| 1 | ANKK1, DRD2, TTC12
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| A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response.
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| Macare C, Ducci F, Zhang Y, Ruggeri B, Jia T, Kaakinen M, Kalsi G, Charoen P, Casoni F, Peters J, Bromberg U, Hill M, Buxton J, Blakemore A, Veijola J, Büchel C, Banaschewski T, Bokde ALW, Conrod P, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Martinot JL, Paus T, Desrivières S, Munafò M, Järvelin MR, Schumann G; IMAGEN Consortium.
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| Eur Neuropsychopharmacol 28(10):1103-1114. doi: 10.1016/j.euroneuro.2018.07.101. Epub 2018 Aug 11.
2018
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| 2 | DRD2, TSPAN7
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| Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking.
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| Lee SA, Suh Y, Lee S, Jeong J, Kim SJ, Kim SJ, Park SK.
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| FASEB J 31(6):2301-2313. doi: 10.1096/fj.201600755RR. Epub 2017 Feb 21.
2017
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| 3 | DRD1, DRD2
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| Adolescent Maturation of Dopamine D1 and D2 Receptor Function and Interactions in Rodents.
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| Dwyer JB, Leslie FM.
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| PLoS One 11(1):e0146966. doi: 10.1371/journal.pone.0146966. eCollection 2016.
2016
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| 4 | DRD2
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| Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity.
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| Peterson SM, Pack TF, Caron MG.
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| PLoS One 10(10):e0141637. doi: 10.1371/journal.pone.0141637. eCollection 2015.
2015
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| 5 | DRD1, DRD2
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| Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization.
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| Kai N, Nishizawa K, Tsutsui Y, Ueda S, Kobayashi K.
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| J Neurochem 135(6):1232-41. doi: 10.1111/jnc.13380. Epub 2015 Oct 28.
2015
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| 6 | DRD2
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| Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium.
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| Gantz SC, Robinson BG, Buck DC, Bunzow JR, Neve RL, Williams JT, Neve KA.
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| Elife 4. doi: 10.7554/eLife.09358.
2015
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| 7 | DRD2
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| De novo expression of dopamine D2 receptors on microglia after stroke.
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| Huck JH, Freyer D, Böttcher C, Mladinov M, Muselmann-Genschow C, Thielke M, Gladow N, Bloomquist D, Mergenthaler P, Priller J.
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| J Cereb Blood Flow Metab 35(11):1804-11. doi: 10.1038/jcbfm.2015.128. Epub 2015 Jun 24.
2015
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| 8 | DRD2
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| Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor.
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| Peterson SM, Pack TF, Wilkins AD, Urs NM, Urban DJ, Bass CE, Lichtarge O, Caron MG.
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| Proc Natl Acad Sci U S A 112(22):7097-102. doi: 10.1073/pnas.1502742112. Epub 2015 May 11.
2015
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| 9 | DRD2
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| Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse.
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| Biezonski DK, Trifilieff P, Meszaros J, Javitch JA, Kellendonk C.
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| J Comp Neurol 523(8):1175-89. doi: 10.1002/cne.23730. Epub 2015 Feb 17.
2015
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| 10 | DRD2
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| Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina.
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| Tian N, Xu HP, Wang P.
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| Eur J Neurosci 41(1):17-30. doi: 10.1111/ejn.12783. Epub 2014 Nov 13.
2015
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| 11 | ANKK1, DRD2
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| Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions.
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| Ma Y, Yuan W, Jiang X, Cui WY, Li MD.
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| Mol Neurobiol 51(1):281-99. doi: 10.1007/s12035-014-8826-2. Epub 2014 Aug 20.
2015
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| 12 | DRD2, SSTR3
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| Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas.
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| Gabalec F, Drastikova M, Cesak T, Netuka D, Masopust V, Machac J, Marek J, Cap J, Beranek M.
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| Physiol Res 64(3):369-77. Epub 2014 Dec 22.
2015
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| 13 | ADBRK1, DRD2, GRK1, NCS1
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| Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.
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| Pandalaneni S, Karuppiah V, Saleem M, Haynes LP, Burgoyne RD, Mayans O, Derrick JP, Lian LY.
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| J Biol Chem 290(30):18744-56. doi: 10.1074/jbc.M114.627059. Epub 2015 May 15. 2015
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| 14 | DRD2, ZDHHC3, ZDHHC8
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| Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability.
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| Ebersole B, Petko J, Woll M, Murakami S, Sokolina K, Wong V, Stagljar I, Lüscher B, Levenson R.
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| PLoS One. Nov 4;10(11):e0140661. doi: 10.1371/journal.pone.0140661. 2015
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| 15 | DRD2, SESN2
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| Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.
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| Yang Y, Cuevas S, Yang S, Villar VA, Escano C, Asico L, Yu P, Jiang X, Weinman EJ, Armando I, Jose PA.
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| Hypertension 64(4):825-32. doi: 10.1161/HYPERTENSIONAHA.114.03840. Epub 2014 Jul 14.
2014
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| 16 | DRD2, GNB5, RGS7
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| G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalization.
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| Octeau JC, Schrader JM, Masuho I, Sharma M, Aiudi C, Chen CK, Kovoor A, Celver J.
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| PLoS One 9(8):e105791. doi: 10.1371/journal.pone.0105791. eCollection 2014.
2014
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| 17 | DRD2
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| Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry.
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| Cazorla M, de Carvalho FD, Chohan MO, Shegda M, Chuhma N, Rayport S, Ahmari SE, Moore H, Kellendonk C.
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| Neuron 81(1):153-64. doi: 10.1016/j.neuron.2013.10.041.
2014
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| 18 | CDK5, DRD2
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| Cdk5 phosphorylates dopamine D2 receptor and attenuates downstream signaling.
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| Jeong J, Park YU, Kim DK, Lee S, Kwak Y, Lee SA, Lee H, Suh YH, Gho YS, Hwang D, Park SK.
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| PLoS One 8(12):e84482. doi: 10.1371/journal.pone.0084482. eCollection 2013.
2013
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| 19 | DRD2
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| Age-dependent regulation of synaptic connections by dopamine D2 receptors.
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| Jia JM, Zhao J, Hu Z, Lindberg D, Li Z.
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| Nat Neurosci 16(11):1627-36. doi: 10.1038/nn.3542. Epub 2013 Oct 13.
2013
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| 20 | DRD2
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| Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area.
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| Madhavan A, Argilli E, Bonci A, Whistler JL.
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| J Neurosci 33(30):12329-36. doi: 10.1523/JNEUROSCI.0809-13.2013.
2013
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| 21 | DRD2
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| Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation.
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| Trifilieff P, Feng B, Urizar E, Winiger V, Ward RD, Taylor KM, Martinez D, Moore H, Balsam PD, Simpson EH, Javitch JA.
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| Mol Psychiatry 18(9):1025-33. doi: 10.1038/mp.2013.57. Epub 2013 May 28.
2013
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| 22 | DRD2
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| Dopamine D2-like receptor signaling suppresses human osteoclastogenesis.
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| Hanami K, Nakano K, Saito K, Okada Y, Yamaoka K, Kubo S, Kondo M, Tanaka Y.
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| Bone 56(1):1-8. doi: 10.1016/j.bone.2013.04.019. Epub 2013 Apr 28.
2013
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| 23 | DRD2
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| Dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both D1 and D2 dopamine receptors.
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| Fasano C, Bourque MJ, Lapointe G, Leo D, Thibault D, Haber M, Kortleven C, Desgroseillers L, Murai KK, Trudeau LÉ.
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| Neuropharmacology 67:432-43. doi: 10.1016/j.neuropharm.2012.11.030. Epub 2012 Dec 8.
2013
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| 24 | ANKK1, DRD2
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| Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language.
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| Eicher JD, Powers NR, Cho K, Miller LL, Mueller KL, Ring SM, Tomblin JB, Gruen JR.
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| PLoS One 8(5):e63762. doi: 10.1371/journal.pone.0063762. Print 2013.
2013
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| 25 | DRD2, PDE4B, ZNF804A
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| ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.
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| Girgenti MJ, LoTurco JJ, Maher BJ.
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| PLoS One 7(2):e32404. doi: 10.1371/journal.pone.0032404. Epub 2012 Feb 27.
2012
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| 26 | DRD2
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| Altered dendritic distribution of dopamine D2 receptors and reduction in mitochondrial number in parvalbumin-containing interneurons in the medial prefrontal cortex of cannabinoid-1 (CB1) receptor knockout mice.
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| Fitzgerald ML, Chan J, Mackie K, Lupica CR, Pickel VM.
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| J Comp Neurol 520(17):4013-31. doi: 10.1002/cne.23141.
2012
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| 27 | DRD2, TAAR1
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| Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor.
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| Espinoza S, Salahpour A, Masri B, Sotnikova TD, Messa M, Barak LS, Caron MG, Gainetdinov RR.
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| Mol Pharmacol 80(3):416-25. Epub 2011 Jun 13.
2011
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| 28 | DRD2, HNRNPM, NOVA1
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| Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA.
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| Park E, Iaccarino C, Lee J, Kwon I, Baik SM, Kim M, Seong JY, Son GH, Borrelli E, Kim K.
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| J Biol Chem 286(28):25301-8. doi: 10.1074/jbc.M110.206540. Epub 2011 May 26.
2011
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| 29 | DRD2
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| Dopamine D2 receptor gene polymorphisms are associated with suicide attempt in the Japanese population.
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| Suda A, Kawanishi C, Kishida I, Sato R, Yamada T, Nakagawa M, Hasegawa H, Kato D, Furuno T, Hirayasu Y.
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| Neuropsychobiology 59(2):130-4. Epub 2009 Apr 22.
2009
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| 30 | DRD2
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| C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo.
|
| Hirvonen MM, Lumme V, Hirvonen J, Pesonen U, Någren K, Vahlberg T, Scheinin H, Hietala J.
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| Prog Neuropsychopharmacol Biol Psychiatry 33(4):630-6. Epub 2009 Mar 11.
2009
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| 31 | ADRBK1, ADRBK2, DRD2
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| G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.
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| Namkung Y, Dipace C, Javitch JA, Sibley DR.
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| J Biol Chem 284(22):15038-51. Epub 2009 Mar 30.
2009
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| 32 | DRD2
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| Association between dopaminergic genes (SLC6A3 and DRD2) and stuttering among Han Chinese.
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| Lan J, Song M, Pan C, Zhuang G, Wang Y, Ma W, Chu Q, Lai Q, Xu F, Li Y, Liu L, Wang W.
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| J Hum Genet 54(8):457-60. Epub 2009 Jul 10.PMID: 19590515 2009
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| 33 | APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SCZD23, SLC6A4, TP53, TPH1
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| Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
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| Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L.
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| Nat Genet 40(7):827-34. 2008
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| 34 | DRD2, S100B
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| Novel interaction of the dopamine D2 receptor and the Ca2+ binding protein S100B: role in D2 receptor function.
|
| Liu Y, Buck DC, Neve KA.
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| Mol Pharmacol 74(2):371-8. Epub 2008 Apr 29.
2008
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| 35 | DRD1, DRD2
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| D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin.
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| Free RB, Hazelwood LA, Cabrera DM, Spalding HN, Namkung Y, Rankin ML, Sibley DR.
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| J Biol Chem 282(29):21285-300. Epub 2007 Mar 29. 2007
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| 36 | DRD2
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| The Cys allele of the DRD2 Ser311Cys polymorphism has a dominant effect on risk for schizophrenia: evidence from fixed- and random-effects meta-analyses.
|
| Glatt SJ, Jonsson EG.
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| Am J Med Genet B Neuropsychiatr Genet 141(2):149-54. 2006
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| 37 | DRD2
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| Association between the DRD2 A1 allele and opium addiction in the Iranian population.
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| Shahmoradgoli Najafabadi M, Ohadi M, Joghataie MT, Valaie F, Riazalhosseini Y, Mostafavi H, Mohammadbeigi F, Najmabadi H.
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| Am J Med Genet B Neuropsychiatr Genet 134(1):39-41. 2005
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| 38 | COMT, HT2A, DRD2, DRD4, SLC6A3
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| Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope.
|
| Abdolmaleky HM, Thiagalingam S, Wilcox M.
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| Am J Pharmacogenomics 5(3):149-60. Review. 2005
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| 39 | ANKK1, DRD2
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| Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1.
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| Neville MJ, Johnstone EC, Walton RT.
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| Hum Mutat 23(6):540-5. 2004
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| 40 | DRD2
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| Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor
|
| Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV.
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| Hum Mol Genet 12(3):205-16. 2003
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| 41 | CLIC6, DRD2, DRD3, DRD4, MPDZ
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| CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors.
|
| Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P.
|
| Brain Res Mol Brain Res 117(1):47-57. 2003
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| 42 | DRD2
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| Association analysis between two functional dopamine D2 receptor gene polymorphisms and schizophrenia.
|
| Hori H, Ohmori O, Shinkai T, Kojima H, Nakamura J.
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| Am J Med Genet 105(2):176-8. 2001
|
| 43 | DRD2
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| Distinct functions of the two isoforms of dopamine D2 receptors.
|
| Usiello A, Baik JH, Rougé-Pont F, Picetti R, Dierich A, LeMeur M, Piazza PV, Borrelli E.
|
| Nature 408(6809):199-203.
2000
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| 44 | DRD2, MD
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| Association of a missense change in the D2 dopamine receptor with myoclonus dystonia.
|
| Klein C, et al.
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| Proc Natl Acad Sci U S A 96(9):5173-6. 1999
|
| 45 | DRD2
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| DNA methylation at the putative promoter region of the human dopamine D2 receptor gene.
|
| Popendikyte V, et al.
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| Neuroreport 10(6):1249-55. 1999
|
| 46 | DRD2
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| Supportive evidence for contribution of the dopamine D2 receptor gene to heritability of stature : linkage and association studies.
|
| Arinami T, Iijima Y, Yamakawa-Kobayashi K, Ishiguro H, Ohtsuki T, Yanagi H, Shimakura Y, Ishikawa H Hamaguchi H.
|
| Ann Hum Genet 63:147-151 1999
|
| 47 | DRD2, DRD3
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| European multicentre association study of schizophrenia : a study of the DRD2 Ser311cys and DRD3 Ser9Gly polymorphisms.
|
| Spurlock G, Williams J, McGuffin P, Aschauer HN, Lenzinger E, Fuchs K, Sieghart WC, Meszaros K, Fathi N, Laurent C, Mallet J, Macciardi F, Pedrini S, Gill M, Hawi Z, Gibson S, Jazin EE, Yang HT, Adolfsson R, Pato CN, Dourado AM, Owen MJ.
|
| Am J Med Genet 81(1):24-8. 1998
|
| 48 | DRD2
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| A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus.
|
| Kidd KK, et al.
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| Hum Genet 103 : 211-227. 1998
|
| 49 | DRD2
|
| Dopamine receptors: from structure to function.
|
| Missale C, et al.
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| Physiol Rev 78(1):189-225. Review. 1998
|
| 50 | DRD2
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| A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia.
|
| Arinami T, et al.
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| Hum Mol Genet 6 : 577-582. 1997
|
| 51 | DRD2
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| Further association study on dopamine D2 receptor variant S311C in schizophrenia and affective disorders.
|
| Arinami T, et al.
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| Am J Med Genet 67 : 133-138. 1996
|
| 52 | DRD2
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| Lack of association between dopamine D2 receptor gene Cys311 vairant andschizophrenia.
|
| Tanaka T, et al.
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| Am J Med Genet 67 : 208-211. 1996
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| 53 | DRD2, DRD3, SLC6A3, TH
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| Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission : DRD2,DRD3,DAT1, and TH genes.
|
| Souery D, et al.
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| Am J Med Genet 67 : 551-555. 1996
|
| 54 | NCAM1, DRD2
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| New localization of NCAM, proximal to DRD2 at chromosome 11q23.
|
| Telatar M, et al.
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| Mamm Genome 6 : 59-60. 1995
|
| 55 | DRD2
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| A new polymorphism in the gene for the dopamine D2 receptor.
|
| Poduslo SE, et al.
|
| Hum Genet 95 : 603-604. 1995
|
| 56 | DRD2
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| PCR detection of the TaqA RFLP at the DRD2 locus.
|
| Grandy DK, et al.
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| Hum Mol Genet 2 : 2197. 1993
|
| 57 | DRD2
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| Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60cM.
|
| Gelernter J, et al.
|
| Cytogenet Cell Genet 60 : 26-28. 1992
|
| 58 | DRD2
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| A rare FokI RFLP in the human dopamine D2 receptor gene (DRD2).
|
| Lu CY, et al.
|
| Hum Genet 89 : 360. 1992
|
| 59 | DRD2
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| Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23.
|
| Eubanks JH, et al.
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| Genomics 14 : 1010-1018. 1992
|
| 60 | DRD2
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| Use of polymerase chain reaction nad denaturing gradient gel electrophoresis to identify polymorphisms in three exons of dopamine D2 receptor gene in schizophrenic and delusional patients.
|
| Catalano M, et al.
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| Neuropsychobiology 26 : 1-3. 1992
|
| 61 | DRD2
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| Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene.
|
| Hauge XY, et al.
|
| Genomics 10 : 527-530. 1991
|
| 62 | GABRB1, FCGR3B, CD247, DRD2, CD4, IGF1R
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| Genetic mapping of six human genes.
|
| Dean M, et al.
|
| (HGM11) Cytogenet Cell Genet 58 : 1853. 1991
|
| 63 | D11S144, D11S351, D11S385, MMP3, NCAM1, DRD2
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| Improved maximum separation of 3 pairs of markers on chromosome 11q22-23.
|
| Formstone CJ, et al.
|
| (HGM11) Cytogenet Cell Genet 58 : 1959. 1991
|
| 64 | DRD2
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| A new TaqI RFLP within intron 2 of human dopamine D2 receptor gene (DRD2).
|
| Parsian A, et al.
|
| Nucleic Acids Res 19 : 6977. 1991
|
| 65 | MMP3, NCAM1, DRD2, D11S35, D11S385, D11S144, D11S351
|
| Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22.
|
| McConville CM, et al.
|
| Nucleic Acids Res 18 : 4335-4343. 1990
|
| 66 | DRD2
|
| D2 dopamine receptor locus (probe hD2G1) maps close to D11S29 (probe L7) and is also linked to PBGD (probe PBGD0.0) and D11S84 (probe p-2-7-ID6) on 11q.
|
| Gelernter J, et al.
|
| (HGM10) Cytogenet Cell Genet 51 : 1002. 1989
|
| 67 | DRD2
|
| Dopamine D2 receptor gene maps to human chromosome 11q22-q23 and identifies a TaqI RFLP.
|
| Grandy DK, et al.
|
| (HGM10) Cytogenet Cell Genet 51 : 1007. 1989
|
| 68 | DRD2
|
| The human dopamine D2 receptor gene is located on chromosome 11 at q22-q23 and identifies a TaqI RFLP.
|
| Grandy DK, et al.
|
| Am J Hum Genet 45 : 778-785. 1989
|
| 69 | DRD2
|
| The dopamine D2 receptor : two molecular forms generated by alternative splicing.
|
| Toso RD, et al.
|
| EMBO J 8 : 4025-4034. 1989
|