Citations for
The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis.
Gibson MP, Zhu Q, Wang S, Liu Q, Liu Y, Wang X, Yuan B, Ruest LB, Feng JQ, D'Souza RN, Qin C, Lu Y.
J Biol Chem 288(10):7204-14. doi: 10.1074/jbc.M112.445775. Epub 2013 Jan 24. 2013
Nuclear localization of DMP1 proteins suggests a role in intracellular signaling.
Siyam A, Wang S, Qin C, Mues G, Stevens R, D'Souza RN, Lu Y.
Biochem Biophys Res Commun 424(3):641-6. doi: 10.1016/j.bbrc.2012.07.037. Epub 2012 Jul 16. 2012
Dentin matrix protein 1 (DMP1) signals via cell surface integrin.
Wu H, Teng PN, Jayaraman T, Onishi S, Li J, Bannon L, Huang H, Close J, Sfeir C.
J Biol Chem 286(34):29462-9. Epub 2011 Jun 3. 2011
Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis.
Sun Y, Chen L, Ma S, Zhou J, Zhang H, Feng JQ, Qin C.
Cells Tissues Organs 194(2-4):199-204. Epub 2011 May 9. 2011
Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling.
Martin A, Liu S, David V, Li H, Karydis A, Feng JQ, Quarles LD.
FASEB J 25(8):2551-62. Epub 2011 Apr 20. 2011
Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation.
Pirotte S, Lamour V, Lambert V, Alvarez Gonzalez ML, Ormenese S, Noël A, Mottet D, Castronovo V, Bellahcène A.
Blood 117(8):2515-26. Epub 2010 Dec 29. 2011
Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis.
Sun Y, Prasad M, Gao T, Wang X, Zhu Q, D'Souza R, Feng JQ, Qin C.
J Biol Chem 285(41):31713-22. Epub 2010 Jul 27. 2010
Immunolocalization of DMP1 and sclerostin in the epiphyseal trabecule and diaphyseal cortical bone of osteoprotegerin deficient mice.
Masuki H, Li M, Hasegawa T, Suzuki R, Ying G, Zhusheng L, Oda K, Yamamoto T, Kawanami M, Amizuka N.
Biomed Res 31(5):307-18. 2010
Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus.
Lv K, Huang H, Lu Y, Qin C, Li Z, Feng JQ.
Int J Biol Sci 6(6):537-45. 2010
Long-term clinical outcome and carrier phenotype in autosomal recessive hypophosphatemia caused by a novel DMP1 mutation.
Mäkitie O, Pereira RC, Kaitila I, Turan S, Bastepe M, Laine T, Kröger H, Cole WG, Jüppner H.
J Bone Miner Res 25(10):2165-74. 2010
Different forms of DMP1 play distinct roles in mineralization.
Gericke A, Qin C, Sun Y, Redfern R, Redfern D, Fujimoto Y, Taleb H, Butler WT, Boskey AL.
J Dent Res 89(4):355-9. Epub 2010 Mar 3. 2010
Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets.
Farrow EG, Davis SI, Ward LM, Summers LJ, Bubbear JS, Keen R, Stamp TC, Baker LR, Bonewald LF, White KE.
Bone 44(2):287-94. Epub 2008 Oct 25. 2009
MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem/progenitor cell.
Chaussain C, Eapen AS, Huet E, Floris C, Ravindran S, Hao J, Menashi S, George A.
Eur Cell Mater 18:84-95. 2009
Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1.
Ravindran S, Narayanan K, Eapen AS, Hao J, Ramachandran A, Blond S, George A.
J Biol Chem 283(44):29658-70. Epub 2008 Aug 28. 2008
Dentin matrix protein-1 isoforms promote differential cell attachment and migration.
von Marschall Z, Fisher LW.
J Biol Chem 283(47):32730-40. Epub 2008 Sep 25. 2008
DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.
Lorenz-Depiereux B, Bastepe M, Benet-Pages A, Amyere M, Wagenstaller J, Muller-Barth U, Badenhoop K, Kaiser SM, Rittmaster RS, Shlossberg AH, Olivares JL, Loris C, Ramos FJ, Glorieux F, Vikkula M, Juppner H, Strom TM.
Nat Genet 38(11):1248-50. Epub 2006 Oct 8. 2006
Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.
Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S, Rios H, Drezner MK, Quarles LD, Bonewald LF, White KE.
Nat Genet 38(11):1310-5. Epub 2006 Oct 8. 2006
Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation.
Narayanan K, Gajjeraman S, Ramachandran A, Hao J, George A.
J Biol Chem 281(28):19064-71. Epub 2006 May 5. 2006
Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store.
Narayanan K, Ramachandran A, Hao J, He G, Park KW, Cho M, George A.
J Biol Chem 278(19):17500-8. Epub 2003 Mar 03. 2003
Dentin matrix protein 1 is expressed in human lung cancer.
Chaplet M, De Leval L, Waltregny D, Detry C, Fornaciari G, Bevilacqua G, Fisher LW, Castronovo V, Bellahcene A.
J Bone Miner Res 18(8):1506-12. 2003
21CD44, DMP1, CFH, SPP1
Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack.
Jain A, Karadag A, Fohr B, Fisher LW, Fedarko NS.
J Biol Chem 277(16):13700-8. 2002
Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene.
Fen JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, Owen M, Harris SE, MacDougall M.
J Bone Miner Res 17(10):1822-31. 2002
Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II.
Hirst KL, Simmons D, Feng J, Aplin H, Dixon MJ, MacDougall M.
Genomics 42(1):38-45. 1997
Assignment of DMP1 to human chromosome 4 band q21 by in situ hybridization.
MacDougall M, et al.
Cytogenet Cell Genet 74 : 189. 1996
25DMP1, DGI1
Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21.
Aplin HM, et al.
Genomics 30 : 347-349. 1995
26DMP1, DGI1
In situ localization and chromosomal mapping of the AG1 (Dmp1) gene.
George A, et al.
J Histochem Cytochem 42 : 1527-1531. 1994
Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization.
George A, Sabsay B, Simonian PA, Veis A.
J Biol Chem 268(17):12624-30. 1993