| 1 | DHCR24, MARCHF6
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| The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.
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| Scott NA, Sharpe LJ, Capell-Hattam IM, Gullo SJ, Luu W, Brown AJ.
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| Biochem J iochem J. 2020 Jan 6. pii: BCJ20190647. doi: 10.1042/BCJ20190647. [Epub ahead of print] 2020
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| 2 | DHCR24, DSMS
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| Desmosterolosis and desmosterol homeostasis in the developing mouse brain.
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| Allen LB, Genaro-Mattos TC, Porter NA, Mirnics K, Korade Z.
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| J Inherit Metab Dis 42(5):934-943. doi: 10.1002/jimd.12088. Epub 2019 Apr 8.
2019
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| 3 | APOM, DHCR24, S1PR1
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| Apolipoprotein M induces inhibition of inflammatory responses via the S1PR1 and DHCR24 pathways.
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| Wang M, Luo GH, Liu H, Zhang YP, Wang B, Di DM, Zhan XH, Yu Y, Yao S, Zhang XY, Xu N.
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| Mol Med Rep 19(2):1272-1283. doi: 10.3892/mmr.2018.9747. Epub 2018 Dec 12.
2019
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| 4 | DHCR24, DHCR7
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| Subcellular localization of sterol biosynthesis enzymes.
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| Koczok K, Gurumurthy CB, Balogh I, Korade Z, Mirnics K.
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| J Mol Histol 50(1):63-73. doi: 10.1007/s10735-018-9807-y. Epub 2018 Dec 8.
2019
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| 5 | DHCR24, DSMS
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| Desmosterolosis presenting with multiple congenital anomalies.
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| Rohanizadegan M, Sacharow S.
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| Eur J Med Genet 61(3):152-156. doi: 10.1016/j.ejmg.2017.11.009. Epub 2017 Nov 23.
2018
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| 6 | DHCR24, DHCR7
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| The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally.
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| Luu W, Hart-Smith G, Sharpe LJ, Brown AJ.
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| J Lipid Res 56(4):888-97. doi: 10.1194/jlr.M056986. Epub 2015 Jan 31. Erratum in: J Lipid Res. 2015 May;56(5):1079.
2015
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| 7 | DHCR24
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| 3 β-hydroxysteroid-Δ 24 reductase (DHCR24) protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum (ER) stress.
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| Lu X, Li Y, Wang W, Chen S, Liu T, Jia D, Quan X, Sun D, Chang AK, Gao B.
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| PLoS One 9(1):e86753. doi: 10.1371/journal.pone.0086753. eCollection 2014.
2014
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| 8 | DHCR24
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| DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains: implications for the activities of this multi-functional enzyme.
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| Zerenturk EJ, Sharpe LJ, Brown AJ.
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| Biosci Rep 34(2). pii: e00098. Print 2014 Apr 1.
2014
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| 9 | DHCR24
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| Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed.
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| Tint GS, Pan L, Shang Q, Sharpe LJ, Brown AJ, Li M, Yu H.
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| Dev Neurosci 36(2):132-42. doi: 10.1159/000362363. Epub 2014 May 24.
2014
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| 10 | DHCR24
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| Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis.
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| Luu W, Zerenturk EJ, Kristiana I, Bucknall MP, Sharpe LJ, Brown AJ.
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| J Lipid Res 55(3):410-20. doi: 10.1194/jlr.M043257. Epub 2013 Dec 20.
2014
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| 11 | DHCR24
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| Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer's disease indicator-1 gene expression.
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| Ishida E, Hashimoto K, Okada S, Satoh T, Yamada M, Mori M.
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| PLoS One 8(1):e54901. doi: 10.1371/journal.pone.0054901. Epub 2013 Jan 24.
2013
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| 12 | DHCR24, KLF5
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| Promoter analysis of the DHCR24 (3β-hydroxysterol Δ(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation.
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| Daimiel LA, Fernández-Suárez ME, Rodríguez-Acebes S, Crespo L, Lasunción MA, Gómez-Coronado D, Martínez-Botas J.
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| Biosci Rep 33(1):57-69. doi: 10.1042/BSR20120095.
2012
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| 13 | DHCR24
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| The membrane topological analysis of 3β-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum.
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| Lu X, Li Y, Liu J, Cao X, Wang X, Wang D, Seo H, Gao B.
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| J Mol Endocrinol 48(1):1-9. doi: 10.1530/JME-11-0132. Print 2012 Feb.
2012
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| 14 | DHCR24, DSMS
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| The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter.
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| Zolotushko J, Flusser H, Markus B, Shelef I, Langer Y, Heverin M, Björkhem I, Sivan S, Birk OS.
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| Eur J Hum Genet 19(9):942-6. doi: 10.1038/ejhg.2011.74. Epub 2011 May 11.
2011
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| 15 | DHCR24
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| Identification and analysis of the promoter region of the human DHCR24 gene: involvement of DNA methylation and histone acetylation.
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| Drzewinska J, Walczak-Drzewiecka A, Ratajewski M.
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| Mol Biol Rep 38(2):1091-101. doi: 10.1007/s11033-010-0206-z. Epub 2010 Jun 22.
2011
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| 16 | DHCR24
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| Inhibition of DHCR24/seladin-1 impairs cellular homeostasis in prostate cancer.
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| Battista MC, Guimond MO, Roberge C, Doueik AA, Fazli L, Gleave M, Sabbagh R, Gallo-Payet N.
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| Prostate 70(9):921-33.
2010
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| 17 | DHCR24
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| 24-dehydrocholesterol reductase/seladin-1: a key protein differentially involved in adrenocorticotropin effects observed in human and rat adrenal cortex.
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| Battista MC, Roberge C, Martinez A, Gallo-Payet N.
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| Endocrinology 150(9):4180-90. Epub 2009 Jun 11.
2009
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| 18 | DHCR24
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| Role of 3beta-hydroxysteroid-delta 24 reductase in mediating antiinflammatory effects of high-density lipoproteins in endothelial cells.
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| McGrath KC, Li XH, Puranik R, Liong EC, Tan JT, Dy VM, DiBartolo BA, Barter PJ, Rye KA, Heather AK.
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| Arterioscler Thromb Vasc Biol 29(6):877-82. Epub 2009 Mar 26.
2009
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| 19 | DHCR24
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| Requirement of DHCR24 for postnatal development of epidermis and hair follicles in mice.
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| Mirza R, Qiao S, Murata Y, Seo H.
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| Am J Dermatopathol 31(5):446-52. doi: 10.1097/DAD.0b013e318196f10c.
2009
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| 20 | DHCR24
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| The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene.
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| Wang Y, Rogers PM, Stayrook KR, Su C, Varga G, Shen Q, Nagpal S, Burris TP.
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| Mol Pharmacol 74(6):1716-21. Epub 2008 Sep 24.
2008
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| 21 | DHCR24
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| Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures.
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| Luciani P, Deledda C, Rosati F, Benvenuti S, Cellai I, Dichiara F, Morello M, Vannelli GB, Danza G, Serio M, Peri A.
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| Endocrinology 149(9):4256-66. Epub 2008 May 22.
2008
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| 22 | DHCR24
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| Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress.
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| Kuehnle K, Crameri A, Kälin RE, Luciani P, Benvenuti S, Peri A, Ratti F, Rodolfo M, Kulic L, Heppner FL, Nitsch RM, Mohajeri MH.
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| Mol Cell Biol 28(2):539-50. Epub 2007 Nov 5.
2008
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| 23 | DHCR24
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| The association study between DHCR24 polymorphisms and Alzheimer's disease.
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| Lämsä R, Helisalmi S, Hiltunen M, Herukka SK, Tapiola T, Pirttilä T, Vepsäläinen S, Soininen H.
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| Am J Med Genet B Neuropsychiatr Genet 144B(7):906-10.
2007
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| 24 | DHCR24
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| Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1.
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| Benvenuti S, Saccardi R, Luciani P, Urbani S, Deledda C, Cellai I, Francini F, Squecco R, Rosati F, Danza G, Gelmini S, Greeve I, Rossi M, Maggi R, Serio M, Peri A.
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| Exp Cell Res 312(13):2592-604. Epub 2006 May 6. 2006
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| 25 | DHCR24
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| The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo.
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| Crameri A, Biondi E, Kuehnle K, Lutjohann D, Thelen KM, Perga S, Dotti CG, Nitsch RM, Ledesma MD, Mohajeri MH.
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| EMBO J 25(2):432-43. Epub 2006 Jan 12. 2006
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| 26 | DHCR24
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| Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.
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| Fuller PJ, Alexiadis M, Jobling T, McNeilage J.
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| Clin Endocrinol (Oxf) 63(1):111-5. 2005
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| 27 | DHCR24, MDM2
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| Regulation of cellular response to oncogenic and oxidative stress by Seladin-1.
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| Wu C, Miloslavskaya I, Demontis S, Maestro R, Galaktionov K.
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| Nature 432(7017):640-5. 2004
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| 28 | CYP51A1, DHCR24, EBP, DHCR7, DSMS, HEMSK, LBR, SC4MOL, SC5DL, SLOS
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| Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes.
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| Herman GE.
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| Hum Mol Genet 12(Suppl 1):R75-88. 2003
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| 29 | DHCR24
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| Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease.
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| Iivonen S, Hiltunen M, Alafuzoff I, Mannermaa A, Kerokoski P, Puolivali J, Salminen A, Helisalmi S, Soininen H.
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| Neuroscience 113(2):301-10. 2002
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| 30 | DHCR24, DSMS
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| Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.
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| Waterham HR, Koster J, Romeijn GJ, Hennekam RC, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJ.
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| Am J Hum Genet 69(4):685-94. 2001
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| 31 | DHCR24
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| The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress.
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| Greeve I, Hermans-Borgmeyer I, Brellinger C, Kasper D, Gomez-Isla T, Behl C, Levkau B, Nitsch RM.
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| J Neurosci 20(19):7345-52. 2000
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| 32 | EBP, DHCR24, DSMS
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| Clinical phenotype of desmosterolosis.
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| FitzPatrick DR, Keeling JW, Evans MJ, Kan AE, Bell JE, Porteous ME, Mills K, Winter RM, Clayton PT.
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| Am J Med Genet 75(2):145-52. 1998
|