| 1 | CYP11A1, FDX1, JUN
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| Transcription factors SF1 and cJUN cooperate to activate the Fdx1 promoter in MA-10 Leydig cells.
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| Roumaud P, Rwigemera A, Martin LJ.
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| J Steroid Biochem Mol Biol 171:121-132. doi: 10.1016/j.jsbmb.2017.03.003. Epub 2017 Mar 6.
2017
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| 2 | CYP11A1, FDX1
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| Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin.
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| Zhu Q, Mak PJ, Tuckey RC, Kincaid JR.
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| Biochemistry 56(43):5786-5797. doi: 10.1021/acs.biochem.7b00766. Epub 2017 Oct 20.
2017
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| 3 | CYP11A1
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| Epigenetic Changes of the Cyp11a1 Promoter Region in Granulosa Cells Undergoing Luteinization During Ovulation in Female Rats.
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| Okada M, Lee L, Maekawa R, Sato S, Kajimura T, Shinagawa M, Tamura I, Taketani T, Asada H, Tamura H, Sugino N.
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| Endocrinology 157(9):3344-54. doi: 10.1210/en.2016-1264. Epub 2016 Jul 18.
2016
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| 4 | CYP11A1
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| 2β- and 16β-hydroxylase activity of CYP11A1 and direct stimulatory effect of estrogens on pregnenolone formation.
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| Mosa A, Neunzig J, Gerber A, Zapp J, Hannemann F, Pilak P, Bernhardt R.
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| J Steroid Biochem Mol Biol 150:1-10. doi: 10.1016/j.jsbmb.2015.02.014. Epub 2015 Mar 3.
2015
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| 5 | CYP11A1
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| Polymorphisms of pentanucleotide repeats (tttta)n in the promoter of CYP11A1 and their relationships to polycystic ovary syndrome (PCOS) risk: a meta-analysis.
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| Yu M, Feng R, Sun X, Wang H, Wang H, Sang Q, Jin L, He L, Wang L.
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| Mol Biol Rep 41(7):4435-45. doi: 10.1007/s11033-014-3314-3. Epub 2014 Mar 9.
2014
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| 6 | CYP11A1
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| The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis.
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| Wang M, Ramirez J, Han J, Jia Y, Domenico J, Seibold MA, Hagman JR, Gelfand EW.
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| J Allergy Clin Immunol 132(5):1174-1183.e8. doi: 10.1016/j.jaci.2013.05.027. Epub 2013 Jul 16.
2013
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| 7 | CYP11A1
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| Abnormal apoptosis of trophoblastic cells is related to the up-regulation of CYP11A gene in placenta of preeclampsia patients.
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| He G, Xu W, Chen Y, Liu X, Xi M.
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| PLoS One 8(3):e59609. doi: 10.1371/journal.pone.0059609. Epub 2013 Mar 29.
2013
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| 8 | CYP11A1, CYP11A1D
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| Varied clinical presentations of seven patients with mutations in CYP11A1 encoding the cholesterol side-chain cleavage enzyme, P450scc.
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| Tee MK, Abramsohn M, Loewenthal N, Harris M, Siwach S, Kaplinsky A, Markus B, Birk O, Sheffield VC, Parvari R, Hershkovitz E, Miller WL.
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| J Clin Endocrinol Metab 98(2):713-20. doi: 10.1210/jc.2012-2828. Epub 2013 Jan 21. Erratum in: J Clin Endocrinol Metab. 2013 Oct;98(10):4213. Pavari, Ru 2013
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| 9 | CYP11A1, DAXX, HIPK3, NR5A1
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| Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription.
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| Lan HC, Wu CF, Shih HM, Chung BC.
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| J Biol Chem 287(8):5910-6. doi: 10.1074/jbc.M111.307603. Epub 2011 Dec 24.
2012
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| 10 | CYP11A1, CYP27A1
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| Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.
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| Heo GY, Liao WL, Turko IV, Pikuleva IA.
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| Arch Biochem Biophys 518(2):119-26. doi: 10.1016/j.abb.2011.12.016. Epub 2011 Dec 29.
2012
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| 11 | CYP11A1, FDX1
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| Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.
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| Strushkevich N, MacKenzie F, Cherkesova T, Grabovec I, Usanov S, Park HW.
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| Proc Natl Acad Sci U S A 108(25):10139-43. doi: 10.1073/pnas.1019441108. Epub 2011 Jun 2. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15535 2011
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| 12 | CYP11A1, UCP2
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| Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.
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| Liu Y, Jiang H, He LY, Huang WJ, He XY, Xing FQ.
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| Reprod Fertil Dev 23(4):520-6. doi: 10.1071/RD10266.
2011
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| 13 | CYP11A1
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| Regulation of steroid production: analysis of Cyp11a1 promoter.
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| Shih MC, Chiu YN, Hu MC, Guo IC, Chung BC.
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| Mol Cell Endocrinol 336(1-2):80-4. doi: 10.1016/j.mce.2010.12.017. Epub 2010 Dec 30. Review.
2011
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| 14 | CYP11A1
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| Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
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| Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA.
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| J Biol Chem 286(7):5607-13. doi: 10.1074/jbc.M110.188433. Epub 2010 Dec 15.
2011
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| 15 | CYP11A1
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| Genetic variation in CYP11A1 and StAR in relation to endometrial cancer risk.
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| Terry K, McGrath M, Lee IM, Buring J, De Vivo I.
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| Gynecol Oncol 117(2):255-9. doi: 10.1016/j.ygyno.2010.02.002. Epub 2010 Mar 2.
2010
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| 16 | CYP11A1, CYP11A1D
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| A novel homozygous mutation in CYP11A1 gene is associated with late-onset adrenal insufficiency and hypospadias in a 46,XY patient.
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| Rubtsov P, Karmanov M, Sverdlova P, Spirin P, Tiulpakov A.
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| J Clin Endocrinol Metab 94(3):936-9. Epub 2008 Dec 30.
2009
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| 17 | CYP11A1
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| Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc.
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| Kim CJ, Lin L, Huang N, Quigley CA, AvRuskin TW, Achermann JC, Miller WL.
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| J Clin Endocrinol Metab 93(3):696-702. Epub 2008 Jan 8.
2008
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| 18 | CYP11A1, GRHL1, TFCP2L1, UBP1
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| LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulation.
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| Henderson YC, Frederick MJ, Wang MT, Hollier LM, Clayman GL.
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| DNA Cell Biol 27(2):71-9.PMID: 18004979 2008
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| 19 | CYP11A1, GRHL1, TFCP2L1
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| LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulation.
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| Henderson YC, Frederick MJ, Wang MT, Hollier LM, Clayman GL.
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| DNA Cell Biol 27(2):71-9.PMID: 18004979 2008
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| 20 | CYP11A1
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| Activating protein-1 cooperates with steroidogenic factor-1 to regulate 3',5'-cyclic adenosine 5'-monophosphate-dependent human CYP11A1 transcription in vitro and in vivo.
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| Guo IC, Huang CY, Wang CK, Chung BC.
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| Endocrinology 148(4):1804-12. Epub 2007 Jan 11.
2007
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| 21 | CYP11A1
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| Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer risk.
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| Yaspan BL, Breyer JP, Cai Q, Dai Q, Elmore JB, Amundson I, Bradley KM, Shu XO, Gao YT, Dupont WD, Zheng W, Smith JR.
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| Cancer Res 67(12):5673-82.
2007
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| 22 | CYP11A1
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| A systematic assessment of common genetic variation in CYP11A and risk of breast cancer.
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| Setiawan VW, Cheng I, Stram DO, Giorgi E, Pike MC, Van Den Berg D, Pooler L, Burtt NP, Le Marchand L, Altshuler D, Hirschhorn J, Henderson BE, Haiman CA.
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| Cancer Res 66(24):12019-25. 2006
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| 23 | CYP11A1, CYP11A1D
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| Expression of aromatase, estrogen receptor alpha and beta, androgen receptor, and cytochrome P-450scc in the human early prepubertal testis.
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| Berensztein EB, Baquedano MS, Gonzalez CR, Saraco NI, Rodriguez J, Ponzio R, Rivarola MA, Belgorosky A.
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| Pediatr Res 60(6):740-4. Epub 2006 Oct 25. 2006
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| 24 | CYP11A1, NR5A2
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| The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome p450 enzyme in human granulosa cells.
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| Kim JW, Havelock JC, Carr BR, Attia GR.
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| J Clin Endocrinol Metab 90(3):1678-85. Epub 2004 Dec 21. 2005
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| 25 | CYP11A1, CYP39A1, CYP46A1, CYP4F22
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| Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
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| Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW.
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| Pharmacogenetics 14(1):1-18. Review. 2004
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| 26 | CYP11A1, CYP11B1, CYP11B2, CYP17A1D, CYP19A1, GATA4, NR0B1, NR2F1, NR2F2, NR5A1, PCNA, COPS2
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| DAX1 and its network partners: exploring complexity in development.
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| Clipsham R, McCabe ER.
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| Mol Genet Metab 80(1-2):81-120. 2003
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| 27 | CYP11A1
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| A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1).
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| Guryev O, Carvalho RA, Usanov S, Gilep A, Estabrook RW.
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| Proc Natl Acad Sci U S A 100(25):14754-9. Epub 2003 Dec 01. 2003
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| 28 | CYP11A1, CYP11B1, CYP11B2, CYP21A2
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| Steroidogenic enzyme gene expression in the human heart.
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| Kayes-Wandover KM, White PC.
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| J Clin Endocrinol Metab 85(7):2519-25. 2000
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| 29 | CYP11A1, GRHL1
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| Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc.
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| Huang N, Miller WL.
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| J Biol Chem 275(4):2852-8.PMID: 10644752 2000
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| 30 | PCOS1, CYP11A1
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| Genetics of polycystic ovary syndrome.
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| Franks S, et al.
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| Mol Cell Endocrinol 145(1-2):123-8. 1998
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| 31 | CYP11A1, CYP17A1, FDX1, FDXR
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| Regional mapping of genes encoding human steroidogenic enzymes : P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25.
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| Sparkes RS, et al.
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| DNA Cell Biol 10 : 359-365. 1991
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| 32 | CYP11A1, CYP11A1D
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| Normal genes for the cholesterol side chain cleavage enzyme, P450scc, in congenital lipoid adrenal hyperplasia.
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| Lin D, et al.
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| J Clin Invest 88 : 1955-1962. 1991
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| 33 | CYP11A1, CYP3A4
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| Gene structure of human cytochrome P-450(scc), cholesterol desmolase.
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| Morohashi K, et al.
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| J Biochem (Tokyo) 101 : 879-887. 1987
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| 34 | CYP11A1
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| Study of cholesterol side-chain cleavage (20,22 desmolase) deficiency causing congenital lipoid adrenal hyperplasia using bovine-sequence P450 scc oligodeoxyribonucleotide probes.
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| Matteson KJ, et al.
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| Endocrinology 118 : 1296-1305. 1986
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| 35 | CYP11A1
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| Cloning and sequence of cDNA for the human cholesterol side-chain cleavage enzyme, P450 sec (20,22 desmolase) and location of its gene on chromosome 15.
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| Matteson KJ, et al.
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| Clin Res 34 : 117A. 1986
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| 36 | CYP11A1, CYP3A4
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| Human cholesterol side-chain cleavage enzyme, P450scc : cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.
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| Chung BC, et al.
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| Proc Natl Acad Sci U S A 83 : 8962-8966. 1986
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