| 1 | CYP3A4, CYP3A5
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| Genetic association in CYP3A4 and CYP3A5 genes elevate the risk of prostate cancer.
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| Bellah SF, Salam MA, Billah SMS, Karim MR.
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| Ann Hum Biol. Feb;50(1):63-74. doi: 10.1080/03014460.2023.2171122. 2023
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| 2 | CYP3A4, NR1I2
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| Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells.
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| Sachar M, Kelly EJ, Unadkat JD.
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| AAPS J 21(3):45. doi: 10.1208/s12248-019-0316-z.
2019
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| 3 | CYP3A4
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| CYP3A4 Gene Is a Novel Biomarker for Predicting a Poor Prognosis in Hepatocellular Carcinoma.
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| Ashida R, Okamura Y, Ohshima K, Kakuda Y, Uesaka K, Sugiura T, Ito T, Yamamoto Y, Sugino T, Urakami K, Kusuhara M, Yamaguchi K.
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| Cancer Genomics Proteomics 14(6):445-453. Review.
2017
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| 4 | AHR, CYP3A4, NR1I2
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| Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG.
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| Rasmussen MK, Daujat-Chavanieu M, Gerbal-Chaloin S.
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| Toxicol Lett 277:1-8. doi: 10.1016/j.toxlet.2017.05.029. Epub 2017 May 29.
2017
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| 5 | CYP3A4
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| CYP3A4 Activity is Markedly Lower in Patients with Crohn's Disease.
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| Wilson A, Tirona RG, Kim RB.
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| Inflamm Bowel Dis 23(5):804-813. doi: 10.1097/MIB.0000000000001062.
2017
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| 6 | CYP3A4
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| Is cytochrome P450 3A4 regulated by menstrual cycle hormones in control endometrium and endometriosis?
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| Piccinato CA, Neme RM, Torres N, Silvério R, Pazzini VB, Rosa E Silva JC, Ferriani RA.
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| Mol Cell Biochem 427(1-2):81-89. doi: 10.1007/s11010-016-2899-3. Epub 2016 Dec 19.
2017
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| 7 | CYP3A4, CYP3A5
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| The expression levels of CYP3A4 and CYP3A5 serve as potential prognostic biomarkers in lung adenocarcinoma.
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| Qixing M, Juqing X, Yajing W, Gaochao D, Wenjie X, Run S, Anpeng W, Lin X, Feng J, Jun W.
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| Tumour Biol. Apr;39(4):1010428317698340. doi: 10.1177/1010428317698340. 2017
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| 8 | CYP3A4, FGF21, NR1I2
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| A Fibroblast Growth Factor 21-Pregnane X Receptor Pathway Downregulates Hepatic CYP3A4 in Nonalcoholic Fatty Liver Disease.
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| Woolsey SJ, Beaton MD, Mansell SE, Leon-Ponte M, Yu J, Pin CL, Adams PC, Kim RB, Tirona RG.
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| Mol Pharmacol 90(4):437-46. doi: 10.1124/mol.116.104687. Epub 2016 Aug 1.
2016
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| 9 | CYP3A4
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| Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4.
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| Cheng CY, Slominski AT, Tuckey RC.
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| J Steroid Biochem Mol Biol 159:131-41. doi: 10.1016/j.jsbmb.2016.03.014. Epub 2016 Mar 9.
2016
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| 10 | CYP3A4, CYP3A7
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| Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.
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| Giebel NL, Shadley JD, McCarver DG, Dorko K, Gramignoli R, Strom SC, Yan K, Simpson PM, Hines RN.
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| Drug Metab Dispos 44(7):1027-37. doi: 10.1124/dmd.116.069344. Epub 2016 Feb 26.
2016
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| 11 | CYP3A4, RXRA
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| Sex-dependent regulation of hepatic CYP3A by growth hormone: Roles of HNF6, C/EBPα, and RXRα.
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| Li J, Wan Y, Na S, Liu X, Dong G, Yang Z, Yang J, Yue J.
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| Biochem Pharmacol 93(1):92-103. doi: 10.1016/j.bcp.2014.10.010. Epub 2014 Oct 31. 2015
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| 12 | CYP3A4
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| Anion-Dependent Stimulation of CYP3A4 Monooxygenase.
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| Sevrioukova IF, Poulos TL.
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| Biochemistry 54(26):4083-96. doi: 10.1021/acs.biochem.5b00510. Epub 2015 Jun 23.
2015
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| 13 | CYP3A4, CYP3A7
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| Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors.
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| Betts S, Björkhem-Bergman L, Rane A, Ekström L.
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| Basic Clin Pharmacol Toxicol 117(4):261-6. doi: 10.1111/bcpt.12392. Epub 2015 Mar 9.
2015
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| 14 | CYP3A4, NR1I2
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| Bile acid malabsorption deactivates pregnane X receptor in patients with Crohn's disease.
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| Iwamoto J, Saito Y, Honda A, Miyazaki T, Ikegami T, Matsuzaki Y.
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| Inflamm Bowel Dis 19(6):1278-84. doi: 10.1097/MIB.0b013e318281f423.
2013
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| 15 | CYP3A4, PPARA
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| Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).
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| Thomas M, Burk O, Klumpp B, Kandel BA, Damm G, Weiss TS, Klein K, Schwab M, Zanger UM.
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| Mol Pharmacol 83(3):709-18. doi: 10.1124/mol.112.082503. Epub 2013 Jan 7.
2013
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| 16 | CYP3A4
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| Interplay between vitamin D and the drug metabolizing enzyme CYP3A4.
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| Wang Z, Schuetz EG, Xu Y, Thummel KE.
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| J Steroid Biochem Mol Biol 136:54-8. doi: 10.1016/j.jsbmb.2012.09.012. Epub 2012 Sep 15. Review.
2013
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| 17 | CYP3A4
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| DNA methylation dynamics in the hepatic CYP3A4 gene promoter.
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| Kacevska M, Ivanov M, Wyss A, Kasela S, Milani L, Rane A, Ingelman-Sundberg M.
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| Biochimie 94(11):2338-44. doi: 10.1016/j.biochi.2012.07.013. Epub 2012 Jul 31.
2012
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| 18 | CYP3A4, PPARA
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| PPARA: a novel genetic determinant of CYP3A4 in vitro and in vivo.
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| Klein K, Thomas M, Winter S, Nussler AK, Niemi M, Schwab M, Zanger UM.
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| Clin Pharmacol Ther 91(6):1044-52. doi: 10.1038/clpt.2011.336.
2012
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| 19 | CYP3A4
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| Inhibition of human cytochrome P450 3A4 by cholesterol.
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| Shinkyo R, Guengerich FP.
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| J Biol Chem 286(21):18426-33. doi: 10.1074/jbc.M111.240457. Epub 2011 Apr 6.
2011
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| 20 | CYP3A4, NR1I2
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| Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells.
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| Habano W, Gamo T, Terashima J, Sugai T, Otsuka K, Wakabayashi G, Ozawa S.
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| BMC Cancer 11:81. doi: 10.1186/1471-2407-11-81.
2011
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| 21 | CYP3A4, NR1I2, NR2F1, NR2F2, THRA, THRB
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| Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.
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| Istrate MA, Nussler AK, Eichelbaum M, Burk O.
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| Biochem Biophys Res Commun 393(4):688-93. Epub 2010 Feb 18.PMID: 20171174 2010
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| 22 | CYP3A4, VDR
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| Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene.
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| Pavek P, Pospechova K, Svecova L, Syrova Z, Stejskalova L, Blazkova J, Dvorak Z, Blahos J.
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| Biochem Pharmacol 79(2):277-87. Epub 2009 Aug 25.PMID: 19712670 2010
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| 23 | CYP3A4
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| The effects of type II binding on metabolic stability and binding affinity in cytochrome P450 CYP3A4.
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| Peng CC, Pearson JT, Rock DA, Joswig-Jones CA, Jones JP.
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| Arch Biochem Biophys 497(1-2):68-81. Epub 2010 Mar 25.PMID: 20346909 2010
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| 24 | CYP3A4
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| Mechanisms of ketamine-involved regulation of cytochrome P450 gene expression.
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| Chen JT, Chen RM.
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| Expert Opin Drug Metab Toxicol 6(3):273-81.PMID: 20163319 2010
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| 25 | CYP1A2, CYP3A4, CYP3A5
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| Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers.
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| Oliver P, Lubomirov R, Carcas A.
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| Clin Chem Lab Med 48(5):635-9.PMID: 20218903 2010
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| 26 | CYP3A4
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| A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradation.
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| Wang Y, Liao M, Hoe N, Acharya P, Deng C, Krutchinsky AN, Correia MA.
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| J Biol Chem 284(9):5671-84. Epub 2008 Dec 18.
2009
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| 27 | CYP3A4
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| The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha.
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| Liu FJ, Song X, Yang D, Deng R, Yan B.
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| Biochem J 409(1):243-50.PMID: 17764444 2008
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| 28 | SMARCA4, ZNF185, CYP3A4
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| Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells.
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| Medina PP, Carretero J, Ballestar E, Angulo B, Lopez-Rios F, Esteller M, Sanchez-Cespedes M.
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| Hum Mol Genet 14(7):973-82. Epub 2005 Feb 24. 2005
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| 29 | CYP3A4
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| Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles.
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| Rodriguez-Antona C, Sayi JG, Gustafsson LL, Bertilsson L, Ingelman-Sundberg M.
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| Biochem Biophys Res Commun 338(1):299-305. Epub 2005 Sep 13. 2005
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| 30 | SRD5A2, CYP17A1, CYP3A4
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| Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2.
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| Loukola A, Chadha M, Penn SG, Rank D, Conti DV, Thompson D, Cicek M, Love B, Bivolarevic V, Yang Q, Jiang Y, Hanzel DK, Dains K, Paris PL, Casey G, Witte JS.
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| Eur J Hum Genet 12(4):321-32. 2004
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| 31 | CYP3A4
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| CYP3A4 is a human microsomal vitamin D 25-hydroxylase.
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| Gupta RP, Hollis BW, Patel SB, Patrick KS, Bell NH.
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| J Bone Miner Res 19(4):680-8. Epub 2003 Dec 22. 2004
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| 32 | CYP3A4
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| CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification?
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| Kittles RA, Chen W, Panguluri RK, Ahaghotu C, Jackson A, Adebamowo CA, Griffin R, Williams T, Ukoli F, Adams-Campbell L, Kwagyan J, Isaacs W, Freeman V, Dunston GM.
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| Hum Genet 110(6):553-60. 2002
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| 33 | CYP2B6, CYP2C9, CYP3A4
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| Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.
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| Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ.
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| J Biol Chem 277(28):25125-32. 2002
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| 34 | CYP3A4
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| Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.
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| Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, Watkins PB, Daly A, Wrighton SA, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Venkataramanan R, Strom S, Thummel K, Boguski MS, Schuetz E.
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| Nat Genet 27(4):383-91. 2001
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| 35 | CYP3A4, CYP3A43, CYP3A5P2
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| Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.
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| Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L.
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| Pharmacogenetics 11(2):111-21. 2001
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| 36 | CYP3A4, CYP3A5, CYP3A5P2, CYP3A7
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| The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.
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| Finta C, Zaphiropoulos PG.
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| Gene 260(1-2):13-23. 2000
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| 37 | CYP3A4
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| Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region.
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| Westlind A, et al.
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| Biochem Biophys Res Commun 259(1):201-5. 1999
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| 38 | CYP3A4
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| Association of CYP3A4 genotype with treatment-related leukemia.
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| Felix CA, et al.
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| Proc Natl Acad Sci U S A 95(22):13176-81. 1998
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| 39 | CYP3A4
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| The human cytochrome P450 CYP3 locus : assignment to chromosome 7q22-qter.
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| Spurr NK, Gough AC, Stevenson K, Wolf CR.
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| Hum Genet 81 : 171-174. 1989
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| 40 | CYP3A4
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| Human P450PCN1 : sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
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| Gonzalez FJ, et al.
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| DNA 7 : 79-86. 1988
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| 41 | CYP3A4
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| The gene CYP3 encoding P450PCNI (nifedipine oxidase) is tightly linked to the gene COLIA2 encoding collagen type I alpha on 7q21-q22.1.
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| Brooks BA, et al.
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| Am J Hum Genet 43 : 280-284. 1988
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| 42 | CYP11A1, CYP3A4
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| Gene structure of human cytochrome P-450(scc), cholesterol desmolase.
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| Morohashi K, et al.
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| J Biochem (Tokyo) 101 : 879-887. 1987
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| 43 | CYP11A1, CYP3A4
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| Human cholesterol side-chain cleavage enzyme, P450scc : cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.
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| Chung BC, et al.
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| Proc Natl Acad Sci U S A 83 : 8962-8966. 1986
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| 44 | CYP3A4
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| Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.
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| Molowa DT, Schuetz EG, Wrighton SA, Watkins PB, Kremers P, Mendez-Picon G, Parker GA, Guzelian PS.
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| Proc Natl Acad Sci U S A 83(14):5311-5.PMID: 3460094 1986
|