelet L, Dumont JE, Miot F, De Deken X.
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| Exp Cell Res 384(1):111620. doi: 10.1016/j.yexcr.2019.111620. Epub 2019 Sep 9.
2019
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| 2 | DUOX1, DUOXA1, HTDI3
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| Identification of Two Missense Mutations in DUOX1 (p.R1307Q) and DUOXA1 (p.R56W) That Can Cause Congenital Hypothyroidism Through Impairing H2O2 Generation.
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| Liu S, Han W, Zang Y, Zang H, Wang F, Jiang P, Wei H, Liu X, Wang Y, Ma X, Ge Y.
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| Front Endocrinol (Lausanne) 10:526. doi: 10.3389/fendo.2019.00526. eCollection 2019. 2019
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| 3 | DUOX1, iL4
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| Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.
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| Sugamata R, Donko A, Murakami Y, Boudreau HE, Qi CF, Kwon J, Leto TL.
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| J Immunol 202(2):428-440. doi: 10.4049/jimmunol.1601395. Epub 2018 Dec 17.
2019
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| 4 | DUOX1, DUOX2, DUOXA1, DUOXA2
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| Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.
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| Louzada RA, Corre R, Ameziane-El-Hassani R, Hecht F, Cazarin J, Buffet C, Carvalho DP, Dupuy C.
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| Thyroid 28(8):1052-1062. doi: 10.1089/thy.2017.0596. Epub 2018 Jul 24.
2018
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| 5 | DUOX1
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| DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress.
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| Fortunato RS, Gomes LR, Munford V, Pessoa CF, Quinet A, Hecht F, Kajitani GS, Milito CB, Carvalho DP, Menck CFM.
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| Oxid Med Cell Longev 2018:3570526. doi: 10.1155/2018/3570526. eCollection 2018.
2018
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| 6 | DUOX1, IL13
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| Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation.
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| Dickinson JD, Sweeter JM, Warren KJ, Ahmad IM, De Deken X, Zimmerman MC, Brody SL.
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| Redox Biol 14:272-284. doi: 10.1016/j.redox.2017.09.013. Epub 2017 Sep 22.
2018
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| 7 | DUOX1, DUOX2, NOX4, PDGFA
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| Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.
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| Tyurin-Kuzmin PA, Zhdanovskaya ND, Sukhova AA, Sagaradze GD, Albert EA, Ageeva LV, Sharonov GV, Vorotnikov AV, Tkachuk VA.
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| PLoS One 11(4):e0154157. doi: 10.1371/journal.pone.0154157. eCollection 2016. 2016
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| 8 | CYBB, DUOX1
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| The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling.
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| Heppner DE, Hristova M, Dustin CM, Danyal K, Habibovic A, van der Vliet A.
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| J Biol Chem 291(44):23282-23293. Epub 2016 Sep 20.
2016
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| 9 | DUOX1
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| Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1.
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| Sirokmány G, Pató A, Zana M, Donkó Á, Bíró A, Nagy P, Geiszt M.
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| Free Radic Biol Med 97:204-211. doi: 10.1016/j.freeradbiomed.2016.05.028. Epub 2016 Jun 1.
2016
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| 10 | DUOX1
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| Dual oxidase 1: A predictive tool for the prognosis of hepatocellular carcinoma patients.
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| Chen S, Ling Q, Yu K, Huang C, Li N, Zheng J, Bao S, Cheng Q, Zhu M, Chen M.
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| Oncol Rep 35(6):3198-208. doi: 10.3892/or.2016.4745. Epub 2016 Apr 14.
2016
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| 11 | DUOX1
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| NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation.
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| Ameziane-El-Hassani R, Talbot M, de Souza Dos Santos MC, Al Ghuzlan A, Hartl D, Bidart JM, De Deken X, Miot F, Diallo I, de Vathaire F, Schlumberger M, Dupuy C.
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| Proc Natl Acad Sci U S A 112(16):5051-6. doi: 10.1073/pnas.1420707112. Epub 2015 Apr 6.
2015
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| 12 | DUOX1, GPRC6A
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| Testosterone stimulates Duox1 activity through GPRC6A in skin keratinocytes.
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| Ko E, Choi H, Kim B, Kim M, Park KN, Bae IH, Sung YK, Lee TR, Shin DW, Bae YS.
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| J Biol Chem 289(42):28835-45. doi: 10.1074/jbc.M114.583450. Epub 2014 Aug 27.
2014
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| 13 | DUOX1
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| Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells.
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| Hristova M, Veith C, Habibovic A, Lam YW, Deng B, Geiszt M, Janssen-Heininger YM, van der Vliet A.
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| Redox Biol 2:436-46. doi: 10.1016/j.redox.2013.12.030. eCollection 2014.
2014
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| 14 | DUOX1, DUOX2
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| Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling.
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| De Deken X, Corvilain B, Dumont JE, Miot F.
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| Antioxid Redox Signal 20(17):2776-93. doi: 10.1089/ars.2013.5602. Epub 2013 Oct 25. Review.
2014
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| 15 | DUOX1, DUOX2, DUOXA1, DUOXA2, IL13, IL4
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| Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2.
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| Raad H, Eskalli Z, Corvilain B, Miot F, De Deken X.
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| Free Radic Biol Med 56:216-25. doi: 10.1016/j.freeradbiomed.2012.09.003. Epub 2012 Sep 23.
2013
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| 16 | DUOX1, DUOX2, DUOXA1
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| Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins.
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| Meitzler JL, Hinde S, Bánfi B, Nauseef WM, Ortiz de Montellano PR.
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| J Biol Chem 288(10):7147-57. doi: 10.1074/jbc.M112.414797. Epub 2013 Jan 28.
2013
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| 17 | DUOX1, IL13, IL4
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| Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes.
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| Hirakawa S, Saito R, Ohara H, Okuyama R, Aiba S.
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| J Immunol 186(8):4762-70. doi: 10.4049/jimmunol.1000791. Epub 2011 Mar 16.
2011
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| 18 | DUOX1, DUOX2, TPO
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| Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membrane.
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| Fortunato RS, Lima de Souza EC, Ameziane-el Hassani R, Boufraqech M, Weyemi U, Talbot M, Lagente-Chevallier O, de Carvalho DP, Bidart JM, Schlumberger M, Dupuy C.
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| J Clin Endocrinol Metab 95(12):5403-11. Epub 2010 Sep 8.
2010
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| 19 | DUOX1, DUOX2, TPO
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| Association of duoxes with thyroid peroxidase and its regulation in thyrocytes.
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| Song Y, Ruf J, Lothaire P, Dequanter D, Andry G, Willemse E, Dumont JE, Van Sande J, De Deken X.
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| J Clin Endocrinol Metab 95(1):375-82. Epub 2009 Dec 1.
2010
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| 20 | DUOX1
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| ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli.
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| Boots AW, Hristova M, Kasahara DI, Haenen GR, Bast A, van der Vliet A.
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| J Biol Chem 284(26):17858-67. Epub 2009 Apr 21.
2009
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| 21 | DUOX1
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| Caenorhabditis elegans and human dual oxidase 1 (DUOX1) "peroxidase" domains: insights into heme binding and catalytic activity.
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| Meitzler JL, Ortiz de Montellano PR.
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| J Biol Chem 284(28):18634-43. Epub 2009 May 21.PMID: 19460756 2009
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| 22 | DUOX1, DUOX2
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| Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
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| Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, Knaus UG.
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| J Cell Sci 122(Pt 8):1238-47.PMID: 19339556 2009
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| 23 | DUOX1, DUOX2
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| Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation.
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| Rigutto S, Hoste C, Grasberger H, Milenkovic M, Communi D, Dumont JE, Corvilain B, Miot F, De Deken X.
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| J Biol Chem 284(11):6725-34. Epub 2009 Jan 14.PMID: 19144650 2009
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| 24 | DUOX1, DUOX2, DUOXA1, DUOXA2
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| Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
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| Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, Knaus UG.
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| J Cell Sci 122(Pt 8):1238-47. doi: 10.1242/jcs.044123.
2009
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| 25 | DUOX1, DUOX2
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| Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.
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| Luxen S, Belinsky SA, Knaus UG.
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| Cancer Res 68(4):1037-45.PMID: 18281478 2008
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| 26 | DUOX1
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| Developmental regulation of DUOX1 expression and function in human fetal lung epithelial cells.
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| Fischer H, Gonzales LK, Kolla V, Schwarzer C, Miot F, Illek B, Ballard PL.
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| Am J Physiol Lung Cell Mol Physiol 292(6):L1506-14. Epub 2007 Mar 2. 2007
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| 27 | DUOX1
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| Developmental regulation of DUOX1 expression and function in human fetal lung epithelial cells.
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| Fischer H, Gonzales LK, Kolla V, Schwarzer C, Miot F, Illek B, Ballard PL.
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| Am J Physiol Lung Cell Mol Physiol 292(6):L1506-14. Epub 2007 Mar 2.PMID: 17337509 2007
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| 28 | DUOX1, DUOX2, DUOXA1, DUOXA2
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| Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.
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| Grasberger H, Refetoff S.
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| J Biol Chem 281(27):18269-72. Epub 2006 May 1. 2006
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| 29 | DUOX1,DUOX2
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| Duox2 exhibits potent heme peroxidase activity in human respiratory tract epithelium.
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| Harper RW, Xu C, McManus M, Heidersbach A, Eiserich JP.
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| FEBS Lett 580(22):5150-4. Epub 2006 Sep 1. 2006
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| 30 | MUC5AC, DUOX1
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| Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells.
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| Shao MX, Nadel JA.
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| Proc Natl Acad Sci U S A 102(3):767-72. Epub 2005 Jan 07. 2005
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| 31 | DUOX1, DUOX2
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| Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.
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| Harper RW, Xu C, Eiserich JP, Chen Y, Kao CY, Thai P, Setiadi H, Wu R.
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| FEBS Lett 579(21):4911-7. 2005
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| 32 | DUOX1, TXNDC11
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| Identification of a novel partner of duox: EFP1, a thioredoxin-related protein.
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| Wang D, De Deken X, Milenkovic M, Song Y, Pirson I, Dumont JE, Miot F.
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| J Biol Chem 280(4):3096-103. Epub 2004 Nov 22. 2005
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| 33 | DUOX1, DUOX2
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| Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
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| De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F.
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| J Biol Chem 275(30):23227-33. 2000
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