Citations for
1BCR, CXCR4, HCLS1
Hematopoietic cell-specific lyn substrate (HCLS1 or HS1): A versatile actin-binding protein in leukocytes.
Castro-Ochoa KF, Guerrero-Fonseca IM, Schnoor M.
J Leukoc Biol. May;105(5):881-890. doi: 10.1002/JLB.MR0618-212R. Epub 2018 Dec 11. 2019
2CXCR4, NRF1
Nuclear Respiratory Factor-1 (NRF-1) Regulates Transcription of the CXC Receptor 4 (CXCR4) in the Rat Retina.
Chen P, Cai X, Yang Y, Chen Z, Qiu J, Yu N, Tang M, Wang Q, Ge J, Yu K, Zhuang J.
Invest Ophthalmol Vis Sci 58(11):4662-4669. doi: 10.1167/iovs.17-22115. 2017
3CXCL12, CXCR4, GNG4
Epigenetically silenced GNG4 inhibits SDF1α/CXCR4 signaling in mesenchymal glioblastoma.
Pal J, Patil V, Mondal B, Shukla S, Hegde AS, Arivazhagan A, Santosh V, Somasundaram K.
Genes Cancer 7(3-4):136-47. doi: 10.18632/genesandcancer.105. 2016
4CCR7, CXCR4, RGS1
The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells.
Caballero-Franco C, Kissler S.
Genes Immun 17(4):228-38. doi: 10.1038/gene.2016.16. Epub 2016 Mar 31. 2016
5ARRB1, CXCR4, STAM
β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.
Alekhina O, Marchese A.
J Biol Chem 291(50):26083-26097. Epub 2016 Oct 27. 2016
6CXCR4, ISL1, LHX3, STAM
Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.
Nam H, Lee S.
Development 143(13):2334-43. doi: 10.1242/dev.135848. Epub 2016 May 9. 2016
7CXCL12, CXCR4, EIF2S2
Association of eukaryotic translation initiation factor eIF2B with fully solubilized CXCR4.
Palmesino E, Apuzzo T, Thelen S, Mueller B, Langen H, Thelen M.
J Leukoc Biol 99(6):971-8. doi: 10.1189/jlb.2MA0915-415R. Epub 2015 Nov 25. 2016
8CXCR4, MATN4
Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4
Uckelmann H, Blaszkiewicz S, Nicolae C, Haas S, Schnell A, Wurzer S, Wagener R, Aszodi A, Essers MA.
J Exp Med. Sep 19;213(10):1961-71. doi: 10.1084/jem.20151713. Epub 2016 Aug 29. 2016
9CXCR4
Functions of the Chemokine Receptor CXCR4 in the Central Nervous System and Its Regulation by μ-Opioid Receptors.
Nash B, Meucci O.
Int Rev Neurobiol 118:105-28. doi: 10.1016/B978-0-12-801284-0.00005-1. 2014
10ACKR3, CXCL12, CXCR4
CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons.
Abe P, Mueller W, Schütz D, MacKay F, Thelen M, Zhang P, Stumm R.
Development 141(9):1857-63. doi: 10.1242/dev.104224. Epub 2014 Apr 9. 2014
11CXCR4
Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis.
Zhang Z, Ni C, Chen W, Wu P, Wang Z, Yin J, Huang J, Qiu F.
BMC Cancer 14:49. doi: 10.1186/1471-2407-14-49. Review. 2014
12ACKR3, CXCR4
Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular α₁-adrenergic receptor function.
Bach HH 4th, Wong YM, Tripathi A, Nevins AM, Gamelli RL, Volkman BF, Byron KL, Majetschak M.
Mol Med 20:435-47. doi: 10.2119/molmed.2014.00101. 2014
13ACKR3, CXCR4
CXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates CXCR4 response to CXCL12.
Melo Rde C, Longhini AL, Bigarella CL, Baratti MO, Traina F, Favaro P, de Melo Campos P, Saad ST.
PLoS One 9(1):e85926. doi: 10.1371/journal.pone.0085926. eCollection 2014. 2014
14CXCR4, DTX3L
The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.
Holleman J, Marchese A.
Mol Biol Cell 25(12):1892-904. doi: 10.1091/mbc.E13-10-0612. Epub 2014 Apr 30. 2014
15CD74, CXCR4, MIF, ZAP70
MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling.
Klasen C, Ohl K, Sternkopf M, Shachar I, Schmitz C, Heussen N, Hobeika E, Levit-Zerdoun E, Tenbrock K, Reth M, Bernhagen J, El Bounkari O.
J Immunol 192(11):5273-84. doi: 10.4049/jimmunol.1302209. Epub 2014 Apr 23. 2014
16CXCL12, CXCR4
CXCL12/CXCR4 signal axis plays an important role in mediating bone morphogenetic protein 9-induced osteogenic differentiation of mesenchymal stem cells.
Liu C, Weng Y, Yuan T, Zhang H, Bai H, Li B, Yang D, Zhang R, He F, Yan S, Zhan X, Shi Q.
Int J Med Sci 10(9):1181-92. doi: 10.7150/ijms.6657. Print 2013. 2013
17CXCR4
CXCR4 prevents dispersion of granule neuron precursors in the adult dentate gyrus.
Schultheiß C, Abe P, Hoffmann F, Mueller W, Kreuder AE, Schütz D, Haege S, Redecker C, Keiner S, Kannan S, Claasen JH, Pfrieger FW, Stumm R.
Hippocampus 23(12):1345-58. doi: 10.1002/hipo.22180. Epub 2013 Sep 10. 2013
18CXCR4
Misregulation of SDF1-CXCR4 signaling impairs early cardiac neural crest cell migration leading to conotruncal defects.
Escot S, Blavet C, Härtle S, Duband JL, Fournier-Thibault C.
Circ Res 113(5):505-16. doi: 10.1161/CIRCRESAHA.113.301333. Epub 2013 Jul 9. 2013
19CXCR4
CXCR4 signaling regulates radial glial morphology and cell fate during embryonic spinal cord development.
Mithal DS, Ren D, Miller RJ.
Glia 61(8):1288-305. doi: 10.1002/glia.22515. Epub 2013 Jul 4. 2013
20CXCR4, WHIM
The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse.
Kallikourdis M, Trovato AE, Anselmi F, Sarukhan A, Roselli G, Tassone L, Badolato R, Viola A.
Blood 122(5):666-73. doi: 10.1182/blood-2012-10-461830. Epub 2013 Jun 21. 2013
21CXCL14, CXCL2, CXCR4
CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis.
Tanegashima K, Suzuki K, Nakayama Y, Tsuji K, Shigenaga A, Otaka A, Hara T.
FEBS Lett 587(12):1731-5. doi: 10.1016/j.febslet.2013.04.046. Epub 2013 May 11. 2013
22CXCR4
Notch signaling regulates CXCR4 expression and the migration of mesenchymal stem cells.
Xie J, Wang W, Si JW, Miao XY, Li JC, Wang YC, Wang ZR, Ma J, Zhao XC, Li Z, Yi H, Han H.
Cell Immunol 281(1):68-75. doi: 10.1016/j.cellimm.2013.02.001. Epub 2013 Feb 13. 2013
23CXCR4, DEFB103B
Human β-defensin-3 structure motifs that are important in CXCR4 antagonism.
Feng Z, Dubyak GR, Jia X, Lubkowski JT, Weinberg A.
FEBS J 280(14):3365-75. doi: 10.1111/febs.12328. Epub 2013 Jun 7. 2013
24CBX5, CXCR4, KLF11, SUV39H1
Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells.
Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R.
J Biol Chem 287(16):12723-35. doi: 10.1074/jbc.M112.351395. Epub 2012 Feb 28. 2012
25CXCR4
Cxcr4 regulation of interneuron migration is disrupted in 22q11.2 deletion syndrome.
Meechan DW, Tucker ES, Maynard TM, LaMantia AS.
Proc Natl Acad Sci U S A 109(45):18601-6. doi: 10.1073/pnas.1211507109. Epub 2012 Oct 22. 2012
26CXCL12, CXCR4, CXCR4
CXCL12 enhances human neural progenitor cell survival through a CXCR7- and CXCR4-mediated endocytotic signaling pathway.
Zhu B, Xu D, Deng X, Chen Q, Huang Y, Peng H, Li Y, Jia B, Thoreson WB, Ding W, Ding J, Zhao L, Wang Y, Wavrin KL, Duan S, Zheng J.
Stem Cells 30(11):2571-83. doi: 10.1002/stem.1239. 2012
27CXCR4
Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance.
Reaux-Le Goazigo A, Rivat C, Kitabgi P, Pohl M, Melik Parsadaniantz S.
Eur J Neurosci 36(5):2619-31. doi: 10.1111/j.1460-9568.2012.08179.x. Epub 2012 Jun 14. 2012
28CXCL12, CXCR4, HMGB1
HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4.
Schiraldi M, Raucci A, Muñoz LM, Livoti E, Celona B, Venereau E, Apuzzo T, De Marchis F, Pedotti M, Bachi A, Thelen M, Varani L, Mellado M, Proudfoot A, Bianchi ME, Uguccioni M.
J Exp Med 209(3):551-63. doi: 10.1084/jem.20111739. Epub 2012 Feb 27. 2012
29CXCL12, CXCR4, IL6
Stromal cell-derived factor-1/CXCR4 promotes IL-6 production in human synovial fibroblasts.
Chen HT, Tsou HK, Hsu CJ, Tsai CH, Kao CH, Fong YC, Tang CH.
J Cell Biochem 112(4):1219-27. doi: 10.1002/jcb.23043. 2011
30CXCL12, CXCR4
Endoderm and mesoderm reciprocal signaling mediated by CXCL12 and CXCR4 regulates the migration of angioblasts and establishes the pancreatic fate.
Katsumoto K, Kume S.
Development 138(10):1947-55. Epub 2011 Apr 13. 2011
31CXCL12, CXCR4
Cxcl12 evolution--subfunctionalization of a ligand through altered interaction with the chemokine receptor.
Boldajipour B, Doitsidou M, Tarbashevich K, Laguri C, Yu SR, Ries J, Dumstrei K, Thelen S, Dörries J, Messerschmidt EM, Thelen M, Schwille P, Brand M, Lortat-Jacob H, Raz E.
Development 138(14):2909-14. 2011
32CXCR4, S1PR5
Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.
Mayol K, Biajoux V, Marvel J, Balabanian K, Walzer T.
Blood 118(18):4863-71. doi: 10.1182/blood-2011-06-362574. Epub 2011 Sep 12. 2011
33ACKR3, CXCL12, CXCR4
The role of CXCR7 on the adhesion, proliferation and angiogenesis of endothelial progenitor cells.
Dai X, Tan Y, Cai S, Xiong X, Wang L, Ye Q, Yan X, Ma K, Cai L.
J Cell Mol Med 15(6):1299-309. doi: 10.1111/j.1582-4934.2011.01301.x. 2011
34CSF3, CXCR4, MMP9, PLG
Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9.
Gong Y, Fan Y, Hoover-Plow J.
Arterioscler Thromb Vasc Biol 31(9):2035-43. doi: 10.1161/ATVBAHA.111.229583. 2011
35CXCR4
CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin.
Saini V, Marchese A, Majetschak M.
J Biol Chem 285(20):15566-76. Epub 2010 Mar 12.PMID: 20228059 2010
36CXCR4, OBFC1
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.
Levy D, Neuhausen SL, Hunt SC, Kimura M, Hwang SJ, Chen W, Bis JC, Fitzpatrick AL, Smith E, Johnson AD, Gardner JP, Srinivasan SR, Schork N, Rotter JI, Herbig U, Psaty BM, Sastrasinh M, Murray SS, Vasan RS, Province MA, Glazer NL, Lu X, Cao X, Kronmal R, Mangino M, Soranzo N, Spector TD, Berenson GS, Aviv A.
Proc Natl Acad Sci U S A 107(20):9293-8. Epub 2010 Apr 26.PMID: 20421499 2010
37CXCL12, CXCR4
CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination.
Patel JR, McCandless EE, Dorsey D, Klein RS.
Proc Natl Acad Sci U S A 107(24):11062-7. Epub 2010 Jun 1. 2010
38CXCL12, CXCR4
Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis.
Carbajal KS, Schaumburg C, Strieter R, Kane J, Lane TE.
Proc Natl Acad Sci U S A 107(24):11068-73. Epub 2010 Jun 1. 2010
39CCR5, CXCR4
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC.
Science 330(6007):1066-71. Epub 2010 Oct 7. 2010
40CCL18, CXCR4
Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B cells.
Catusse J, Wollner S, Leick M, Schröttner P, Schraufstätter I, Burger M.
J Cell Physiol 225(3):792-800. doi: 10.1002/jcp.22284. 2010
41CDC42, CXCR4, UBE2I
Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.
Zhu S, Sachdeva M, Wu F, Lu Z, Mo YY.
Oncogene 29(12):1763-72. doi: 10.1038/onc.2009.459. Epub 2009 Dec 21. 2010
42CCR7, CXCR4
Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells.
Kochetkova M, Kumar S, McColl SR.
Cell Death Differ 16(5):664-73. Epub 2009 Jan 9. 2009
43CXCR4
Lipopolysaccharide-induced maturation of bone marrow-derived dendritic cells is regulated by notch signaling through the up-regulation of CXCR4.
Wang YC, Hu XB, He F, Feng F, Wang L, Li W, Zhang P, Li D, Jia ZS, Liang YM, Han H.
J Biol Chem 284(23):15993-6003. Epub 2009 Apr 7. 2009
44CD74, CXCR4, MIF
A functional heteromeric MIF receptor formed by CD74 and CXCR4.
Schwartz V, Lue H, Kraemer S, Korbiel J, Krohn R, Ohl K, Bucala R, Weber C, Bernhagen J.
FEBS Lett 583(17):2749-57. Epub 2009 Aug 6. 2009
45CXCR4, ITCH
The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction.
Bhandari D, Robia SL, Marchese A.
Mol Biol Cell 20(5):1324-39. Epub 2008 Dec 30.PMID: 19116316 2009
46CXCR4, WHIM
Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor.
McCormick PJ, Segarra M, Gasperini P, Gulino AV, Tosato G.
PLoS One 4(12):e8102. 2009
47CXCR4, FOXC1, FOXC2
Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration.
Hayashi H, Kume T.
Biochem Biophys Res Commun 367(3):584-9. Epub 2008 Jan 8. 2008
48CXCR4, ZBTB16
A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis.
Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, Foà R, Brunetti E, Grignani F, Testa U, Peschle C.
Nat Cell Biol 10(7):788-801. Epub 2008 Jun 22. 2008
49CCR5, CXCR4
CXCR4-CCR5: a couple modulating T cell functions.
Contento RL, Molon B, Boularan C, Pozzan T, Manes S, Marullo S, Viola A.
Proc Natl Acad Sci U S A 105(29):10101-6. Epub 2008 Jul 15. 2008
50CXCL12, CXCR4, SLIT1, SLIT2
SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.
Marlow R, Strickland P, Lee JS, Wu X, Pebenito M, Binnewies M, Le EK, Moran A, Macias H, Cardiff RD, Sukumar S, Hinck L.
Cancer Res 68(19):7819-27. 2008
51CXCL13, CXCR4, CXCR5
Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection.
Cagigi A, Mowafi F, Phuong Dang LV, Tenner-Racz K, Atlas A, Grutzmeier S, Racz P, Chiodi F, Nilsson A.
Blood 112(12):4401-10. Epub 2008 Sep 9.PMID: 18780835 2008
52CXCR4, PLEC
Plectin regulates the signaling and trafficking of the HIV-1 co-receptor CXCR4 and plays a role in HIV-1 infection.
Ding Y, Zhang L, Goodwin JS, Wang Z, Liu B, Zhang J, Fan GH.
Exp Cell Res 314(3):590-602. Epub 2007 Nov 17.PMID: 18155192 2008
53CXCR4
Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer.
Akashi T, Koizumi K, Tsuneyama K, Saiki I, Takano Y, Fuse H.
Cancer Sci 99(3):539-42. Epub 2008 Jan 14.PMID: 18201276 2008
54CXCR4
Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4.
Skommer J, Wlodkowic D, Pelkonen J.
Exp Hematol 35(1):84-95. 2007
55CD74, CXCR2, CXCR4, MIF
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.
Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koenen RR, Dewor M, Georgiev I, Schober A, Leng L, Kooistra T, Fingerle-Rowson G, Ghezzi P, Kleemann R, McColl SR, Bucala R, Hickey MJ, Weber C.
Nat Med 13(5):587-96. Epub 2007 Apr 15. 2007
56CXCR4
Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone.
Hirbe AC, Rubin J, Uluckan O, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Weilbaecher KN.
Proc Natl Acad Sci U S A 104(35):14062-7. Epub 2007 Aug 22. 2007
57CXCR4
CXCR4 engagement promotes dendritic cell survival and maturation.
Kabashima K, Sugita K, Shiraishi N, Tamamura H, Fujii N, Tokura Y.
Biochem Biophys Res Commun 361(4):1012-6. Epub 2007 Jul 30. 2007
58CD164, CXCR4
Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells.
Forde S, Tye BJ, Newey SE, Roubelakis M, Smythe J, McGuckin CP, Pettengell R, Watt SM.
Blood 109(5):1825-33. Epub 2006 Oct 31. 2007
59CXCR4, WHIM
Recurrent CXCR4 sequence variation in a girl with WHIM syndrome.
Alapi K, Erdos M, Kovács G, Maródi L.
Eur J Haematol 78(1):86-8. Epub 2006 Nov 6. 2007
60CXCR4, SYT3
Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration.
Masztalerz A, Zeelenberg IS, Wijnands YM, de Bruijn R, Drager AM, Janssen H, Roos E.
J Cell Sci 120(Pt 2):219-28. Epub 2006 Dec 19. 2007
61CXCR4
Differential expression of stromal cell-derived factor 1 and its receptor CXCR4 in the skin and endothelial cells of systemic sclerosis patients: Pathogenetic implications.
Cipriani P, Franca Milia A, Liakouli V, Pacini A, Manetti M, Marrelli A, Toscano A, Pingiotti E, Fulminis A, Guiducci S, Perricone R, Kahaleh B, Matucci-Cerinic M, Ibba-Manneschi L, Giacomelli R.
Arthritis Rheum 54(9):3022-33. 2006
62CXCR4
Expression of chemokine receptor CXCR4 in esophageal squamous cell and adenocarcinoma.
Gockel I, Schimanski CC, Heinrich C, Wehler T, Frerichs K, Drescher D, von Langsdorff C, Domeyer M, Biesterfeld S, Galle PR, Junginger T, Moehler M.
BMC Cancer 6:290. 2006
63CXCR4, CXCL12, CTTN
CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis.
Luo C, Pan H, Mines M, Watson K, Zhang J, Fan GH.
J Biol Chem 281(40):30081-93. Epub 2006 Aug 11. 2006
64CXCL12, CXCR4
CXCR4 modulates contractility in adult cardiac myocytes.
Pyo RT, Sui J, Dhume A, Palomeque J, Blaxall BC, Diaz G, Tunstead J, Logothetis DE, Hajjar RJ, Schecter AD.
J Mol Cell Cardiol 41(5):834-44. Epub 2006 Sep 28. 2006
65CXCR4, JAK2, STAT3
Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation.
Ahr B, Denizot M, Robert-Hebmann V, Brelot A, Biard-Piechaczyk M.
J Biol Chem 280(8):6692-700. Epub 2004 Dec 22. 2005
66SDC4, CXCL12, CXCR4
Syndecan-4 is a signaling molecule for stromal cell-derived factor-1 (SDF-1)/ CXCL12.
Charnaux N, Brule S, Hamon M, Chaigneau T, Saffar L, Prost C, Lievre N, Gattegno L.
FEBS J 272(8):1937-51. 2005
67CXCL12,CXCR4,GAB1
CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells.
Vasyutina E, Stebler J, Brand-Saberi B, Schulz S, Raz E, Birchmeier C.
Genes Dev 19(18):2187-98. 2005
68CXCR3,CXCR4
Clinical significance of CXCR3 and CXCR4 expression in primary melanoma.
Longo-Imedio MI, Longo N, Trevino I, Lazaro P, Sanchez-Mateos P.
Int J Cancer 117(5):861-5. 2005
69CD164, CXCR4
The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis.
Arya M, Patel HR, McGurk C, Tatoud R, Klocker H, Masters J, Williamson M.
J Exp Ther Oncol 4(4):291-303. 2004
70CXCR4, WHIM
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease.
Hernandez PA, Gorlin RJ, Lukens JN, Taniuchi S, Bohinjec J, Francois F, Klotman ME, Diaz GA.
Nat Genet 34(1):70-4. 2003
71CXCR4, VHL
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.
Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W.
Nature 425(6955):307-11. 2003
72CXCL12, CXCR4
Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling.
Roland J, Murphy BJ, Ahr B, Robert-Hebmann V, Delauzun V, Nye KE, Devaux C, Biard-Piechaczyk M.
Blood 101(2):399-406. Epub 2002 Sep 05. 2003
73CXCR4
CXCR4 expression in vitreoretinal membranes.
Cabay L, Willermain F, Bruyns C, Verdebout JM, Witta Y, Baffi J, Velu T, Libert J, Caspers-Velu L, Maho A, Lespagnard L.
Br J Ophthalmol 87(5):567-9. 2003
74CXCL12, CXCR4
NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4.
Helbig G, Christopherson KW 2nd, Bhat-Nakshatri P, Kumar S, Kishimoto H, Miller KD, Broxmeyer HE, Nakshatri H.
J Biol Chem 278(24):21631-8. Epub 2003 Apr 09. 2003
75CXCR4, YY1
Regulation of CXCR4 expression in human T lymphocytes by calcium and calcineurin.
Cristillo AD, Bierer BE.
Mol Immunol 40(8):539-53. 2003
76CXCL12, CXCR4
Guidance of Primordial Germ Cell Migration by the Chemokine SDF-1.
Doitsidou M, Reichman-Fried M, Stebler J, Koprunner M, Dorries J, Meyer D, Esguerra CV, Leung T, Raz E.
Cell 111(5):647-59. 2002
77CCR7, CXCR4
Involvement of chemokine receptors in breast cancer metastasis.
Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verastegui E, Zlotnik A.
Nature 410(6824):50-6. 2001
78CXCR4, CXCL12
Cloning and characterization of SDF-1gamma, a novel SDF-1 chemokine transcript with developmentally regulated expression in the nervous system.
Gleichmann M, Gillen C, Czardybon M, Bosse F, Greiner-Petter R, Auer J, Muller HW.
Eur J Neurosci 12(6):1857-66. 2000
79CCR1, CCR3, CCR4, CXCR4
Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets.
Clemetson KJ, Clemetson JM, Proudfoot AE, Power CA, Baggiolini M, Wells TN.
Blood 96(13):4046-54. 2000
80CCR5, CXCR4
Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors.
Ling K, et al.
Proc Natl Acad Sci U S A 96(14):7922-7. 1999
81CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CX3CR1, CXCR1, CXCR2, CXCR3, CXCR4, XCR1
Intracellular signalling pathways induced by chemokines in natural killer cells.
Maghazachi AA.
Cell Signal 11(6):385-90. Review 1999
82CXCR4
Cutting edge: CXCR4-Lo: molecular cloning and functional expression of a novel human CXCR4 splice variant.
Gupta SK, Pillarisetti K.
J Immunol 163(5):2368-72 1999
83CXCR4
Genomic organization and promoter characterization of human CXCR4 gene.
Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F.
FEBS Lett 426 : 271-278. 1998
84CXCR4
The human immnodeficiency virus (HIV)-type 1 coreceptor CXCR-4 (fusin) is preferentially expressed on the more immature CD34+ hematopoietic stem cells.
Viardot A, et al.
Ann Hematol 77 : 193-197. 1998
85CXCR4
Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes.
Loetscher M, Geiser T, O'Reilly T, Zwahlen R, Baggiolini M, Moser B.
J Biol Chem 269 : 232-237. 1994
86CXCR4
Molecular cloning of cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen.
Federsppiel B, Melhado IG, Duncan AM, Delaney A, Schappert K, Clark-Lewis I, Jirik FR.
Genomics 16 : 707-712. 1993
87CXCR4
Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor : lack of NPY binding and activation.
Herzog H, Hort YJ, Shine J, Selbie LA.
DNA Cell Biol 12 : 465-471. 1993