| 1 | CDK1, DNA2, EXO1, WRN
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| CDK1 phosphorylates WRN at collapsed replication forks.
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| Palermo V, Rinalducci S, Sanchez M, Grillini F, Sommers JA, Brosh RM Jr, Zolla L, Franchitto A, Pichierri P.
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| Nat Commun 7:12880. doi: 10.1038/ncomms12880.
2016
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| 2 | BLM, DNA2, WRN
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| Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.
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| Pinto C, Kasaciunaite K, Seidel R, Cejka P.
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| Elife 5. pii: e18574. doi: 10.7554/eLife.18574.
2016
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| 3 | DNA2, RPA1
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| Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.
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| Zhou C, Pourmal S, Pavletich NP.
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| Elife 4. pii: e09832. doi: 10.7554/eLife.09832. [Epub ahead of print]
2015
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| 4 | DNA2
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| DNA double-strand breaks with 5' adducts are efficiently channeled to the DNA2-mediated resection pathway.
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| Tammaro M, Liao S, Beeharry N, Yan H.
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| Nucleic Acids Res ucleic Acids Res. 2015 Sep 29. pii: gkv969. [Epub ahead of print]
2015
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| 5 | DNA2, RECQL, RPA1
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| DNA2 drives processing and restart of reversed replication forks in human cells.
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| Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, Zellweger R, Moore H, Lee EH, Hendrickson EA, Cejka P, Stewart S, Lopes M, Vindigni A.
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| J Cell Biol 208(5):545-62. doi: 10.1083/jcb.201406100.
2015
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| 6 | BLM, DNA2, RMI1, RMI2, WRN
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| DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.
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| Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, Janscak P.
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| J Biol Chem 289(39):27314-26. doi: 10.1074/jbc.M114.578823. Epub 2014 Aug 13.
2014
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| 7 | DNA2, SCKL8
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| Genomic analysis of primordial dwarfism reveals novel disease genes.
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| Shaheen R, Faqeih E, Ansari S, Abdel-Salam G, Al-Hassnan ZN, Al-Shidi T, Alomar R, Sogaty S, Alkuraya FS.
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| Genome Res 24(2):291-9. doi: 10.1101/gr.160572.113. Epub 2014 Jan 3.
2014
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| 8 | DNA2
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| The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers.
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| Strauss C, Kornowski M, Benvenisty A, Shahar A, Masury H, Ben-Porath I, Ravid T, Arbel-Eden A, Goldberg M.
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| Oncotarget 5(19):9396-409.
2014
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| 9 | BLM, DNA2, WRN
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| DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.
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| Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, Janscak P.
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| J Biol Chem 289(39):27314-26. doi: 10.1074/jbc.M114.578823. Epub 2014 Aug 13.
2014
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| 10 | DNA2, HUS1, RAD1, RAD9A, RAD9B
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| Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery.
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| Kumar S, Burgers PM.
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| Genes Dev 27(3):313-21. doi: 10.1101/gad.204750.112. Epub 2013 Jan 25.
2013
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| 11 | DNA2
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| The N-terminal 45-kDa domain of Dna2 targets the enzyme to secondary-structured DNA.
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| Lee CH, Lee M, Kang HJ, Kim DH, Kang YH, Bae SH, Seo YS.
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| J Biol Chem Biol Chem. 2013 Jan 22. [Epub ahead of print]
2013
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| 12 | DNA2, PEOA6
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| Mutations in DNA2 Link Progressive Myopathy to Mitochondrial DNA Instability.
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| Ronchi D, Di Fonzo A, Lin W, Bordoni A, Liu C, Fassone E, Pagliarani S, Rizzuti M, Zheng L, Filosto M, Ferrņ MT, Ranieri M, Magri F, Peverelli L, Li H, Yuan YC, Corti S, Sciacco M, Moggio M, Bresolin N, Shen B, Comi GP.
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| Am J Hum Genet 92(2):293-300. doi: 10.1016/j.ajhg.2012.12.014. Epub 2013 Jan 24. 2013
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| 13 | DNA2
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| Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.
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| Lin W, Sampathi S, Dai H, Liu C, Zhou M, Hu J, Huang Q, Campbell J, Shin-Ya K, Zheng L, Chai W, Shen B.
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| EMBO J 32(10):1425-39. doi: 10.1038/emboj.2013.88. Epub 2013 Apr 19.
2013
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| 14 | DNA2, FANCD2
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| DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network.
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| Karanja KK, Cox SW, Duxin JP, Stewart SA, Campbell JL.
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| Cell Cycle 11(21):3983-96. doi: 10.4161/cc.22215. Epub 2012 Sep 17.
2012
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| 15 | DNA2
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| Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron-sulfur cluster domain.
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| Pokharel S, Campbell JL.
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| Nucleic Acids Res 40(16):7821-30. doi: 10.1093/nar/gks534. Epub 2012 Jun 7.
2012
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| 16 | DNA2
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| The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing.
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| Hu J, Sun L, Shen F, Chen Y, Hua Y, Liu Y, Zhang M, Hu Y, Wang Q, Xu W, Sun F, Ji J, Murray JM, Carr AM, Kong D.
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| Cell 149(6):1221-32. doi: 10.1016/j.cell.2012.04.030.
2012
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| 17 | DNA2
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| Dna2 offers support for stalled forks.
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| Lai MS, Foiani M.
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| Cell 149(6):1181-3. doi: 10.1016/j.cell.2012.05.021.
2012
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| 18 | DNA2
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| Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication.
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| Duxin JP, Moore HR, Sidorova J, Karanja K, Honaker Y, Dao B, Piwnica-Worms H, Campbell JL, Monnat RJ Jr, Stewart SA.
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| J Biol Chem 287(26):21980-91. doi: 10.1074/jbc.M112.359018. Epub 2012 May 7.
2012
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| 19 | BLM, DNA2, EXO1, NBN
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| BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
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| Nimonkar AV, Genschel J, Kinoshita E, Polaczek P, Campbell JL, Wyman C, Modrich P, Kowalczykowski SC.
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| Genes Dev 25(4):350-62.
2011
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| 20 | DNA2, EXO1
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| Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation.
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| Chen X, Niu H, Chung WH, Zhu Z, Papusha A, Shim EY, Lee SE, Sung P, Ira G.
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| Nat Struct Mol Biol 18(9):1015-9. doi: 10.1038/nsmb.2105.
2011
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| 21 | DNA2
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| Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.
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| Fortini BK, Pokharel S, Polaczek P, Balakrishnan L, Bambara RA, Campbell JL.
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| J Biol Chem 286(27):23763-70. doi: 10.1074/jbc.M111.243071. Epub 2011 May 13.
2011
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| 22 | DNA2
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| Dna2 exhibits a unique strand end-dependent helicase function.
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| Balakrishnan L, Polaczek P, Pokharel S, Campbell JL, Bambara RA.
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| J Biol Chem 285(50):38861-8. doi: 10.1074/jbc.M110.165191. Epub 2010 Oct 6.
2010
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| 23 | DNA2
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| Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes.
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| Kang YH, Lee CH, Seo YS.
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| Crit Rev Biochem Mol Biol 45(2):71-96. doi: 10.3109/10409230903578593. Review.
2010
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| 24 | DNA2
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| Human Dna2 is a nuclear and mitochondrial DNA maintenance protein.
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| Duxin JP, Dao B, Martinsson P, Rajala N, Guittat L, Campbell JL, Spelbrink JN, Stewart SA.
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| Mol Cell Biol 29(15):4274-82. Epub 2009 Jun 1.
2009
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| 25 | DNA2
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| Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates.
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| Zheng L, Zhou M, Guo Z, Lu H, Qian L, Dai H, Qiu J, Yakubovskaya E, Bogenhagen DF, Demple B, Shen B.
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| Mol Cell 32(3):325-36.
2008
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| 26 | DNA2
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| rocessing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition.
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| Masuda-Sasa T, Polaczek P, Peng XP, Chen L, Campbell JL.
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| J Biol Chem 283(36):24359-73. Epub 2008 Jun 30.
2008
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| 27 | DNA2
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| Biochemical analysis of human Dna2.
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| Masuda-Sasa T, Imamura O, Campbell JL.
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| Nucleic Acids Res 34(6):1865-75. Print 2006.
2006
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| 28 | DNA2
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| Isolation of human Dna2 endonuclease and characterization of its enzymatic properties.
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| Kim JH, Kim HD, Ryu GH, Kim DH, Hurwitz J, Seo YS.
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| Nucleic Acids Res 34(6):1854-64. Print 2006.
2006
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| 29 | DNA2
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| Assignment of the closest human homologue (DNA2L; KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1.
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| Eki T, et al.
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| Genomics 37 : 408-410. 1996
|