| 1 | CUL4B, DDB1, HIDDA, PHIP
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| A DNA repair disorder caused by de novo monoallelic DDB1 variants is associated with a neurodevelopmental syndrome
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| White SM, Bhoj E, Nellĺker C, Lachmeijer AMA, Marshall AE, Boycott KM, Li D, Smith W, Hartley T, McBride A, Ernst ME, May AS, Wieczorek D, Abou Jamra R, Koch-Hogrebe M, Őunap K, Pajusalu S, van Gassen KLI, Sadedin S, Ellingwood S, Tan TY, Christodoulou J, Barea J, Lockhart PJ; Care4Rare Canada Consortium, Nezarati MM, Kernohan KD.
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| Am J Hum Genet. Apr 1;108(4):749-756. doi: 10.1016/j.ajhg.2021.03.007. Epub 2021 Mar 19. 2021
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| 2 | DDB1
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| DDB1 promotes the proliferation and hypertrophy of chondrocytes during mouse skeleton development
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| Zhao L, Wang X, Pomlok K, Liao H, Yang G, Yang X, Chen YG.
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| Dev Biol. Sep 15;465(2):100-107. doi: 10.1016/j.ydbio.2020.05.011. Epub 2020 May 29. 2020
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| 3 | CUL1, CUL4A, DDB1, SKP2, YTHDF2
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| YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators
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| Fei Q, Zou Z, Roundtree IA, Sun HL, He C.
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| PLoS Biol. Apr 8;18(4):e3000664. doi: 10.1371/journal.pbio.3000664. 2020
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| 4 | DDB1
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| DDB1 Regulates Sertoli Cell Proliferation and Testis Cord Remodeling by TGFβ Pathway
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| Zheng W, Nazish J, Wahab F, Khan R, Jiang X, Shi Q.
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| Genes (Basel). Nov 26;10(12):974. doi: 10.3390/genes10120974. 2019
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| 5 | CUL4B, DDB1, SIRT7
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| SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes
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| Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan KL, Yuan HX.
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| FEBS J. Nov;284(21):3619-3636. doi: 10.1111/febs.14259. Epub 2017 Oct 10. 2017
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| 6 | CDH1, DDB1, XPC
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| TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair.
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| Qiang L, Shah P, Barcellos-Hoff MH, He YY.
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| Oncogene. Jun 23;35(25):3293-302. doi: 10.1038/onc.2015.390. Epub 2015 Oct 19. 2016
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| 7 | DDB1, TP53
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| The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis.
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| Gao J, Buckley SM, Cimmino L, Guillamot M, Strikoudis A, Cang Y, Goff SP, Aifantis I.
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| Elife. Nov 27;4:e07539. doi: 10.7554/eLife.07539. 2015
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| 8 | CHEK1, DDB1, SETMAR
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| The DNA repair component Metnase regulates Chk1 stability.
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| Williamson EA, Wu Y, Singh S, Byrne M, Wray J, Lee SH, Nickoloff JA, Hromas R.
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| Cell Div 9:1. doi: 10.1186/1747-1028-9-1.
2014
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| 9 | DDB1, DYRK2, TERT, UBR5, VPRBP
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| Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.
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| Jung HY, Wang X, Jun S, Park JI.
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| J Biol Chem 288(10):7252-62. doi: 10.1074/jbc.M112.416792. Epub 2013 Jan 28.
2013
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| 10 | DDB1
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| Damage-specific DNA binding protein 1 (DDB1) is involved in ubiquitin-mediated proteolysis of p27Kip1 in response to UV irradiation.
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| Iovine B, Iannella ML, Bevilacqua MA.
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| Biochimie 93(5):867-75. Epub 2011 Jan 13.
2011
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| 11 | DDB1, RBX1, VPRBP
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| The Cullin-RING E3 ubiquitin ligase CRL4-DCAF1 complex dimerizes via a short helical region in DCAF1.
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| Ahn J, Novince Z, Concel J, Byeon CH, Makhov AM, Byeon IJ, Zhang P, Gronenborn AM.
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| Biochemistry 50(8):1359-67. Epub 2011 Jan 31.
2011
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| 12 | ACTR5, ACTR8, DDB1, INO80
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| INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway.
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| Jiang Y, Wang X, Bao S, Guo R, Johnson DG, Shen X, Li L.
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| Proc Natl Acad Sci U S A 107(40):17274-9. Epub 2010 Sep 20.
2010
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| 13 | DDB1
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| Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis.
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| Yamaji S, Zhang M, Zhang J, Endo Y, Bibikova E, Goff SP, Cang Y.
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| Proc Natl Acad Sci U S A 107(51):22237-42. Epub 2010 Dec 6.
2010
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| 14 | CDH1, DDB1
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| Damaged DNA-binding protein 1 (DDB1) interacts with Cdh1 and modulates the function of APC/CCdh1.
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| Lv XB, Xie F, Hu K, Wu Y, Cao LL, Han X, Sang Y, Zeng YX, Kang T.
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| J Biol Chem 285(24):18234-40. Epub 2010 Apr 15.
2010
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| 15 | DDB1, DDB2, XPA
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| Physical and functional interaction between DDB and XPA in nucleotide excision repair.
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| Wakasugi M, Kasashima H, Fukase Y, Imura M, Imai R, Yamada S, Cleaver JE, Matsunaga T.
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| Nucleic Acids Res 37(2):516-25. Epub 2008 Dec 4.
2009
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| 16 | CUL4A, DDB1, KMT2A
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| DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation.
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| Kotake Y, Zeng Y, Xiong Y.
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| Cancer Res 69(5):1809-14. Epub 2009 Feb 10. 2009
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| 17 | CUL4A, DDB1, FBXW5, RBX1, TSC1, TSC2
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| WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.
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| Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y.
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| Genes Dev 22(7):866-71. 2008
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| 18 | DDB1, DDB2
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| Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
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| Scrima A, Konícková R, Czyzewski BK, Kawasaki Y, Jeffrey PD, Groisman R, Nakatani Y, Iwai S, Pavletich NP, Thomä NH.
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| Cell 135(7):1213-23.PMID: 19109893 2008
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| 19 | DDB1
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| DDB1 is essential for genomic stability in developing epidermis.
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| Cang Y, Zhang J, Nicholas SA, Kim AL, Zhou P, Goff SP.
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| Proc Natl Acad Sci U S A [Epub ahead of print] 2007
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| 20 | DDB1, CUL4A
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| Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
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| Angers S, Li T, Yi X, MacCoss MJ, Moon RT, Zheng N.
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| Nature 443(7111):590-3. 2006
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| 21 | CDT1, DDB1
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| DDB1 maintains genome integrity through regulation of Cdt1.
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| Lovejoy CA, Lock K, Yenamandra A, Cortez D.
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| Mol Cell Biol 26(21):7977-90. Epub 2006 Aug 28.
2006
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| 22 | CDT1, CDT2, DDB1
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| L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.
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| Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H.
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| Cell Cycle 5(15):1675-80. Epub 2006 Aug 1.
2006
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| 23 | CUL4A, CUL4B, DDB1, WDR26
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| CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
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| Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H.
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| Nat Cell Biol 8(11):1277-83. Epub 2006 Oct 15. 2006
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| 24 | DDB1,DDB2
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| Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.
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| Kulaksiz G, Reardon JT, Sancar A.
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| Mol Cell Biol 25(22):9784-92. 2005
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| 25 | DDB2, DDB1
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| Human DDB2 splicing variants are dominant negative inhibitors of UV-damaged DNA repair.
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| Inoki T, Yamagami S, Inoki Y, Tsuru T, Hamamoto T, Kagawa Y, Mori T, Endo H.
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| Biochem Biophys Res Commun 314(4):1036-43. 2004
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| 26 | CUL4A, DDB1
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| Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.
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| Hu J, McCall CM, Ohta T, Xiong Y.
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| Nat Cell Biol 6(10):1003-9. Epub 2004 Sep 26. 2004
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| 27 | DDB1, DDB2, ERCC2, ERCC3, ERCC4, ERCC5, XPA, XPC
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| Clusters of transcription-coupled repair in the human genome.
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| Surralles J, Ramirez MJ, Marcos R, Natarajan AT, Mullenders LH.
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| Proc Natl Acad Sci U S A 99(16):10571-4. 2002
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| 28 | DDB1, DDB2
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| Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex.
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| Bergametti F, Sitterlin D, Transy C.
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| J Virol 76(13):6495-501. 2002
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| 29 | DDB1, DDB2
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| Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation.
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| Rapic-Otrin V, McLenigan MP, Bisi DC, Gonzalez M, Levine AS.
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| Nucleic Acids Res 30(11):2588-98. 2002
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| 30 | DDB1, BEST1
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| Refined mapping of the gene encoding the p127 kDa UV-damaged DNA-binding protein (DDB1) within 11q12-q13.1 and its exclusion in Best's vitelliform macular dystrophy.
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| Stohr H, Marquardt A, Rivera A, Kellner U, Weber BH.
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| Eur J Hum Genet 6(4):400-5. 1998
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| 31 | DDB1, DDB2
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| Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.
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| Dualan R, et al.
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| Genomics 29 : 62-69. 1995
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| 32 | DDB1, DDB2
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| Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein.
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| Keeney S, et al.
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| Proc Natl Acad Sci U S A 91 : 4053-4056. 1994
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| 33 | DDB1, DDB2
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| Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E.
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| Keeney S, Chang GJ, Linn S.
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| J Biol Chem 268(28):21293-300. 1993
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| 34 | G6PD, ERVK2, ERVK3, DDB1, TAZ, ATP6AP1, GDI1, FAM50A, FAM3A, PLXNA3, ATP6AP1
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| Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection.
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| Sedlacek Z, Korn B, Konecki DS, Siebenhaar R, Coy JF, Kioschis P, Poustka A.
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| Hum Mol Genet 2(11):1865-9. 1993
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