1 | CHEK1, DTL
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| CRL4(CDT2) targets CHK1 for PCNA-independent destruction.
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| Huh J, Piwnica-Worms H.
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| Mol Cell Biol 33(2):213-26. doi: 10.1128/MCB.00847-12. Epub 2012 Oct 29.
2013
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2 | DTL, FBXO11
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| Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase.
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| Rossi M, Duan S, Jeong YT, Horn M, Saraf A, Florens L, Washburn MP, Antebi A, Pagano M.
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| Mol Cell 49(6):1159-66. doi: 10.1016/j.molcel.2013.02.004. Epub 2013 Mar 7.
2013
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3 | DTL, FBXO11
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| CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.
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| Abbas T, Mueller AC, Shibata E, Keaton M, Rossi M, Dutta A.
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| Mol Cell 49(6):1147-58. doi: 10.1016/j.molcel.2013.02.003. Epub 2013 Mar 7.
2013
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4 | DTL, FBXO11
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| Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.
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| Abbas T, Keaton M, Dutta A.
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| Cell Cycle 12(14):2175-82. doi: 10.4161/cc.25314.
2013
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5 | CUL4A, DTL
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| Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.
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| Sertic S, Evolvi C, Tumini E, Plevani P, Muzi-Falconi M, Rotondo G.
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| PLoS One 8(3):e60000. doi: 10.1371/journal.pone.0060000. Epub 2013 Mar 29.
2013
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6 | ATR, CDT1, DTL
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| Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.
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| Sakaguchi H, Takami T, Yasutani Y, Maeda T, Morino M, Ishii T, Shiomi Y, Nishitani H.
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| PLoS One 7(9):e46480. doi: 10.1371/journal.pone.0046480. Epub 2012 Sep 28.
2012
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7 | DTL, KAT2A, WDHD1
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| The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase.
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| Li Y, Jaramillo-Lambert A, Hao J, Yang Y, Zhu W.
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| J Biol Chem 286(48):41344-52. doi: 10.1074/jbc.M111.290767. Epub 2011 Oct 10.
2011
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8 | DTL
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| Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase.
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| Havens CG, Walter JC.
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| Genes Dev 25(15):1568-82. doi: 10.1101/gad.2068611. Review.
2011
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9 | CDT1, DTL, PCNA
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| A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.
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| Raman M, Havens CG, Walter JC, Harper JW.
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| Mol Cell 44(1):72-84. doi: 10.1016/j.molcel.2011.06.036.
2011
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10 | DTL, SETD8
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| SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.
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| Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS.
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| J Cell Biol 192(1):43-54. doi: 10.1083/jcb.201009076.
2011
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11 | DTL, PCNA, SETD8
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| Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.
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| Oda H, Hübner MR, Beck DB, Vermeulen M, Hurwitz J, Spector DL, Reinberg D.
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| Mol Cell 40(3):364-76. doi: 10.1016/j.molcel.2010.10.011. Epub 2010 Oct 28.
2010
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12 | DTL, SETD8
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| CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.
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| Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L.
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| Mol Cell 40(1):22-33. doi: 10.1016/j.molcel.2010.09.015.
2010
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13 | DTL, SETD8
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| CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.
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| Abbas T, Shibata E, Park J, Jha S, Karnani N, Dutta A.
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| Mol Cell 40(1):9-21. doi: 10.1016/j.molcel.2010.09.014.
2010
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14 | CDT1, DTL, PCNA
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| Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2.
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| Havens CG, Walter JC.
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| Mol Cell 35(1):93-104. doi: 10.1016/j.molcel.2009.05.012.
2009
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15 | DTL
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| Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells.
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| Ueki T, Nishidate T, Park JH, Lin ML, Shimo A, Hirata K, Nakamura Y, Katagiri T.
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| Oncogene 27(43):5672-83. Epub 2008 Jun 9.
2008
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16 | DTL, PCNA
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| PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
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| Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A.
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| Genes Dev 22(18):2496-506. doi: 10.1101/gad.1676108.
2008
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17 | DTL, INTS7
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| Transcriptional regulation of an evolutionary conserved intergenic region of CDT2-INTS7
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| Nakagawa H, Tategu M, Yamauchi R, Sasaki K, Sekimachi S, Yoshida K.
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| PLoS One. Jan 23;3(1):e1484. doi: 10.1371/journal.pone.0001484. 2008
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18 | DTL
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| Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma.
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| Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC.
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| Cell Cycle 5(22):2676-87. Epub 2006 Nov 15.
2006
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19 | CDT1, DTL
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| DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.
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| Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA.
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| Genes Dev 20(22):3117-29. Epub 2006 Nov 3.
2006
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20 | DTL
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| Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation.
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| Cheung WM, Chu AH, Chu PW, Ip NY.
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| J Biol Chem 276(20):17083-91. 2001
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