| 1 | DLX5, DLX6
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| Posterior axis formation requires Dlx5/Dlx6 expression at the neural plate border.
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| Narboux-Neme N, Ekker M, Levi G, Heude E.
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| PLoS One 14(3):e0214063. doi: 10.1371/journal.pone.0214063. eCollection 2019.
2019
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| 2 | DLX5, STAT5A
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| Inhibition of STAT5A promotes osteogenesis by DLX5 regulation.
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| Lee KM, Park KH, Hwang JS, Lee M, Yoon DS, Ryu HA, Jung HS, Park KW, Kim J, Park SW, Kim SH, Chun YM, Choi WJ, Lee JW.
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| Cell Death Dis 9(11):1136. doi: 10.1038/s41419-018-1184-7.
2018
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| 3 | DLX5
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| Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice.
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| Johnson KR, Gagnon LH, Tian C, Longo-Guess CM, Low BE, Wiles MV, Kiernan AE.
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| Genetics 208(3):1165-1179. doi: 10.1534/genetics.117.300447. Epub 2018 Jan 3.
2018
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| 4 | DLX5, FGF10
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| The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development.
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| Sugii H, Grimaldi A, Li J, Parada C, Vu-Ho T, Feng J, Jing J, Yuan Y, Guo Y, Maeda H, Chai Y.
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| Development 144(21):4037-4045. doi: 10.1242/dev.155176. Epub 2017 Oct 5.
2017
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| 5 | DLX5
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| Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker.
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| Zadora J, Singh M, Herse F, Przybyl L, Haase N, Golic M, Yung HW, Huppertz B, Cartwright JE, Whitley G, Johnsen GM, Levi G, Isbruch A, Schulz H, Luft FC, Müller DN, Staff AC, Hurst LD, Dechend R, Izsvák Z.
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| Circulation 136(19):1824-1839. doi: 10.1161/CIRCULATIONAHA.117.028110. Epub 2017 Sep 13. Erratum in: Circulation. 2018 Oct 9;138(15):e423.
2017
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| 6 | DLX5, MAGED1, NDN
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| Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1.
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| Ju H, Lee S, Lee J, Ghil S.
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| Biochem Biophys Res Commun 489(2):109-115. doi: 10.1016/j.bbrc.2017.05.101. Epub 2017 May 19.
2017
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| 7 | DLX5, DLX6
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| Measuring inputs to a common function: The case of Dlx5 and Dlx6.
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| Quach A, MacKenzie RK, Bendall AJ.
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| Biochem Biophys Res Commun 478(1):371-377. doi: 10.1016/j.bbrc.2016.07.044. Epub 2016 Jul 11.
2016
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| 8 | DLX5, DLX6, SHFM1
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| The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6-/- shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand.
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| Conte D, Garaffo G, Lo Iacono N, Mantero S, Piccolo S, Cordenonsi M, Perez-Morga D, Orecchia V, Poli V, Merlo GR.
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| Hum Mol Genet 25(4):740-54. doi: 10.1093/hmg/ddv514. Epub 2015 Dec 18.
2016
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| 9 | DLX5, DLX6
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| Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis.
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| Bellessort B, Le Cardinal M, Bachelot A, Narboux-Nęme N, Garagnani P, Pirazzini C, Barbieri O, Mastracci L, Jonchere V, Duvernois-Berthet E, Fontaine A, Alfama G, Levi G.
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| Hum Mol Genet 25(1):97-108. doi: 10.1093/hmg/ddv452. Epub 2015 Oct 28.
2016
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| 10 | DLX5, DLX6, SHFM1
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| Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.
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| Rattanasopha S, Tongkobpetch S, Srichomthong C, Kitidumrongsook P, Suphapeetiporn K, Shotelersuk V.
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| J Med Genet 51(12):817-23. doi: 10.1136/jmedgenet-2014-102576.
2014
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| 11 | DLX5, SHFM1
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| Exome sequencing reveals a heterozygous DLX5 mutation in a Chinese family with autosomal-dominant split-hand/foot malformation.
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| Wang X, Xin Q, Li L, Li J, Zhang C, Qiu R, Qian C, Zhao H, Liu Y, Shan S, Dang J, Bian X, Shao C, Gong Y, Liu Q.
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| Eur J Hum Genet 22(9):1105-10. doi: 10.1038/ejhg.2014.7.
2014
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| 12 | DLX5, DLX6, DYNC1L1
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| Next generation sequencing of chromosomal rearrangements in patients with split-hand/split-foot malformation provides evidence for DYNC1I1 exonic enhancers of DLX5/6 expression in humans.
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| Lango Allen H, Caswell R, Xie W, Xu X, Wragg C, Turnpenny PD, Turner CL, Weedon MN, Ellard S.
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| J Med Genet 51(4):264-7. doi: 10.1136/jmedgenet-2013-102142. Epub 2014 Jan 23.
2014
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| 13 | DLX5, DLX6, MSX1, MSX2
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| BMP-Mediated Functional Cooperation between Dlx5;Dlx6 and Msx1;Msx2 during Mammalian Limb Development.
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| Vieux-Rochas M, Bouhali K, Mantero S, Garaffo G, Provero P, Astigiano S, Barbieri O, Caratozzolo MF, Tullo A, Guerrini L, Lallemand Y, Robert B, Levi G, Merlo GR.
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| PLoS One 8(1):e51700. doi: 10.1371/journal.pone.0051700. Epub 2013 Jan 29.
2013
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| 14 | DLX5, DLX6, EDN1
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| Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms.
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| Kim KS, Arima Y, Kitazawa T, Nishiyama K, Asai R, Uchijima Y, Sato T, Levi G, Kitanaka S, Igarashi T, Kurihara Y, Kurihara H.
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| Mech Dev ech Dev. 2013 Aug 8. doi:pii: S0925-4773(13)00060-9. 10.1016/j.mod.2013.07.005. [Epub ahead of print]
2013
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| 15 | DLX5
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| The transcription factors myeloid elf-1-like factor (MEF) and distal-less homeobox 5 (Dlx5) inversely regulate the differentiation of osteoblasts and adipocytes in bone marrow.
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| Baek K, Baek JH.
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| Adipocyte 2(1):50-54.
2013
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| 16 | DLX5, GATA4, RUNX2
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| GATA4 negatively regulates osteoblast differentiation by downregulation of Runx2.
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| Song I, Kim K, Kim JH, Lee YK, Jung HJ, Byun HO, Yoon G, Kim N.
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| BMB Rep MB Rep. 2013 Dec 22. pii: 2539. [Epub ahead of print]
2013
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| 17 | DLX5, EPHA5, EPHA7, MSX2
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| Dlx5 and Msx2 regulate mouse anterior neural tube closure through ephrinA5-EphA7.
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| Lee J, Corcoran A, Han M, Gardiner DM, Muneoka K.
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| Dev Growth Differ 55(3):341-9. doi: 10.1111/dgd.12044. Epub 2013 Feb 21.
2013
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| 18 | DLX5, SHFM1
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| Identification of a novel DLX5 mutation in a family with autosomal recessive split hand and foot malformation.
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| Shamseldin HE, Faden MA, Alashram W, Alkuraya FS.
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| J Med Genet 49(1):16-20. doi: 10.1136/jmedgenet-2011-100556. Epub 2011 Nov 25.
2012
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| 19 | DLX3, DLX5, GPNMB, MSX2
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| Homeodomain transcription factors regulate BMP-2-induced osteoactivin transcription in osteoblasts.
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| Singh M, Del Carpio-Cano FE, Monroy MA, Popoff SN, Safadi FF.
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| J Cell Physiol 227(1):390-9. doi: 10.1002/jcp.22791.
2012
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| 20 | DLX5, DLX6, SHFM1
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| Functional characterization of tissue-specific enhancers in the DLX5/6 locus.
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| Birnbaum RY, Everman DB, Murphy KK, Gurrieri F, Schwartz CE, Ahituv N.
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| Hum Mol Genet 21(22):4930-8. doi: 10.1093/hmg/dds336. Epub 2012 Aug 21.
2012
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| 21 | DLX5
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| Identification of direct downstream targets of Dlx5 during early inner ear development.
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| Sajan SA, Rubenstein JL, Warchol ME, Lovett M.
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| Hum Mol Genet 20(7):1262-73. Epub 2011 Jan 12.
2011
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| 22 | BMP2, DLX5, PRKACA
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| Protein kinase A phosphorylates and regulates the osteogenic activity of Dlx5.
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| Han Y, Jin YH, Yum J, Jeong HM, Choi JK, Yeo CY, Lee KY.
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| Biochem Biophys Res Commun 407(3):461-5. Epub 2011 Mar 22.
2011
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| 23 | DLX5
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| Akt phosphorylates and regulates the function of Dlx5.
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| Jeong HM, Jin YH, Kim YJ, Yum J, Choi YH, Yeo CY, Lee KY.
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| Biochem Biophys Res Commun 409(4):681-6. doi: 10.1016/j.bbrc.2011.05.064. Epub 2011 May 17.
2011
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| 24 | DLX5, DLX6
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| Dlx5 and Dlx6 expression in the anterior neural fold is essential for patterning the dorsal nasal capsule.
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| Gitton Y, Benouaiche L, Vincent C, Heude E, Soulika M, Bouhali K, Couly G, Levi G.
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| Development 138(5):897-903. doi: 10.1242/dev.057505. Epub 2011 Jan 26.
2011
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| 25 | DEL7Q21, DLX5, DLX6
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| Deletion of an enhancer near DLX5 and DLX6 in a family with hearing loss, craniofacial defects, and an inv(7)(q21.3q35).
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| Brown KK, Reiss JA, Crow K, Ferguson HL, Kelly C, Fritzsch B, Morton CC.
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| Hum Genet 127(1):19-31. Epub .PMID: 19707792 2010
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| 26 | DLX5, DLX6, SHFM1
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| Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus.
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| Kouwenhoven EN, van Heeringen SJ, Tena JJ, Oti M, Dutilh BE, Alonso ME, de la Calle-Mustienes E, Smeenk L, Rinne T, Parsaulian L, Bolat E, Jurgelenaite R, Huynen MA, Hoischen A, Veltman JA, Brunner HG, Roscioli T, Oates E, Wilson M, Manzanares M, Gómez-Skarmeta JL, Stunnenberg HG, Lohrum M, van Bokhoven H, Zhou H.
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| PLoS Genet 6(8):e1001065.PMID: 20808887 2010
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| 27 | DLX5, DLX6
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| Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.
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| Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL.
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| J Neurosci 30(15):5334-45.PMID: 20392955 2010
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| 28 | DLX5, MSX1
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| Msx1 and Dlx5 function synergistically to regulate frontal bone development.
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| Chung IH, Han J, Iwata J, Chai Y.
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| Genesis 48(11):645-55. doi: 10.1002/dvg.20671. Epub 2010 Nov 2.
2010
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| 29 | DLX5, MYC
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| DLX5 (Distal-less Homeobox 5) Promotes Tumor Cell Proliferation by Transcriptionally Regulating MYC.
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| Xu J, Testa JR.
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| J Biol Chem 284(31):20593-601. Epub 2009 Jun 4.
2009
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| 30 | DLX5, DLX6
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| Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification.
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| Zhu H, Bendall AJ.
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| PLoS One 4(11):e8097.PMID: 19956613 2009
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| 31 | DLX5, DLX6
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| Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry.
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| Bond AM, Vangompel MJ, Sametsky EA, Clark MF, Savage JC, Disterhoft JF, Kohtz JD.
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| Nat Neurosci 12(8):1020-7. Epub 2009 Jul 20.PMID: 19620975 2009
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| 32 | DEL7Q21, SHFM1, DLX5, DLX6
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| Complex rearrangement of chromosomes 7q21.13-q22.1 confirms the ectrodactyly-deafness locus and suggests new candidate genes.
|
| Bernardini L, Palka C, Ceccarini C, Capalbo A, Bottillo I, Mingarelli R, Novelli A, Dallapiccola B.
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| Am J Med Genet A 146(2):238-44. 2008
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| 33 | SP7, DLX5, BMP2
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| BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38.
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| Ulsamer A, Ortu–o MJ, Ruiz S, Susperregui AR, Osses N, Rosa JL, Ventura F.
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| J Biol Chem 283(7):3816-26. Epub 2007 Dec 3. 2008
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| 34 | DLX5, DLX6, SHFM1, SHFM4
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| Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects.
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| Lo Iacono N, Mantero S, Chiarelli A, Garcia E, Mills AA, Morasso MI, Costanzo A, Levi G, Guerrini L, Merlo GR.
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| Development 135(7):1377-88.PMID: 18326838 2008
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| 35 | SHFM1, DEL7Q21, DLX5, DLX6
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| Characterization of a 16 Mb interstitial chromosome 7q21 deletion by tiling path array CGH.
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| Tzschach A, Menzel C, Erdogan F, Schubert M, Hoeltzenbein M, Barbi G, Petzenhauser C, Ropers HH, Ullmann R, Kalscheuer V.
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| Am J Med Genet A 143(4):333-7. 2007
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| 36 | DLX5,DLX6,MECP2
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| DLX5 and DLX6 Expression Is Biallelic and Not Modulated by MeCP2 Deficiency.
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| Schule B, Li HH, Fisch-Kohl C, Purmann C, Francke U.
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| Am J Hum Genet 81(3):492-506. Epub 2007 Aug 2. 2007
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| 37 | DLX5, MECP2
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| Imprinting status of paternally imprinted DLX5 gene in Japanese patients with Rett syndrome.
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| Itaba-Matsumoto N, Maegawa S, Yamagata H, Kondo I, Oshimura M, Nanba E.
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| Brain Dev 29(8):491-5. Epub 2007 Mar 23.
2007
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| 38 | DLX1,DLX2,DLX3,DLX4,DLX5,DLX6
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| Dlx homeobox gene control of mammalian limb and craniofacial development.
|
| Kraus P, Lufkin T.
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| Am J Med Genet A 140(13):1366-74. Review. 2006
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| 39 | MECP2, RTT, DLX5
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| Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome.
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| Horike S, Cai S, Miyano M, Cheng JF, Kohwi-Shigematsu T.
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| Nat Genet 37(1):31-40. Epub 2004 Dec 19. 2005
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| 40 | RTT, DLX5
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| Is Rett syndrome a loss-of-imprinting disorder?
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| Pescucci C, Meloni I, Renieri A.
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| Nat Genet 37(1):10-1. No abstract available. 2005
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| 41 | DLX5, PEG10
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| A new imprinted cluster on the human chromosome 7q21-q31, identified by human-mouse monochromosomal hybrids.
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| Okita C, Meguro M, Hoshiya H, Haruta M, Sakamoto YK, Oshimura M.
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| Genomics 81(6):556-9. 2003
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| 42 | DLX5
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| DLX5 regulates development of peripheral and central components of the olfactory system.
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| Long JE, Garel S, Depew MJ, Tobet S, Rubenstein JL.
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| J Neurosci 23(2):568-78. 2003
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| 43 | DLX5, MAGED1, PJA1, PJA2
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| A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.
|
| Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K.
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| J Biol Chem 277(25):22541-6. 2002
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| 44 | DEL7Q21,DLX5,DLX6,SHFM1
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| The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development.
|
| Robledo RF, Rajan L, Li X, Lufkin T.
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| Genes Dev 16(9):1089-101. 2002
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| 45 | DLX4, DLX5, MSX2
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| Comparative study of MSX-2, DLX-5, and DLX-7 gene expression during early human tooth development.
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| Davideau JL, Demri P, Hotton D, Gu TT, MacDougall M, Sharpe P, Forest N, Berdal A.
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| Pediatr Res 46(6):650-6. 1999
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| 46 | DLX5, DLX6, SHFM1, DEL7Q21
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| Characterization of the split hand/split foot malformation locus SHFM1at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development.
|
| Crackower MA, et al.
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| Hum Mol Genet 5 : 571-579. 1996
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| 47 | DLX1, DLX2, DLX5, DLX6
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| Cloning and characterization of two members of the vertebrate Dlx gene family.
|
| Simeone A, et al.
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| Proc Natl Acad Sci U S A 91 : 2250-2254. 1994
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| 48 | DLX5, SHFM1, DEL7Q21
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| Physical mapping of the split hand/split foot locus on chromosome 7 and implication in syndromic ectrodactyly.
|
| Scherer SW, et al.
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| Hum Mol Genet 3 : 1345-1354. 1994
|