Citations for
1CUL2, CUL4B, CUL5
Association of mRNA expression levels of Cullin family members with prognosis in breast cancer: An online database analysis.
Liu A, Zhang S, Shen Y, Lei R, Wang Y.
Medicine (Baltimore) Aug;98(31):e16625. doi: 10.1097/MD.0000000000016625 2019
2CUL4B, MRXSC
A new CUL4B variant associated with a mild phenotype and an exceptional pattern of leukoencephalopathy.
Weissbach S, Reinert MC, Altmüller J, Krätzner R, Thiele H, Rosenbaum T, Nürnberg P, Gärtner J.
Am J Med Genet A 173(10):2803-2807. doi: 10.1002/ajmg.a.38390. Epub 2017 Aug 17. 2017
3CUL4A, CUL4B
Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.
Jia L, Yan F, Cao W, Chen Z, Zheng H, Li H, Pan Y, Narula N, Ren X, Li H, Zhou P.
J Biol Chem 292(7):2966-2978. doi: 10.1074/jbc.M116.765230. Epub 2016 Dec 14. 2017
4CUL4B
Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity.
Li P, Song Y, Zan W, Qin L, Han S, Jiang B, Dou H, Shao C, Gong Y.
Diabetes 66(2):300-313. doi: 10.2337/db16-0743. Epub 2016 Nov 29. 2017
5CUL4A, CUL4B, INSL6
Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis.
Yin Y, Liu L, Yang C, Lin C, Veith GM, Wang C, Sutovsky P, Zhou P, Ma L.
J Biol Chem 291(13):6923-35. doi: 10.1074/jbc.M115.699660. Epub 2016 Feb 4. 2016
6CUL4B
Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility.
Lin CY, Chen CY, Yu CH, Yu IS, Lin SR, Wu JT, Lin YH, Kuo PL, Wu JC, Lin SW.
Sci Rep 6:20227. doi: 10.1038/srep20227. 2016
7CUL4A, CUL4B, TUBG1
Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its polyubiquitination.
Thirunavukarasou A, Govindarajalu G, Singh P, Bandi V, Muthu K, Baluchamy S.
Mol Cell Biochem 401(1-2):219-28. doi: 10.1007/s11010-014-2309-7. Epub 2014 Dec 27. 2015
8CUL4B
CUL4B promotes proliferation and inhibits apoptosis of human osteosarcoma cells.
Chen Z, Shen BL, Fu QG, Wang F, Tang YX, Hou CL, Chen L.
Oncol Rep 32(5):2047-53. doi: 10.3892/or.2014.3465. Epub 2014 Sep 5. 2014
9CUL4B, MRXSC
Donor splice-site mutation in CUL4B is likely cause of X-linked intellectual disability.
Londin ER, Adijanto J, Philp N, Novelli A, Vitale E, Perria C, Serra G, Alesi V, Surrey S, Fortina P.
Am J Med Genet A 164A(9):2294-9. doi: 10.1002/ajmg.a.36629. Epub 2014 Jun 4. 2014
10CUL4A, CUL4B
E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation.
Thirunavukarasou A, Singh P, Govindarajalu G, Bandi V, Baluchamy S.
Mol Cell Biochem 390(1-2):93-100. doi: 10.1007/s11010-014-1960-3. Epub 2014 Jan 23. 2014
11CDC6, CDK2, CUL4B, MCM2
CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.
Zou Y, Mi J, Wang W, Lu J, Zhao W, Liu Z, Hu H, Yang Y, Gao X, Jiang B, Shao C, Gong Y.
J Cell Biol 200(6):743-56. doi: 10.1083/jcb.201206065. Epub 2013 Mar 11. 2013
12CUL4B
Cullin 4B is a novel prognostic marker that correlates with colon cancer progression and pathogenesis.
Jiang T, Tang HM, Wu ZH, Chen J, Lu S, Zhou CZ, Yan DW, Peng ZH.
Med Oncol 30(2):534. doi: 10.1007/s12032-013-0534-7. Epub 2013 May 7. 2013
13COPS5, CUL4A, CUL4B
X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling.
He F, Lu D, Jiang B, Wang Y, Liu Q, Liu Q, Shao C, Li X, Gong Y.
Biochim Biophys Acta 1832(5):595-605. doi: 10.1016/j.bbadis.2013.01.015. Epub 2013 Jan 26. 2013
14CUL4B
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis.
Hu H, Yang Y, Ji Q, Zhao W, Jiang B, Liu R, Yuan J, Liu Q, Li X, Zou Y, Shao C, Shang Y, Wang Y, Gong Y.
Cancer Cell 22(6):781-95. doi: 10.1016/j.ccr.2012.10.024. 2012
15CUL4B
Cul4B regulates neural progenitor cell growth.
Liu HC, Enikolopov G, Chen Y.
BMC Neurosci 13:112. doi: 10.1186/1471-2202-13-112. 2012
16CUL4B
Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.
Jiang B, Zhao W, Yuan J, Qian Y, Sun W, Zou Y, Guo C, Chen B, Shao C, Gong Y.
PLoS One 7(5):e37070. doi: 10.1371/journal.pone.0037070. Epub 2012 May 14. 2012
17CUL4B
CUL4B: trash talking at chromatin.
Green EM, Gozani O.
Mol Cell. 43(3):321-3. 2011
18CUL4B
X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression.
Nakagawa T, Xiong Y.
Mol Cell. 43(3):381-91. 2011
19CUL4B, MRXSC
Deletion of the CUL4B gene in a boy with mental retardation, minor facial anomalies, short stature, hypogonadism, and ataxia.
Isidor B, Pichon O, Baron S, David A, Le Caignec C.
Am J Med Genet A 152A(1):175-80.PMID: 20014135 2010
20CUL4B, MRXSC
A novel nonsense mutation in CUL4B gene in three brothers with X-linked mental retardation syndrome.
Badura-Stronka M, Jamsheer A, Materna-Kiryluk A, Sowińska A, Kiryluk K, Budny B, Latos-Bieleńska A.
Clin Genet 77(2):141-4. Epub 2009 Dec 10.PMID: 20002452 2010
21CUL4A, CUL4B, MRXSC
Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.
Kerzendorfer C, Whibley A, Carpenter G, Outwin E, Chiang SC, Turner G, Schwartz C, El-Khamisy S, Raymond FL, O'Driscoll M.
Hum Mol Genet 19(7):1324-34. Epub 2010 Jan 11. 2010
22AP1S2, BRWD3, CASK, CUL4B, MRX65, MRX96, SLC9A6, SYP, UPF3B, ZDHHC9, ZNF711
A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.
Tarpey PS, Smith R, Pleasance E, Whibley A, Edkins S, Hardy C, O'Meara S, Latimer C, Dicks E, Menzies A, Stephens P, Blow M, Greenman C, Xue Y, Tyler-Smith C, Thompson D, Gray K, Andrews J, Barthorpe S, Buck G, Cole J, Dunmore R, Jones D, Maddison M, Mironenko T, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Teague J, Butler A, Jenkinson A, Jia M, Richardson D, Shepherd R, Wooster R, Tejada MI, Martinez F, Carvill G, Goliath R, de Brouwer AP, van Bokhoven H, Van Esch H, Chelly J, Raynaud M, Ropers HH, Abidi FE, Srivastava AK, Cox J, Luo Y, Mallya U, Moon J, Parnau J, Mohammed S, Tolmie JL, Shoubridge C, Corbett M, Gardner A, Haan E, Rujirabanjerd S, Shaw M, Vandeleur L, Fullston T, Easton DF, Boyle J, Partington M, Hackett A, Field M, Skinner C, Stevenson RE, Bobrow M, Turner G, Schwartz CE, Gecz J, Raymond FL, Futreal PA, Stratton MR.
Nat Genet 41(5):535-43. Epub 2009 Apr 19. 2009
23CUL4B
Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.
Zou Y, Mi J, Cui J, Lu D, Zhang X, Guo C, Gao G, Liu Q, Chen B, Shao C, Gong Y.
J Biol Chem 284(48):33320-32. Epub 2009 Oct 2. 2009
24CUL4B
The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.
Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapić-Otrin V.
Cancer Res 68(13):5014-22. 2008
25CUL4B, MRXSC
Mutation in CUL4B, Which Encodes a Member of Cullin-RING Ubiquitin Ligase Complex, Causes X-Linked Mental Retardation.
Zou Y, Liu Q, Chen B, Zhang X, Guo C, Zhou H, Li J, Gao G, Guo Y, Yan C, Wei J, Shao C, Gong Y.
Am J Hum Genet 80(3):561-6. Epub 2007 Jan 25. 2007
26CUL4B, MRXSC
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor.
Tarpey PS, Raymond FL, O'Meara S, Edkins S, Teague J, Butler A, Dicks E, Stevens C, Tofts C, Avis T, Barthorpe S, Buck G, Cole J, Gray K, Halliday K, Harrison R, Hills K, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Varian J, West S, Widaa S, Mallya U, Moon J, Luo Y, Holder S, Smithson SF, Hurst JA, Clayton-Smith J, Kerr B, Boyle J, Shaw M, Vandeleur L, Rodriguez J, Slaugh R, Easton DF, Wooster R, Bobrow M, Srivastava AK, Stevenson RE, Schwartz CE, Turner G, Gecz J, Futreal PA, Stratton MR, Partington M.
Am J Hum Genet 80(2):345-52. Epub 2007 Jan 4. 2007
27CDT1, CUL4A, CUL4B
PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.
Senga T, Sivaprasad U, Zhu W, Park JH, Arias EE, Walter JC, Dutta A.
J Biol Chem 281(10):6246-52. Epub 2006 Jan 9. 2006
28CUL4A, CUL4B, DDB1, WDR26
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H.
Nat Cell Biol 8(11):1277-83. Epub 2006 Oct 15. 2006
29CAND1, CUL1, CUL2, CUL3, CUL4A, CUL4B
TIP120A associates with cullins and modulates ubiquitin ligase activity.
Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB.
J Biol Chem 278(18):15905-10. Epub 2003 Feb 27. 2003
30AATK, ACIN1, ACOT11, ACSBG1, ADAMTS4, ADGRV1, AKAP11, ANKLE2, ARHGAP26, ARHGEF2, ASTN2, ATP2C2, ATP9A, BICD2, BZRAP1, C12orf51, CAND2, CEP135, CLASP1, CLASP2, CLUAP1, CLUH, CNOT3, COBL, CPNE3, CRTC1, CRY2, CSTF2T, CUL3, CUL4B, DAAM1, DAGLA, DEPDC5, DNAJC13, DOCK10, DZIP3, FBXW11, FKBP15, G3BP2, HEPH, HIP1R, HIPK1, ICOSLG, KIAA0649, KIAA0652, KIF13B, KIF1C, KIF21A, L3MBTL1, LDB3, MAGI2, MAP4K4, MFAP3L, MGEA5, MRC2, MTMR4, N4BP1, NPHP4, OBSL1, PAN2, PHACTR2, PHF2, PHLDB1, PLXND1, PPFIA3, PTCD1, RAB11FIP3, RBM19, RICH2, RNF40, RNF8, ROCK2, RRP12, SAPS2, SETX, SIN3B, SLC24A1, SMCHD1, SNAP91, SOCS5, SS18L1, SWAP70, TBC1D9B, TELO2, TNRC15, TSC22D2, UBE4B, UHRF1BP1L, ULK2, ZBED4, ZC3H11A, ZNF623
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N,Ohara O.
DNA Res 5(3):169-76. 1998
31CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM.
Cell 85(6):829-39. 1996