1 | DOK1, PTK6
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| BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.
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| Miah S, Goel RK, Dai C, Kalra N, Beaton-Brown E, Bagu ET, Bonham K, Lukong KE.
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| PLoS One 9(2):e87684. doi: 10.1371/journal.pone.0087684. eCollection 2014. Erratum in: PLoS One. 2014;9(5):e98814.
2014
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2 | CRKL, DOK1
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| Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity.
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| Ng KY, Yin T, Machida K, Wu YI, Mayer BJ.
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| Oncogene ncogene. 2014 Jul 21. doi: 10.1038/onc.2014.210. [Epub ahead of print]
2014
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3 | DOK1, DOK2
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| Dok1 and Dok2 proteins regulate natural killer cell development and function.
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| Celis-Gutierrez J, Boyron M, Walzer T, Pandolfi PP, Jonjić S, Olive D, Dalod M, Vivier E, Nunès JA.
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| EMBO J 33(17):1928-40. doi: 10.15252/embj.201387404. Epub 2014 Jun 24.
2014
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4 | DOK1, DOK2
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| Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia.
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| Downer EJ, Johnston DG, Lynch MA.
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| Mol Cell Neurosci 56:148-58. doi: 10.1016/j.mcn.2013.04.007. Epub 2013 May 7.
2013
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5 | DOK1, DOK2, DOK3
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| Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.
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| Mashima R, Arimura S, Kajikawa S, Oda H, Nakae S, Yamanashi Y.
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| Genes Cells 18(1):56-65. doi: 10.1111/gtc.12016. Epub 2012 Dec 4.
2013
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6 | DOK1, E2F1
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| Transcriptional regulation of the human tumor suppressor DOK1 by E2F1.
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| Siouda M, Yue J, Shukla R, Guillermier S, Herceg Z, Creveaux M, Accardi R, Tommasino M, Sylla BS.
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| Mol Cell Biol 32(23):4877-90. doi: 10.1128/MCB.01050-12. Epub 2012 Oct 1.
2012
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7 | DOK1
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| Dok-1 overexpression promotes development of γδ natural killer T cells.
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| Besin G, Yousefi M, Saba I, Klinck R, Pandolfi PP, Duplay P.
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| Eur J Immunol 42(9):2491-504. doi: 10.1002/eji.201242421. Epub 2012 Jul 16.
2012
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8 | DOK1
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| Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers.
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| Saulnier A, Vaissière T, Yue J, Siouda M, Malfroy M, Accardi R, Creveaux M, Sebastian S, Shahzad N, Gheit T, Hussain I, Torrente M, Maffini FA, Calabrese L, Chiesa F, Cuenin C, Shukla R, Fathallah I, Matos E, Daudt A, Koifman S, Wünsch-Filho V, Menezes AM, Curado MP, Zaridze D, Boffetta P, Brennan P, Tommasino M, Herceg Z, Sylla BS.
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| Int J Cancer 130(11):2484-94. doi: 10.1002/ijc.26299. Epub 2011 Sep 22.
2012
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9 | DOK1, DOK2, INPP5D
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| The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling.
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| Waterman PM, Marschner S, Brandl E, Cambier JC.
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| Immunol Lett 143(1):122-30. doi: 10.1016/j.imlet.2012.02.009. Epub 2012 Feb 24.
2012
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10 | DOK1
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| Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer.
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| Mercier PL, Bachvarova M, Plante M, Gregoire J, Renaud MC, Ghani K, Têtu B, Bairati I, Bachvarov D.
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| Mol Oncol 5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
2011
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11 | DOK1, DOK2
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| Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts.
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| Kawamata A, Inoue A, Miyajima D, Hemmi H, Mashima R, Hayata T, Ezura Y, Amagasa T, Yamanashi Y, Noda M.
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| J Cell Physiol 226(12):3087-93. doi: 10.1002/jcp.22909.
2011
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12 | DOK1
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| Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation.
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| Janas JA, Van Aelst L.
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| Mol Cell Biol 31(13):2552-65. doi: 10.1128/MCB.05045-11. Epub 2011 May 2.
2011
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13 | DOK1, DOK2, DOK3
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| Identification of DOK genes as lung tumor suppressors.
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| Berger AH, Niki M, Morotti A, Taylor BS, Socci ND, Viale A, Brennan C, Szoke J, Motoi N, Rothman PB, Teruya-Feldstein J, Gerald WL, Ladanyi M, Pandolfi PP.
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| Nat Genet 42(3):216-23. Epub 2010 Feb 7.
2010
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14 | DOK1, DOK2, DOK3
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| Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.
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| Guittard G, Gérard A, Dupuis-Coronas S, Tronchère H, Mortier E, Favre C, Olive D, Zimmermann P, Payrastre B, Nunès JA.
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| J Immunol 182(7):3974-8. 2009
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15 | DOK1, PTPRC
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| CD45 recruits adapter protein DOK-1 and negatively regulates JAK-STAT signaling in hematopoietic cells.
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| Wu L, Bijian K, Shen SH.
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| Mol Immunol 46(11-12):2167-77. Epub 2009 May 28. Erratum in: Mol Immunol. 2010 Jan;47(4):41. Shen, Shi-Shiang [corrected to Shen, Shi-Hsiang 2009
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16 | DOK1
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| Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.
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| Hosooka T, Noguchi T, Kotani K, Nakamura T, Sakaue H, Inoue H, Ogawa W, Tobimatsu K, Takazawa K, Sakai M, Matsuki Y, Hiramatsu R, Yasuda T, Lazar MA, Yamanashi Y, Kasuga M.
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| Nat Med 14(2):188-93. Epub 2008 Jan 20. 2008
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17 | DOK1, DOK3
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| Dok-3 plays a nonredundant role in negative regulation of B-cell activation.
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| Ng CH, Xu S, Lam KP.
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| Blood 110(1):259-66. Epub 2007 Mar 15.
2007
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18 | DOK1, DOK2
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| Differential regulation of adapter proteins Dok2 and Dok1 in platelets, leading to an association of Dok2 with integrin alphaIIbbeta3.
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| Hughan SC, Watson SP.
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| J Thromb Haemost 5(2):387-94. Epub 2006 Nov 9.
2007
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19 | DOK1, DOK2, DOK3, GRB2
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| Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.
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| Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura S, Natsume T, Yamanashi Y.
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| Genes Cells 11(2):143-51.
2006
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20 | DOK1, DOK2, TEC
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| Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase.
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| Gérard A, Favre C, Garçon F, Némorin JG, Duplay P, Pastor S, Collette Y, Olive D, Nunès JA.
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| Oncogene 23(8):1594-8. 2004
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21 | DOK1, SMAD3
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| The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors.
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| Yamakawa N, Tsuchida K, Sugino H.
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| EMBO J 21(7):1684-94. 2002
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22 | DOK1, KITLG
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| Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling.
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| Liang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD.
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| J Biol Chem 277(16):13732-8. 2002
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23 | CCT4, DCTN1, DOK1, DUSP11, EGR4, EXOC6B, PARK3, SEMA4F, SMYD5, SPR, STAMBP, TIA1, ZNF638
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| Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.
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| West AB, Zimprich A, Lockhart PJ, Farrer M, Singleton A, Holtom B, Lincoln S, Hofer A, Hill L, Muller-Myhsok B, Wszolek ZK, Hardy J, Gasser T.
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| Eur J Hum Genet 9(9):659-66. 2001
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24 | DOK1
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| Molecular cloning of a truncated p62Dok1 isoform, p22Dok(del).
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| Hubert P, Ferreira V, Debre P, Bismuth G.
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| Eur J Immunogenet 27(3):145-8. 2000
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25 | DOK1, DOK2, LCK
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| Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling.
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| Nemorin JG, Duplay P.
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| J Biol Chem 275(19):14590-7. 2000
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26 | DOK1, SH2D1A
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| The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B.
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| Sylla BS, Murphy K, Cahir-McFarland E, Lane WS, Mosialos G, Kieff E.
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| Proc Natl Acad Sci U S A 97(13):7470-5. 2000
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27 | DOK1
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| Dok1 encoding p62dok maps to mouse chromosome 6 and human chromosome 2 in a region of translocation in chronic lymphocytic leukemia.
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| Nelms K, et al.
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| Genomics 53 : 243-245. 1998
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28 | DOK1
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| p62(dok) : a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells.
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| Carpino N, et al.
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| Cell 88 : 197-204. 1997
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29 | DOK1
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| A 62-kilodalton tyrosine phosphoprotein constitutively present in primary chronic phase chronic myelogenous leukemia enriched lineage negative blast populations.
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| Wisniewski D, et al.
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| Leukemia 8 : 688-693. 1994
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