1 | DIABLO, PARL
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| PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.
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| Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T.
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| Nat Cell Biol 19(4):318-328. doi: 10.1038/ncb3488. Epub 2017 Mar 13.
2017
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2 | DIABLO, IRF1
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| Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response.
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| Eckhardt I, Weigert A, Fulda S.
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| Cell Death Dis 5:e1562. doi: 10.1038/cddis.2014.498.
2014
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3 | AREL1, DIABLO, HTRA2, SEPTIN4
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| Identification of a Novel Anti-apoptotic E3 Ubiquitin Ligase That Ubiquitinates Antagonists of Inhibitor of Apoptosis Proteins SMAC, HtrA2, and ARTS.
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| Kim JB, Kim SY, Kim BM, Lee H, Kim I, Yun J, Jo Y, Oh T, Jo Y, Chae HD, Shin DY.
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| J Biol Chem 288(17):12014-21. doi: 10.1074/jbc.M112.436113. Epub 2013 Mar 11. 2013
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4 | DIABLO, MTCH1
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| PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins.
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| Li T, Zeng L, Gao W, Cui MZ, Fu X, Xu X.
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| Biochim Biophys Acta 1832(3):453-74. doi: 10.1016/j.bbadis.2012.11.016. Epub 2012 Nov 30.
2013
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5 | DIABLO
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| Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy.
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| Emeagi PU, Van Lint S, Goyvaerts C, Maenhout S, Cauwels A, McNeish IA, Bos T, Heirman C, Thielemans K, Aerts JL, Breckpot K.
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| Cancer Res 72(6):1342-52. doi: 10.1158/0008-5472.CAN-11-2400. Epub 2012 Feb 29.
2012
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6 | BIRC5, DIABLO
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| Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin.
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| Du J, Kelly AE, Funabiki H, Patel DJ.
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| Structure 20(1):185-95. doi: 10.1016/j.str.2011.12.001.
2012
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7 | DIABLO
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| Smac: Its role in apoptosis induction and use in lung cancer diagnosis and treatment.
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| Qin S, Yang C, Li S, Xu C, Zhao Y, Ren H.
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| Cancer Lett 318(1):9-13. doi: 10.1016/j.canlet.2011.12.024. Epub 2012 Jan 3. Review.
2012
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8 | DIABLO
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| Reciprocal expression of survivin and SMAC/DIABLO in primary breast cancer.
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| Mansour A, Nabil M, Ali-Labib R, Said H, Annos F.
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| Med Oncol 29(4):2535-42. doi: 10.1007/s12032-011-0129-0. Epub 2011 Dec 8.
2012
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9 | DIABLO, SEPTIN4
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| The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo.
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| Edison N, Zuri D, Maniv I, Bornstein B, Lev T, Gottfried Y, Kemeny S, Garcia-Fernandez M, Kagan J, Larisch S.
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| Cell Death Differ 19(2):356-68. doi: 10.1038/cdd.2011.112. Epub 2011 Aug 26. 2012
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10 | BIRC6, DIABLO
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| Identification of BIRC6 as a novel intervention target for neuroblastoma therapy.
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| Lamers F, Schild L, Koster J, Speleman F, Řra I, Westerhout EM, van Sluis P, Versteeg R, Caron HN, Molenaar JJ.
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| BMC Cancer 12:285. doi: 10.1186/1471-2407-12-285. 2012
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11 | CASP3, DIABLO
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| Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death.
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| Hui KK, Kanungo AK, Elia AJ, Henderson JT.
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| Cell Death Differ 18(11):1780-90. doi: 10.1038/cdd.2011.50. Epub 2011 May 20. 2011
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12 | DFNA64, DIABLO
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| Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64.
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| Cheng J, Zhu Y, He S, Lu Y, Chen J, Han B, Petrillo M, Wrzeszczynski KO, Yang S, Dai P, Zhai S, Han D, Zhang MQ, Li W, Liu X, Li H, Chen ZY, Yuan H.
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| Am J Hum Genet 89(1):56-66. doi: 10.1016/j.ajhg.2011.05.027. Epub 2011 Jun 30.
2011
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13 | DIABLO, UBE2K
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| Hip2 interacts with and destabilizes Smac/DIABLO.
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| Bae Y, Kho CW, Lee SY, Rhim H, Kang S.
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| Biochem Biophys Res Commun 397(4):718-23. Epub 2010 Jun 9.
2010
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14 | DIABLO, XIAP
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| Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation.
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| Maas C, Verbrugge I, de Vries E, Savich G, van de Kooij LW, Tait SW, Borst J.
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| Cell Death Differ 17(10):1613-23. Epub 2010 Apr 16.
2010
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15 | DIABLO, HTRA2, S100A8, S100A9
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| S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2.
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| Ghavami S, Kerkhoff C, Chazin WJ, Kadkhoda K, Xiao W, Zuse A, Hashemi M, Eshraghi M, Schulze-Osthoff K, Klonisch T, Los M.
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| Biochim Biophys Acta 1783(2):297-311. Epub 2007 Nov 7. 2008
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16 | DIABLO
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| The proapoptotic protein Smac/DIABLO dimer has the highest stability as measured by pressure and urea denaturation.
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| Gonçalves RB, Sanches D, Souza TL, Silva JL, Oliveira AC.
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| Biochemistry 47(12):3832-41. Epub 2008 Feb 29.
2008
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17 | BCL7A, DIABLO, RHOF
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| Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF.
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| Carbone A, Bernardini L, Valenzano F, Bottillo I, De Simone C, Capizzi R, Capalbo A, Romano F, Novelli A, Dallapiccola B, Amerio P.
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| Genes Chromosomes Cancer 47(12):1067-75.
2008
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18 | DIABLO
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| IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
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| Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, Koentgen F, Vaux DL, Silke J.
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| Cell 131(4):682-93. 2007
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19 | DIABLO
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| Smac/DIABLO is required for effector caspase activation during apoptosis in human cells.
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| Rajalingam K, Oswald M, Gottschalk K, Rudel T.
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| Apoptosis 12(8):1503-10.
2007
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20 | BBC3, DIABLO
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| SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events.
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| Yu J, Wang P, Ming L, Wood MA, Zhang L.
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| Oncogene 26(29):4189-98. Epub 2007 Jan 22.
2007
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21 | E2F1, DIABLO
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| Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.
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| Xie W, Jiang P, Miao L, Zhao Y, Zhimin Z, Qing L, Zhu WG, Wu M.
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| Nucleic Acids Res 34(7):2046-55. Print 2006. 2006
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22 | BIRC7, DIABLO
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| Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway.
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| Ma L, Huang Y, Song Z, Feng S, Tian X, Du W, Qiu X, Heese K, Wu M.
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| Cell Death Differ 13(12):2079-88. Epub 2006 May 26. 2006
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23 | BIRC2, DIABLO, TRAF2
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| Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.
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| Samuel T, Welsh K, Lober T, Togo SH, Zapata JM, Reed JC.
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| J Biol Chem 281(2):1080-90. Epub 2005 Nov 10. 2006
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24 | CASP9, DIABLO, XIAP
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| X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO.
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| Morizane Y, Honda R, Fukami K, Yasuda H.
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| J Biochem (Tokyo) 137(2):125-32. 2005
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25 | DIABLO
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| SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells.
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| Kohli M, Yu J, Seaman C, Bardelli A, Kinzler KW, Vogelstein B, Lengauer C, Zhang L.
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| Proc Natl Acad Sci U S A 101(48):16897-902. Epub 2004 Nov 30. 2004
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26 | MALT1, BIRC3, DIABLO, MALTLY
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| Antiapoptotic function of apoptosis inhibitor 2-MALT1 fusion protein involved in t(11;18)(q21;q21) mucosa-associated lymphoid tissue lymphoma.
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| Hosokawa Y, Suzuki H, Suzuki Y, Takahashi R, Seto M.
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| Cancer Res 64(10):3452-7. 2004
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27 | DIABLO
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| Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins.
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| Creagh EM, Murphy BM, Duriez PJ, Duckett CS, Martin SJ.
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| J Biol Chem 279(26):26906-14. Epub 2004 Apr 12. 2004
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28 | BID, CASP8, DIABLO, MAPK8, TNF
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| A JNK-dependent pathway is required for TNFalpha-induced apoptosis.
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| Deng Y, Ren X, Yang L, Lin Y, Wu X.
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| Cell 115(1):61-70. 2003
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29 | XAF1, DIABLO
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| Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas.
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| Byun DS, Cho K, Ryu BK, Lee MG, Kang MJ, Kim HR, Chi SG.
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| Cancer Res 63(21):7068-75. 2003
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30 | DIABLO, XIAP
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| Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac.
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| Huang Y, Rich RL, Myszka DG, Wu H.
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| J Biol Chem 278(49):49517-22. Epub 2003 Sep 25. 2003
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31 | DIABLO, XIAP
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| Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.
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| Silke J, Ekert PG, Day CL, Hawkins CJ, Baca M, Chew J, Pakusch M, Verhagen AM, Vaux DL.
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| EMBO J 20(12):3114-23. 2001
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32 | CASP9, DIABLO, XIAP
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| A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.
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| Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y, Alnemri ES.
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| Nature 410(6824):112-6. 2001
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33 | BCL2, CASP9, DIABLO
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| Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.
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| Adrain C, Creagh EM, Martin SJ.
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| EMBO J 20(23):6627-36. 2001
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34 | DIABLO, XIAP
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| Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
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| Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW.
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| Nature 408(6815):1004-8. 2000
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35 | DIABLO
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| Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
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| Du C, Fang M, Li Y, Li L, Wang X.
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| Cell 102(1):33-42. 2000
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36 | DIABLO, XIAP
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| Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
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| Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL.
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| Cell 102(1):43-53. 2000
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