| 1 | CUL1, CUL4A, DDB1, SKP2, YTHDF2
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| YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators
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| Fei Q, Zou Z, Roundtree IA, Sun HL, He C.
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| PLoS Biol. Apr 8;18(4):e3000664. doi: 10.1371/journal.pbio.3000664. 2020
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| 2 | CUL1
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| Increasing the Unneddylated Cullin1 Portion Rescues the csn Phenotypes by Stabilizing Adaptor Modules To Drive SCF Assembly.
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| Liu Q, Zhou Y, Tang R, Wang X, Hu Q, Wang Y, He Q.
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| Mol Cell Biol 37(23). pii: e00109-17. doi: 10.1128/MCB.00109-17. Print 2017 Dec 1. Erratum in: Mol Cell Biol. 2018 Jan 29;38(4):.
2017
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| 3 | CUL1
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| The expression of Cullin1 is increased in renal cell carcinoma and promotes cancer cell proliferation, migration, and invasion.
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| Ping JG, Wang F, Pu JX, Hou PF, Chen YS, Bai J, Zheng JN.
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| Tumour Biol 37(9):12823-12831. Epub 2016 Jul 23.
2016
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| 4 | CUL1, DEPTOR, MTOR
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| Cul1 promotes melanoma cell proliferation by promoting DEPTOR degradation and enhancing cap-dependent translation.
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| Chen L, Liu T, Tu Y, Rong D, Cao Y.
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| Oncol Rep 35(2):1049-56. doi: 10.3892/or.2015.4442. Epub 2015 Nov 23.
2016
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| 5 | CUL1
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| Cullin1 is up-regulated and associated with poor patients' survival in hepatocellular carcinoma.
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| Liu W, Wang Y, Zhang C, Huang B, Bai J, Tian L.
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| Int J Clin Exp Pathol 8(4):4001-7. eCollection 2015.
2015
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| 6 | CUL1
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| Cullin1 is a novel prognostic marker and regulates the cell proliferation and metastasis in colorectal cancer.
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| Wang W, Chen Y, Deng J, Zhou J, Gu X, Tang Y, Zhang G, Tan Y, Ge Z, Huang Y, Wang S, Zhou J, Zhou Y, Zhou S.
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| J Cancer Res Clin Oncol 141(9):1603-12. doi: 10.1007/s00432-015-1931-4. Epub 2015 Feb 5.
2015
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| 7 | CUL1
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| Cullin1 regulates proliferation, migration and invasion of glioma cells.
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| Fan YC, Zhu YS, Mei PJ, Sun SG, Zhang H, Chen HF, Chen C, Miao FA.
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| Med Oncol 31(10):227. doi: 10.1007/s12032-014-0227-x. Epub 2014 Sep 9.
2014
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| 8 | CUL1, SF3B3, SKP1, SKP2
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| Regulation of Cullin-RING ubiquitin ligase 1 by Spliceosome-associated protein 130 (SAP130).
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| Cordero-Espinoza L, Hagen T.
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| Biol Open 2(8):838-44. doi: 10.1242/bio.20134374. eCollection 2013 Aug 15.
2013
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| 9 | CUL1
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| CUL1 promotes trophoblast cell invasion at the maternal-fetal interface.
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| Zhang Q, Chen Q, Lu X, Zhou Z, Zhang H, Lin HY, Duan E, Zhu C, Tan Y, Wang H.
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| Cell Death Dis 4:e502. doi: 10.1038/cddis.2013.1.
2013
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| 10 | CUL1
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| Diagnostic and prognostic relevance of Cullin1 expression in invasive ductal carcinoma of the breast.
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| Min KW, Kim DH, Do SI, Sohn JH, Chae SW, Pyo JS, Park CH, Oh YH, Jang KS, Kim HL, Kim M.
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| J Clin Pathol 65(10):896-901. Epub 2012 Jul 12.
2012
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| 11 | CUL1, DRG2, SKP1
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| SKP1-CULLIN1-F-box (SCF)-mediated DRG2 degradation facilitated chemotherapeutic drugs induced apoptosis in hepatocellular carcinoma cells.
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| Chen J, Shen BY, Deng XX, Zhan Q, Peng CH.
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| Biochem Biophys Res Commun 420(3):651-5. doi: 10.1016/j.bbrc.2012.03.058. Epub 2012 Mar 17.
2012
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| 12 | CUL1, GLMN, RBX1
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| Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.
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| Duda DM, Olszewski JL, Tron AE, Hammel M, Lambert LJ, Waddell MB, Mittag T, DeCaprio JA, Schulman BA.
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| Mol Cell 47(3):371-82. doi: 10.1016/j.molcel.2012.05.044. Epub 2012 Jun 28.
2012
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| 13 | CUL1
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| Association of Cullin1 haplotype variants with rheumatoid arthritis and response to methotrexate.
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| Negi S, Kumar A, Thelma BK, Juyal RC.
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| Pharmacogenet Genomics 21(9):590-3.
2011
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| 14 | CUL1, FBXL4, KDM4A
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| The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein.
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| Van Rechem C, Black JC, Abbas T, Allen A, Rinehart CA, Yuan GC, Dutta A, Whetstine JR.
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| J Biol Chem 286(35):30462-70. Epub 2011 Jul 8.
2011
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| 15 | CUL1, PLK4
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| Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.
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| Korzeniewski N, Zheng L, Cuevas R, Parry J, Chatterjee P, Anderton B, Duensing A, Münger K, Duensing S.
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| Cancer Res 69(16):6668-75.PMID: 19679553 2009
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| 16 | CAND1, CUL1, DCUN1D1, UBE2M
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| SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
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| Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B.
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| J Biol Chem 283(48):33211-20. Epub 2008 Sep 30.
2008
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| 17 | CUL1, CUL3
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| The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.
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| Rencus-Lazar S, Amir Y, Wu J, Chien CT, Chamovitz DA, Segal D.
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| PLoS One 3(5):e2239.
2008
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| 18 | CUL1
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| A dominant-negative form of the E3 ubiquitin ligase Cullin-1 disrupts the correct allocation of cell fate in the neural crest lineage.
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| Voigt J, Papalopulu N.
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| Development 133(3):559-68. Epub 2006 Jan 5.
2006
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| 19 | CUL1
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| CUL1, a component of E3 ubiquitin ligase, alters lymphocyte signal transduction with possible effect on rheumatoid arthritis.
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| Kawaida R, Yamada R, Kobayashi K, Tokuhiro S, Suzuki A, Kochi Y, Chang X, Sekine A, Tsunoda T, Sawada T, Furukawa H, Nakamura Y, Yamamoto K.
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| Genes Immun 6(3):194-202. 2005
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| 20 | CAND1, CUL1
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| CAND1 enhances deneddylation of CUL1 by COP9 signalosome.
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| Min KW, Kwon MJ, Park HS, Park Y, Yoon SK, Yoon JB.
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| Biochem Biophys Res Commun 334(3):867-74. 2005
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| 21 | CAND1, CUL1
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| Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation.
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| Feng S, Shen Y, Sullivan JA, Rubio V, Xiong Y, Sun TP, Deng XW.
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| Plant Cell 16(7):1870-82. Epub 2004 Jun 18. 2004
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| 22 | SENP8, NEDD8, CUL1
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| DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.
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| Wu K, Yamoah K, Dolios G, Gan-Erdene T, Tan P, Chen A, Lee CG, Wei N, Wilkinson KD, Wang R, Pan ZQ.
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| J Biol Chem 278(31):28882-91. Epub 2003 May 19. 2003
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| 23 | CAND1, CUL1, CUL2, CUL3, CUL4A, CUL4B
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| TIP120A associates with cullins and modulates ubiquitin ligase activity.
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| Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB.
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| J Biol Chem 278(18):15905-10. Epub 2003 Feb 27. 2003
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| 24 | COPS5, COPS6, CUL1
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| Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.
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| Cope GA, Suh GS, Aravind L, Schwarz SE, Zipursky SL, Koonin EV, Deshaies RJ.
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| Science 298(5593):608-11. 2002
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| 25 | CUL1, SKP1
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| In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.
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| Piva R, Liu J, Chiarle R, Podda A, Pagano M, Inghirami G.
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| Mol Cell Biol 22(23):8375-87. 2002
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| 26 | CDKN1B, CUL1, NEDD8, SKP2
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| The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.
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| Yang X, Menon S, Lykke-Andersen K, Tsuge T, Di Xiao, Wang X, Rodriguez-Suarez RJ, Zhang H, Wei N.
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| Curr Biol 12(8):667-72. 2002
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| 27 | CUL1, RBX1, SKP1, SKP1B, SKP2
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| Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
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| Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP.
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| Nature 416(6882):703-9. 2002
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| 28 | CUL1
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| The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1.
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| Furukawa M, Zhang Y, McCarville J, Ohta T, Xiong Y.
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| Mol Cell Biol 20(21):8185-97. 2000
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| 29 | CUL1
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| Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E.
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| Dealy MJ, Nguyen KV, Lo J, Gstaiger M, Krek W, Elson D, Arbeit J, Kipreos ET, Johnson RS.
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| Nat Genet 23(2):245-8. 1999
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| 30 | CUL1
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| Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins.
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| Yu ZK, Gervais JL, Zhang H.
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| Proc Natl Acad Sci U S A 95(19):11324-9. 1998
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| 31 | CUL1
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| Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
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| Michel JJ, Xiong Y.
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| Cell Growth Differ 9(6):435-49. 1998
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| 32 | CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5
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| cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
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| Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM.
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| Cell 85(6):829-39. 1996
|