| 1 | DRD4
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| The interactions among organophosphate pesticide exposure, oxidative stress, and genetic polymorphisms of dopamine receptor D4 increase the risk of attention deficit/hyperactivity disorder in children.
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| Chang CH, Yu CJ, Du JC, Chiou HC, Chen HC, Yang W, Chung MY, Chen YS, Hwang B, Mao IF, Chen ML.
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| Environ Res 160:339-346. doi: 10.1016/j.envres.2017.10.011. Epub 2017 Oct 17.
2018
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| 2 | DRD4
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| Family-based association study of DRD4 gene in methylphenidate-responded Attention Deficit/Hyperactivity Disorder.
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| Leung PW, Chan JK, Chen LH, Lee CC, Hung SF, Ho TP, Tang CP, Moyzis RK, Swanson JM.
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| PLoS One 12(3):e0173748. doi: 10.1371/journal.pone.0173748. eCollection 2017.
2017
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| 3 | ARRB1, ARRB2, DRD4, KLHL12
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| Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins.
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| Skieterska K, Shen A, Clarisse D, Rondou P, Borroto-Escuela DO, Lintermans B, Fuxe K, Xiang YK, Van Craenenbroeck K.
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| Cell Signal 28(8):1001-14. doi: 10.1016/j.cellsig.2016.05.003. Epub 2016 May 5.
2016
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| 4 | DRD4, KLHL12
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| Dopamine D4 receptor ubiquitination.
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| Skieterska K, Rondou P, Van Craenenbroeck K.
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| Biochem Soc Trans 44(2):601-5. doi: 10.1042/BST20150281. Review.
2016
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| 5 | DRD4
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| Palmitoylation of the carboxyl-terminal tail of dopamine D4 receptor is required for surface expression, endocytosis, and signaling.
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| Zhang X, Kim KM.
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| Biochem Biophys Res Commun 479(2):398-403. doi: 10.1016/j.bbrc.2016.09.094. Epub 2016 Sep 20.
2016
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| 6 | DRD4
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| Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males.
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| Ji H, Wang Y, Jiang D, Liu G, Xu X, Dai D, Zhou X, Cui W, Li J, Chen Z, Li Y, Zhou D, Zha Q, Zhuo R, Jiang L, Liu Y, Shen L, Zhang B, Xu L, Hu H, Zhang Y, Yin H, Duan S, Wang Q.
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| Mol Med Rep 14(3):2732-8. doi: 10.3892/mmr.2016.5560. Epub 2016 Jul 27.
2016
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| 7 | DRD4, KLHL12
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| KLHL12 Promotes Non-Lysine Ubiquitination of the Dopamine Receptors D4.2 and D4.4, but Not of the ADHD-Associated D4.7 Variant.
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| Skieterska K, Rondou P, Lintermans B, Van Craenenbroeck K.
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| PLoS One 10(12):e0145654. doi: 10.1371/journal.pone.0145654. eCollection 2015.
2015
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| 8 | DRD4
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| The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age.
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| Wazana A, Moss E, Jolicoeur-Martineau A, Graffi J, Tsabari G, Lecompte V, Pascuzzo K, Babineau V, Gordon-Green C, Mileva V, Atkinson L, Minde K, Bouvette-Turcot AA, Sassi R, St-André M, Carrey N, Matthews S, Sokolowski M, Lydon J, Gaudreau H, Steiner M, Kennedy JL, Fleming A, Levitan R, Meaney MJ.
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| Dev Psychopathol 27(4 Pt 1):1145-61. doi: 10.1017/S0954579415000735.
2015
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| 9 | DRD4
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| Dopamine receptor D4 internalization requires a beta-arrestin and a visual arrestin.
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| Deming JD, Shin JA, Lim K, Lee EJ, Van Craenenbroeck K, Craft CM.
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| Cell Signal 27(10):2002-13. doi: 10.1016/j.cellsig.2015.06.008. Epub 2015 Jul 11.
2015
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| 10 | AGTR1, DRD4
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| Activation of the D4 dopamine receptor attenuates proliferation and migration of vascular smooth muscle cells through downregulation of AT1a receptor expression.
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| Yu C, Chen J, Guan W, Han Y, Wang WE, Wang X, Wang H, Jose PA, Zeng C.
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| Hypertens Res 38(9):588-96. doi: 10.1038/hr.2015.48. Epub 2015 Apr 2.
2015
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| 11 | DRD4
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| Variable number tandem repeats in dopamine receptor D4 in Tourette's syndrome.
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| Liu S, Cui J, Zhang X, Wu W, Niu H, Ma X, Xu H, Yi M.
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| Mov Disord 29(13):1687-91. doi: 10.1002/mds.26027. Epub 2014 Sep 25.
2014
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| 12 | DRD4
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| Dopamine D₄ receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin receptor expression.
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| Yu C, Wang Z, Han Y, Liu Y, Wang WE, Chen C, Wang H, Jose PA, Zeng C.
|
| Cardiovasc Diabetol 13:97. doi: 10.1186/1475-2840-13-97.
2014
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| 13 | DRD4
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| Male-specific association between dopamine receptor D4 gene methylation and schizophrenia.
|
| Cheng J, Wang Y, Zhou K, Wang L, Li J, Zhuang Q, Xu X, Xu L, Zhang K, Dai D, Zheng R, Li G, Zhang A, Gao S, Duan S.
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| PLoS One 9(2):e89128. doi: 10.1371/journal.pone.0089128. eCollection 2014.
2014
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| 14 | DRD4
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| Association between dopamine D4 receptor polymorphism and age related changes in brain glucose metabolism.
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| Volkow ND, Tomasi D, Wang GJ, Telang F, Fowler JS, Goldstein RZ, Klein N, Wong C, Swanson JM, Shumay E.
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| PLoS One 8(5):e63492. doi: 10.1371/journal.pone.0063492. Print 2013.
2013
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| 15 | DRD4
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| DRD4 genotype predicts longevity in mouse and human.
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| Grady DL, Thanos PK, Corrada MM, Barnett JC Jr, Ciobanu V, Shustarovich D, Napoli A, Moyzis AG, Grandy D, Rubinstein M, Wang GJ, Kawas CH, Chen C, Dong Q, Wang E, Volkow ND, Moyzis RK.
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| J Neurosci 33(1):286-91. doi: 10.1523/JNEUROSCI.3515-12.2013.
2013
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| 16 | DRD4
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| Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors.
|
| Andersson RH, Johnston A, Herman PA, Winzer-Serhan UH, Karavanova I, Vullhorst D, Fisahn A, Buonanno A.
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| Proc Natl Acad Sci U S A 109(32):13118-23. doi: 10.1073/pnas.1201011109. Epub 2012 Jul 20.
2012
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| 17 | DRD4
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| Dopamine D₄ receptor activation controls circadian timing of the adenylyl cyclase 1/cyclic AMP signaling system in mouse retina.
|
| Jackson CR, Chaurasia SS, Hwang CK, Iuvone PM.
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| Eur J Neurosci 34(1):57-64. doi: 10.1111/j.1460-9568.2011.07734.x. Epub 2011 Jun 16.
2011
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| 18 | DRD4, KLHL12
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| KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation.
|
| Rondou P, Skieterska K, Packeu A, Lintermans B, Vanhoenacker P, Vauquelin G, Haegeman G, Van Craenenbroeck K.
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| Cell Signal 22(6):900-13. doi: 10.1016/j.cellsig.2010.01.014. Epub 2010 Jan 25.
2010
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| 19 | ADRA2A, CHRNA4, DRD4, DRD5, SLC6A3, SNAP25
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| Candidate gene studies of ADHD: a meta-analytic review.
|
| Gizer IR, Ficks C, Waldman ID.
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| Hum Genet 126(1):51-90. Epub 2009 Jun 9. Review. 2009
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| 20 | DRD4
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| Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia.
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| Hattori E, Nakajima M, Yamada K, Iwayama Y, Toyota T, Saitou N, Yoshikawa T.
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| Eur J Hum Genet 17(6):793-801. Epub 2008 Dec 17.
2009
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| 21 | DRD4
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| Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals.
|
| Lasky-Su J, Lange C, Biederman J, Tsuang M, Doyle AE, Smoller JW, Laird N, Faraone S.
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| Am J Med Genet B Neuropsychiatr Genet 147(1):100-6. 2008
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| 22 | DRD4, KLHL12
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| BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase.
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| Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K.
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| J Biol Chem 283(17):11083-96. Epub 2008 Feb 26. 2008
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| 23 | APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SCZD23, SLC6A4, TP53, TPH1
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| Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
| Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L.
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| Nat Genet 40(7):827-34. 2008
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| 24 | ADHD, COMT, DRD4, SLC6A3
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| An exploratory study of the relationship between four candidate genes and neurocognitive performance in adult ADHD.
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| Boonstra AM, Kooij JJ, Buitelaar JK, Oosterlaan J, Sergeant JA, Heister JG, Franke B.
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| Am J Med Genet B Neuropsychiatr Genet [Epub ahead of print] 2007
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| 25 | DRD4
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| A dopamine D4 receptor exon 3 VNTR allele protecting against migraine without aura.
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| de Sousa SC, Karwautz A, Wöber C, Wagner G, Breen G, Zesch HE, Konrad A, Zormann A, Wanner C, Kienbacher C, Collier DA, Wöber-Bingöl C.
|
| Ann Neurol 61(6):574-8.
2007
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| 26 | PLP1, PMDX, DRD4, DRD5
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| Role of genomic architecture in PLP1 duplication causing Pelizaeus-Merzbacher disease.
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| Lee JA, Inoue K, Cheung SW, Shaw CA, Stankiewicz P, Lupski JR.
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| Hum Mol Genet 15(14):2250-65. Epub 2006 Jun 14. 2006
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| 27 | DRD4
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| Exon 3 polymorphisms of dopamine D4 receptor (DRD4) gene and attention deficit hyperactivity disorder in Chinese children.
|
| Cheuk DK, Li SY, Wong V.
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| Am J Med Genet B Neuropsychiatr Genet 141(8):907-11. 2006
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| 28 | ADHD, DRD4, DRD5, SLC6A3, SLC6A4, SNAP25
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| The genetics of attention deficit hyperactivity disorder.
|
| Thapar A, O'Donovan M, Owen MJ.
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| Hum Mol Genet 14 Spec No. 2:R275-82. 2005
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| 29 | ADHD, DBH, DRD4, DRD5, HTR1B, SLC6A3, SNAP25, TPH2
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| Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.
|
| Hawi Z, Segurado R, Conroy J, Sheehan K, Lowe N, Kirley A, Shields D, Fitzgerald M, Gallagher L, Gill M.
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| Am J Hum Genet 77(6):958-65. Epub 2005 Oct 26. 2005
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| 30 | DRD4
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| Identification and characterization of tandem repeats in exon III of dopamine receptor D4 (DRD4) genes from different mammalian species.
|
| Larsen SA, Mogensen L, Dietz R, Baagoe HJ, Andersen M, Werge T, Rasmussen HB.
|
| DNA Cell Biol 24(12):795-804. 2005
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| 31 | COMT, HT2A, DRD2, DRD4, SLC6A3
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| Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope.
|
| Abdolmaleky HM, Thiagalingam S, Wilcox M.
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| Am J Pharmacogenomics 5(3):149-60. Review. 2005
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| 32 | DYX7, DRD4
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| A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5.
|
| Hsiung GY, Kaplan BJ, Petryshen TL, Lu S, Field LL.
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| Am J Med Genet 125B(1):112-9. 2004
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| 33 | DRD4
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| The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus.
|
| Wang E, Ding YC, Flodman P, Kidd JR, Kidd KK, Grady DL, Ryder OA, Spence MA, Swanson JM, Moyzis RK.
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| Am J Hum Genet 74(5):931-44. Epub 2004 Apr 09. 2004
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| 34 | CLIC6, DRD2, DRD3, DRD4, MPDZ
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| CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors.
|
| Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P.
|
| Brain Res Mol Brain Res 117(1):47-57. 2003
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| 35 | DRD4, PTNS
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| Novelty seeking traits and D4 dopamine receptors.
|
| Swift G, Larsen B, Hawi Z, Gill M.
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| Am J Med Genet 96(2):222-3. No abstract available. 2000
|
| 36 | DRD4
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| Adult attention deficit hyperactivity disorder and the dopamine D4 receptor gene.
|
| Muglia P, Jain U, Macciardi F, Kennedy JL.
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| Am J Med Genet 96(3):273-7. 2000
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| 37 | DRD4
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| A haplotype relative risk study of the dopamine D4 receptor (DRD4) exon III repeat polymorphism and attention deficit hyperactivity disorder (ADHD).
|
| Eisenberg J, Zohar A, Mei-Tal G, Steinberg A, Tartakovsky E, Gritsenko I, Nemanov L, Ebstein RP.
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| Am J Med Genet 96(3):258-61. Review. 2000
|
| 38 | DRD4
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| No association of the dopamine DRD4 receptor (DRD4) gene polymorphism with attention deficit hyperactivity disorder (ADHD) in the Irish population.
|
| Hawi Z, McCarron M, Kirley A, Daly G, Fitzgerald M, Gill M.
|
| Am J Med Genet 96(3):268-72. 2000
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| 39 | DRD4
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| Further evidence from haplotype analysis for linkage of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder.
|
| Barr CL, Wigg KG, Bloom S, Schachar R, Tannock R, Roberts W, Malone M, Kennedy JL.
|
| Am J Med Genet 96(3):262-7. 2000
|
| 40 | DRD4
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| Failure to replicate an excess of the long dopamine D4 exon III repeat polymorphism in ADHD in a family-based study.
|
| Kotler M, Manor I, Sever Y, Eisenberg J, Cohen H, Ebstein RP, Tyano S.
|
| Am J Med Genet 96(3):278-81. 2000
|
| 41 | DRD4
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| Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention.
|
| Swanson J, Oosterlaan J, Murias M, Schuck S, Flodman P, Spence MA, Wasdell M, Ding Y, Chi HC, Smith M, Mann M, Carlson C, Kennedy JL, Sergeant JA, Leung P, Zhang YP, Sadeh A, Chen C, Whalen CK, Babb KA, Moyzis R, Posner MI.
|
| Proc Natl Acad Sci U S A 97(9):4754-9. 2000
|
| 42 | DRD4
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| A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia.
|
| Okuyama Y, et al.
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| Biochem Biophys Res Commun 258(2):292-5. 1999
|
| 43 | DRD4, PTNS
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| Association between novelty seeking and dopamine receptor D4 (DRD4) exon III polymorphism in Japanese subjects.
|
| Tomitaka M, et al.
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| Am J Med Genet 88(5):469-471 1999
|
| 44 | DRD4
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| Tandem duplication polymorphism upstream of the dopamine D4 receptor gene.
|
| Seaman MI, Fisher JB, Chang F, Kidd KK.
|
| Am J Med Genet 88(6):705-9 1999
|
| 45 | DRD4, PTNS
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| Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms : a twin and genetic association study.
|
| Pogue-Geile M, Ferrell R, Deka R, Debski T, Manuck S.
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| Am J Med Genet 81(1):44-8. 1998
|
| 46 | DRD3, DRD4, HTR2C, PTNS, PTNS2, PTNS3
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| 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence : interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms.
|
| Ebstein RP, et al.
|
| Am J med Genet 74 : 65-72. 1997
|
| 47 | DRD4
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| Dopamine D4 receptor variants in Chinese sporadic and familial schizophrenics.
|
| Hong CJ, Lee YL, Sim CB, Hwu HG.
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| Am J Med Genet 74(4):412-5. 1997
|
| 48 | DRD4, PTNS2
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| D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects.
|
| Gelernter J, Kranzler H, Coccaro E, Siever L, New A, Mulgrew CL.
|
| Am J Hum Genet 61(5):1144-52. 1997
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| 49 | DRD4, PTNS
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| Mapping genes for human personality.
|
| Cloninger CR, et al.
|
| Nat Genet 12 : 3-4. 1996
|
| 50 | DRD4, PTNS
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| Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking.
|
| Ebstein RP, et al.
|
| Nat Genet 12 : 78-80. 1996
|
| 51 | DRD4, PTNS
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| Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking.
|
| Benjamin J, et al.
|
| Nat Genet 12 : 81-84. 1996
|
| 52 | DRD4
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| Lack of imprinting of the human dopamine D4 receptor (DRD4) gene.
|
| Cichon S, et al.
|
| Am J Med Genet 67 : 229-231. 1996
|
| 53 | DRD4
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| No evidence for a major gene effect of the dopamine D4 receptor gene in the susceptibility to Gilles de la Tourette syndrome in five Canadian families.
|
| Barr CL, et al.
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| Am J Med Genet 67 : 301-305. 1996
|
| 54 | DRD4
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| Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test.
|
| Grice DE, et al.
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| Am J Hum Genet 59 : 644-652. 1996
|
| 55 | DRD4
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| A Smal PCR-RFLP in the 5' noncoding region of the human D4 dopamine receptor gene (DRD4).
|
| Petronis A, et al.
|
| Hum Hered 44 : 58-60. 1994
|
| 56 | DRD4
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| (G)n-mononucleotide polymorphism in the human D4 dopamine receptor (DRD4) gene.
|
| Petronis A, et al.
|
| Hum Genet 93 : 719. 1994
|
| 57 | DRD4
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| Identification of a null mutation in the human dopamine D4 receptor gene. (abstr)
|
| Nthen MM, et al.
|
| Am J Hum Genet 55 : A351. 1994
|
| 58 | DRD4
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| Human dopamine D4 receptor gene : frequent occurrence of a null allele and observation of homozygosity.
|
| Nthen MM, et al.
|
| Hum Mol Genet 3 : 2207-2212. 1994
|
| 59 | DRD4
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| Dopamine D4 receptor polymorphism and schizophrenia.
|
| Nanko S, et al.
|
| Lancet 341 : 689-690. 1993
|
| 60 | DRD4
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| Polymorphism in the human dopamine D4 receptor gene (DRD4) in Japanese detected by PCR.
|
| Inoue A, et al.
|
| Hum Mol Genet 2 : 2197. 1993
|
| 61 | DRD4
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| A hypervariable segment in the human dopamine receptor D4 (DRD4) gene.
|
| Lichter JB, et al.
|
| Hum Mol Genet 2 : 767-773. 1993
|
| 62 | DRD4
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| The D4 dopamine receptor gene maps on 11p proximal to HRAS.
|
| Petronis A, et al.
|
| Genomics 18 : 161-163. 1993
|
| 63 | DRD4
|
| The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS.
|
| Gelernter J, et al.
|
| Genomics 13 : 208-210. 1992
|
| 64 | DRD4
|
| Genetic analysis of variable repeat sequence in DRD4 gene exon.
|
| Petronis A, et al.
|
| Am J Hum Genet 51 : A198. 1992
|
| 65 | DRD4
|
| A HincII RFLP in the human D4 dopamine receptor locus (DRD4).
|
| Kennedy JL, et al.
|
| Nucleic Acids Res 19 : 5801. 1991
|
| 66 | DRD4
|
| DRD4, the D4 dopamine receptor, maps to distal 11p.
|
| Gelernter J, et al.
|
| Am J Hum Genet 49S : 340. 1991
|
| 67 | DRD4
|
| Cloning of the gene for a human dopamine D4 receptor with high affinity for antipsychotic clozapine.
|
| Van Tol HH, et al.
|
| Nature 350 : 610-614. 1991
|