| 1 | BLOC1S6, CYTH2
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| Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.
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| Ito A, Fukaya M, Saegusa S, Kobayashi E, Sugawara T, Hara Y, Yamauchi J, Okamoto H, Sakagami H.
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| J Neurochem 147(2):153-177. doi: 10.1111/jnc.14579. Epub 2018 Oct 19.
2018
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| 2 | ARF1, CYTH2
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| Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO.
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| Rafiq NB, Lieu ZZ, Jiang T, Yu CH, Matsudaira P, Jones GE, Bershadsky AD.
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| J Cell Biol 216(1):181-197. doi: 10.1083/jcb.201605104. Epub 2016 Dec 22.
2017
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| 3 | CYTH2
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| Lack of Evidence that CYTH2/ARNO Functions as a Direct Intracellular EGFR Activator.
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| Anastasi S, Zhu SJ, Ballarò C, Manca S, Lamberti D, Wang LJ, Alemà S, Yun CH, Segatto O.
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| Cell 165(5):1031-1034. doi: 10.1016/j.cell.2016.05.009. No abstract available.
2016
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| 4 | CYTH2, TBC1D10A
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| PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a.
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| Yamaoka M, Ando T, Terabayashi T, Okamoto M, Takei M, Nishioka T, Kaibuchi K, Matsunaga K, Ishizaki R, Izumi T, Niki I, Ishizaki T, Kimura T.
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| J Cell Sci 129(3):637-49. doi: 10.1242/jcs.180141. Epub 2015 Dec 18.
2016
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| 5 | ARF6, CYTH2
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| Arf6 guanine-nucleotide exchange factor cytohesin-2 regulates myelination in nerves.
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| Torii T, Ohno N, Miyamoto Y, Kawahara K, Saitoh Y, Nakamura K, Takashima S, Sakagami H, Tanoue A, Yamauchi J.
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| Biochem Biophys Res Commun iochem Biophys Res Commun. 2015 Mar 28. pii: S0006-291X(15)00579-3. doi: 10.1016/j.bbrc.2015.03.113. [Epub ahead of print]
2015
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| 6 | ARF6, CYTH2, RALBP1, RRAS
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| RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
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| Wurtzel JG, Lee S, Singhal SS, Awasthi S, Ginsberg MH, Goldfinger LE.
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| Biochem Biophys Res Commun 467(4):785-91. doi: 10.1016/j.bbrc.2015.10.064. Epub 2015 Oct 20.
2015
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| 7 | ARF6, CYTH2, RALBP1
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| The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration.
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| Lee S, Wurtzel JG, Goldfinger LE.
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| Biochem Biophys Res Commun 454(4):560-565. doi: 10.1016/j.bbrc.2014.10.114. [Epub ahead of print]
2014
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| 8 | ARF6, CYTH2
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| Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2.
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| Davies JC, Tamaddon-Jahromi S, Jannoo R, Kanamarlapudi V.
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| Biochem Pharmacol 92(4):651-60. doi: 10.1016/j.bcp.2014.09.023. Epub 2014 Oct 20.
2014
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| 9 | CCDC120, CYTH2
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| Arf6 guanine nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth.
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| Torii T, Miyamoto Y, Tago K, Sango K, Nakamura K, Sanbe A, Tanoue A, Yamauchi J.
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| J Biol Chem 289(49):33887-903. doi: 10.1074/jbc.M114.575787. Epub 2014 Oct 17.
2014
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| 10 | ATP6V1H, CYTH2
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| The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase) and cytohesin-2.
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| Hosokawa H, Dip PV, Merkulova M, Bakulina A, Zhuang Z, Khatri A, Jian X, Keating SM, Bueler SA, Rubinstein JL, Randazzo PA, Ausiello DA, Grüber G, Marshansky V.
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| J Biol Chem 288(8):5896-913. doi: 10.1074/jbc.M112.409169. Epub 2013 Jan 3.
2013
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| 11 | CYTH2, DOCK1, GRASP
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| The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration.
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| Attar MA, Santy LC.
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| BMC Cell Biol 14:9. doi: 10.1186/1471-2121-14-9.
2013
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| 12 | CYTH2
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| Arf6 guanine-nucleotide exchange factor, cytohesin-2, interacts with actinin-1 to regulate neurite extension.
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| Torii T, Miyamoto Y, Nakamura K, Maeda M, Yamauchi J, Tanoue A.
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| Cell Signal 24(9):1872-82. Epub 2012 May 31.
2012
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| 13 | CYTH2, DOCK1, GRASP
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| PDZ-scaffold protein, Tamalin promotes dendritic outgrowth and arborization in rat hippocampal neuron.
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| Mo J, Choi S, Ahn PG, Sun W, Lee HW, Kim H.
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| Biochem Biophys Res Commun 422(2):250-5. doi: 10.1016/j.bbrc.2012.04.136. Epub 2012 Apr 30.
2012
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| 14 | ARF6, CYTH2, MYD88
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| Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.
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| Zhu W, London NR, Gibson CC, Davis CT, Tong Z, Sorensen LK, Shi DS, Guo J, Smith MC, Grossmann AH, Thomas KR, Li DY.
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| Nature 492(7428):252-5. doi: 10.1038/nature11603. Epub 2012 Nov 11.
2012
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| 15 | CYTH2, PXN
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| Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6.
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| Torii T, Miyamoto Y, Sanbe A, Nishimura K, Yamauchi J, Tanoue A.
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| J Biol Chem 285(31):24270-81. Epub 2010 Jun 4. 2010
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| 16 | CYTH2, CYTH3
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| Differential effects of cytohesins 2 and 3 on beta1 integrin recycling.
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| Oh SJ, Santy LC.
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| J Biol Chem 285(19):14610-6. Epub 2010 Mar 11.
2010
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| 17 | ATP6V0A2, CYTH2
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| Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO.
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| Merkulova M, Bakulina A, Thaker YR, Grüber G, Marshansky V.
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| Biochim Biophys Acta 1797(8):1398-409. Epub 2010 Feb 11.
2010
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| 18 | CYTH2, DOCK1, GRASP, IPCEF1
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| GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180.
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| White DT, McShea KM, Attar MA, Santy LC.
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| Mol Biol Cell 21(4):562-71. doi: 10.1091/mbc.E09-03-0217. Epub 2009 Dec 16. 2010
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| 19 | ARF6, ARL4D, ARP6, CYTH2
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| Valproic acid-inducible Arl4D and cytohesin-2/ARNO, acting through the downstream Arf6, regulate neurite outgrowth in N1E-115 cells.
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| Yamauchi J, Miyamoto Y, Torii T, Mizutani R, Nakamura K, Sanbe A, Koide H, Kusakawa S, Tanoue A.
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| Exp Cell Res 315(12):2043-52. Epub 2009 Mar 25.PMID: 19327349 2009
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| 20 | ACTN1, ADORA2A, CYTH2, TSNAX, USP4
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| The A(2A)-adenosine receptor: a GPCR with unique features?
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| Zezula J, Freissmuth M.
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| Br J Pharmacol 153 Suppl 1:S184-90. Epub 2008 Feb 4. Review.PMID: 18246094 2008
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| 21 | ARL4D, CYTH2
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| ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling.
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| Li CC, Chiang TC, Wu TS, Pacheco-Rodriguez G, Moss J, Lee FJ.
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| Mol Biol Cell 18(11):4420-37. Epub 2007 Sep 5.PMID: 17804820 2007
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| 22 | ARL4A, ARL4C, ARL4D, CYTH2
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| The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.
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| Hofmann I, Thompson A, Sanderson CM, Munro S.
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| Curr Biol 17(8):711-6. Epub 2007 Mar 29.PMID: 17398095 2007
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| 23 | ARF6, CYTH2
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| The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network.
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| Bouschet T, Martin S, Kanamarlapudi V, Mundell S, Henley JM.
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| J Cell Sci 120(Pt 15):2489-97. Epub 2007 Jul 10.
2007
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| 24 | CYTH2
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| The N-terminal coiled-coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with Galphaq.
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| Laroche G, Giguère PM, Dupré E, Dupuis G, Parent JL.
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| Mol Cell Biochem 306(1-2):141-52. Epub 2007 Sep 6.
2007
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| 25 | CYTH2
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| ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells.
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| Shmuel M, Santy LC, Frank S, Avrahami D, Casanova JE, Altschuler Y.
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| J Biol Chem 281(19):13300-8. Epub 2006 Feb 16. 2006
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| 26 | ATP6V1C1, CYTH2
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| V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
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| Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V.
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| Nat Cell Biol 8(2):124-36. Epub 2006 Jan 15. 2006
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| 27 | ADORA2A, CYTH2
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| Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway.
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| Gsandtner I, Charalambous C, Stefan E, Ogris E, Freissmuth M, Zezula J.
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| J Biol Chem 280(36):31898-905. Epub 2005 Jul 18. 2005
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| 28 | CYTH2, IPCEF1
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| Analysis of the interaction between cytohesin 2 and IPCEF1.
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| Venkateswarlu K.
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| Methods Enzymol 404:252-66.
2005
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| 29 | CYTH2
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| Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2.
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| Theis MG, Knorre A, Kellersch B, Moelleken J, Wieland F, Kolanus W, Famulok M.
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| Proc Natl Acad Sci U S A 101(31):11221-6. Epub 2004 Jul 26.
2004
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| 30 | ACTN4, AURKC, CKM, CYP2B6, CYTH2, DMPK, FOSB, IRF3, ITPKC, MIA, SIX5, VASP
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| The telomeric region of BTA18 containing a potential QTL region for health in cattle exhibits high similarity to the HSA19q region in humans small star, filled
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| Brunner RM, Sanftleben H, Goldammer T, Kuhn C, Weikard R, Kata SR, Womack JE, Schwerin M.
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| Genomics 81(3):270-8. 2003
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| 31 | CYTH2, IPCEF1
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| Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.
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| Venkateswarlu K.
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| J Biol Chem 278(44):43460-9. Epub 2003 Aug 14.
2003
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| 32 | ACAP1, ACAP2, ADAP1, ADAP2, CYTH1, CYTH2, CYTH3, CYTH4
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| Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.
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| Jackson TR, Kearns BG, Theibert AB.
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| Trends Biochem Sci 25(10):489-95. Review. 2000
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| 33 | CYTH2
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| Assignment of the human cts 18.1 gene PSCD2L to chromosome 19 band q13 using a radiation hybrid mapping panel.
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| Kim HS.
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| Cytogenet Cell Genet 83 : 43. 1998
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| 34 | CYTH2
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| Human cts18.1 gene: chromosomal localization and PH-domain analysis.
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| Kim HS.
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| Genes Genet Syst 73(5):293-6. 1998
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| 35 | CYTH2
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| Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase.
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| Mossessova E, et al.
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| Cell 92(3):415-23. 1998
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| 36 | ARF1, CYTH2, CYTH3
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| A human exchange factor for ARF contains Sec7-and pleckstrin-homology domains.
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| Chardin P, et al.
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| Nature 384 : 481-484. 1996
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| 37 | CYTH2
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| A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains.
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| Chardin P, et al.
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| Nature 384(6608):481-4. 1996
|