Citations for
1AFF1, AFF4, DKK1
AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs.
Zhou CC, Xiong QC, Zhu XX, Du W, Deng P, Li XB, Jiang YZ, Zou SJ, Wang CY, Yuan Q.
Bone Res. Sep 26;5:17044. doi: 10.1038/boneres.2017.44. eCollection 2017. 2017
2DKK1, GDF5, MMP13
GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition.
Enochson L, Stenberg J, Brittberg M, Lindahl A.
Osteoarthritis Cartilage steoarthritis Cartilage. 2014 Feb 19. pii: S1063-4584(14)00043-0. doi: 10.1016/j.joca.2014.02.004. [Epub ahead of print] 2014
3DKK1, DKK2
Distinct roles of DKK1 and DKK2 in tumor angiogenesis.
Park H, Jung HY, Choi HJ, Kim DY, Yoo JY, Yun CO, Min JK, Kim YM, Kwon YG.
Angiogenesis 17(1):221-34. doi: 10.1007/s10456-013-9390-5. Epub 2013 Oct 4. 2014
4DKK1, LHX1, OTX2
Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm.
Ip CK, Fossat N, Jones V, Lamonerie T, Tam PP.
Development 141(20):3859-67. doi: 10.1242/dev.114900. Epub 2014 Sep 17. 2014
5DKK1, WNT10B
Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration.
Lei M, Guo H, Qiu W, Lai X, Yang T, Widelitz RB, Chuong CM, Lian X, Yang L.
Exp Dermatol 23(6):407-13. doi: 10.1111/exd.12416. 2014
6BMP2, DKK1, SOST
High-concentration of BMP2 reduces cell proliferation and increases apoptosis via DKK1 and SOST in human primary periosteal cells.
Kim HK, Oxendine I, Kamiya N.
Bone 54(1):141-50. doi: 10.1016/j.bone.2013.01.031. Epub 2013 Jan 27. 2013
7DKK1, KDM6A, KDM6B, WNT3
Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway.
Jiang W, Wang J, Zhang Y.
Cell Res 23(1):122-30. doi: 10.1038/cr.2012.119. Epub 2012 Aug 21. 2013
8DKK1
Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein.
Barbolina MV, Liu Y, Gurler H, Kim M, Kajdacsy-Balla AA, Rooper L, Shepard J, Weiss M, Shea LD, Penzes P, Ravosa MJ, Stack MS.
J Biol Chem 288(1):141-51. doi: 10.1074/jbc.M112.431411. Epub 2012 Nov 14. 2013
9DKK1, LRP6
LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.
Ren S, Johnson BG, Kida Y, Ip C, Davidson KC, Lin SL, Kobayashi A, Lang RA, Hadjantonakis AK, Moon RT, Duffield JS.
Proc Natl Acad Sci U S A 110(4):1440-5. doi: 10.1073/pnas.1211179110. Epub 2013 Jan 9. 2013
10DKK1, TNC
Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model.
Saupe F, Schwenzer A, Jia Y, Gasser I, Spenlé C, Langlois B, Kammerer M, Lefebvre O, Hlushchuk R, Rupp T, Marko M, van der Heyden M, Cremel G, Arnold C, Klein A, Simon-Assmann P, Djonov V, Neuville-Méchine A, Esposito I, Slotta-Huspenina J, Janssen KP, de Wever O, Christofori G, Hussenet T, Orend G.
Cell Rep 5(2):482-92. doi: 10.1016/j.celrep.2013.09.014. Epub 2013 Oct 17. 2013
11DKK1, DKK2, DKK3, DKK4
The effects of Dickkopf-4 on the proliferation, differentiation, and apoptosis of osteoblasts.
Hiramitsu S, Terauchi M, Kubota T.
Endocrinology 154(12):4618-26. doi: 10.1210/en.2013-1387. 2013
12DKK1, DNAJB6, MSX1
DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity.
Menezes ME, Mitra A, Shevde LA, Samant RS.
Biochem J 444(3):573-80. doi: 10.1042/BJ20120205. 2012
13DKK1, SP7
Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx.
Zhang C, Dai H, de Crombrugghe B.
Biochem Biophys Res Commun 420(4):782-6. doi: 10.1016/j.bbrc.2012.03.073. Epub 2012 Mar 20. 2012
14DKK1, SOST
Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases.
Ke HZ, Richards WG, Li X, Ominsky MS.
Endocr Rev 33(5):747-83. doi: 10.1210/er.2011-1060. Epub 2012 Jun 20. Review. 2012
15DKK1
Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling.
Pietilä I, Ellwanger K, Railo A, Jokela T, Barrantes Idel B, Shan J, Niehrs C, Vainio SJ.
Dev Biol 353(1):50-60. Epub 2011 Feb 24. 2011
16DKK1, LRP6
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.
Cheng Z, Biechele T, Wei Z, Morrone S, Moon RT, Wang L, Xu W.
Nat Struct Mol Biol 18(11):1204-10. doi: 10.1038/nsmb.2139. 2011
17DKK1
Post-natal effect of overexpressed DKK1 on mandibular molar formation.
Han XL, Liu M, Voisey A, Ren YS, Kurimoto P, Gao T, Tefera L, Dechow P, Ke HZ, Feng JQ.
J Dent Res 90(11):1312-7. Epub 2011 Sep 13. 2011
18DKK1
Human Dickkopf-1 (huDKK1) protein: characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains.
Haniu M, Horan T, Spahr C, Hui J, Fan W, Chen C, Richards WG, Lu HS.
Protein Sci 20(11):1802-13. doi: 10.1002/pro.705. Epub 2011 Sep 27. 2011
19DKK1
The Dkk1 dose is critical for eye development.
Lieven O, Rüther U.
Dev Biol 355(1):124-37. Epub 2011 Apr 22. 2011
20ACVR1, BMP7, DKK1, SOST
Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1.
Kamiya N, Kaartinen VM, Mishina Y.
Biochem Biophys Res Commun 414(2):326-30. doi: 10.1016/j.bbrc.2011.09.060. Epub 2011 Sep 17. 2011
21DKK1, DKK2
The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.
Min JK, Park H, Choi HJ, Kim Y, Pyun BJ, Agrawal V, Song BW, Jeon J, Maeng YS, Rho SS, Shim S, Chai JH, Koo BK, Hong HJ, Yun CO, Choi C, Kim YM, Hwang KC, Kwon YG.
J Clin Invest 121(5):1882-93. doi: 10.1172/JCI42556. Epub 2011 Apr 11. 2011
22DKK1, DKK2
Dkk1 and Dkk2 regulate epicardial specification during mouse heart development.
Phillips MD, Mukhopadhyay M, Poscablo C, Westphal H.
Int J Cardiol 150(2):186-92. doi: 10.1016/j.ijcard.2010.04.007. Epub 2010 May 2. 2011
23DKK1, PROK1, PROKR1
Prokineticin 1 induces Dickkopf 1 expression and regulates cell proliferation and decidualization in the human endometrium.
Macdonald LJ, Sales KJ, Grant V, Brown P, Jabbour HN, Catalano RD.
Mol Hum Reprod. Oct;17(10):626-36. doi: 10.1093/molehr/gar031. Epub 2011 May 5. 2011
24DKK1, LRP6
LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse.
Sakane H, Yamamoto H, Kikuchi A.
J Cell Sci 123(Pt 3):360-8. Epub 2010 Jan 5.PMID: 20053636 2010
25DKK1, DKK2
Dkk1 and Dkk2 regulate epicardial specification during mouse heart development.
Phillips MD, Mukhopadhyay M, Poscablo C, Westphal H.
Int J Cardiol nt J Cardiol. 2010 May 2. [Epub ahead of print]PMID: 20439124 2010
26DKK1
Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.
Mastroiacovo F, Busceti CL, Biagioni F, Moyanova SG, Meisler MH, Battaglia G, Caricasole A, Bruno V, Nicoletti F.
J Cereb Blood Flow Metab 29(2):264-76. Epub 2008 Oct 1. 2009
27DKK1, KREMEN1, KREMEN2
Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.
Wang K, Zhang Y, Li X, Chen L, Wang H, Wu J, Zheng J, Wu D.
J Biol Chem 283(34):23371-5. Epub 2008 May 23. 2008
28DKK1, LRP6
DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation.
Semënov MV, Zhang X, He X.
J Biol Chem 283(31):21427-32. Epub 2008 May 27. 2008
29DKK1, KREMEN1
Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice.
Li J, Liu WM, Cao YJ, Peng S, Zhang Y, Duan EK.
Fertil Steril 90(4 Suppl):1470-9. Epub 2008 Feb 20.PMID: 18068158 2008
30DKK1, LRP6, WNT3A
Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling.
Yamamoto H, Sakane H, Yamamoto H, Michiue T, Kikuchi A.
Dev Cell 15(1):37-48. 2008
31DKK1
Dickkopf-1 is a master regulator of joint remodeling.
Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G.
Nat Med 13(2):156-163. Epub 2007 Jan 21. 2007
32DKK1, KREMEN1, LRP6, RSPO1
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.
Binnerts ME, Kim KA, Bright JM, Patel SM, Tran K, Zhou M, Leung JM, Liu Y, Lomas WE 3rd, Dixon M, Hazell SA, Wagle M, Nie WS, Tomasevic N, Williams J, Zhan X, Levy MD, Funk WD, Abo A.
Proc Natl Acad Sci U S A 104(37):14700-5. Epub 2007 Sep 5. 2007
33DKK1
Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek.
Caneparo L, Huang YL, Staudt N, Tada M, Ahrendt R, Kazanskaya O, Niehrs C, Houart C.
Genes Dev 21(4):465-80. 2007
34DKK1
Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma.
Qian J, Xie J, Hong S, Yang J, Zhang L, Han X, Wang M, Zhan F, Shaughnessy JD Jr, Epstein J, Kwak LW, Yi Q.
Blood 110(5):1587-94. Epub 2007 May 21. 2007
35DKK1
Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling.
Peng S, Miao C, Li J, Fan X, Cao Y, Duan E.
Biochem Biophys Res Commun 350(3):641-7. Epub 2006 Sep 27. 2006
36DKK1
The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer.
Gonzalez-Sancho JM, Aguilera O, Garcia JM, Pendas-Franco N, Pena C, Cal S, Garcia de Herreros A, Bonilla F, Munoz A.
Oncogene 24(6):1098-103. 2005
37DKK1
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.
Cappuccio I, Calderone A, Busceti CL, Biagioni F, Pontarelli F, Bruno V, Storto M, Terstappen GT, Gaviraghi G, Fornai F, Battaglia G, Melchiorri D, Zukin RS, Nicoletti F, Caricasole A.
J Neurosci 25(10):2647-57. Erratum in: J Neurosci. 2005 Mar 23;25(12):table of contents. Zukin, Suzanne [corrected to Zukin, R Suzanne]. 2005
38DKK1
Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma.
Lee AY, He B, You L, Xu Z, Mazieres J, Reguart N, Mikami I, Batra S, Jablons DM.
Biochem Biophys Res Commun 323(4):1246-50. 2004
39DKK1
Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.
Shou J, Ali-Osman F, Multani AS, Pathak S, Fedi P, Srivenugopal KS.
Oncogene 21(6):878-89. 2002
40DKK1, DKK2, DKK3, LRP6
LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.
Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C.
Nature 411(6835):321-5. 2001
41DKK1
The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly.
Roessler E, Du Y, Glinka A, Dutra A, Niehrs C, Muenke M.
Cytogenet Cell Genet 89(3-4):220-4. 2000
42DKK1, DKK2, DKK3, DKK4, DKKL1
Functional and structural diversity of the human Dickkopf gene family.
Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA.
Gene 238(2):301-13. 1999
43DKK1, DKK2, DKK3
Dickkopf genes are co-ordinately expressed in mesodermal lineages.
Monaghan AP, Kioschis P, Wu W, Zuniga A, Bock D, Poustka A, Delius H, Niehrs C.
Mech Dev 87(1-2):45-56. 1999
44DKK1
Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.
Fedi P, Bafico A, Nieto Soria A, Burgess WH, Miki T, Bottaro DP, Kraus MH, Aaronson SA.
J Biol Chem 274(27):19465-72. 1999
45DKK1
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.
Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C.
Nature 391(6665):357-62. 1998