| 1 | DHPS, DOHH, EIF5A, NEDMVIC
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| Bi-allelic variants in DOHH, catalyzing the last step of hypusine biosynthesis, are associated with a neurodevelopmental disorder
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| Ziegler A, Steindl K, Hanner AS, Kumar Kar R, Prouteau C, Boland A, Deleuze JF, Coubes C, Bézieau S, Küry S, Maystadt I, Le Mao M, Lenaers G, Navet B, Faivre L, Tran Mau-Them F, Zanoni P, Chung WK, Rauch A, Bonneau D, Park MH.
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| Am J Hum Genet. Aug 4;109(8):1549-1558. doi: 10.1016/j.ajhg.2022.06.010. Epub 2022 Jul 19. 2022
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| 2 | DHPS, DHPSD, DOHH, EIF5A
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| Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.
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| Ganapathi M, Padgett LR, Yamada K, Devinsky O, Willaert R, Person R, Au PB, Tagoe J, McDonald M, Karlowicz D, Wolf B, Lee J, Shen Y, Okur V, Deng L, LeDuc CA, Wang J, Hanner A, Mirmira RG, Park MH, Mastracci TL, Chung WK.
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| Am J Hum Genet 104(2):287-298. doi: 10.1016/j.ajhg.2018.12.017. Epub 2019 Jan 17.
2019
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| 3 | DHPS, EIF5A
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| Hypusine, a polyamine-derived amino acid critical for eukaryotic translation.
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| Park MH, Wolff EC.
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| J Biol Chem 293(48):18710-18718. doi: 10.1074/jbc.TM118.003341. Epub 2018 Sep 26. Review.
2018
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| 4 | DHPS, EIF5A
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| The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma.
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| Muramatsu T, Kozaki KI, Imoto S, Yamaguchi R, Tsuda H, Kawano T, Fujiwara N, Morishita M, Miyano S, Inazawa J.
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| Oncogene 35(40):5304-5316. doi: 10.1038/onc.2016.71. Epub 2016 Apr 4.
2016
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| 5 | DHPS, EIF5A
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| Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
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| Pällmann N, Braig M, Sievert H, Preukschas M, Hermans-Borgmeyer I, Schweizer M, Nagel CH, Neumann M, Wild P, Haralambieva E, Hagel C, Bokemeyer C, Hauber J, Balabanov S.
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| J Biol Chem 290(30):18343-60. doi: 10.1074/jbc.M115.664490. Epub 2015 Jun 2.
2015
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| 6 | DHPS, IL2RA
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| Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes.
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| Colvin SC, Maier B, Morris DL, Tersey SA, Mirmira RG.
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| J Biol Chem 288(51):36226-35. doi: 10.1074/jbc.M113.473942. Epub 2013 Nov 6.
2013
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| 7 | DHPS, WDR83
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| Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer.
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| Su WY, Li JT, Cui Y, Hong J, Du W, Wang YC, Lin YW, Xiong H, Wang JL, Kong X, Gao QY, Wei LP, Fang JY.
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| Cell Res 22(9):1374-89. doi: 10.1038/cr.2012.57. Epub 2012 Apr 10.
2012
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| 8 | DHPS, EIF5A
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| Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
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| Nishimura K, Lee SB, Park JH, Park MH.
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| Amino Acids 42(2-3):703-10. doi: 10.1007/s00726-011-0986-z. Epub 2011 Aug 18.
2012
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| 9 | DHPS, DOHH, EIF5A
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| Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapies.
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| Preukschas M, Hagel C, Schulte A, Weber K, Lamszus K, Sievert H, Pällmann N, Bokemeyer C, Hauber J, Braig M, Balabanov S.
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| PLoS One 7(8):e43468. doi: 10.1371/journal.pone.0043468. Epub 2012 Aug 21.
2012
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| 10 | DHPS, EIF5A
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| Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.
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| Templin AT, Maier B, Nishiki Y, Tersey SA, Mirmira RG.
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| Cell Cycle 10(7):1043-9. Epub 2011 Apr 1.
2011
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| 11 | DDIT3, DHPS
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| Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes.
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| Robbins RD, Tersey SA, Ogihara T, Gupta D, Farb TB, Ficorilli J, Bokvist K, Maier B, Mirmira RG.
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| J Biol Chem 285(51):39943-52. doi: 10.1074/jbc.M110.170142. Epub 2010 Oct 18.
2010
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| 12 | DHPS, DOHH, EIF5A
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| Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.
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| Wolff EC, Kang KR, Kim YS, Park MH.
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| Amino Acids 33(2):341-50. Epub 2007 May 4. Review.PMID: 17476569 2007
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| 13 | DHPS, DOHH, EIF5A
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| The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A).
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| Park MH.
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| J Biochem 139(2):161-9. Review.PMID: 1645230 2006
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| 14 | DHPS
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| A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex.
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| Umland TC, Wolff EC, Park MH, Davies DR.
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| J Biol Chem 279(27):28697-705. Epub 2004 Apr 20. 2004
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| 15 | DHPS
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| Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase.
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| Park JH, Wolff EC, Folk JE, Park MH.
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| J Biol Chem 278(35):32683-91. Epub 2003 Jun 4. 2003
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| 16 | DHPS
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| Localization and genomic structure of human deoxyphypusine synthase gene on chromosome 19p13.2-distal 19p13.1.
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| Mantuano E, et al.
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| Gene 215 : 153-157. 1998
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| 17 | DHPS
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| Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus.
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| Bevec D, et al.
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| FEBS Lett 378 : 195-198. 1996
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| 18 | DHPS
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| The gene coding for human deoxyhypusine synthase (DHPS) maps to chromosome 19p13.11-p13.12.
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| Jones T, et al.
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| Genomics 35 : 635-636. 1996
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| 19 | DHPS
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| Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins.
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| Joe YA, et al.
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| J Biol Chem 270 : 22386-22392. 1995
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| 20 | DHPS
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| Is hypusine essential for eukaryotic cell proliferation ?
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| Park MH, et al.
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| Trends Biochem Sci 18 : 475-479. 1993
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