| 1 | CUL3, DCUN1D1
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| Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization.
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| Huang G, Kaufman AJ, Ryan RJH, Romin Y, Huryn L, Bains S, Manova-Todorova K, Morris PL, Hunnicutt GR, Adelman CA, Petrini JHJ, Ramanathan Y, Singh B.
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| PLoS One. Jan 17;14(1):e0209995. doi: 10.1371/journal.pone.0209995. eCollection 2019 2019
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| 2 | CUL3, KLHL20, ULK1
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| Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.
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| Liu CC, Lin YC, Chen YH, Chen CM, Pang LY, Chen HA, Wu PR, Lin MY, Jiang ST, Tsai TF, Chen RH.
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| Mol Cell 61(1):84-97. doi: 10.1016/j.molcel.2015.11.001. Epub 2015 Dec 10.
2016
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| 3 | CUL3, KLHL2
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| Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.
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| Zhang C, Meermeier NP, Terker AS, Blankenstein KI, Singer JD, Hadchouel J, Ellison DH, Yang CL.
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| Biochem Biophys Res Commun 469(1):44-8. doi: 10.1016/j.bbrc.2015.11.067. Epub 2015 Nov 23.
2016
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| 4 | ACLY, CUL3, KLHL25
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| Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. 2016
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| Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W, Feng Z.
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| Genes Dev. Sep 1;30(17):1956-70. doi: 10.1101/gad.283283.116 2016
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| 5 | CUL3, KLHL3, PHA2B, PHA2C, PHA2D, PHA2E, WNK2, WNK4
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| Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.
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| Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E.
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| Biochem Biophys Res Commun 467(2):229-34. doi: 10.1016/j.bbrc.2015.09.184. Epub 2015 Oct 3. 2015
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| 6 | CUL3, PHA2E
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| Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.
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| Ibeawuchi SR, Agbor LN, Quelle FW, Sigmund CD.
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| J Biol Chem 290(31):19208-17. doi: 10.1074/jbc.M115.645358. Epub 2015 Jun 22.
2015
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| 7 | CUL3, KCTD11, KCTD6
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| Cullin 3 Recognition Is Not a Universal Property among KCTD Proteins.
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| Smaldone G, Pirone L, Balasco N, Di Gaetano S, Pedone EM, Vitagliano L.
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| PLoS One 10(5):e0126808. doi: 10.1371/journal.pone.0126808. eCollection 2015.
2015
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| 8 | CUL3, KCTD5, ZNF711
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| Interactions of cullin3/KCTD5 complexes with both cytoplasmic and nuclear proteins: Evidence for a role in protein stabilization.
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| Rutz N, Heilbronn R, Weger S.
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| Biochem Biophys Res Commun 464(3):922-8. doi: 10.1016/j.bbrc.2015.07.069. Epub 2015 Jul 16.
2015
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| 9 | CUL3
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| Hypertension: new roles for CUL-3 in the kidney.
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| Edwards JK.
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| Nat Rev Nephrol 10(12):675. doi: 10.1038/nrneph.2014.193. Epub 2014 Oct 14. No abstract available.
2014
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| 10 | CUL3, PHA2E
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| Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.
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| McCormick JA, Yang CL, Zhang C, Davidge B, Blankenstein KI, Terker AS, Yarbrough B, Meermeier NP, Park HJ, McCully B, West M, Borschewski A, Himmerkus N, Bleich M, Bachmann S, Mutig K, Argaiz ER, Gamba G, Singer JD, Ellison DH.
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| J Clin Invest 124(11):4723-36. doi: 10.1172/JCI76126. Epub 2014 Sep 24.
2014
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| 11 | BCL6, CUL3
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| A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation.
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| Mathew R, Mao AP, Chiang AH, Bertozzi-Villa C, Bunker JJ, Scanlon ST, McDonald BD, Constantinides MG, Hollister K, Singer JD, Dent AL, Dinner AR, Bendelac A.
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| J Exp Med 211(6):1137-51. doi: 10.1084/jem.20132267. Epub 2014 May 26.
2014
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| 12 | CORO7, CUL3, KLHL20
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| K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking.
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| Yuan WC, Lee YR, Lin SY, Chang LY, Tan YP, Hung CC, Kuo JC, Liu CH, Lin MY, Xu M, Chen ZJ, Chen RH.
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| Mol Cell 54(4):586-600. doi: 10.1016/j.molcel.2014.03.035. Epub 2014 Apr 24.
2014
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| 13 | CUL3, KLHL3, WNK4
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| Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis.
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| Andérica-Romero AC, Escobar L, Padilla-Flores T, Pedraza-Chaverri J.
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| Cell Signal 26(6):1166-72. doi: 10.1016/j.cellsig.2014.01.032. Epub 2014 Feb 8. Review.
2014
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| 14 | CUL3, KLHL3, PHA2D, PHA2E, WNK4
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| Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.
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| Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S.
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| Biochem Biophys Res Commun 439(1):30-4. doi: 10.1016/j.bbrc.2013.08.035. Epub 2013 Aug 17. 2013
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| 15 | CUL3, PHA2E
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| A young child with pseudohypoaldosteronism type II by a mutation of Cullin 3.
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| Tsuji S, Yamashita M, Unishi G, Takewa R, Kimata T, Isobe K, Chiga M, Uchida S, Kaneko K.
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| BMC Nephrol 14:166. doi: 10.1186/1471-2369-14-166.
2013
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| 16 | CUL3, KLHL3, WNK4
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| Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
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| Shibata S, Zhang J, Puthumana J, Stone KL, Lifton RP.
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| Proc Natl Acad Sci U S A 110(19):7838-43. doi: 10.1073/pnas.1304592110. Epub 2013 Apr 1.
2013
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| 17 | CUL3, KLHL3
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| Crystal structure of KLHL3 in complex with Cullin3.
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| Ji AX, Privé GG.
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| PLoS One 8(4):e60445. doi: 10.1371/journal.pone.0060445. Epub 2013 Apr 3.
2013
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| 18 | CUL3, KLHL3, PHA2D, PHA2E
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| The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
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| Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T.
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| Biochem J 451(1):111-22. doi: 10.1042/BJ20121903.
2013
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| 19 | ATP6, CUL3, ZBTB16
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| BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
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| Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
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| Nature 491(7425):618-21. doi: 10.1038/nature11548. Epub 2012 Oct 21.
2012
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| 20 | CUL3, RBX1
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| Cullin-3 regulates late endosome maturation.
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| Huotari J, Meyer-Schaller N, Hubner M, Stauffer S, Katheder N, Horvath P, Mancini R, Helenius A, Peter M.
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| Proc Natl Acad Sci U S A 109(3):823-8. doi: 10.1073/pnas.1118744109. Epub 2012 Jan 4.
2012
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| 21 | CUL3, KLHL3, KLHL3, PHA2D, PHA2E, WNK4
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| Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
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| Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, Lebel M, Gordon RD, Semmekrot BA, Poujol A, Välimäki MJ, De Ferrari ME, Sanjad SA, Gutkin M, Karet FE, Tucci JR, Stockigt JR, Keppler-Noreuil KM, Porter CC, Anand SK, Whiteford ML, Davis ID, Dewar SB, Bettinelli A, Fadrowski JJ, Belsha CW, Hunley TE, Nelson RD, Trachtman H, Cole TR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan P, Foreman JW, Rasoulpour M, Thameem F, Al-Shahrouri HZ, Radhakrishnan J, Gharavi AG, Goilav B, Lifton RP.
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| Nature 482(7383):98-102. doi: 10.1038/nature10814.
2012
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| 22 | CUL3, KBTBD13
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| KBTBD13 interacts with Cullin 3 to form a functional ubiquitin ligase.
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| Sambuughin N, Swietnicki W, Techtmann S, Matrosova V, Wallace T, Goldfarb L, Maynard E.
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| Biochem Biophys Res Commun 421(4):743-9. doi: 10.1016/j.bbrc.2012.04.074. Epub 2012 Apr 20.
2012
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| 23 | CUL3, KLHL12
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| Ubiquitin-dependent regulation of COPII coat size and function.
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| Jin L, Pahuja KB, Wickliffe KE, Gorur A, Baumgärtel C, Schekman R, Rape M.
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| Nature 482(7386):495-500. doi: 10.1038/nature10822.
2012
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| 24 | CUL3, KLHL7, RP42
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| Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation.
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| Kigoshi Y, Tsuruta F, Chiba T.
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| J Biol Chem 286(38):33613-21. Epub 2011 Aug 2.
2011
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| 25 | BRMS1, CUL3, SPOP
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| Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex.
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| Kim B, Nam HJ, Pyo KE, Jang MJ, Kim IS, Kim D, Boo K, Lee SH, Yoon JB, Baek SH, Kim JH.
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| Biochem Biophys Res Commun 415(4):720-6. doi: 10.1016/j.bbrc.2011.10.154. Epub 2011 Nov 9.
2011
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| 26 | CUL3, NCOA3
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| Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response.
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| Ferry C, Gaouar S, Fischer B, Boeglin M, Paul N, Samarut E, Piskunov A, Pankotai-Bodo G, Brino L, Rochette-Egly C.
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| Proc Natl Acad Sci U S A 108(51):20603-8. doi: 10.1073/pnas.1102572108. Epub 2011 Dec 6.
2011
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| 27 | CUL3, DAPK1, KLHL20, RBX1
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| The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.
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| Lee YR, Yuan WC, Ho HC, Chen CH, Shih HM, Chen RH.
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| EMBO J 29(10):1748-61. Epub 2010 Apr 13. 2010
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| 28 | CUL3, NFE2L2, RBX1
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| An autoregulatory loop between Nrf2 and Cul3-Rbx1 controls their cellular abundance.
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| Kaspar JW, Jaiswal AK.
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| J Biol Chem 285(28):21349-58. Epub 2010 May 7.
2010
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| 29 | CUL3, SPOP
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| Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
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| Zhuang M, Calabrese MF, Liu J, Waddell MB, Nourse A, Hammel M, Miller DJ, Walden H, Duda DM, Seyedin SN, Hoggard T, Harper JW, White KP, Schulman BA.
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| Mol Cell 36(1):39-50.PMID: 19818708 2009
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| 30 | CUL3, KLHL21, KLHL22
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| The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
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| Maerki S, Olma MH, Staubli T, Steigemann P, Gerlich DW, Quadroni M, Sumara I, Peter M.
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| J Cell Biol 187(6):791-800. Epub .
2009
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| 31 | CUL3
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| COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch.
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| Djagaeva I, Doronkin S.
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| PLoS One 4(10):e7598.
2009
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| 32 | CUL3, TNFAIP1
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| Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.
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| Chen Y, Yang Z, Meng M, Zhao Y, Dong N, Yan H, Liu L, Ding M, Peng HB, Shao F.
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| Mol Cell 35(6):841-55. doi: 10.1016/j.molcel.2009.09.004. Erratum in: Mol Cell. 2011 Dec 23;44(6):1005.
2009
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| 33 | CUL3, KEAP1, NFE2L2
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| Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
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| Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S.
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| Proc Natl Acad Sci U S A 105(36):13568-73. Epub 2008 Aug 29. 2008
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| 34 | CUL1, CUL3
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| The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.
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| Rencus-Lazar S, Amir Y, Wu J, Chien CT, Chamovitz DA, Segal D.
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| PLoS One 3(5):e2239.
2008
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| 35 | CUL3, SPOP
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| BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
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| Kwon JE, La M, Oh KH, Oh YM, Kim GR, Seol JH, Baek SH, Chiba T, Tanaka K, Bang OS, Joe CO, Chung CH.
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| J Biol Chem 281(18):12664-72. Epub 2006 Mar 8.PMID: 16524876 2006
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| 36 | CUL3
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| Identification and characterization of cul-3b, a novel hominine CUL-3 transcript variant.
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| Lu L, Zhou ZM, Huang XY, Xu M, Yin LL, Wang H, Xu ZY, Sha JH.
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| Asian J Androl 7(2):205-11. 2005
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| 37 | CUL3
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| BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
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| Furukawa M, Xiong Y.
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| Mol Cell Biol 25(1):162-71. 2005
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| 38 | CUL3
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| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
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| Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M.
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| Mol Cell Biol 24(16):7130-9. 2004
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| 39 | CAND1, CUL1, CUL2, CUL3, CUL4A, CUL4B
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| TIP120A associates with cullins and modulates ubiquitin ligase activity.
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| Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB.
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| J Biol Chem 278(18):15905-10. Epub 2003 Feb 27. 2003
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| 40 | CUL3
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| Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family.
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| Du M, Sansores-Garcia L, Zu Z, Wu KK.
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| J Biol Chem 273(38):24289-92. 1998
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| 41 | AATK, ACIN1, ACOT11, ACSBG1, ADAMTS4, ADGRV1, AKAP11, ANKLE2, ARHGAP26, ARHGEF2, ASTN2, ATP2C2, ATP9A, BICD2, BZRAP1, C12orf51, CAND2, CEP135, CLASP1, CLASP2, CLUAP1, CLUH, CNOT3, COBL, CPNE3, CRTC1, CRY2, CSTF2T, CUL3, CUL4B, DAAM1, DAGLA, DEPDC5, DNAJC13, DOCK10, DZIP3, FBXW11, FKBP15, G3BP2, HEPH, HIP1R, HIPK1, ICOSLG, KIAA0649, KIAA0652, KIF13B, KIF1C, KIF21A, L3MBTL1, LDB3, MAGI2, MAP4K4, MFAP3L, MGEA5, MRC2, MTMR4, N4BP1, NPHP4, OBSL1, PAN2, PHACTR2, PHF2, PHLDB1, PLXND1, PPFIA3, PTCD1, RAB11FIP3, RBM19, RICH2, RNF40, RNF8, ROCK2, RRP12, SAPS2, SETX, SIN3B, SLC24A1, SMCHD1, SNAP91, SOCS5, SS18L1, SWAP70, TBC1D9B, TELO2, TNRC15, TSC22D2, UBE4B, UHRF1BP1L, ULK2, ZBED4, ZC3H11A, ZNF623
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| Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
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| Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N,Ohara O.
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| DNA Res 5(3):169-76. 1998
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| 42 | CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5
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| cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
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| Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM.
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| Cell 85(6):829-39. 1996
|