Citations for
Posterior axis formation requires Dlx5/Dlx6 expression at the neural plate border.
Narboux-Neme N, Ekker M, Levi G, Heude E.
PLoS One 14(3):e0214063. doi: 10.1371/journal.pone.0214063. eCollection 2019. 2019
Measuring inputs to a common function: The case of Dlx5 and Dlx6.
Quach A, MacKenzie RK, Bendall AJ.
Biochem Biophys Res Commun 478(1):371-377. doi: 10.1016/j.bbrc.2016.07.044. Epub 2016 Jul 11. 2016
The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand.
Conte D, Garaffo G, Lo Iacono N, Mantero S, Piccolo S, Cordenonsi M, Perez-Morga D, Orecchia V, Poli V, Merlo GR.
Hum Mol Genet 25(4):740-54. doi: 10.1093/hmg/ddv514. Epub 2015 Dec 18. 2016
Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis.
Bellessort B, Le Cardinal M, Bachelot A, Narboux-NÍme N, Garagnani P, Pirazzini C, Barbieri O, Mastracci L, Jonchere V, Duvernois-Berthet E, Fontaine A, Alfama G, Levi G.
Hum Mol Genet 25(1):97-108. doi: 10.1093/hmg/ddv452. Epub 2015 Oct 28. 2016
Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.
Rattanasopha S, Tongkobpetch S, Srichomthong C, Kitidumrongsook P, Suphapeetiporn K, Shotelersuk V.
J Med Genet 51(12):817-23. doi: 10.1136/jmedgenet-2014-102576. 2014
Next generation sequencing of chromosomal rearrangements in patients with split-hand/split-foot malformation provides evidence for DYNC1I1 exonic enhancers of DLX5/6 expression in humans.
Lango Allen H, Caswell R, Xie W, Xu X, Wragg C, Turnpenny PD, Turner CL, Weedon MN, Ellard S.
J Med Genet 51(4):264-7. doi: 10.1136/jmedgenet-2013-102142. Epub 2014 Jan 23. 2014
BMP-Mediated Functional Cooperation between Dlx5;Dlx6 and Msx1;Msx2 during Mammalian Limb Development.
Vieux-Rochas M, Bouhali K, Mantero S, Garaffo G, Provero P, Astigiano S, Barbieri O, Caratozzolo MF, Tullo A, Guerrini L, Lallemand Y, Robert B, Levi G, Merlo GR.
PLoS One 8(1):e51700. doi: 10.1371/journal.pone.0051700. Epub 2013 Jan 29. 2013
Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms.
Kim KS, Arima Y, Kitazawa T, Nishiyama K, Asai R, Uchijima Y, Sato T, Levi G, Kitanaka S, Igarashi T, Kurihara Y, Kurihara H.
Mech Dev ech Dev. 2013 Aug 8. doi:pii: S0925-4773(13)00060-9. 10.1016/j.mod.2013.07.005. [Epub ahead of print] 2013
Functional characterization of tissue-specific enhancers in the DLX5/6 locus.
Birnbaum RY, Everman DB, Murphy KK, Gurrieri F, Schwartz CE, Ahituv N.
Hum Mol Genet 21(22):4930-8. doi: 10.1093/hmg/dds336. Epub 2012 Aug 21. 2012
10DLX5, DLX6
Dlx5 and Dlx6 expression in the anterior neural fold is essential for patterning the dorsal nasal capsule.
Gitton Y, Benouaiche L, Vincent C, Heude E, Soulika M, Bouhali K, Couly G, Levi G.
Development 138(5):897-903. doi: 10.1242/dev.057505. Epub 2011 Jan 26. 2011
11DEL7Q21, DLX5, DLX6
Deletion of an enhancer near DLX5 and DLX6 in a family with hearing loss, craniofacial defects, and an inv(7)(q21.3q35).
Brown KK, Reiss JA, Crow K, Ferguson HL, Kelly C, Fritzsch B, Morton CC.
Hum Genet 127(1):19-31. Epub .PMID: 19707792 2010
Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus.
Kouwenhoven EN, van Heeringen SJ, Tena JJ, Oti M, Dutilh BE, Alonso ME, de la Calle-Mustienes E, Smeenk L, Rinne T, Parsaulian L, Bolat E, Jurgelenaite R, Huynen MA, Hoischen A, Veltman JA, Brunner HG, Roscioli T, Oates E, Wilson M, Manzanares M, Gůmez-Skarmeta JL, Stunnenberg HG, Lohrum M, van Bokhoven H, Zhou H.
PLoS Genet 6(8):e1001065.PMID: 20808887 2010
13DLX5, DLX6
Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.
Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL.
J Neurosci 30(15):5334-45.PMID: 20392955 2010
Expression analysis and mutation detection of DLX5 and DLX6 in autism.
Nakashima N, Yamagata T, Mori M, Kuwajima M, Suwa K, Momoi MY.
Brain Dev 32(2):98-104. Epub 2009 Feb 4.PMID: 19195802 2010
15DLX5, DLX6
Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification.
Zhu H, Bendall AJ.
PLoS One 4(11):e8097.PMID: 19956613 2009
16DLX5, DLX6
Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry.
Bond AM, Vangompel MJ, Sametsky EA, Clark MF, Savage JC, Disterhoft JF, Kohtz JD.
Nat Neurosci 12(8):1020-7. Epub 2009 Jul 20.PMID: 19620975 2009
17DEL7Q21, SHFM1, DLX5, DLX6
Complex rearrangement of chromosomes 7q21.13-q22.1 confirms the ectrodactyly-deafness locus and suggests new candidate genes.
Bernardini L, Palka C, Ceccarini C, Capalbo A, Bottillo I, Mingarelli R, Novelli A, Dallapiccola B.
Am J Med Genet A 146(2):238-44. 2008
Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects.
Lo Iacono N, Mantero S, Chiarelli A, Garcia E, Mills AA, Morasso MI, Costanzo A, Levi G, Guerrini L, Merlo GR.
Development 135(7):1377-88.PMID: 18326838 2008
19SHFM1, DEL7Q21, DLX5, DLX6
Characterization of a 16 Mb interstitial chromosome 7q21 deletion by tiling path array CGH.
Tzschach A, Menzel C, Erdogan F, Schubert M, Hoeltzenbein M, Barbi G, Petzenhauser C, Ropers HH, Ullmann R, Kalscheuer V.
Am J Med Genet A 143(4):333-7. 2007
DLX5 and DLX6 Expression Is Biallelic and Not Modulated by MeCP2 Deficiency.
Schule B, Li HH, Fisch-Kohl C, Purmann C, Francke U.
Am J Hum Genet 81(3):492-506. Epub 2007 Aug 2. 2007
Dlx homeobox gene control of mammalian limb and craniofacial development.
Kraus P, Lufkin T.
Am J Med Genet A 140(13):1366-74. Review. 2006
The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development.
Robledo RF, Rajan L, Li X, Lufkin T.
Genes Dev 16(9):1089-101. 2002
The coding region of the human DLX6 gene contains a polymorphic CAG/CCG repeat.
Pfeffer U, Ferro P, Pavia V, Trombino S, Dell'Eva R, Merlo G, Levi G.
Int J Oncol 18(6):1293-7. 2001
Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer.
Charite J, McFadden DG, Merlo G, Levi G, Clouthier DE, Yanagisawa M, Richardson JA, Olson EN.
Genes Dev 15(22):3039-49. 2001
25DLX5, DLX6, SHFM1, DEL7Q21
Characterization of the split hand/split foot malformation locus SHFM1at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development.
Crackower MA, et al.
Hum Mol Genet 5 : 571-579. 1996
26DLX1, DLX2, DLX5, DLX6
Cloning and characterization of two members of the vertebrate Dlx gene family.
Simeone A, et al.
Proc Natl Acad Sci U S A 91 : 2250-2254. 1994