Citations for
1CYP11A1, FDX1, JUN
Transcription factors SF1 and cJUN cooperate to activate the Fdx1 promoter in MA-10 Leydig cells.
Roumaud P, Rwigemera A, Martin LJ.
J Steroid Biochem Mol Biol 171:121-132. doi: 10.1016/j.jsbmb.2017.03.003. Epub 2017 Mar 6. 2017
2CYP11A1, FDX1
Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin.
Zhu Q, Mak PJ, Tuckey RC, Kincaid JR.
Biochemistry 56(43):5786-5797. doi: 10.1021/acs.biochem.7b00766. Epub 2017 Oct 20. 2017
3CYP11A1
Epigenetic Changes of the Cyp11a1 Promoter Region in Granulosa Cells Undergoing Luteinization During Ovulation in Female Rats.
Okada M, Lee L, Maekawa R, Sato S, Kajimura T, Shinagawa M, Tamura I, Taketani T, Asada H, Tamura H, Sugino N.
Endocrinology 157(9):3344-54. doi: 10.1210/en.2016-1264. Epub 2016 Jul 18. 2016
4CYP11A1
2β- and 16β-hydroxylase activity of CYP11A1 and direct stimulatory effect of estrogens on pregnenolone formation.
Mosa A, Neunzig J, Gerber A, Zapp J, Hannemann F, Pilak P, Bernhardt R.
J Steroid Biochem Mol Biol 150:1-10. doi: 10.1016/j.jsbmb.2015.02.014. Epub 2015 Mar 3. 2015
5CYP11A1
Polymorphisms of pentanucleotide repeats (tttta)n in the promoter of CYP11A1 and their relationships to polycystic ovary syndrome (PCOS) risk: a meta-analysis.
Yu M, Feng R, Sun X, Wang H, Wang H, Sang Q, Jin L, He L, Wang L.
Mol Biol Rep 41(7):4435-45. doi: 10.1007/s11033-014-3314-3. Epub 2014 Mar 9. 2014
6CYP11A1
The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis.
Wang M, Ramirez J, Han J, Jia Y, Domenico J, Seibold MA, Hagman JR, Gelfand EW.
J Allergy Clin Immunol 132(5):1174-1183.e8. doi: 10.1016/j.jaci.2013.05.027. Epub 2013 Jul 16. 2013
7CYP11A1
Abnormal apoptosis of trophoblastic cells is related to the up-regulation of CYP11A gene in placenta of preeclampsia patients.
He G, Xu W, Chen Y, Liu X, Xi M.
PLoS One 8(3):e59609. doi: 10.1371/journal.pone.0059609. Epub 2013 Mar 29. 2013
8CYP11A1, CYP11A1D
Varied clinical presentations of seven patients with mutations in CYP11A1 encoding the cholesterol side-chain cleavage enzyme, P450scc.
Tee MK, Abramsohn M, Loewenthal N, Harris M, Siwach S, Kaplinsky A, Markus B, Birk O, Sheffield VC, Parvari R, Hershkovitz E, Miller WL.
J Clin Endocrinol Metab 98(2):713-20. doi: 10.1210/jc.2012-2828. Epub 2013 Jan 21. Erratum in: J Clin Endocrinol Metab. 2013 Oct;98(10):4213. Pavari, Ru 2013
9CYP11A1, DAXX, HIPK3, NR5A1
Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription.
Lan HC, Wu CF, Shih HM, Chung BC.
J Biol Chem 287(8):5910-6. doi: 10.1074/jbc.M111.307603. Epub 2011 Dec 24. 2012
10CYP11A1, CYP27A1
Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.
Heo GY, Liao WL, Turko IV, Pikuleva IA.
Arch Biochem Biophys 518(2):119-26. doi: 10.1016/j.abb.2011.12.016. Epub 2011 Dec 29. 2012
11CYP11A1, FDX1
Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.
Strushkevich N, MacKenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW.
Proc Natl Acad Sci U S A 108(25):10139-43. doi: 10.1073/pnas.1019441108. Epub 2011 Jun 2. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15535 2011
12CYP11A1, UCP2
Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.
Liu Y, Jiang H, He LY, Huang WJ, He XY, Xing FQ.
Reprod Fertil Dev 23(4):520-6. doi: 10.1071/RD10266. 2011
13CYP11A1
Regulation of steroid production: analysis of Cyp11a1 promoter.
Shih MC, Chiu YN, Hu MC, Guo IC, Chung BC.
Mol Cell Endocrinol 336(1-2):80-4. doi: 10.1016/j.mce.2010.12.017. Epub 2010 Dec 30. Review. 2011
14CYP11A1
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA.
J Biol Chem 286(7):5607-13. doi: 10.1074/jbc.M110.188433. Epub 2010 Dec 15. 2011
15CYP11A1
Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk.
Terry K, McGrath M, Lee IM, Buring J, De Vivo I.
Gynecol Oncol 117(2):255-9. doi: 10.1016/j.ygyno.2010.02.002. Epub 2010 Mar 2. 2010
16CYP11A1, CYP11A1D
A novel homozygous mutation in CYP11A1 gene is associated with late-onset adrenal insufficiency and hypospadias in a 46,XY patient.
Rubtsov P, Karmanov M, Sverdlova P, Spirin P, Tiulpakov A.
J Clin Endocrinol Metab 94(3):936-9. Epub 2008 Dec 30. 2009
17CYP11A1
Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc.
Kim CJ, Lin L, Huang N, Quigley CA, AvRuskin TW, Achermann JC, Miller WL.
J Clin Endocrinol Metab 93(3):696-702. Epub 2008 Jan 8. 2008
18CYP11A1, GRHL1, TFCP2L1, UBP1
LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulation.
Henderson YC, Frederick MJ, Wang MT, Hollier LM, Clayman GL.
DNA Cell Biol 27(2):71-9.PMID: 18004979 2008
19CYP11A1, GRHL1, TFCP2L1
LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulation.
Henderson YC, Frederick MJ, Wang MT, Hollier LM, Clayman GL.
DNA Cell Biol 27(2):71-9.PMID: 18004979 2008
20CYP11A1
Activating protein-1 cooperates with steroidogenic factor-1 to regulate 3',5'-cyclic adenosine 5'-monophosphate-dependent human CYP11A1 transcription in vitro and in vivo.
Guo IC, Huang CY, Wang CK, Chung BC.
Endocrinology 148(4):1804-12. Epub 2007 Jan 11. 2007
21CYP11A1
Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer risk.
Yaspan BL, Breyer JP, Cai Q, Dai Q, Elmore JB, Amundson I, Bradley KM, Shu XO, Gao YT, Dupont WD, Zheng W, Smith JR.
Cancer Res 67(12):5673-82. 2007
22CYP11A1
A systematic assessment of common genetic variation in CYP11A and risk of breast cancer.
Setiawan VW, Cheng I, Stram DO, Giorgi E, Pike MC, Van Den Berg D, Pooler L, Burtt NP, Le Marchand L, Altshuler D, Hirschhorn J, Henderson BE, Haiman CA.
Cancer Res 66(24):12019-25. 2006
23CYP11A1, CYP11A1D
Expression of aromatase, estrogen receptor alpha and beta, androgen receptor, and cytochrome P-450scc in the human early prepubertal testis.
Berensztein EB, Baquedano MS, Gonzalez CR, Saraco NI, Rodriguez J, Ponzio R, Rivarola MA, Belgorosky A.
Pediatr Res 60(6):740-4. Epub 2006 Oct 25. 2006
24CYP11A1, NR5A2
The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome p450 enzyme in human granulosa cells.
Kim JW, Havelock JC, Carr BR, Attia GR.
J Clin Endocrinol Metab 90(3):1678-85. Epub 2004 Dec 21. 2005
25CYP11A1, CYP39A1, CYP46A1, CYP4F22
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW.
Pharmacogenetics 14(1):1-18. Review. 2004
26CYP11A1, CYP11B1, CYP11B2, CYP17A1D, CYP19A1, GATA4, NR0B1, NR2F1, NR2F2, NR5A1, PCNA, COPS2
DAX1 and its network partners: exploring complexity in development.
Clipsham R, McCabe ER.
Mol Genet Metab 80(1-2):81-120. 2003
27CYP11A1
A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1).
Guryev O, Carvalho RA, Usanov S, Gilep A, Estabrook RW.
Proc Natl Acad Sci U S A 100(25):14754-9. Epub 2003 Dec 01. 2003
28CYP11A1, CYP11B1, CYP11B2, CYP21A2
Steroidogenic enzyme gene expression in the human heart.
Kayes-Wandover KM, White PC.
J Clin Endocrinol Metab 85(7):2519-25. 2000
29CYP11A1, GRHL1
Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc.
Huang N, Miller WL.
J Biol Chem 275(4):2852-8.PMID: 10644752 2000
30PCOS1, CYP11A1
Genetics of polycystic ovary syndrome.
Franks S, et al.
Mol Cell Endocrinol 145(1-2):123-8. 1998
31CYP11A1, CYP17A1, FDX1, FDXR
Regional mapping of genes encoding human steroidogenic enzymes : P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25.
Sparkes RS, et al.
DNA Cell Biol 10 : 359-365. 1991
32CYP11A1, CYP11A1D
Normal genes for the cholesterol side chain cleavage enzyme, P450scc, in congenital lipoid adrenal hyperplasia.
Lin D, et al.
J Clin Invest 88 : 1955-1962. 1991
33CYP11A1, CYP3A4
Gene structure of human cytochrome P-450(scc), cholesterol desmolase.
Morohashi K, et al.
J Biochem (Tokyo) 101 : 879-887. 1987
34CYP11A1
Study of cholesterol side-chain cleavage (20,22 desmolase) deficiency causing congenital lipoid adrenal hyperplasia using bovine-sequence P450 scc oligodeoxyribonucleotide probes.
Matteson KJ, et al.
Endocrinology 118 : 1296-1305. 1986
35CYP11A1
Cloning and sequence of cDNA for the human cholesterol side-chain cleavage enzyme, P450 sec (20,22 desmolase) and location of its gene on chromosome 15.
Matteson KJ, et al.
Clin Res 34 : 117A. 1986
36CYP11A1, CYP3A4
Human cholesterol side-chain cleavage enzyme, P450scc : cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.
Chung BC, et al.
Proc Natl Acad Sci U S A 83 : 8962-8966. 1986