| 1 | DOCK2
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| Novel DOCK2-selective inhibitory peptide that suppresses B-cell line migration.
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| Sakamoto K, Adachi Y, Komoike Y, Kamada Y, Koyama R, Fukuda Y, Kadotani A, Asami T, Sakamoto JI.
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| Biochem Biophys Res Commun 483(1):183-190. doi: 10.1016/j.bbrc.2016.12.170. Epub 2016 Dec 27.
2017
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| 2 | DOCK2, DOCK8, HIES, iMD40
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| Current Status of Dedicator of Cytokinesis-Associated Immunodeficiency: DOCK8 and DOCK2.
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| Dimitrova D, Freeman AF.
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| Dermatol Clin 35(1):11-19. doi: 10.1016/j.det.2016.07.002. Review.
2017
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| 3 | DOCK2, FLT3
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| DOCK2 interacts with FLT3 and modulates the survival of FLT3-expressing leukemia cells.
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| Wu M, Hamaker M, Li L, Small D, Duffield AS.
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| Leukemia 31(3):688-696. doi: 10.1038/leu.2016.284. Epub 2016 Oct 17.
2017
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| 4 | DOCK2
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| Dedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development.
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| Guo X, Chen SY.
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| J Cell Physiol 232(8):1931-1940. doi: 10.1002/jcp.25512. Epub 2017 Feb 28. Review.
2017
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| 5 | DOCK2, IMD40
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| Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
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| Dobbs K, Domínguez Conde C, Zhang SY, Parolini S, Audry M, Chou J, Haapaniemi E, Keles S, Bilic I, Okada S, Massaad MJ, Rounioja S, Alwahadneh AM, Serwas NK, Capuder K, Çiftçi E, Felgentreff K, Ohsumi TK, Pedergnana V, Boisson B, Haskoloğlu Ş, Ensari A, Schuster M, Moretta A, Itan Y, Patrizi O, Rozenberg F, Lebon P, Saarela J, Knip M, Petrovski S, Goldstein DB, Parrott RE, Savas B, Schambach A, Tabellini G, Bock C, Chatila TA, Comeau AM, Geha RS, Abel L, Buckley RH, İkincioğulları A, Al-Herz W, Helminen M, Doğu F, Casanova JL, Boztuğ K, Notarangelo LD.
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| N Engl J Med 372(25):2409-22. doi: 10.1056/NEJMoa1413462.
2015
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| 6 | DOCK2
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| Dedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling.
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| Guo X, Shi N, Cui XB, Wang JN, Fukui Y, Chen SY.
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| Circ Res 116(10):e71-80. doi: 10.1161/CIRCRESAHA.116.305863. Epub 2015 Mar 18.
2015
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| 7 | DOCK2, ELMO1
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| Essential role of Elmo1 in Dock2-dependent lymphocyte migration.
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| Stevenson C, de la Rosa G, Anderson CS, Murphy PS, Capece T, Kim M, Elliott MR.
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| J Immunol 192(12):6062-70. doi: 10.4049/jimmunol.1303348. Epub 2014 May 12.
2014
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| 8 | DOCK2, DOCK5
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| DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.
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| Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Côté JF, Sumimoto H, Fukui Y.
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| J Immunol 193(11):5660-7. doi: 10.4049/jimmunol.1400885.
2014
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| 9 | DOCK2, PREX1, RHOG
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| P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
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| Damoulakis G, Gambardella L, Rossman KL, Lawson CD, Anderson KE, Fukui Y, Welch HC, Der CJ, Stephens LR, Hawkins PT
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| J Cell Sci. Jun 1;127(Pt 11):2589-600. doi: 10.1242/jcs.153049. Epub 2014 Mar 21 2014
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| 10 | DOCK2
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| Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.
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| Yasuda K, Nündel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR.
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| Int Immunol 25(5):295-306. doi: 10.1093/intimm/dxs114. Epub 2013 Jan 4.
2013
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| 11 | DOCK2
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| Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease.
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| Cimino PJ, Yang Y, Li X, Hemingway JF, Cherne MK, Khademi SB, Fukui Y, Montine KS, Montine TJ, Keene CD.
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| Exp Mol Pathol 94(2):366-71. doi: 10.1016/j.yexmp.2013.01.002. Epub 2013 Jan 11.
2013
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| 12 | DOCK2
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| Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration.
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| Terasawa M, Uruno T, Mori S, Kukimoto-Niino M, Nishikimi A, Sanematsu F, Tanaka Y, Yokoyama S, Fukui Y.
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| PLoS One 7(9):e46277. doi: 10.1371/journal.pone.0046277. Epub 2012 Sep 26.
2012
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| 13 | DOCK2
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| Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
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| Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y.
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| Chem Biol 19(4):488-97. doi: 10.1016/j.chembiol.2012.03.008.
2012
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| 14 | DOCK2, ELMO1
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| Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
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| Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S.
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| Proc Natl Acad Sci U S A 109(9):3305-10. doi: 10.1073/pnas.1113512109. Epub 2012 Feb 13.
2012
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| 15 | DOCK2
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| CXCL13 mediates prostate cancer cell proliferation through JNK signalling and invasion through ERK activation.
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| El-Haibi CP, Singh R, Sharma PK, Singh S, Lillard JW Jr.
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| Cell Prolif 44(4):311-9. doi: 10.1111/j.1365-2184.2011.00757.x. Epub 2011 Jun 6.
2011
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| 16 | DOCK2
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| Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
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| Kulkarni K, Yang J, Zhang Z, Barford D.
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| J Biol Chem 286(28):25341-51. doi: 10.1074/jbc.M111.236455. Epub 2011 May 24.
2011
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| 17 | DOCK2
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| DOCK2 regulates cell proliferation through Rac and ERK activation in B cell lymphoma.
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| Wang L, Nishihara H, Kimura T, Kato Y, Tanino M, Nishio M, Obara M, Endo T, Koike T, Tanaka S.
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| Biochem Biophys Res Commun 395(1):111-5. Epub 2010 Mar 27.
2010
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| 18 | DOCK1, DOCK2, DOCK3, DOCK4, WASF1
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| Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.
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| Namekata K, Harada C, Taya C, Guo X, Kimura H, Parada LF, Harada T.
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| Proc Natl Acad Sci U S A 107(16):7586-91. Epub 2010 Apr 5.
2010
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| 19 | DOCK2
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| Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.
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| Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y.
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| Science 324(5925):384-7. Epub 2009 Mar 26.
2009
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| 20 | DOCK2
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| DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain.
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| Cimino PJ, Sokal I, Leverenz J, Fukui Y, Montine TJ.
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| Am J Pathol 175(4):1622-30. doi: 10.2353/ajpath.2009.090443. Epub 2009 Sep 3.
2009
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| 21 | DOCK1, DOCK2
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| Role of DOCK2 and DOCK180 in fetal thymus colonization.
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| Lei Y, Liu C, Saito F, Fukui Y, Takahama Y.
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| Eur J Immunol 39(10):2695-702. doi: 10.1002/eji.200939630.
2009
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| 22 | DOCK2
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| Dock2 participates in bone marrow lympho-hematopoiesis.
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| Kikuchi T, Kubonishi S, Shibakura M, Namba N, Matsui T, Fukui Y, Tanimoto M, Katayama Y.
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| Biochem Biophys Res Commun 367(1):90-6. Epub 2007 Dec 26. 2008
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| 23 | DOCK2, DOCK9
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| Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors.
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| Kwofie MA, Skowronski J.
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| J Biol Chem 283(6):3088-96. Epub 2007 Dec 3. 2008
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| 24 | DOCK2, IL4R
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| T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-alpha subunit controlled by the Rac activator Dock2.
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| Tanaka Y, Hamano S, Gotoh K, Murata Y, Kunisaki Y, Nishikimi A, Takii R, Kawaguchi M, Inayoshi A, Masuko S, Himeno K, Sasazuki T, Fukui Y.
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| Nat Immunol 8(10):1067-75. Epub 2007 Sep 2.
2007
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| 25 | WDHD1, CABP2, CEBPZ, DOCK2, NPFFR2, KLRB1, MMP24, PPM1G, SGCD, SLC4A8
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| Human-specific subfamilies of HERV-K (HML-2) long terminal repeats: three master genes were active simultaneously during branching of hominoid lineages( small star, filled )
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| Buzdin A, Ustyugova S, Khodosevich K, Mamedov I, Lebedev Y, Hunsmann G, Sverdlov E.
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| Genomics 81(2):149-56. 2003
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| 26 | DOCK2, ELMO1
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| DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1.
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| Sanui T, Inayoshi A, Noda M, Iwata E, Stein JV, Sasazuki T, Fukui Y.
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| Blood 102(8):2948-50. Epub 2003 Jun 26. 2003
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| 27 | DOCK2
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| Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration.
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| Fukui Y, Hashimoto O, Sanui T, Oono T, Koga H, Abe M, Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T.
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| Nature 412(6849):826-31. 2001
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