| 1 | BCLAF1, DDIT4, FAM126B, FKBP1A, YWHAQ
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| Peripheral blood transcriptome identifies high-risk benign and malignant breast lesions
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| Hou H, Lyu Y, Jiang J, Wang M, Zhang R, Liew CC, Wang B, Cheng C.
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| PLoS One. Jun 4;15(6):e0233713. doi: 10.1371/journal.pone.0233713. 2020
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| 2 | DDIT4, TAL1
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| The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells.
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| Benyoucef A, Calvo J, Renou L, Arcangeli ML, van den Heuvel A, Amsellem S, Mehrpour M, Larghero J, Soler E, Naguibneva I, Pflumio F.
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| Stem Cells 33(7):2268-79. doi: 10.1002/stem.2028. Epub 2015 May 25.
2015
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| 3 | DDIT4
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| REDD1 protects osteoblast cells from gamma radiation-induced premature senescence.
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| Li XH, Ha CT, Fu D, Xiao M.
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| PLoS One 7(5):e36604. doi: 10.1371/journal.pone.0036604. Epub 2012 May 18.
2012
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| 4 | DDIT4, MTOR
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| Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.
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| Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P.
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| Cell Cycle 11(12):2391-401. doi: 10.4161/cc.20683. Epub 2012 Jun 15.
2012
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| 5 | DDIT4, EIF2AK3, EIF2S1
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| Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK, eIF2α phosphorylation, ATF4-dependent cascade.
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| Kimball SR, Jefferson LS.
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| Biochem Biophys Res Commun 427(3):485-9. doi: 10.1016/j.bbrc.2012.09.074. Epub 2012 Sep 20.
2012
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| 6 | DDIT4
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| RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration.
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| Malagelada C, López-Toledano MA, Willett RT, Jin ZH, Shelanski ML, Greene LA.
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| J Neurosci 31(9):3186-96.
2011
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| 7 | DDIT4
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| Redd1 inhibits the invasiveness of non-small cell lung cancer cells.
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| Jin HO, Seo SK, Woo SH, Kim YS, Hong SE, Yi JY, Noh WC, Kim EK, Lee JK, Hong SI, Choe TB, Park IC.
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| Biochem Biophys Res Commun 407(3):507-11. Epub 2011 Mar 23.
2011
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| 8 | DDIT4, MTOR, TXNIP
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| TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1.
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| Jin HO, Seo SK, Kim YS, Woo SH, Lee KH, Yi JY, Lee SJ, Choe TB, Lee JH, An S, Hong SI, Park IC.
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| Oncogene 30(35):3792-801. doi: 10.1038/onc.2011.102. Epub 2011 Apr 4.
2011
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| 9 | DDIT4
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| Feedback control of p53 translation by REDD1 and mTORC1 limits the p53-dependent DNA damage response.
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| Vadysirisack DD, Baenke F, Ory B, Lei K, Ellisen LW.
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| Mol Cell Biol 31(21):4356-65. doi: 10.1128/MCB.05541-11. Epub 2011 Sep 6.
2011
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| 10 | DDIT4
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| Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes.
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| Molitoris JK, McColl KS, Swerdlow S, Matsuyama M, Lam M, Finkel TH, Matsuyama S, Distelhorst CW.
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| J Biol Chem 286(34):30181-9. doi: 10.1074/jbc.M111.245423. Epub 2011 Jul 6. Erratum in: J Biol Chem. 2011 Nov 11;286(45):39673.
2011
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| 11 | DDIT4, MTOR
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| Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
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| Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J.
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| Mol Cell Biol 31(9):1870-84. doi: 10.1128/MCB.01393-10. Epub 2011 Mar 7.
2011
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| 12 | DDIT4, HIF1A
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| Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes.
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| Regazzetti C, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S.
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| J Biol Chem 285(8):5157-64. Epub 2009 Dec 8. 2010
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| 13 | DDIT4, MTOR
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| Structural analysis and functional implications of the negative mTORC1 regulator REDD1.
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| Vega-Rubin-de-Celis S, Abdallah Z, Kinch L, Grishin NV, Brugarolas J, Zhang X.
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| Biochemistry 49(11):2491-501. doi: 10.1021/bi902135e.
2010
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| 14 | ATF4, DDIT4
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| ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression.
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| Whitney ML, Jefferson LS, Kimball SR.
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| Biochem Biophys Res Commun 379(2):451-5. Epub 2008 Dec 27.
2009
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| 15 | DDIT4
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| REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase.
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| Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, Sankar S, Toth JI, Petroski MD, Ronai Z, Chiang GG.
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| EMBO Rep 10(8):866-72. Epub 2009 Jun 26.
2009
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| 16 | DDIT4
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| Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4.
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| Knowles LM, Yang C, Osterman A, Smith JW.
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| J Biol Chem 283(46):31378-84. Epub 2008 Sep 16.
2008
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| 17 | DDIT4
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| RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.
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| Malagelada C, Ryu EJ, Biswas SC, Jackson-Lewis V, Greene LA.
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| J Neurosci 26(39):9996-10005.
2006
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| 18 | DDIT4, DDIT4L
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| The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.
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| Corradetti MN, Inoki K, Guan KL.
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| J Biol Chem 280(11):9769-72. Epub 2005 Jan 4. 2005
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| 19 | DDIT4
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| REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase.
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| Schwarzer R, Tondera D, Arnold W, Giese K, Klippel A, Kaufmann J.
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| Oncogene 24(7):1138-49. 2005
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| 20 | DDIT4
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| Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity.
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| Kim JR, Lee SR, Chung HJ, Kim S, Baek SH, Kim JH, Kim YS.
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| Exp Mol Med 35(5):403-11. 2003
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| 21 | DDIT4
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| Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.
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| Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, Gorodin S, Moshel Y,Elbaz S, Budanov A, Chajut A, Kalinski H, Kamer I, Rozen A, Mor O, Keshet E,Leshkowitz D, Einat P, Skaliter R, Feinstein E.
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| Mol Cell Biol 22(7):2283-93. 2002
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