Citations for
1CHEK1, DTL
CRL4(CDT2) targets CHK1 for PCNA-independent destruction.
Huh J, Piwnica-Worms H.
Mol Cell Biol 33(2):213-26. doi: 10.1128/MCB.00847-12. Epub 2012 Oct 29. 2013
2DTL, FBXO11
Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase.
Rossi M, Duan S, Jeong YT, Horn M, Saraf A, Florens L, Washburn MP, Antebi A, Pagano M.
Mol Cell 49(6):1159-66. doi: 10.1016/j.molcel.2013.02.004. Epub 2013 Mar 7. 2013
3DTL, FBXO11
CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.
Abbas T, Mueller AC, Shibata E, Keaton M, Rossi M, Dutta A.
Mol Cell 49(6):1147-58. doi: 10.1016/j.molcel.2013.02.003. Epub 2013 Mar 7. 2013
4DTL, FBXO11
Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.
Abbas T, Keaton M, Dutta A.
Cell Cycle 12(14):2175-82. doi: 10.4161/cc.25314. 2013
5CUL4A, DTL
Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.
Sertic S, Evolvi C, Tumini E, Plevani P, Muzi-Falconi M, Rotondo G.
PLoS One 8(3):e60000. doi: 10.1371/journal.pone.0060000. Epub 2013 Mar 29. 2013
6ATR, CDT1, DTL
Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.
Sakaguchi H, Takami T, Yasutani Y, Maeda T, Morino M, Ishii T, Shiomi Y, Nishitani H.
PLoS One 7(9):e46480. doi: 10.1371/journal.pone.0046480. Epub 2012 Sep 28. 2012
7DTL, KAT2A, WDHD1
The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase.
Li Y, Jaramillo-Lambert A, Hao J, Yang Y, Zhu W.
J Biol Chem 286(48):41344-52. doi: 10.1074/jbc.M111.290767. Epub 2011 Oct 10. 2011
8DTL
Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase.
Havens CG, Walter JC.
Genes Dev 25(15):1568-82. doi: 10.1101/gad.2068611. Review. 2011
9CDT1, DTL, PCNA
A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.
Raman M, Havens CG, Walter JC, Harper JW.
Mol Cell 44(1):72-84. doi: 10.1016/j.molcel.2011.06.036. 2011
10DTL, SETD8
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation.
Jørgensen S, Eskildsen M, Fugger K, Hansen L, Larsen MS, Kousholt AN, Syljuåsen RG, Trelle MB, Jensen ON, Helin K, Sørensen CS.
J Cell Biol 192(1):43-54. doi: 10.1083/jcb.201009076. 2011
11DTL, PCNA, SETD8
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.
Oda H, Hübner MR, Beck DB, Vermeulen M, Hurwitz J, Spector DL, Reinberg D.
Mol Cell 40(3):364-76. doi: 10.1016/j.molcel.2010.10.011. Epub 2010 Oct 28. 2010
12DTL, SETD8
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.
Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L.
Mol Cell 40(1):22-33. doi: 10.1016/j.molcel.2010.09.015. 2010
13DTL, SETD8
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.
Abbas T, Shibata E, Park J, Jha S, Karnani N, Dutta A.
Mol Cell 40(1):9-21. doi: 10.1016/j.molcel.2010.09.014. 2010
14CDT1, DTL, PCNA
Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2.
Havens CG, Walter JC.
Mol Cell 35(1):93-104. doi: 10.1016/j.molcel.2009.05.012. 2009
15DTL
Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells.
Ueki T, Nishidate T, Park JH, Lin ML, Shimo A, Hirata K, Nakamura Y, Katagiri T.
Oncogene 27(43):5672-83. Epub 2008 Jun 9. 2008
16DTL, PCNA
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A.
Genes Dev 22(18):2496-506. doi: 10.1101/gad.1676108. 2008
17DTL
Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma.
Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC.
Cell Cycle 5(22):2676-87. Epub 2006 Nov 15. 2006
18CDT1, DTL
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.
Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA.
Genes Dev 20(22):3117-29. Epub 2006 Nov 3. 2006
19DTL
Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation.
Cheung WM, Chu AH, Chu PW, Ip NY.
J Biol Chem 276(20):17083-91. 2001