| 1 | DSC2, DSG2
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| Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration.
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| Flemming S, Luissint AC, Kusters DHM, Raya-Sandino A, Fan S, Zhou DW, Hasegawa M, Garcia-Hernandez V, García AJ, Parkos CA, Nusrat A.
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| Mol Biol Cell 31(6):407-418. doi: 10.1091/mbc.E19-12-0692. Epub 2020 Jan 22.
2020
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| 2 | ARVD10, DSG2
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| A founder homozygous DSG2 variant in East Asia results in ARVC with full penetrance and heart failure phenotype.
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| Chen L, Rao M, Chen X, Chen K, Ren J, Zhang N, Zhao Q, Yu W, Yuan B, Song J.
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| Int J Cardiol 274:263-270. doi: 10.1016/j.ijcard.2018.06.105. Epub 2018 Jun 28.
2019
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| 3 | DSG2, MAPK14
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| Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase.
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| Ungewiß H, Vielmuth F, Suzuki ST, Maiser A, Harz H, Leonhardt H, Kugelmann D, Schlegel N, Waschke J.
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| Sci Rep 7(1):6329. doi: 10.1038/s41598-017-06713-y.
2017
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| 4 | DSG2
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| Loss of desmoglein 2 promotes tumorigenic behavior in pancreatic cancer cells.
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| Hütz K, Zeiler J, Sachs L, Ormanns S, Spindler V.
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| Mol Carcinog 56(8):1884-1895. doi: 10.1002/mc.22644. Epub 2017 Mar 30.
2017
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| 5 | CMD1BB, DSG2
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| Disturbed Desmoglein-2 in the intercalated disc of pediatric patients with dilated cardiomyopathy.
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| Kessler EL, Nikkels PG, van Veen TA.
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| Hum Pathol 67:101-108. doi: 10.1016/j.humpath.2017.07.012. Epub 2017 Jul 29.
2017
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| 6 | ARVD10, CMD1BB, DSG2
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| Whole Genome Sequence Identified a Rare Homozygous Pathogenic Mutation of the DSG2 Gene in a Familial Arrhythmogenic Cardiomyopathy Involving Both Ventricles.
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| Lin Y, Zhang Q, Zhong ZA, Xu Z, He S, Rao F, Liu Y, Tang J, Wang F, Liu H, Xie J, Wu H, Wang S, Li X, Shan Z, Deng C, Liao Z, Deng H, Liao H, Xue Y, Chen W, Zhan X, Zhang B, Wu S.
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| Cardiology 138(1):41-54. doi: 10.1159/000462962. Epub 2017 Jun 3.
2017
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| 7 | DSG2
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| Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover.
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| Roberts BJ, Svoboda RA, Overmiller AM, Lewis JD, Kowalczyk AP, Mahoney MG, Johnson KR, Wahl JK 3rd.
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| J Biol Chem 291(48):24857-24865. Epub 2016 Oct 4.
2016
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| 8 | DSG2
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| A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis.
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| Ebert LM, Tan LY, Johan MZ, Min KK, Cockshell MP, Parham KA, Betterman KL, Szeto P, Boyle S, Silva L, Peng A, Zhang Y, Ruszkiewicz A, Zannettino AC, Gronthos S, Koblar S, Harvey NL, Lopez AF, Shackleton M, Bonder CS.
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| Angiogenesis 19(4):463-86. doi: 10.1007/s10456-016-9520-y. Epub 2016 Jun 23.
2016
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| 9 | CMD1BB, DSG2
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| Desmoglein 2-Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function.
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| Kant S, Holthöfer B, Magin TM, Krusche CA, Leube RE.
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| Circ Cardiovasc Genet 8(4):553-63. doi: 10.1161/CIRCGENETICS.114.000974. Epub 2015 Jun 17.
2015
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| 10 | DSG2
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| Cadherin flexibility provides a key difference between desmosomes and adherens junctions.
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| Tariq H, Bella J, Jowitt TA, Holmes DF, Rouhi M, Nie Z, Baldock C, Garrod D, Tabernero L.
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| Proc Natl Acad Sci U S A 112(17):5395-400. doi: 10.1073/pnas.1420508112. Epub 2015 Apr 8.
2015
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| 11 | DSG2, LGALS3
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| Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion.
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| Jiang K, Rankin CR, Nava P, Sumagin R, Kamekura R, Stowell SR, Feng M, Parkos CA, Nusrat A.
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| J Biol Chem 289(15):10510-7. doi: 10.1074/jbc.M113.538538. Epub 2014 Feb 24.
2014
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| 12 | DSG2
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| Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function.
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| Schlipp A, Schinner C, Spindler V, Vielmuth F, Gehmlich K, Syrris P, Mckenna WJ, Dendorfer A, Hartlieb E, Waschke J.
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| Cardiovasc Res 104(2):245-57. doi: 10.1093/cvr/cvu206. Epub 2014 Sep 11.
2014
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| 13 | CDH1, DSG2, SNAI1
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| The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells.
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| Kume K, Haraguchi M, Hijioka H, Ishida T, Miyawaki A, Nakamura N, Ozawa M.
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| Biochem Biophys Res Commun 430(3):889-94. doi: 10.1016/j.bbrc.2012.12.060. Epub 2012 Dec 20.
2013
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| 14 | DSC2, DSG2
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| Loss of the desmosomal cadherin desmoglein-2 suppresses colon cancer cell proliferation through EGFR signaling.
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| Kamekura R, Kolegraff KN, Nava P, Hilgarth RS, Feng M, Parkos CA, Nusrat A.
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| Oncogene ncogene. 2013 Oct 28. doi: 10.1038/onc.2013.442. [Epub ahead of print]
2013
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| 15 | ARVD10, DSG2
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| Desmosomal cadherins are decreased in explanted arrhythmogenic right ventricular dysplasia/cardiomyopathy patient hearts.
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| Vite A, Gandjbakhch E, Prost C, Fressart V, Fouret P, Neyroud N, Gary F, Donal E, Varnous S, Fontaine G, Fornes P, Hidden-Lucet F, Komajda M, Charron P, Villard E.
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| PLoS One 8(9):e75082. doi: 10.1371/journal.pone.0075082. eCollection 2013.
2013
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| 16 | DSG2, DSG3
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| Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion.
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| Hartlieb E, Kempf B, Partilla M, Vigh B, Spindler V, Waschke J.
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| PLoS One 8(1):e53739. doi: 10.1371/journal.pone.0053739. Epub 2013 Jan 11.
2013
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| 17 | CAV1, DSG2
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| A role for caveolin-1 in desmoglein binding and desmosome dynamics.
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| Brennan D, Peltonen S, Dowling A, Medhat W, Green KJ, Wahl JK 3rd, Del Galdo F, Mahoney MG.
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| Oncogene 31(13):1636-48. doi: 10.1038/onc.2011.346. Epub 2011 Aug 15.
2012
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| 18 | DSG2
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| The C-terminal unique region of desmoglein 2 inhibits its internalization via tail-tail interactions.
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| Chen J, Nekrasova OE, Patel DM, Klessner JL, Godsel LM, Koetsier JL, Amargo EV, Desai BV, Green KJ.
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| J Cell Biol 199(4):699-711. doi: 10.1083/jcb.201202105. Epub 2012 Nov 5.
2012
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| 19 | DSG2
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| Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.
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| Wang H, Li ZY, Liu Y, Persson J, Beyer I, Möller T, Koyuncu D, Drescher MR, Strauss R, Zhang XB, Wahl JK 3rd, Urban N, Drescher C, Hemminki A, Fender P, Lieber A.
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| Nat Med 17(1):96-104. Epub 2010 Dec 12.
2011
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| 20 | DSC2, DSG2
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| Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes.
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| Nekrasova OE, Amargo EV, Smith WO, Chen J, Kreitzer GE, Green KJ.
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| J Cell Biol 195(7):1185-203. doi: 10.1083/jcb.201106057. Epub 2011 Dec 19. Erratum in: J Cell Biol. 2013 Jun 24;201(7):1085. J Cell Biol. 20 2011
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| 21 | ARVD10, DSG2
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| Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia.
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| Barahona-Dussault C, Benito B, Campuzano O, Iglesias A, Leung TL, Robb L, Talajic M, Brugada R.
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| Clin Genet 77(1):37-48. Epub 2009 Oct 15.PMID: 19863551 2010
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| 22 | ARVD10, ARVD8, ARVD9, ARVDPPK, DSC2, DSG2, DSP, JUP, PKP
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| Wide spectrum of desmosomal mutations in Danish patients with arrhythmogenic right ventricular cardiomyopathy.
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| Christensen AH, Benn M, Bundgaard H, Tybjaerg-Hansen A, Haunso S, Svendsen JH.
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| J Med Genet 47(11):736-44. Epub 2010 Sep 23.
2010
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| 23 | DSG2
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| Desmoglein 2-mediated adhesion is required for intestinal epithelial barrier integrity.
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| Schlegel N, Meir M, Heupel WM, Holthöfer B, Leube RE, Waschke J.
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| Am J Physiol Gastrointest Liver Physiol 298(5):G774-83. doi: 10.1152/ajpgi.00239.2009. Epub 2010 Mar 11.
2010
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| 24 | DSG2
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| Increased expression of Dsg2 in malignant skin carcinomas: A tissue-microarray based study.
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| Brennan D, Mahoney MG.
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| Cell Adh Migr 3(2):148-54. Epub 2009 Apr 4.PMID: 19458482 2009
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| 25 | DSG2
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| A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy.
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| Posch MG, Posch MJ, Geier C, Erdmann B, Mueller W, Richter A, Ruppert V, Pankuweit S, Maisch B, Perrot A, Buttgereit J, Dietz R, Haverkamp W, Ozcelik C.
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| Mol Genet Metab 95(1-2):74-80. Epub 2008 Aug 3.
2008
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| 26 | CASP3, DSG2
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| The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery.
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| Cirillo N, Lanza M, De Rosa A, Cammarota M, La Gatta A, Gombos F, Lanza A.
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| J Cell Biochem 103(2):598-606.PMID: 17559062 2008
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| 27 | DSG2
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| Desmoglein-2: a novel regulator of apoptosis in the intestinal epithelium.
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| Nava P, Laukoetter MG, Hopkins AM, Laur O, Gerner-Smidt K, Green KJ, Parkos CA, Nusrat A.
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| Mol Biol Cell 18(11):4565-78. Epub 2007 Sep 5.PMID: 17804817 2007
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| 28 | ARVD10, DSG2
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| Desmoglein-2 mutations in arrhythmogenic right ventricular cardiomyopathy: a genotype-phenotype characterization of familial disease.
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| Syrris P, Ward D, Asimaki A, Evans A, Sen-Chowdhry S, Hughes SE, McKenna WJ.
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| Eur Heart J 28(5):581-8. Epub 2006 Nov 14.PMID: 17105751 2007
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| 29 | DSG2, ARVD10
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| DSG2 Mutations Contribute to Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy.
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| Awad MM, Dalal D, Cho E, Amat-Alarcon N, James C, Tichnell C, Tucker A, Russell SD, Bluemke DA, Dietz HC, Calkins H, Judge DP.
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| Am J Hum Genet 79(1):136-42. Epub 2006 Apr 28. 2006
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| 30 | DSG2, ARVD10
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| Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy.
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| Pilichou K, Nava A, Basso C, Beffagna G, Bauce B, Lorenzon A, Frigo G, Vettori A, Valente M, Towbin J, Thiene G, Danieli GA, Rampazzo A.
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| Circulation 113(9):1171-9. Epub 2006 Feb 27. 2006
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| 31 | DSC1, DSC2, DSC3, DSG1, DSG2, DSG3
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| A YAC contig joining the desmocollin and desmoglein loci on human chromosome 18 and ordering of the desmocollin genes.
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| Cowley CM, Simrak D, Marsden MD, King IA, Arnemann J, Buxton RS.
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| Genomics 42(2):208-16. 1997
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| 32 | DSG2
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| Immunological identification and characterization of the desmosomal cadherin Dsg2 in coupled and uncoupled epithelial cells and in human tissues.
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| Schäfer S, Stumpp S, Franke WW.
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| Differentiation 60(2):99-108.PMID: 8641550 1996
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| 33 | DSG1, DSG2, DSG3
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| Tandem arrangement of the closely linked desmoglein genes on human chromosome 18.
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| Simrak D, et al.
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| Genomics 25 : 591-594. 1995
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| 34 | DSG2, DSG1, DSG3
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| The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12.
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| Wang Y, et al.
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| Genomics 20 : 492-495. 1994
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| 35 | DSC1, DSC2, DSC3, DSG1, DSG2, DSG3
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| Nomenclature of the desmosomal cadherins.
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| Buxton RS, et al.
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| J Cell Biol 121 : 481-483. 1993
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| 36 | DSG2
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| The human gene (DSG2) coding for HDGC, a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to chromosome 18.
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| Arnemann J, et al.
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| Genomics 13 : 484-486. 1992
|