| 1 | DLG1, KIF11, PTEN
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| Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.
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| van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM.
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| Nat Cell Biol 18(7):814-21. doi: 10.1038/ncb3369. Epub 2016 May 30.
2016
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| 2 | AKAP5, DLG1, DLG4, GPER1
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| G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production.
|
| Broselid S, Berg KA, Chavera TA, Kahn R, Clarke WP, Olde B, Leeb-Lundberg LM.
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| J Biol Chem 289(32):22117-27. doi: 10.1074/jbc.M114.566893. Epub 2014 Jun 24.
2014
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| 3 | ADRB1, DLG1, PDE4D
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| A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.
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| Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK.
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| J Biol Chem 289(21):14771-81. doi: 10.1074/jbc.M113.542589. Epub 2014 Apr 8.
2014
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| 4 | ADAM10, DLG1
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| SAP97-mediated ADAM10 trafficking from Golgi outposts depends on PKC phosphorylation.
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| Saraceno C, Marcello E, Di Marino D, Borroni B, Claeysen S, Perroy J, Padovani A, Tramontano A, Gardoni F, Di Luca M.
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| Cell Death Dis 5:e1547. doi: 10.1038/cddis.2014.492.
2014
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| 5 | DLG1
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| Emerging role of the scaffolding protein dlg1 in vesicle trafficking.
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| Walch L.
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| Traffic 14(9):964-73. doi: 10.1111/tra.12089.
2013
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| 6 | CASK, DLG1
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| Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development.
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| Ahn SY, Kim Y, Kim ST, Swat W, Miner JH.
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| J Am Soc Nephrol 24(7):1127-38. doi: 10.1681/ASN.2012111074. Epub 2013 May 9.
2013
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| 7 | DLG1
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| Crystal structure of the guanylate kinase domain from discs large homolog 1 (DLG1/SAP97).
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| Mori S, Tezuka Y, Arakawa A, Handa N, Shirouzu M, Akiyama T, Yokoyama S.
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| Biochem Biophys Res Commun 435(3):334-8. doi: 10.1016/j.bbrc.2013.04.056. Epub 2013 Apr 25.
2013
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| 8 | CRHR1, DLG1
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| Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling.
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| Dunn HA, Walther C, Godin CM, Hall RA, Ferguson SS.
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| J Biol Chem 288(21):15023-34. doi: 10.1074/jbc.M113.473660. Epub 2013 Apr 10.
2013
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| 9 | DLG1
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| Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development.
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| Rivera C, Simonson SJ, Yamben IF, Shatadal S, Nguyen MM, Beurg M, Lambert PF, Griep AE.
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| PLoS One 8(1):e54410. doi: 10.1371/journal.pone.0054410. Epub 2013 Jan 22.
2013
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| 10 | CASK, DLG1
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| CASK Regulates SAP97 Conformation and Its Interactions with AMPA and NMDA Receptors.
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| Lin EI, Jeyifous O, Green WN.
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| J Neurosci 33(29):12067-76. doi: 10.1523/JNEUROSCI.0816-13.2013.
2013
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| 11 | ADRB1, AKAP5, DLG1
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| SAP97 controls the trafficking and resensitization of the beta-1-adrenergic receptor through its PDZ2 and I3 domains.
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| Nooh MM, Naren AP, Kim SJ, Xiang YK, Bahouth SW.
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| PLoS One 8(5):e63379. doi: 10.1371/journal.pone.0063379. Print 2013.
2013
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| 12 | DLG1, DLG2, DLG3, DLG4, EPHB1, PAK1
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| Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.
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| Murata Y, Constantine-Paton M.
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| J Neurosci 33(11):5040-52. doi: 10.1523/JNEUROSCI.2896-12.2013.
2013
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| 13 | DLG1
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| Characterization of in vivo Dlg1 deletion on T cell development and function.
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| Humphries LA, Shaffer MH, Sacirbegovic F, Tomassian T, McMahon KA, Humbert PO, Silva O, Round JL, Takamiya K, Huganir RL, Burkhardt JK, Russell SM, Miceli MC.
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| PLoS One 7(9):e45276. doi: 10.1371/journal.pone.0045276. Epub 2012 Sep 18.
2012
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| 14 | DLG1, SCN7A
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| SAP97 promotes the stability of Nax channels at the plasma membrane.
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| Matsumoto M, Fujikawa A, Suzuki R, Shimizu H, Kuboyama K, Hiyama TY, Hall RA, Noda M.
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| FEBS Lett 586(21):3805-12. doi: 10.1016/j.febslet.2012.09.018. Epub 2012 Sep 25.
2012
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| 15 | CALM1, DLG1, GJB1
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| Characterization of the structure and intermolecular interactions between the connexin 32 carboxyl-terminal domain and the protein partners synapse-associated protein 97 and calmodulin.
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| Stauch K, Kieken F, Sorgen P.
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| J Biol Chem 287(33):27771-88. doi: 10.1074/jbc.M112.382572. Epub 2012 Jun 20.
2012
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| 16 | DLG1
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| Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function.
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| Zanin-Zhorov A, Lin J, Scher J, Kumari S, Blair D, Hippen KL, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML.
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| Proc Natl Acad Sci U S A 109(5):1625-30. doi: 10.1073/pnas.1110120109. Epub 2012 Jan 17.
2012
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| 17 | DLG1, LCK
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| Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.
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| Stephen TL, Wilson BS, Laufer TM.
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| Proc Natl Acad Sci U S A 109(19):7415-20. doi: 10.1073/pnas.1119272109. Epub 2012 Apr 23.
2012
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| 18 | DLG1
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| SAP97 directs NMDA receptor spine targeting and synaptic plasticity.
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| Li D, Specht CG, Waites CL, Butler-Munro C, Leal-Ortiz S, Foote JW, Genoux D, Garner CC, Montgomery JM.
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| J Physiol 589(Pt 18):4491-510. doi: 10.1113/jphysiol.2011.215566. Epub 2011 Jul 18.
2011
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| 19 | DLG1, SCN5A
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| SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes.
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| Petitprez S, Zmoos AF, Ogrodnik J, Balse E, Raad N, El-Haou S, Albesa M, Bittihn P, Luther S, Lehnart SE, Hatem SN, Coulombe A, Abriel H.
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| Circ Res 108(3):294-304. doi: 10.1161/CIRCRESAHA.110.228312. Epub 2010 Dec 16.
2011
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| 20 | DLG1, MAP2K2
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| The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring.
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| Gaudet S, Langlois MJ, Lue RA, Rivard N, Viel A.
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| BMC Cell Biol 12:55. doi: 10.1186/1471-2121-12-55.
2011
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| 21 | DLG1, GPSM2
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| Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules.
|
| Zhu J, Shang Y, Xia C, Wang W, Wen W, Zhang M.
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| EMBO J 30(24):4986-97. doi: 10.1038/emboj.2011.428.
2011
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| 22 | DLG1
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| The role of SAP97 in synaptic glutamate receptor dynamics.
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| Howard MA, Elias GM, Elias LA, Swat W, Nicoll RA.
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| Proc Natl Acad Sci U S A 107(8):3805-10. Epub 2010 Feb 3.PMID: 20133708 2010
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| 23 | DEL3Q29, DLG1, PAK2, SCZD28
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| Microdeletions of 3q29 Confer High Risk for Schizophrenia.
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| Mulle JG, Dodd AF, McGrath JA, Wolyniec PS, Mitchell AA, Shetty AC, Sobreira NL, Valle D, Rudd MK, Satten G, Cutler DJ, Pulver AE, Warren ST.
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| Am J Hum Genet 87(2):229-236.PMID: 20691406 2010
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| 24 | DLG1, DLG2, DLG3, DLG4
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| Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.
|
| Akgul G, Wollmuth LP.
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| J Comp Neurol 518(24):4842-54.
2010
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| 25 | CDC42, DLG1, DLGAP1
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| Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarity
|
| Manneville JB, Jehanno M, Etienne-Manneville S.
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| J Cell Biol. Nov 1;191(3):585-98. doi: 10.1083/jcb.201002151. 2010
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| 26 | DLG1
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| CDK phosphorylation of the discs large tumour suppressor controls its localisation and stability.
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| Narayan N, Massimi P, Banks L.
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| J Cell Sci 122(Pt 1):65-74. Epub 2008 Dec 9.PMID: 19066288 2009
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| 27 | DLG1
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| DLG1/SAP97 modulates transforming growth factor alpha bioavailability.
|
| Surena AL, de Faria GP, Studler JM, Peiretti F, Pidoux M, Camonis J, Chneiweiss H, Formstecher E, Junier MP.
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| Biochim Biophys Acta 1793(2):264-72. Epub 2008 Sep 27.PMID: 18930083 2009
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| 28 | CASK, DLG1
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| SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.
|
| Jeyifous O, Waites CL, Specht CG, Fujisawa S, Schubert M, Lin EI, Marshall J, Aoki C, de Silva T, Montgomery JM, Garner CC, Green WN.
|
| Nat Neurosci. 12(8):1011-9. 2009
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| 29 | CASK, DLG1, LIN7C
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| CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.
|
| Lozovatsky L, Abayasekara N, Piawah S, Walther Z.
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| Mol Biol Cell 20(21):4489-99. Epub 2009 Sep 2.PMID: 19726564 2009
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| 30 | DLG1, EXOC4, MTMR2
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| Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination.
|
| Bolis A, Coviello S, Visigalli I, Taveggia C, Bachi A, Chishti AH, Hanada T, Quattrini A, Previtali SC, Biffi A, Bolino A.
|
| J Neurosci 29(27):8858-70.PMID: 19587293 2009
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| 31 | DLG1
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| Cloning and functional analysis of the promoter region of the human Disc large gene.
|
| Cavatorta AL, Giri AA, Banks L, Gardiol D.
|
| Gene 424(1-2):87-95. Epub 2008 Aug 7.
2008
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| 32 | DLG1, MARCHF2
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| DLG1 is an anchor for the E3 ligase MARCH2 at sites of cell-cell contact.
|
| Cao Z, Huett A, Kuballa P, Giallourakis C, Xavier RJ.
|
| Cell Signal 20(1):73-82. Epub 2007 Sep 12.PMID: 17980554 2008
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| 33 | DLG1, LLGL1, SCRIB
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| Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex.
|
| Massimi P, Narayan N, Thomas M, Gammoh N, Strand S, Strand D, Banks L.
|
| Exp Cell Res 314(18):3306-17. Epub 2008 Sep 3.PMID: 18793635 2008
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| 34 | SCRIB, DLG1
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| The PDZ domain-binding motif of the human T cell leukemia virus type 1 tax protein induces mislocalization of the tumor suppressor hScrib in T cells.
|
| Arpin-AndrŽ C, Mesnard JM.
|
| J Biol Chem 282(45):33132-41. Epub 2007 Sep 11. 2007
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| 35 | DLG1
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| DLGH1 is a negative regulator of T-lymphocyte proliferation.
|
| Stephenson LM, Sammut B, Graham DB, Chan-Wang J, Brim KL, Huett AS, Miletic AV, Kloeppel T, Landry A, Xavier R, Swat W.
|
| Mol Cell Biol 27(21):7574-81. Epub 2007 Aug 27.PMID: 17724087 2007
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| 36 | DLG1, NET1
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| The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.
|
| García-Mata R, Dubash AD, Sharek L, Carr HS, Frost JA, Burridge K.
|
| Mol Cell Biol 27(24):8683-97. Epub 2007 Oct 15.
2007
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| 37 | DLG1, EPB41L1, ITPR1
|
| Differential neuronal and glial expression of GluR1 AMPA receptor subunit and the scaffolding proteins SAP97 and 4.1N during rat cerebellar development.
|
| Douyard J, Shen L, Huganir RL, Rubio ME.
|
| J Comp Neurol 502(1):141-56.
2007
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| 38 | SCRIB, DLG1
|
| Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.
|
| Gardiol D, Zacchi A, Petrera F, Stanta G, Banks L.
|
| Int J Cancer 119(6):1285-90. 2006
|
| 39 | KCNA5, DLG1
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| A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97.
|
| Mathur R, Choi WS, Eldstrom J, Wang Z, Kim J, Steele DF, Fedida D.
|
| Biochem Biophys Res Commun 342(1):1-8. Epub 2006 Jan 31. 2006
|
| 40 | DLG1
|
| Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins.
|
| He J, Bellini M, Inuzuka H, Xu J, Xiong Y, Yang X, Castleberry AM, Hall RA.
|
| J Biol Chem. 281(5):2820-7 2006
|
| 41 | DLG1
|
| Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter.
|
| Mahoney, Z. X.; Sammut, B.; Xavier, R. J.; Cunninham, J.; Go, G.; Brim, K. L.; Stappenbeck, T. S.; Miner, J. H.; Swat, W.
|
| Proc. Nat. Acad. Sci. 103: 19872-19877 2006
|
| 42 | DLG1
|
| Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells.
|
| Round JL, Tomassian T, Zhang M, Patel V, Schoenberger SP, Miceli MC.
|
| J Exp Med 201(3):419-30. 2005
|
| 43 | DLG1
|
| hDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis.
|
| Gregorc U, Ivanova S, Thomas M, Turk V, Banks L, Turk B.
|
| Biol Chem 386(7):705-10. 2005
|
| 44 | DLG1
|
| p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.
|
| Sabio G, Arthur JS, Kuma Y, Peggie M, Carr J, Murray-Tait V, Centeno F, Goedert M, Morrice NA, Cuenda A.
|
| EMBO J. 24(6):1134-45. 2005
|
| 45 | DLG1
|
| Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells.
|
| Laprise P, Viel A, Rivard N.
|
| J Biol Chem 279(11):10157-66. Epub 2003 Dec 29. 2004
|
| 46 | DLG1, LLGL1, SCRIB
|
| The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo.
|
| Grifoni D, Garoia F, Schimanski CC, Schmitz G, Laurenti E, Galle PR, Pession A, Cavicchi S, Strand D.
|
| Oncogene 23(53):8688-94.PMID: 15467749 2004
|
| 47 | DLG1
|
| Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.
|
| Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y.
|
| Oncogene. 23(22):3889-97. 2004
|
| 48 | DLG1
|
| Different isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5.
|
| Godreau D, Vranckx R, Maguy A, Goyenvalle C, Hatem SN.
|
| J Biol Chem 278(47):47046-52. Epub 2003 Sep 10. 2003
|
| 49 | ADAM17, DLG1
|
| Identification of SAP97 as an intracellular binding partner of TACE.
|
| Peiretti F, Deprez-Beauclair P, Bonardo B, Aubert H, Juhan-Vague I, Nalbone G.
|
| J Cell Sci. 116(Pt 10):1949-57. 2003
|
| 50 | DLG1
|
| Binding of the human homolog of the Drosophila discs large tumor suppressor protein to the mitochondrial ribosomal protein MRP-S34.
|
| Ogawa F, Adachi S, Kohu K, Shige K, Akiyama T.
|
| Biochem Biophys Res Commun. 300(3):789-92. 2003
|
| 51 | DLG1
|
| SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism.
|
| Eldstrom J, Choi WS, Steele DF, Fedida D.
|
| FEBS Lett. 547(1-3):205-11. 2003
|
| 52 | DLG1
|
| CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction.
|
| Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M.
|
| J Biol Chem. 278(45):44745-52. 2003
|
| 53 | DLG1
|
| Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor.
|
| Mantovani F, Banks L.
|
| J Biol Chem. 278(43):42477-86. 2003
|
| 54 | CRIPT, DLG1, DLG3
|
| Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif.
|
| Cai C, Coleman SK, Niemi K, Keinänen K.
|
| J Biol Chem 277(35):31484-90. Epub 2002 Jun 17. 2002
|
| 55 | DLG1, DLG4
|
| Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium.
|
| Godreau D, Vranckx R, Maguy A, Rucker-Martin C, Goyenvalle C, Abdelshafy S, Tessier S, Couetil JP, Hatem SN.
|
| Cardiovasc Res 56(3):433-42. 2002
|
| 56 | DLG1, CALM2
|
| Formation of complexes between Ca2+.calmodulin and the synapse-associated protein SAP97 requires the SH3 domain-guanylate kinase domain-connecting HOOK region.
|
| Paarmann I, Spangenberg O, Lavie A, Konrad M.
|
| J Biol Chem 277(43):40832-8. Epub 2002 Aug 19. 2002
|
| 57 | DLG1
|
| Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97.
|
| Karnak D, Lee S, Margolis B.
|
| J Biol Chem. 277(48):46730-5. 2002
|
| 58 | DLG1, DLG4, LRRC1, PSD95
|
| Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells.
|
| Saito H, Santoni MJ, Arsanto JP, Jaulin-Bastard F, Le Bivic A, Marchetto S, Audebert S, Isnardon D, Adelaide J, Birnbaum D, Borg JP.
|
| J Biol Chem 276(34):32051-5. 2001
|
| 59 | DLG1
|
| DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation
|
| Firestein BL, Rongo C.
|
| Mol Biol Cell 12(11):3465-75. 2001
|
| 60 | DLG1
|
| Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97.
|
| Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C.
|
| J Cell Sci. 114(Pt 5):987-98. 2001
|
| 61 | DLG1
|
| Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97.
|
| Mehta S, Wu H, Garner CC, Marshall J.
|
| J Biol Chem. 276(19):16092-9. 2001
|
| 62 | DLG1
|
| Polarity and developmental regulation of two PDZ proteins in the retinal pigment epithelium.
|
| Bonilha VL, Rodriguez-Boulan E.
|
| Invest Ophthalmol Vis Sci. 42(13):3274-82. 2001
|
| 63 | DLG1
|
| Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway.
|
| Sans N, Racca C, Petralia RS, Wang YX, McCallum J, Wenthold RJ.
|
| J Neurosci. 21(19):7506-16. 2001
|
| 64 | DLG1, DLG4, KIF13B, PSD95
|
| GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.
|
| Hanada T, Lin L, Tibaldi EV, Reinherz EL, Chishti AH.
|
| J Biol Chem 275(37):28774-84. 2000
|
| 65 | DLG1, DLG4, PSD95
|
| Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex.
|
| Colledge M, Dean RA, Scott GK, Langeberg LK, Huganir RL, Scott JD.
|
| Neuron. 27(1):107-19 2000
|
| 66 | DLG1
|
| The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase.
|
| Ishidate T, Matsumine A, Toyoshima K, Akiyama T.
|
| Oncogene. 19(3):365-72. 2000
|
| 67 | DLG1
|
| E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton.
|
| Reuver SM, Garner CC.
|
| J Cell Sci. 111 ( Pt 8):1071-80. 1998
|
| 68 | DLG1
|
| Fine scale mapping places DLG1, the gene encoding hDlg, telomeric to the OPA1 candidate region.
|
| Alexander C, Stathakis DG, Lin L, Rahman S, Bryant PJ, Auburger G, Chishti AH.
|
| Mamm Genome 8(10):795-6. 1997
|
| 69 | DLG1
|
| Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes.
|
| Hanada T, Lin L, Chandy KG, Oh SS, Chishti AH.
|
| J Biol Chem. 272(43):26899-904. 1997
|
| 70 | DLG1
|
| DLG1 : chromosome location of the closest human homologue of the Drosophila discs large tumor suppressor gene.
|
| Azim AC, et al.
|
| Genomics 30 : 613-616. 1995
|