| 1 | DHFR, DHFRD
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| Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency.
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| Banka S, Blom HJ, Walter J, Aziz M, Urquhart J, Clouthier CM, Rice GI, de Brouwer AP, Hilton E, Vassallo G, Will A, Smith DE, Smulders YM, Wevers RA, Steinfeld R, Heales S, Crow YJ, Pelletier JN, Jones S, Newman WG.
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| Am J Hum Genet 88(2):216-25.
2011
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| 2 | DHFR, DHFRD
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| Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease.
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| Cario H, Smith DE, Blom H, Blau N, Bode H, Holzmann K, Pannicke U, Hopfner KP, Rump EM, Ayric Z, Kohne E, Debatin KM, Smulders Y, Schwarz K.
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| Am J Hum Genet 88(2):226-31.
2011
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| 3 | DHFR, DHFRD
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| Dihydrofolate Reductase Mutations-associated Megaloblastic Anemia and Cerebral Folate Deficiency.
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| Wijesekara N.
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| Clin Genet lin Genet. 2011 Mar 9. doi: 10.1111/j.1399-0004.2011.01662.x. [Epub ahead of print]
2011
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| 4 | DHFR
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| Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.
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| Iskandar BJ, Rizk E, Meier B, Hariharan N, Bottiglieri T, Finnell RH, Jarrard DF, Banerjee RV, Skene JH, Nelson A, Patel N, Gherasim C, Simon K, Cook TD, Hogan KJ.
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| J Clin Invest 120(5):1603-16. doi: 10.1172/JCI40000. Epub 2010 Apr 26.
2010
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| 5 | DHFR
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| A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling.
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| Klinghoffer RA, Frazier J, Annis J, Berndt JD, Roberts BS, Arthur WT, Lacson R, Zhang XD, Ferrer M, Moon RT, Cleary MA.
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| PLoS One 4(9):e6892.
2009
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| 6 | DHFR
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| Pivotal role of dihydrofolate reductase knockdown in the anticancer activity of 2-hydroxyoleic acid.
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| Lladó V, Terés S, Higuera M, Alvarez R, Noguera-Salva MA, Halver JE, Escribá PV, Busquets X.
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| Proc Natl Acad Sci U S A 106(33):13754-8. Epub 2009 Aug 3.
2009
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| 7 | DHFR
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| A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate.
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| Kalmbach RD, Choumenkovitch SF, Troen AP, Jacques PF, D'Agostino R, Selhub J.
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| J Nutr 138(12):2323-7.
2008
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| 8 | CBS, DHFR
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| Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms.
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| Semmler A, Linnebank M, Krex D, Götz A, Moskau S, Ziegler A, Simon M.
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| Cerebrovasc Dis 26(4):425-9. Epub 2008 Sep 18. 2008
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| 9 | DHFR
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| MDM2 regulates dihydrofolate reductase activity through monoubiquitination.
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| Maguire M, Nield PC, Devling T, Jenkins RE, Park BK, Polański R, Vlatković N, Boyd MT.
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| Cancer Res 68(9):3232-42.
2008
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| 10 | DHFR
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| Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript.
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| Martianov I, Ramadass A, Serra Barros A, Chow N, Akoulitchev A.
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| Nature 445(7128):666-70. Epub 2007 Jan 21. 2007
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| 11 | DHFR
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| New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): a risk factor for spina bifida acting in mothers during pregnancy?
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| Johnson WG, Stenroos ES, Spychala JR, Chatkupt S, Ming SX, Buyske S.
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| Am J Med Genet 124A(4):339-45. 2004
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| 12 | DHFR
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| Characterization of a cis-acting regulatory element in the protein-coding region of human dihydrofolate reductase mRNA.
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| Tai N, Schmitz JC, Chen TM, Chu E.
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| Biochem J 378(Pt 3):999-1006. 2004
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| 13 | ALB, CAD, CCNA2, CDC25A, CDK1, CEBPA, COL1A1, COL1A2, COL3A1, COL6A3, DHFR, DMTF1, GADD45A, JUN, LDHA, MXI1, MYC, ODC1, RCC1, SERPINE1, TERT, TK1, TK2, TP53
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| c-Myc target genes involved in cell growth, apoptosis, and metabolism.
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| Dang CV.
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| Mol Cell Biol 19(1):1-11. Review. No abstract available 1999
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| 14 | DHFR
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| A frequent DHFR polymorphism detected by an intron fragment.
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| Detera-Wadleigh SD, et al.
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| Nucleic Acids Res 17 : 6432. 1989
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| 15 | DHFR
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| Two RFLPs for the human dihydrofolate reductase gene (DHFR).
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| Feder JN, et al.
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| Nucleic Acids Res 15 : 5906. 1987
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| 16 | DHFR, DHFRP2
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| Chromosomal location of the normal human DHFR gene and of its amplified copies in methotrexate resistant cell variants.
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| Maurer B, et al.
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| (HGM7) Cytogenet Cell Genet 37 : 534. 1984
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| 17 | DHFR, DHFRP2
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| Human dihydrofolate reductase gene is located in chromosome 5 and isunlinked to the related pseudogenes.
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| Maurer BJ, et al.
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| Proc Natl Acad Sci U S A 81 : 1484-1488. 1984
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| 18 | DHFR
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| Assignment of the human dihydrofolate reductase gene to the q11-q22region of chromosome 5.
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| Funanage VL, et al.
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| Mol Cell Biol 4 : 2010-2016. 1984
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| 19 | DHFR, DHFRL1
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| Chromosomal organization of the human dihydrofolate reductase genes:dispersion, selective amplification, and a novel form of polymorphism.
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| Anagnou NP, et al.
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| Proc Natl Acad Sci U S A 81 : 5170-5174. 1984
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| 20 | DHFR
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| Dihydrofolate reductase deficiency causing megaloblastic anemia in two families.
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| Tauro GP, et al.
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| N Engl J Med 294 : 466-470. 1976
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| 21 | DHFR
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| Congenital megaloblastic anemia responsive to N(5)-formyl tetrahydrofolic acid administration.
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| Walters TR.
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| J Pediatr 70 : 686-687. 1967
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