| 1 | ALD1H1, DDB2
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| DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1
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| Cui T, Srivastava AK, Han C, Wu D, Wani N, Liu L, Gao Z, Qu M, Zou N, Zhang X, Yi P, Yu J, Bell EH, Yang SM, Maloney DJ, Zheng Y, Wani AA, Wang QE.
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| Cell Death Dis. May 1;9(5):561. doi: 10.1038/s41419-018-0585-y. 2018
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| 2 | DDB2, RNF43
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| DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer.
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| Huang S, Fantini D, Merrill BJ, Bagchi S, Guzman G, Raychaudhuri P.
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| Cancer Res ancer Res. 2017 Oct 11. doi: 10.1158/0008-5472.CAN-17-1570. [Epub ahead of print]
2017
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| 3 | DDB2
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| UV radiation-induced SUMOylation of DDB2 regulates nucleotide excision repair.
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| Han C, Zhao R, Kroger J, He J, Wani G, Wang QE, Wani AA.
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| Carcinogenesis 38(10):976-985. doi: 10.1093/carcin/bgx076.
2017
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| 4 | DDB2, PARP1, XPC
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| Poly(ADP-ribose) polymerase 1 escorts XPC to UV-induced DNA lesions during nucleotide excision repair.
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| Robu M, Shah RG, Purohit NK, Zhou P, Naegeli H, Shah GM.
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| Proc Natl Acad Sci U S A 114(33):E6847-E6856. doi: 10.1073/pnas.1706981114. Epub 2017 Jul 31.
2017
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| 5 | DDB2, XRCC5, XRCC6
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| Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2.
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| Fantini D, Huang S, Asara JM, Bagchi S, Raychaudhuri P.
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| Mol Biol Cell 28(1):192-200. doi: 10.1091/mbc.E16-08-0573. Epub 2016 Nov 9.
2017
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| 6 | DDB2, UVRAG
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| Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase.
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| Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O'Connell D, Zhang T, Pirooz SD, Jeon Y, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C.
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| Mol Cell 62(4):507-19. doi: 10.1016/j.molcel.2016.04.014.
2016
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| 7 | DDB2, XPC
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| Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein.
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| Matsumoto S, Fischer ES, Yasuda T, Dohmae N, Iwai S, Mori T, Nishi R, Yoshino K, Sakai W, Hanaoka F, Thomä NH, Sugasawa K.
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| Nucleic Acids Res 43(3):1700-13. doi: 10.1093/nar/gkv038. Epub 2015 Jan 27.
2015
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| 8 | DDB2, XPE
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| α-N-methylation of damaged DNA-binding protein 2 (DDB2) and its function in nucleotide excision repair.
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| Cai Q, Fu L, Wang Z, Gan N, Dai X, Wang Y.
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| J Biol Chem 289(23):16046-56. doi: 10.1074/jbc.M114.558510. Epub 2014 Apr 21.
2014
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| 9 | DDB2, PCNA
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| DDB2 association with PCNA is required for its degradation after UV-induced DNA damage.
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| Cazzalini O, Perucca P, Mocchi R, Sommatis S, Prosperi E, Stivala LA.
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| Cell Cycle 13(2):240-8. doi: 10.4161/cc.26987. Epub 2013 Nov 4.
2014
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| 10 | DDB2
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| DDB2: a novel regulator of NF-κB and breast tumor invasion.
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| Ennen M, Klotz R, Touche N, Pinel S, Barbieux C, Besancenot V, Brunner E, Thiebaut D, Jung AC, Ledrappier S, Domenjoud L, Abecassis J, Plénat F, Grandemange S, Becuwe P.
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| Cancer Res 73(16):5040-52. doi: 10.1158/0008-5472.CAN-12-3655. Epub 2013 Jun 17.
2013
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| 11 | ATM, ATR, DDB2, XPC
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| NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites.
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| Ray A, Milum K, Battu A, Wani G, Wani AA.
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| DNA Repair (Amst) 12(4):273-83. doi: 10.1016/j.dnarep.2013.01.003. Epub 2013 Feb 17.
2013
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| 12 | AR, DDB2
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| DDB2 is a novel AR interacting protein and mediates AR ubiquitination/degradation.
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| Chang SW, Su CH, Chen HH, Huang CW, Tsao LP, Tsao YP, Chen SL.
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| Int J Biochem Cell Biol 44(11):1952-61. doi: 10.1016/j.biocel.2012.07.023. Epub 2012 Jul 28.
2012
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| 13 | CHD1L, DDB2, PARP1
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| PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1.
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| Pines A, Vrouwe MG, Marteijn JA, Typas D, Luijsterburg MS, Cansoy M, Hensbergen P, Deelder A, de Groot A, Matsumoto S, Sugasawa K, Thoma N, Vermeulen W, Vrieling H, Mullenders L.
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| J Cell Biol 199(2):235-49. doi: 10.1083/jcb.201112132. Epub 2012 Oct 8.
2012
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| 14 | CUL4A, DDB2
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| DDB2, an essential mediator of premature senescence.
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| Roy N, Stoyanova T, Dominguez-Brauer C, Park HJ, Bagchi S, Raychaudhuri P.
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| Mol Cell Biol 30(11):2681-92. Epub 2010 Mar 29.
2010
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| 15 | DDB1, DDB2, XPA
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| Physical and functional interaction between DDB and XPA in nucleotide excision repair.
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| Wakasugi M, Kasashima H, Fukase Y, Imura M, Imai R, Yamada S, Cleaver JE, Matsunaga T.
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| Nucleic Acids Res 37(2):516-25. Epub 2008 Dec 4.
2009
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| 16 | DDB2, SOD2
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| Identification of DDB2 protein as a transcriptional regulator of constitutive SOD2 gene expression in human breast cancer cells.
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| Minig V, Kattan Z, van Beeumen J, Brunner E, Becuwe P.
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| J Biol Chem 284(21):14165-76. Epub 2009 Apr 1.
2009
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| 17 | DDB2
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| DDB2 decides cell fate following DNA damage.
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| Stoyanova T, Roy N, Kopanja D, Bagchi S, Raychaudhuri P.
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| Proc Natl Acad Sci U S A 106(26):10690-5. Epub 2009 Jun 16.PMID: 19541625 2009
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| 18 | DDB2
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| The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21Waf1/Cip1.
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| Stoyanova T, Yoon T, Kopanja D, Mokyr MB, Raychaudhuri P.
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| Mol Cell Biol 28(1):177-87. Epub 2007 Oct 29.PMID: 17967871 2008
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| 19 | DDB1, DDB2
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| Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
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| Scrima A, Konícková R, Czyzewski BK, Kawasaki Y, Jeffrey PD, Groisman R, Nakatani Y, Iwai S, Pavletich NP, Thomä NH.
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| Cell 135(7):1213-23.PMID: 19109893 2008
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| 20 | DDB2
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| Damaged DNA binding protein 2 plays a role in breast cancer cell growth.
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| Kattan Z, Marchal S, Brunner E, Ramacci C, Leroux A, Merlin JL, Domenjoud L, Dauça M, Becuwe P.
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| PLoS One 3(4):e2002.PMID: 18431487 2008
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| 21 | DDB2, ACP2
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| Identification of a Novel Risk Locus for Progressive Supranuclear Palsy by a Pooled Genomewide Scan of 500,288 Single-Nucleotide Polymorphisms.
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| Melquist S, Craig DW, Huentelman MJ, Crook R, Pearson JV, Baker M, Zismann VL, Gass J, Adamson J, Szelinger S, Corneveaux J, Cannon A, Coon KD, Lincoln S, Adler C, Tuite P, Calne DB, Bigio EH, Uitti RJ, Wszolek ZK, Golbe LI, Caselli RJ, Graff-Radford N, Litvan I, Farrer MJ, Dickson DW, Hutton M, Stephan DA.
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| Am J Hum Genet 80(4):769-778. Epub 2007 Mar 8. 2007
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| 22 | DDB2
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| Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC.
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| El-Mahdy MA, Zhu Q, Wang QE, Wani G, Praetorius-Ibba M, Wani AA.
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| J Biol Chem 281(19):13404-11. Epub 2006 Mar 8. 2006
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| 23 | DDB2
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| DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.
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| Wittschieben BO, Iwai S, Wood RD.
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| J Biol Chem 280(48):39982-9. Epub 2005 Aug 24. 2005
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| 24 | DDB1,DDB2
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| Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.
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| Kulaksiz G, Reardon JT, Sancar A.
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| Mol Cell Biol 25(22):9784-92. 2005
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| 25 | DDB2, DDB1
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| Human DDB2 splicing variants are dominant negative inhibitors of UV-damaged DNA repair.
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| Inoki T, Yamagami S, Inoki Y, Tsuru T, Hamamoto T, Kagawa Y, Mori T, Endo H.
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| Biochem Biophys Res Commun 314(4):1036-43. 2004
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| 26 | CKN1, COPS8, DDB2, XPE, ERCC8
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| The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
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| Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, Kisselev AF, Tanaka K, Nakatani Y.
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| Cell 113(3):357-67. 2003
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| 27 | DDB1, DDB2, ERCC2, ERCC3, ERCC4, ERCC5, XPA, XPC
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| Clusters of transcription-coupled repair in the human genome.
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| Surralles J, Ramirez MJ, Marcos R, Natarajan AT, Mullenders LH.
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| Proc Natl Acad Sci U S A 99(16):10571-4. 2002
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| 28 | DDB1, DDB2
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| Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex.
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| Bergametti F, Sitterlin D, Transy C.
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| J Virol 76(13):6495-501. 2002
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| 29 | DDB2, TP53
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| p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.
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| Tan T, Chu G.
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| Mol Cell Biol 22(10):3247-54. 2002
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| 30 | DDB1, DDB2
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| Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation.
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| Rapic-Otrin V, McLenigan MP, Bisi DC, Gonzalez M, Levine AS.
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| Nucleic Acids Res 30(11):2588-98. 2002
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| 31 | DDB2
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| Restoration of UV sensitivity in UV-resistant HeLa cells by antisense-mediated depletion of damaged DNA-binding protein 2 (DDB2).
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| Sun NK, Kamarajan P, Huang H, Chao CC.
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| FEBS Lett 512(1-3):168-72. 2002
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| 32 | CUL4A, DDB2
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| The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells.
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| Nag A, Bondar T, Shiv S, Raychaudhuri P.
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| Mol Cell Biol 21(20):6738-47. 2001
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| 33 | DDB2, XPE
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| A newly identified patient with clinical xeroderma pigmentosum phenotype has a non-sense mutation in the DDB2 gene and incomplete repair in (6-4) photoproducts.
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| Itoh T, et al.
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| J Invest Dermatol 113(2):251-7 1999
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| 34 | DDB1, DDB2
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| Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.
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| Dualan R, et al.
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| Genomics 29 : 62-69. 1995
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| 35 | DDB1, DDB2
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| Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein.
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| Keeney S, et al.
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| Proc Natl Acad Sci U S A 91 : 4053-4056. 1994
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| 36 | DDB1, DDB2
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| Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E.
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| Keeney S, Chang GJ, Linn S.
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| J Biol Chem 268(28):21293-300. 1993
|