| 1 | DKK2, MSX1
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| MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity.
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| Lee JM, Qin C, Chai OH, Lan Y, Jiang R, Kwon HE
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| J Dent Res. Jul;101(7):832-839. doi: 10.1177/00220345211070583. Epub 2022 Feb 3 2022
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| 2 | DKK2
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| Association study of DKK2 polymorphisms with alcohol dependence and alcohol-related harm.
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| Kim JY, Bae JS, Park BL, Kim JH, Kim LH, Kim JW, Lee BC, Kang TC, Choi IG, Shin HD.
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| Alcohol Clin Exp Res 38(2):545-50. doi: 10.1111/acer.12265. Epub 2013 Oct 7.
2014
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| 3 | DKK1, DKK2
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| Distinct roles of DKK1 and DKK2 in tumor angiogenesis.
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| Park H, Jung HY, Choi HJ, Kim DY, Yoo JY, Yun CO, Min JK, Kim YM, Kwon YG.
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| Angiogenesis 17(1):221-34. doi: 10.1007/s10456-013-9390-5. Epub 2013 Oct 4.
2014
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| 4 | DKK2
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| DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma.
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| Hauer K, Calzada-Wack J, Steiger K, Grunewald TG, Baumhoer D, Plehm S, Buch T, Prazeres da Costa O, Esposito I, Burdach S, Richter GH.
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| Cancer Res 73(2):967-77. doi: 10.1158/0008-5472.CAN-12-1492. Epub 2012 Nov 30.
2013
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| 5 | BMP4, DKK2, MSX1, OSR2
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| Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.
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| Jia S, Zhou J, Gao Y, Baek JA, Martin JF, Lan Y, Jiang R.
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| Development 140(2):423-32. doi: 10.1242/dev.081927.
2013
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| 6 | DKK1, DKK2, DKK3, DKK4
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| The effects of Dickkopf-4 on the proliferation, differentiation, and apoptosis of osteoblasts.
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| Hiramitsu S, Terauchi M, Kubota T.
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| Endocrinology 154(12):4618-26. doi: 10.1210/en.2013-1387.
2013
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| 7 | DKK2
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| Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.
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| Li X, Shan J, Chang W, Kim I, Bao J, Lee HJ, Zhang X, Samuel VT, Shulman GI, Liu D, Zheng JJ, Wu D.
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| Proc Natl Acad Sci U S A 109(28):11402-7. doi: 10.1073/pnas.1205015109. Epub 2012 Jun 25. Erratum in: Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17141 2012
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| 8 | DKK1, DKK2
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| The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.
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| Min JK, Park H, Choi HJ, Kim Y, Pyun BJ, Agrawal V, Song BW, Jeon J, Maeng YS, Rho SS, Shim S, Chai JH, Koo BK, Hong HJ, Yun CO, Choi C, Kim YM, Hwang KC, Kwon YG.
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| J Clin Invest 121(5):1882-93. doi: 10.1172/JCI42556. Epub 2011 Apr 11. 2011
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| 9 | DKK1, DKK2
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| Dkk1 and Dkk2 regulate epicardial specification during mouse heart development.
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| Phillips MD, Mukhopadhyay M, Poscablo C, Westphal H.
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| Int J Cardiol 150(2):186-92. doi: 10.1016/j.ijcard.2010.04.007. Epub 2010 May 2.
2011
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| 10 | DKK1, DKK2
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| Dkk1 and Dkk2 regulate epicardial specification during mouse heart development.
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| Phillips MD, Mukhopadhyay M, Poscablo C, Westphal H.
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| Int J Cardiol nt J Cardiol. 2010 May 2. [Epub ahead of print]PMID: 20439124 2010
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| 11 | DKK2
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| A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
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| Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP.
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| Hum Mol Genet 19(12):2497-506. Epub 2010 Mar 23.PMID: 20332099 2010
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| 12 | DKK2
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| Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways.
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| Hirata H, Hinoda Y, Nakajima K, Kawamoto K, Kikuno N, Kawakami K, Yamamura S, Ueno K, Majid S, Saini S, Ishii N, Dahiya R.
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| Clin Cancer Res 15(18):5678-87.PMID: 19755393 2009
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| 13 | DKK2
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| Expression and regulation of Dickkopf2 during periimplantation in mice.
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| Zhang Y, Peng S, Kuang H, Chen Q, Liu S, Zhang L, Duan E.
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| J Reprod Dev 55(1):17-22. Epub 2008 Aug 8.PMID: 18689976 2009
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| 14 | DKK2, DKK4
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| DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer.
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| Matsui A, Yamaguchi T, Maekawa S, Miyazaki C, Takano S, Uetake T, Inoue T, Otaka M, Otsuka H, Sato T, Yamashita A, Takahashi Y, Enomoto N.
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| Cancer Sci 100(10):1923-30. doi: 10.1111/j.1349-7006.2009.01272.x.
2009
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| 15 | DKK2
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| Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.
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| Chen L, Wang K, Shao Y, Huang J, Li X, Shan J, Wu D, Zheng JJ.
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| J Biol Chem 283(34):23364-70. Epub 2008 Jun 3.PMID: 18524778 2008
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| 16 | DKK2
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| The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development.
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| Gage PJ, Qian M, Wu D, Rosenberg KI.
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| Dev Biol 317(1):310-24. Epub 2008 Mar 4.PMID: 18367164 2008
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| 17 | DKK2
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| WNT antagonist, DKK2, is a Notch signaling target in intestinal stem cells: augmentation of a negative regulation system for canonical WNT signaling pathway by the Notch-DKK2 signaling loop in primates.
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| Katoh M, Katoh M.
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| Int J Mol Med 19(1):197-201.PMID: 17143565 2007
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| 18 | DKK2
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| Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium.
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| Mukhopadhyay M, Gorivodsky M, Shtrom S, Grinberg A, Niehrs C, Morasso MI, Westphal H.
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| Development 133(11):2149-54. Epub 2006 May 3. Erratum in: Development. 2006 Jun;133(12):2447. Development. 2006 Jul;133(13):2595. PMID: 1667 2006
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| 19 | DKK2, WNT7B
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| Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation.
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| Li X, Liu P, Liu W, Maye P, Zhang J, Zhang Y, Hurley M, Guo C, Boskey A, Sun L, Harris SE, Rowe DW, Ke HZ, Wu D.
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| Nat Genet 37(9):945-52. Epub 2005 Jul 31. 2005
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| 20 | DKK2, LRP6
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| Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled.
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| Li L, Mao J, Sun L, Liu W, Wu D.
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| J Biol Chem 277(8):5977-81. 2002
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| 21 | DKK1, DKK2, DKK3, LRP6
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| LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.
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| Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C.
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| Nature 411(6835):321-5. 2001
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| 22 | DKK1, DKK2, DKK3, DKK4, DKKL1
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| Functional and structural diversity of the human Dickkopf gene family.
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| Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA.
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| Gene 238(2):301-13. 1999
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| 23 | DKK1, DKK2, DKK3
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| Dickkopf genes are co-ordinately expressed in mesodermal lineages.
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| Monaghan AP, Kioschis P, Wu W, Zuniga A, Bock D, Poustka A, Delius H, Niehrs C.
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| Mech Dev 87(1-2):45-56. 1999
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