Citations for
1DIABLO, PARL
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.
Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T.
Nat Cell Biol 19(4):318-328. doi: 10.1038/ncb3488. Epub 2017 Mar 13. 2017
2DIABLO, IRF1
Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response.
Eckhardt I, Weigert A, Fulda S.
Cell Death Dis 5:e1562. doi: 10.1038/cddis.2014.498. 2014
3AREL1, DIABLO, HTRA2, SEPTIN4
Identification of a Novel Anti-apoptotic E3 Ubiquitin Ligase That Ubiquitinates Antagonists of Inhibitor of Apoptosis Proteins SMAC, HtrA2, and ARTS.
Kim JB, Kim SY, Kim BM, Lee H, Kim I, Yun J, Jo Y, Oh T, Jo Y, Chae HD, Shin DY.
J Biol Chem 288(17):12014-21. doi: 10.1074/jbc.M112.436113. Epub 2013 Mar 11. 2013
4DIABLO, MTCH1
PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins.
Li T, Zeng L, Gao W, Cui MZ, Fu X, Xu X.
Biochim Biophys Acta 1832(3):453-74. doi: 10.1016/j.bbadis.2012.11.016. Epub 2012 Nov 30. 2013
5DIABLO
Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy.
Emeagi PU, Van Lint S, Goyvaerts C, Maenhout S, Cauwels A, McNeish IA, Bos T, Heirman C, Thielemans K, Aerts JL, Breckpot K.
Cancer Res 72(6):1342-52. doi: 10.1158/0008-5472.CAN-11-2400. Epub 2012 Feb 29. 2012
6BIRC5, DIABLO
Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin.
Du J, Kelly AE, Funabiki H, Patel DJ.
Structure 20(1):185-95. doi: 10.1016/j.str.2011.12.001. 2012
7DIABLO
Smac: Its role in apoptosis induction and use in lung cancer diagnosis and treatment.
Qin S, Yang C, Li S, Xu C, Zhao Y, Ren H.
Cancer Lett 318(1):9-13. doi: 10.1016/j.canlet.2011.12.024. Epub 2012 Jan 3. Review. 2012
8DIABLO
Reciprocal expression of survivin and SMAC/DIABLO in primary breast cancer.
Mansour A, Nabil M, Ali-Labib R, Said H, Annos F.
Med Oncol 29(4):2535-42. doi: 10.1007/s12032-011-0129-0. Epub 2011 Dec 8. 2012
9DIABLO, SEPTIN4
The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo.
Edison N, Zuri D, Maniv I, Bornstein B, Lev T, Gottfried Y, Kemeny S, Garcia-Fernandez M, Kagan J, Larisch S.
Cell Death Differ 19(2):356-68. doi: 10.1038/cdd.2011.112. Epub 2011 Aug 26. 2012
10BIRC6, DIABLO
Identification of BIRC6 as a novel intervention target for neuroblastoma therapy.
Lamers F, Schild L, Koster J, Speleman F, Řra I, Westerhout EM, van Sluis P, Versteeg R, Caron HN, Molenaar JJ.
BMC Cancer 12:285. doi: 10.1186/1471-2407-12-285. 2012
11CASP3, DIABLO
Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death.
Hui KK, Kanungo AK, Elia AJ, Henderson JT.
Cell Death Differ 18(11):1780-90. doi: 10.1038/cdd.2011.50. Epub 2011 May 20. 2011
12DFNA64, DIABLO
Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64.
Cheng J, Zhu Y, He S, Lu Y, Chen J, Han B, Petrillo M, Wrzeszczynski KO, Yang S, Dai P, Zhai S, Han D, Zhang MQ, Li W, Liu X, Li H, Chen ZY, Yuan H.
Am J Hum Genet 89(1):56-66. doi: 10.1016/j.ajhg.2011.05.027. Epub 2011 Jun 30. 2011
13DIABLO, UBE2K
Hip2 interacts with and destabilizes Smac/DIABLO.
Bae Y, Kho CW, Lee SY, Rhim H, Kang S.
Biochem Biophys Res Commun 397(4):718-23. Epub 2010 Jun 9. 2010
14DIABLO, XIAP
Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation.
Maas C, Verbrugge I, de Vries E, Savich G, van de Kooij LW, Tait SW, Borst J.
Cell Death Differ 17(10):1613-23. Epub 2010 Apr 16. 2010
15DIABLO, HTRA2, S100A8, S100A9
S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2.
Ghavami S, Kerkhoff C, Chazin WJ, Kadkhoda K, Xiao W, Zuse A, Hashemi M, Eshraghi M, Schulze-Osthoff K, Klonisch T, Los M.
Biochim Biophys Acta 1783(2):297-311. Epub 2007 Nov 7. 2008
16DIABLO
The proapoptotic protein Smac/DIABLO dimer has the highest stability as measured by pressure and urea denaturation.
Gonçalves RB, Sanches D, Souza TL, Silva JL, Oliveira AC.
Biochemistry 47(12):3832-41. Epub 2008 Feb 29. 2008
17BCL7A, DIABLO, RHOF
Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF.
Carbone A, Bernardini L, Valenzano F, Bottillo I, De Simone C, Capizzi R, Capalbo A, Romano F, Novelli A, Dallapiccola B, Amerio P.
Genes Chromosomes Cancer 47(12):1067-75. 2008
18DIABLO
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, Koentgen F, Vaux DL, Silke J.
Cell 131(4):682-93. 2007
19DIABLO
Smac/DIABLO is required for effector caspase activation during apoptosis in human cells.
Rajalingam K, Oswald M, Gottschalk K, Rudel T.
Apoptosis 12(8):1503-10. 2007
20BBC3, DIABLO
SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events.
Yu J, Wang P, Ming L, Wood MA, Zhang L.
Oncogene 26(29):4189-98. Epub 2007 Jan 22. 2007
21E2F1, DIABLO
Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.
Xie W, Jiang P, Miao L, Zhao Y, Zhimin Z, Qing L, Zhu WG, Wu M.
Nucleic Acids Res 34(7):2046-55. Print 2006. 2006
22BIRC7, DIABLO
Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway.
Ma L, Huang Y, Song Z, Feng S, Tian X, Du W, Qiu X, Heese K, Wu M.
Cell Death Differ 13(12):2079-88. Epub 2006 May 26. 2006
23BIRC2, DIABLO, TRAF2
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.
Samuel T, Welsh K, Lober T, Togo SH, Zapata JM, Reed JC.
J Biol Chem 281(2):1080-90. Epub 2005 Nov 10. 2006
24CASP9, DIABLO, XIAP
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO.
Morizane Y, Honda R, Fukami K, Yasuda H.
J Biochem (Tokyo) 137(2):125-32. 2005
25DIABLO
SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells.
Kohli M, Yu J, Seaman C, Bardelli A, Kinzler KW, Vogelstein B, Lengauer C, Zhang L.
Proc Natl Acad Sci U S A 101(48):16897-902. Epub 2004 Nov 30. 2004
26MALT1, BIRC3, DIABLO, MALTLY
Antiapoptotic function of apoptosis inhibitor 2-MALT1 fusion protein involved in t(11;18)(q21;q21) mucosa-associated lymphoid tissue lymphoma.
Hosokawa Y, Suzuki H, Suzuki Y, Takahashi R, Seto M.
Cancer Res 64(10):3452-7. 2004
27DIABLO
Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins.
Creagh EM, Murphy BM, Duriez PJ, Duckett CS, Martin SJ.
J Biol Chem 279(26):26906-14. Epub 2004 Apr 12. 2004
28BID, CASP8, DIABLO, MAPK8, TNF
A JNK-dependent pathway is required for TNFalpha-induced apoptosis.
Deng Y, Ren X, Yang L, Lin Y, Wu X.
Cell 115(1):61-70. 2003
29XAF1, DIABLO
Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas.
Byun DS, Cho K, Ryu BK, Lee MG, Kang MJ, Kim HR, Chi SG.
Cancer Res 63(21):7068-75. 2003
30DIABLO, XIAP
Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac.
Huang Y, Rich RL, Myszka DG, Wu H.
J Biol Chem 278(49):49517-22. Epub 2003 Sep 25. 2003
31DIABLO, XIAP
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.
Silke J, Ekert PG, Day CL, Hawkins CJ, Baca M, Chew J, Pakusch M, Verhagen AM, Vaux DL.
EMBO J 20(12):3114-23. 2001
32CASP9, DIABLO, XIAP
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.
Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y, Alnemri ES.
Nature 410(6824):112-6. 2001
33BCL2, CASP9, DIABLO
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.
Adrain C, Creagh EM, Martin SJ.
EMBO J 20(23):6627-36. 2001
34DIABLO, XIAP
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW.
Nature 408(6815):1004-8. 2000
35DIABLO
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
Du C, Fang M, Li Y, Li L, Wang X.
Cell 102(1):33-42. 2000
36DIABLO, XIAP
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL.
Cell 102(1):43-53. 2000