Citations for
1DLG1, KIF11, PTEN
Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.
van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM.
Nat Cell Biol 18(7):814-21. doi: 10.1038/ncb3369. Epub 2016 May 30. 2016
2AKAP5, DLG1, DLG4, GPER1
G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production.
Broselid S, Berg KA, Chavera TA, Kahn R, Clarke WP, Olde B, Leeb-Lundberg LM.
J Biol Chem 289(32):22117-27. doi: 10.1074/jbc.M114.566893. Epub 2014 Jun 24. 2014
3ADRB1, DLG1, PDE4D
A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.
Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK.
J Biol Chem 289(21):14771-81. doi: 10.1074/jbc.M113.542589. Epub 2014 Apr 8. 2014
4ADAM10, DLG1
SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation.
Saraceno C, Marcello E, Di Marino D, Borroni B, Claeysen S, Perroy J, Padovani A, Tramontano A, Gardoni F, Di Luca M.
Cell Death Dis 5:e1547. doi: 10.1038/cddis.2014.492. 2014
5DLG1
Emerging role of the scaffolding protein dlg1 in vesicle trafficking.
Walch L.
Traffic 14(9):964-73. doi: 10.1111/tra.12089. 2013
6CASK, DLG1
Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development.
Ahn SY, Kim Y, Kim ST, Swat W, Miner JH.
J Am Soc Nephrol 24(7):1127-38. doi: 10.1681/ASN.2012111074. Epub 2013 May 9. 2013
7DLG1
Crystal structure of the guanylate kinase domain from discs large homolog 1 (DLG1/SAP97).
Mori S, Tezuka Y, Arakawa A, Handa N, Shirouzu M, Akiyama T, Yokoyama S.
Biochem Biophys Res Commun 435(3):334-8. doi: 10.1016/j.bbrc.2013.04.056. Epub 2013 Apr 25. 2013
8CRHR1, DLG1
Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling.
Dunn HA, Walther C, Godin CM, Hall RA, Ferguson SS.
J Biol Chem 288(21):15023-34. doi: 10.1074/jbc.M113.473660. Epub 2013 Apr 10. 2013
9DLG1
Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development.
Rivera C, Simonson SJ, Yamben IF, Shatadal S, Nguyen MM, Beurg M, Lambert PF, Griep AE.
PLoS One 8(1):e54410. doi: 10.1371/journal.pone.0054410. Epub 2013 Jan 22. 2013
10CASK, DLG1
CASK Regulates SAP97 Conformation and Its Interactions with AMPA and NMDA Receptors.
Lin EI, Jeyifous O, Green WN.
J Neurosci 33(29):12067-76. doi: 10.1523/JNEUROSCI.0816-13.2013. 2013
11ADRB1, AKAP5, DLG1
SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains.
Nooh MM, Naren AP, Kim SJ, Xiang YK, Bahouth SW.
PLoS One 8(5):e63379. doi: 10.1371/journal.pone.0063379. Print 2013. 2013
12DLG1, DLG2, DLG3, DLG4, EPHB1, PAK1
Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.
Murata Y, Constantine-Paton M.
J Neurosci 33(11):5040-52. doi: 10.1523/JNEUROSCI.2896-12.2013. 2013
13DLG1
Characterization of in vivo Dlg1 deletion on T cell development and function.
Humphries LA, Shaffer MH, Sacirbegovic F, Tomassian T, McMahon KA, Humbert PO, Silva O, Round JL, Takamiya K, Huganir RL, Burkhardt JK, Russell SM, Miceli MC.
PLoS One 7(9):e45276. doi: 10.1371/journal.pone.0045276. Epub 2012 Sep 18. 2012
14DLG1, SCN7A
SAP97 promotes the stability of Nax channels at the plasma membrane.
Matsumoto M, Fujikawa A, Suzuki R, Shimizu H, Kuboyama K, Hiyama TY, Hall RA, Noda M.
FEBS Lett 586(21):3805-12. doi: 10.1016/j.febslet.2012.09.018. Epub 2012 Sep 25. 2012
15CALM1, DLG1, GJB1
Characterization of the structure and intermolecular interactions between the connexin 32 carboxyl-terminal domain and the protein partners synapse-associated protein 97 and calmodulin.
Stauch K, Kieken F, Sorgen P.
J Biol Chem 287(33):27771-88. doi: 10.1074/jbc.M112.382572. Epub 2012 Jun 20. 2012
16DLG1
Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function.
Zanin-Zhorov A, Lin J, Scher J, Kumari S, Blair D, Hippen KL, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML.
Proc Natl Acad Sci U S A 109(5):1625-30. doi: 10.1073/pnas.1110120109. Epub 2012 Jan 17. 2012
17DLG1, LCK
Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.
Stephen TL, Wilson BS, Laufer TM.
Proc Natl Acad Sci U S A 109(19):7415-20. doi: 10.1073/pnas.1119272109. Epub 2012 Apr 23. 2012
18DLG1
SAP97 directs NMDA receptor spine targeting and synaptic plasticity.
Li D, Specht CG, Waites CL, Butler-Munro C, Leal-Ortiz S, Foote JW, Genoux D, Garner CC, Montgomery JM.
J Physiol 589(Pt 18):4491-510. doi: 10.1113/jphysiol.2011.215566. Epub 2011 Jul 18. 2011
19DLG1, SCN5A
SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes.
Petitprez S, Zmoos AF, Ogrodnik J, Balse E, Raad N, El-Haou S, Albesa M, Bittihn P, Luther S, Lehnart SE, Hatem SN, Coulombe A, Abriel H.
Circ Res 108(3):294-304. doi: 10.1161/CIRCRESAHA.110.228312. Epub 2010 Dec 16. 2011
20DLG1, MAP2K2
The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring.
Gaudet S, Langlois MJ, Lue RA, Rivard N, Viel A.
BMC Cell Biol 12:55. doi: 10.1186/1471-2121-12-55. 2011
21DLG1, GPSM2
Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules.
Zhu J, Shang Y, Xia C, Wang W, Wen W, Zhang M.
EMBO J 30(24):4986-97. doi: 10.1038/emboj.2011.428. 2011
22DLG1
The role of SAP97 in synaptic glutamate receptor dynamics.
Howard MA, Elias GM, Elias LA, Swat W, Nicoll RA.
Proc Natl Acad Sci U S A 107(8):3805-10. Epub 2010 Feb 3.PMID: 20133708 2010
23DEL3Q29, DLG1, PAK2, SCZD28
Microdeletions of 3q29 Confer High Risk for Schizophrenia.
Mulle JG, Dodd AF, McGrath JA, Wolyniec PS, Mitchell AA, Shetty AC, Sobreira NL, Valle D, Rudd MK, Satten G, Cutler DJ, Pulver AE, Warren ST.
Am J Hum Genet 87(2):229-236.PMID: 20691406 2010
24DLG1, DLG2, DLG3, DLG4
Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.
Akgul G, Wollmuth LP.
J Comp Neurol 518(24):4842-54. 2010
25CDC42, DLG1, DLGAP1
Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarity
Manneville JB, Jehanno M, Etienne-Manneville S.
J Cell Biol. Nov 1;191(3):585-98. doi: 10.1083/jcb.201002151. 2010
26DLG1
CDK phosphorylation of the discs large tumour suppressor controls its localisation and stability.
Narayan N, Massimi P, Banks L.
J Cell Sci 122(Pt 1):65-74. Epub 2008 Dec 9.PMID: 19066288 2009
27DLG1
DLG1/SAP97 modulates transforming growth factor alpha bioavailability.
Surena AL, de Faria GP, Studler JM, Peiretti F, Pidoux M, Camonis J, Chneiweiss H, Formstecher E, Junier MP.
Biochim Biophys Acta 1793(2):264-72. Epub 2008 Sep 27.PMID: 18930083 2009
28CASK, DLG1
SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.
Jeyifous O, Waites CL, Specht CG, Fujisawa S, Schubert M, Lin EI, Marshall J, Aoki C, de Silva T, Montgomery JM, Garner CC, Green WN.
Nat Neurosci. 12(8):1011-9. 2009
29CASK, DLG1, LIN7C
CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.
Lozovatsky L, Abayasekara N, Piawah S, Walther Z.
Mol Biol Cell 20(21):4489-99. Epub 2009 Sep 2.PMID: 19726564 2009
30DLG1, EXOC4, MTMR2
Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination.
Bolis A, Coviello S, Visigalli I, Taveggia C, Bachi A, Chishti AH, Hanada T, Quattrini A, Previtali SC, Biffi A, Bolino A.
J Neurosci 29(27):8858-70.PMID: 19587293 2009
31DLG1
Cloning and functional analysis of the promoter region of the human Disc large gene.
Cavatorta AL, Giri AA, Banks L, Gardiol D.
Gene 424(1-2):87-95. Epub 2008 Aug 7. 2008
32DLG1, MARCHF2
DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.
Cao Z, Huett A, Kuballa P, Giallourakis C, Xavier RJ.
Cell Signal 20(1):73-82. Epub 2007 Sep 12.PMID: 17980554 2008
33DLG1, LLGL1, SCRIB
Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex.
Massimi P, Narayan N, Thomas M, Gammoh N, Strand S, Strand D, Banks L.
Exp Cell Res 314(18):3306-17. Epub 2008 Sep 3.PMID: 18793635 2008
34SCRIB, DLG1
The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells.
Arpin-André C, Mesnard JM.
J Biol Chem 282(45):33132-41. Epub 2007 Sep 11. 2007
35DLG1
DLGH1 is a negative regulator of T-lymphocyte proliferation.
Stephenson LM, Sammut B, Graham DB, Chan-Wang J, Brim KL, Huett AS, Miletic AV, Kloeppel T, Landry A, Xavier R, Swat W.
Mol Cell Biol 27(21):7574-81. Epub 2007 Aug 27.PMID: 17724087 2007
36DLG1, NET1
The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.
GarcŪa-Mata R, Dubash AD, Sharek L, Carr HS, Frost JA, Burridge K.
Mol Cell Biol 27(24):8683-97. Epub 2007 Oct 15. 2007
37DLG1, EPB41L1, ITPR1
Differential neuronal and glial expression of GluR1 AMPA receptor subunit and the scaffolding proteins SAP97 and 4.1N during rat cerebellar development.
Douyard J, Shen L, Huganir RL, Rubio ME.
J Comp Neurol 502(1):141-56. 2007
38SCRIB, DLG1
Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.
Gardiol D, Zacchi A, Petrera F, Stanta G, Banks L.
Int J Cancer 119(6):1285-90. 2006
39KCNA5, DLG1
A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97.
Mathur R, Choi WS, Eldstrom J, Wang Z, Kim J, Steele DF, Fedida D.
Biochem Biophys Res Commun 342(1):1-8. Epub 2006 Jan 31. 2006
40DLG1
Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins.
He J, Bellini M, Inuzuka H, Xu J, Xiong Y, Yang X, Castleberry AM, Hall RA.
J Biol Chem. 281(5):2820-7 2006
41DLG1
Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.
Mahoney, Z. X.; Sammut, B.; Xavier, R. J.; Cunninham, J.; Go, G.; Brim, K. L.; Stappenbeck, T. S.; Miner, J. H.; Swat, W.
Proc. Nat. Acad. Sci. 103: 19872-19877 2006
42DLG1
Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells.
Round JL, Tomassian T, Zhang M, Patel V, Schoenberger SP, Miceli MC.
J Exp Med 201(3):419-30. 2005
43DLG1
hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis.
Gregorc U, Ivanova S, Thomas M, Turk V, Banks L, Turk B.
Biol Chem 386(7):705-10. 2005
44DLG1
p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.
Sabio G, Arthur JS, Kuma Y, Peggie M, Carr J, Murray-Tait V, Centeno F, Goedert M, Morrice NA, Cuenda A.
EMBO J. 24(6):1134-45. 2005
45DLG1
Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells.
Laprise P, Viel A, Rivard N.
J Biol Chem 279(11):10157-66. Epub 2003 Dec 29. 2004
46DLG1, LLGL1, SCRIB
The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo.
Grifoni D, Garoia F, Schimanski CC, Schmitz G, Laurenti E, Galle PR, Pession A, Cavicchi S, Strand D.
Oncogene 23(53):8688-94.PMID: 15467749 2004
47DLG1
Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.
Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y.
Oncogene. 23(22):3889-97. 2004
48DLG1
Different isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5.
Godreau D, Vranckx R, Maguy A, Goyenvalle C, Hatem SN.
J Biol Chem 278(47):47046-52. Epub 2003 Sep 10. 2003
49ADAM17, DLG1
Identification of SAP97 as an intracellular binding partner of TACE.
Peiretti F, Deprez-Beauclair P, Bonardo B, Aubert H, Juhan-Vague I, Nalbone G.
J Cell Sci. 116(Pt 10):1949-57. 2003
50DLG1
Binding of the human homolog of the Drosophila discs large tumor suppressor protein to the mitochondrial ribosomal protein MRP-S34.
Ogawa F, Adachi S, Kohu K, Shige K, Akiyama T.
Biochem Biophys Res Commun. 300(3):789-92. 2003
51DLG1
SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism.
Eldstrom J, Choi WS, Steele DF, Fedida D.
FEBS Lett. 547(1-3):205-11. 2003
52DLG1
CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction.
Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M.
J Biol Chem. 278(45):44745-52. 2003
53DLG1
Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor.
Mantovani F, Banks L.
J Biol Chem. 278(43):42477-86. 2003
54CRIPT, DLG1, DLG3
Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif.
Cai C, Coleman SK, Niemi K, Keinšnen K.
J Biol Chem 277(35):31484-90. Epub 2002 Jun 17. 2002
55DLG1, DLG4
Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium.
Godreau D, Vranckx R, Maguy A, Rucker-Martin C, Goyenvalle C, Abdelshafy S, Tessier S, Couetil JP, Hatem SN.
Cardiovasc Res 56(3):433-42. 2002
56DLG1, CALM2
Formation of complexes between Ca2+.calmodulin and the synapse-associated protein SAP97 requires the SH3 domain-guanylate kinase domain-connecting HOOK region.
Paarmann I, Spangenberg O, Lavie A, Konrad M.
J Biol Chem 277(43):40832-8. Epub 2002 Aug 19. 2002
57DLG1
Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97.
Karnak D, Lee S, Margolis B.
J Biol Chem. 277(48):46730-5. 2002
58DLG1, DLG4, LRRC1, PSD95
Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells.
Saito H, Santoni MJ, Arsanto JP, Jaulin-Bastard F, Le Bivic A, Marchetto S, Audebert S, Isnardon D, Adelaide J, Birnbaum D, Borg JP.
J Biol Chem 276(34):32051-5. 2001
59DLG1
DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation
Firestein BL, Rongo C.
Mol Biol Cell 12(11):3465-75. 2001
60DLG1
Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.
Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C.
J Cell Sci. 114(Pt 5):987-98. 2001
61DLG1
Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97.
Mehta S, Wu H, Garner CC, Marshall J.
J Biol Chem. 276(19):16092-9. 2001
62DLG1
Polarity and developmental regulation of two PDZ proteins in the retinal pigment epithelium.
Bonilha VL, Rodriguez-Boulan E.
Invest Ophthalmol Vis Sci. 42(13):3274-82. 2001
63DLG1
Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway.
Sans N, Racca C, Petralia RS, Wang YX, McCallum J, Wenthold RJ.
J Neurosci. 21(19):7506-16. 2001
64DLG1, DLG4, KIF13B, PSD95
GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.
Hanada T, Lin L, Tibaldi EV, Reinherz EL, Chishti AH.
J Biol Chem 275(37):28774-84. 2000
65DLG1, DLG4, PSD95
Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex.
Colledge M, Dean RA, Scott GK, Langeberg LK, Huganir RL, Scott JD.
Neuron. 27(1):107-19 2000
66DLG1
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase.
Ishidate T, Matsumine A, Toyoshima K, Akiyama T.
Oncogene. 19(3):365-72. 2000
67DLG1
E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton.
Reuver SM, Garner CC.
J Cell Sci. 111 ( Pt 8):1071-80. 1998
68DLG1
Fine scale mapping places DLG1, the gene encoding hDlg, telomeric to the OPA1 candidate region.
Alexander C, Stathakis DG, Lin L, Rahman S, Bryant PJ, Auburger G, Chishti AH.
Mamm Genome 8(10):795-6. 1997
69DLG1
Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes.
Hanada T, Lin L, Chandy KG, Oh SS, Chishti AH.
J Biol Chem. 272(43):26899-904. 1997
70DLG1
DLG1 : chromosome location of the closest human homologue of the Drosophila discs large tumor suppressor gene.
Azim AC, et al.
Genomics 30 : 613-616. 1995