| 1 | DDX6, IDDF
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| Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation.
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| Balak C, Benard M, Schaefer E, Iqbal S, Ramsey K, Ernoult-Lange M, Mattioli F, Llaci L, Geoffroy V, Courel M, Naymik M, Bachman KK, Pfundt R, Rump P, Ter Beest J, Wentzensen IM, Monaghan KG, McWalter K, Richholt R, Le Béchec A, Jepsen W, De Both M, Belnap N, Boland A, Piras IS, Deleuze JF, Szelinger S, Dollfus H, Chelly J, Muller J, Campbell A, Lal D, Rangasamy S, Mandel JL, Narayanan V, Huentelman M, Weil D, Piton A.
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| Am J Hum Genet 105(3):509-525. doi: 10.1016/j.ajhg.2019.07.010. Epub 2019 Aug 15.
2019
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| 2 | DDX6
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| The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis.
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| Di Stefano B, Luo EC, Haggerty C, Aigner S, Charlton J, Brumbaugh J, Ji F, Rabano Jiménez I, Clowers KJ, Huebner AJ, Clement K, Lipchina I, de Kort MAC, Anselmo A, Pulice J, Gerli MFM, Gu H, Gygi SP, Sadreyev RI, Meissner A, Yeo GW, Hochedlinger K.
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| Cell Stem Cell ell Stem Cell. 2019 Sep 27. pii: S1934-5909(19)30385-6. doi: 10.1016/j.stem.2019.08.018. [Epub ahead of print]
2019
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| 3 | DDX6
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| The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency.
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| Kami D, Kitani T, Nakamura A, Wakui N, Mizutani R, Ohue M, Kametani F, Akimitsu N, Gojo S.
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| PLoS One 13(10):e0203708. doi: 10.1371/journal.pone.0203708. eCollection 2018.
2018
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| 4 | DDX6, ERBB2, FGFR2
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| DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells.
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| Tajirika T, Tokumaru Y, Taniguchi K, Sugito N, Matsuhashi N, Futamura M, Yanagihara K, Akao Y, Yoshida K.
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| Int J Mol Sci 19(7). pii: E2005. doi: 10.3390/ijms19072005.
2018
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| 5 | DDX6
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| Dual mechanisms regulate the nucleocytoplasmic localization of human DDX6.
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| Huang JH, Ku WC, Chen YC, Chang YL, Chu CY.
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| Sci Rep 7:42853. doi: 10.1038/srep42853.
2017
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| 6 | DDX6, EIF4ENIF1
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| The DDX6-4E-T interaction mediates translational repression and P-body assembly.
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| Kamenska A, Simpson C, Vindry C, Broomhead H, Bénard M, Ernoult-Lange M, Lee BP, Harries LW, Weil D, Standart N.
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| Nucleic Acids Res 44(13):6318-34. doi: 10.1093/nar/gkw565. Epub 2016 Jun 24.
2016
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| 7 | DDX6, TRIM32
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| The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs.
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| Nicklas S, Okawa S, Hillje AL, González-Cano L, Del Sol A, Schwamborn JC.
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| Nucleic Acids Res 43(5):2638-54. doi: 10.1093/nar/gkv138. Epub 2015 Feb 26.
2015
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| 8 | CNOT1, DDX6, EDC3, EIF4ENIF1
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| Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex.
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| Ozgur S, Basquin J, Kamenska A, Filipowicz W, Standart N, Conti E.
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| Cell Rep 13(4):703-11. doi: 10.1016/j.celrep.2015.09.033. Epub 2015 Oct 17.
2015
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| 9 | CNOT1, DDX6
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| Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.
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| Rouya C, Siddiqui N, Morita M, Duchaine TF, Fabian MR, Sonenberg N.
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| RNA 20(9):1398-409. doi: 10.1261/rna.045302.114. Epub 2014 Jul 17.
2014
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| 10 | DDX6
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| DDX6 and its orthologs as modulators of cellular and viral RNA expression.
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| Ostareck DH, Naarmann-de Vries IS, Ostareck-Lederer A.
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| Wiley Interdiscip Rev RNA 5(5):659-78. doi: 10.1002/wrna.1237. Epub 2014 Apr 30. Review.
2014
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| 11 | DDX6
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| DDX6 localizes to nuage structures and the annulus of mammalian spermatogenic cells.
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| Kawahara C, Yokota S, Fujita H.
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| Histochem Cell Biol 141(1):111-21. doi: 10.1007/s00418-013-1153-2. Epub 2013 Oct 20.
2014
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| 12 | CNOT1, DDX6
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| Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.
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| Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W.
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| Mol Cell 54(5):751-65. doi: 10.1016/j.molcel.2014.03.036. Epub 2014 Apr 24.
2014
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| 13 | DDX6, DMPK
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| DDX6 regulates sequestered nuclear CUG-expanded DMPK-mRNA in dystrophia myotonica type 1.
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| Pettersson OJ, Aagaard L, Andrejeva D, Thomsen R, Jensen TG, Damgaard CK.
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| Nucleic Acids Res 42(11):7186-200. doi: 10.1093/nar/gku352. Epub 2014 May 3.
2014
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| 14 | DDX6, EIF4E, EIF4ENIF1, LSM1
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| An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.
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| Yang G, Smibert CA, Kaplan DR, Miller FD.
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| Neuron 84(4):723-39. doi: 10.1016/j.neuron.2014.10.022. Epub 2014 Nov 6.
2014
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| 15 | DDX6, VEGFA
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| Identification of DEAD-box RNA helicase 6 (DDX6) as a cellular modulator of vascular endothelial growth factor expression under hypoxia.
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| de Vries S, Naarmann-de Vries IS, Urlaub H, Lue H, Bernhagen J, Ostareck DH, Ostareck-Lederer A.
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| J Biol Chem 288(8):5815-27. doi: 10.1074/jbc.M112.420711. Epub 2013 Jan 4.
2013
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| 16 | DDX6
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| Multiple binding of repressed mRNAs by the P-body protein Rck/p54.
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| Ernoult-Lange M, Baconnais S, Harper M, Minshall N, Souquere S, Boudier T, Bénard M, Andrey P, Pierron G, Kress M, Standart N, le Cam E, Weil D.
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| RNA 18(9):1702-15. doi: 10.1261/rna.034314.112. Epub 2012 Jul 26.
2012
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| 17 | DDX6, ZFP36
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| AU-rich-element-dependent translation repression requires the cooperation of tristetraprolin and RCK/P54.
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| Qi MY, Wang ZZ, Zhang Z, Shao Q, Zeng A, Li XQ, Li WQ, Wang C, Tian FJ, Li Q, Zou J, Qin YW, Brewer G, Huang S, Jing Q.
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| Mol Cell Biol 32(5):913-28. doi: 10.1128/MCB.05340-11. Epub 2011 Dec 27.
2012
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| 18 | ATXN2, ATXN2L, DDX6
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| Ataxin-2-like is a regulator of stress granules and processing bodies.
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| Kaehler C, Isensee J, Nonhoff U, Terrey M, Hucho T, Lehrach H, Krobitsch S.
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| PLoS One 7(11):e50134. doi: 10.1371/journal.pone.0050134. Epub 2012 Nov 27.
2012
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| 19 | DDX6
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| The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome.
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| Yu SF, Lujan P, Jackson DL, Emerman M, Linial ML.
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| PLoS Pathog 7(10):e1002303. doi: 10.1371/journal.ppat.1002303. Epub 2011 Oct 13.
2011
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| 20 | DDX1, DDX17, DDX20, DDX21, DDX25, DDX39, DDX3X, DDX42, DDX5, DDX54, DDX6
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| DEAD-box helicases: posttranslational regulation and function.
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| Gustafson EA, Wessel GM.
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| Biochem Biophys Res Commun 395(1):1-6. Epub 2010 Mar 3. Review. No abstract available. PMID: 20206133 2010
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| 21 | DCP1A, DCP2, DDX6, EDC3, EDC4, LSM1, LSM4, PATL1, PATL2
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| Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies.
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| Ozgur S, Chekulaeva M, Stoecklin G.
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| Mol Cell Biol 30(17):4308-23. Epub 2010 Jun 28. 2010
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| 22 | DDX6, EDC3
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| Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B.
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| Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E, Weichenrieder O.
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| Mol Cell 33(5):661-8.PMID: 19285948 2009
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| 23 | ATXN2, DDX6
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| Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
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| Nonhoff U, Ralser M, Welzel F, Piccini I, Balzereit D, Yaspo ML, Lehrach H, Krobitsch S.
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| Mol Biol Cell 18(4):1385-96. Epub 2007 Feb 7. 2007
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| 24 | ATXN2, DDX6
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| Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules.
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| Nonhoff U, Ralser M, Welzel F, Piccini I, Balzereit D, Yaspo ML, Lehrach H, Krobitsch S.
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| Mol Biol Cell 18(4):1385-96. Epub 2007 Feb 7.
2007
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| 25 | AGO1, AGO2, DDX6
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| Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.
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| Chu CY, Rana TM.
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| PLoS Biol 4(7):e210. 2006
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| 26 | DDX6
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| Structural insight of human DEAD-box protein rck/p54 into its substrate recognition with conformational changes.
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| Matsui T, Hogetsu K, Usukura J, Sato T, Kumasaka T, Akao Y, Tanaka N.
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| Genes Cells 11(4):439-52. 2006
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| 27 | DDX6
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| Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
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| Miyaji K, Nakagawa Y, Matsumoto K, Yoshida H, Morikawa H, Hongou Y, Arisaka Y, Kojima H, Inoue T, Hirata I, Katsu K, Akao Y.
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| J Viral Hepat 10(4):241-8. 2003
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| 28 | DDX6
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| RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles.
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| Smillie DA, Sommerville J.
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| J Cell Sci 115(Pt 2):395-407. 2002
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| 29 | DDX6
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| Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours.
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| Nakagawa Y, et al.
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| Br J Cancer 80(5-6):914-7. 1999
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| 30 | DDX6
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| Cloning and expression of a murine cDNA homologous to the human RCK/P54, a lymphoma-linked chromosomal translocation junction gene on 11q23.
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| Seto M, et al.
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| Gene 166 : 293-296. 1995
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| 31 | BALMCR, DDX6
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| Molecular cloning of a novel 11q23 breakpoint associated with non-Hodgkin's lymphoma.
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| Meerabux JM, et al.
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| oncogene 9 : 893-898. 1994
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| 32 | DDX6, KMT2A
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| Long-range mapping of the 11q23 region involved in chromosome aberrations in human tumors by pulsed-field gel electrophoresis with a yeast artificial chromosome.
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| Akao Y, et al.
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| Genes Chromosomes Cancer 8 : 167-171. 1993
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| 33 | DDX6
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| Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3.
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| Lu D, et al.
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| Nucleic Acids Res 20 : 1967-1972. 1992
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| 34 | DDX6
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| The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations.
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| Akao Y, et al.
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| Cancer Res 52 : 6083-6087. 1992
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| 35 | DDX1, DDX39B, DDX6, DHX16, EIF4A2, RFC1
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| D-E-A-D protein family of putative RNA helicases.
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| Schmid SR, et al.
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| Mol Microbiol 6 : 283-292. 1992
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| 36 | DDX6
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| Molecular characterization of a t(11;14)(q23;q32) chromosome translocation in a B-cell lymphoma.
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| Akao Y, et al.
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| Cancer Res 50 : 4856-4859. 1991
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| 37 | BALMCR, DDX6
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| Molecular cloning of the chromosomal breakpoint of a B-cell lymphoma with the t(11;14)(q23;q32) translocation.
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| Akao Y, et al.
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| Cancer Res 51 : 1574-1576. 1991
|