Citations for
1CTTN, NAA15, SRC
Tubedown regulation of retinal endothelial permeability signaling pathways.
Ho N, Gendron RL, Grozinger K, Whelan MA, Hicks EA, Tennakoon B, Gardiner D, Good WV, Paradis H.
Biol Open 4(8):970-9. doi: 10.1242/bio.010496. 2015
2CTTN, FBXL5
FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration.
Cen G, Ding HH, Liu B, Wu WD.
Tumour Biol umour Biol. 2014 May 28. [Epub ahead of print] 2014
3CTTN, WASF2, WASL
Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens.
Han SP, Gambin Y, Gomez GA, Verma S, Giles N, Michael M, Wu SK, Guo Z, Johnston W, Sierecki E, Parton RG, Alexandrov K, Yap AS.
J Biol Chem 289(11):7764-75. doi: 10.1074/jbc.M113.544478. Epub 2014 Jan 27. 2014
4CTTN, PFN1
The association of cortactin with profilin-1 is critical for smooth muscle contraction.
Wang R, Cleary RA, Wang T, Li J, Tang DD.
J Biol Chem 289(20):14157-69. doi: 10.1074/jbc.M114.548099. Epub 2014 Apr 3. 2014
5ABL1, CTTN
Role of c-Abl tyrosine kinase in smooth muscle cell migration.
Cleary RA, Wang R, Waqar O, Singer HA, Tang DD.
Am J Physiol Cell Physiol 306(8):C753-61. doi: 10.1152/ajpcell.00327.2013. Epub 2014 Jan 29. 2014
6CTTN, SKAP2, WASF2
The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.
Shimamura S, Sasaki K, Tanaka M.
J Biol Chem 288(2):1171-83. doi: 10.1074/jbc.M112.386722. Epub 2012 Nov 16. 2013
7CTTN
Cortactin is a sensitive biomarker relative to the poor prognosis of human hepatocellular carcinoma.
Zhao G, Huang ZM, Kong YL, Wen DQ, Li Y, Ren L, Zhang HY.
World J Surg Oncol 11:74. doi: 10.1186/1477-7819-11-74. 2013
8CD2AP, CTTN
CD2AP links cortactin and capping protein at the cell periphery to facilitate formation of lamellipodia.
Zhao J, Bruck S, Cemerski S, Zhang L, Butler B, Dani A, Cooper JA, Shaw AS.
Mol Cell Biol 33(1):38-47. doi: 10.1128/MCB.00734-12. Epub 2012 Oct 22. 2013
9CTTN, DLG4
Regulation of synapse composition by protein acetylation: the role of acetylated cortactin.
Catarino T, Ribeiro L, Santos SD, Carvalho AL.
J Cell Sci 126(Pt 1):149-62. doi: 10.1242/jcs.110742. Epub 2012 Oct 4. 2013
10CTTN, SDC1
Molecular mediators for raft-dependent endocytosis of syndecan-1, a highly conserved, multifunctional receptor.
Chen K, Williams KJ.
J Biol Chem 288(20):13988-99. doi: 10.1074/jbc.M112.444737. Epub 2013 Mar 22. 2013
11CTTN, KCNH1
Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1.
Herrmann S, Ninkovic M, Kohl T, Lörinczi É, Pardo LA.
J Biol Chem 287(53):44151-63. doi: 10.1074/jbc.M112.372540. Epub 2012 Nov 9. 2012
12CTTN, KCNH1
Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1.
Herrmann S, Ninkovic M, Kohl T, Lörinczi É, Pardo LA.
J Biol Chem 287(53):44151-63. doi: 10.1074/jbc.M112.372540. Epub 2012 Nov 9. 2012
13CTTN
Regulation of late endosomal/lysosomal maturation and trafficking by cortactin affects Golgi morphology.
Kirkbride KC, Hong NH, French CL, Clark ES, Jerome WG, Weaver AM.
Cytoskeleton (Hoboken) 69(9):625-43. doi: 10.1002/cm.21051. Epub 2012 Jul 31. 2012
14CTTN, PTK2
Cortactin tyrosine phosphorylation promotes its deacetylation and inhibits cell spreading.
Meiler E, Nieto-Pelegrín E, Martinez-Quiles N.
PLoS One 7(3):e33662. doi: 10.1371/journal.pone.0033662. Epub 2012 Mar 30. 2012
15CTTN, DBNL
Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts.
Boateng LR, Cortesio CL, Huttenlocher A.
J Cell Sci 125(Pt 5):1329-41. doi: 10.1242/jcs.096529. Epub 2012 Feb 2. Erratum in: J Cell Sci. 2012 Jul 1;125(Pt 13):3255. 2012
16CTTN, RCC2
Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells.
Grigera PR, Ma L, Borgman CA, Pinto AF, Sherman NE, Parsons JT, Fox JW.
J Proteomics 75(7):2153-9. doi: 10.1016/j.jprot.2012.01.012. Epub 2012 Jan 17. 2012
17BTRC, CTTN
Extracellular signal-regulated kinase (ERK) regulates cortactin ubiquitination and degradation in lung epithelial cells.
Zhao J, Wei J, Mialki R, Zou C, Mallampalli RK, Zhao Y.
J Biol Chem 287(23):19105-14. doi: 10.1074/jbc.M112.339507. Epub 2012 Apr 18. 2012
18CDH2, CTTN, KCNA5
Cortactin is required for N-cadherin regulation of Kv1.5 channel function.
Cheng L, Yung A, Covarrubias M, Radice GL.
J Biol Chem 286(23):20478-89. Epub 2011 Apr 20. 2011
19CTTN
Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway.
Magalhaes MA, Larson DR, Mader CC, Bravo-Cordero JJ, Gil-Henn H, Oser M, Chen X, Koleske AJ, Condeelis J.
J Cell Biol 195(5):903-20. doi: 10.1083/jcb.201103045. Epub 2011 Nov 21. 2011
20CTTN
Cortactin controls cell motility and lamellipodial dynamics by regulating ECM secretion.
Sung BH, Zhu X, Kaverina I, Weaver AM.
Curr Biol 21(17):1460-9. doi: 10.1016/j.cub.2011.06.065. 2011
21CTTN
Cortactin: a multifunctional regulator of cellular invasiveness.
Kirkbride KC, Sung BH, Sinha S, Weaver AM.
Cell Adh Migr 5(2):187-98. Epub 2011 Mar 1. Review. 2011
22CTTN, SH3PXD2B, SRC
The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading.
Lányi Á, Baráth M, Péterfi Z, Bogel G, Orient A, Simon T, Petrovszki E, Kis-Tóth K, Sirokmány G, Rajnavölgyi É, Terhorst C, Buday L, Geiszt M.
PLoS One 6(8):e23653. doi: 10.1371/journal.pone.0023653. 2011
23CTTN, PRKD1, SSH1
Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin.
Eiseler T, Hausser A, De Kimpe L, Van Lint J, Pfizenmaier K.
J Biol Chem 285(24):18672-83. Epub 2010 Apr 2.PMID: 20363754 2010
24CTTN, SIRT1
Deacetylation of cortactin by SIRT1 promotes cell migration
Zhang Y, Zhang M, Dong H, Yong S, Li X, Olashaw N, Kruk PA, Cheng JQ, Bai W, Chen J, Nicosia SV, Zhang X.
Oncogene. 28(3):445-60 2009
25CTTN, DNM2
Dynamin2 GTPase and cortactin remodel actin filaments.
Mooren OL, Kotova TI, Moore AJ, Schafer DA.
J Biol Chem 284(36):23995-4005. Epub 2009 Jul 15.PMID: 19605363 2009
26CTTN
Overexpression of cortactin in head and neck squamous cell carcinomas can be uncoupled from augmented EGF receptor expression.
Fantozzi I, Grall D, Cagnol S, Stanchi F, Sudaka A, Brunstein MC, Bozec A, Fischel JL, Milano G, Van Obberghen-Schilling E.
Acta Oncol 47(8):1502-12. 2008
27CTTN
Cortactin in tumor invasiveness.
Weaver AM.
Cancer Lett 265(2):157-66. Epub 2008 Apr 10. Review. 2008
28CTTN, NAA10, NAA15
Tubedown associates with cortactin and controls permeability of retinal endothelial cells to albumin.
Paradis H, Islam T, Tucker S, Tao L, Koubi S, Gendron RL.
J Cell Sci 121(Pt 12):1965-72. doi: 10.1242/jcs.028597. Epub 2008 May 21. 2008
29KCNA2, CTTN
An essential role for cortactin in the modulation of the potassium channel Kv1.2.
Williams MR, Markey JC, Doczi MA, Morielli AD.
Proc Natl Acad Sci U S A 104(44):17412-7. Epub 2007 Oct 24. 2007
30CTTN, FGF10, FGF7
Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes.
Ceccarelli S, Cardinali G, Aspite N, Picardo M, Marchese C, Torrisi MR, Mancini P.
Exp Cell Res 313(9):1758-77. Epub 2007 Mar 24. 2007
31CTTN
HDAC6 modulates cell motility by altering the acetylation level of cortactin.
Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang XJ, Dent SR, Yao TP, Lane WS, Seto E.
Mol Cell. 27(2):197-213 2007
32CTTN, HDAC6
HDAC6 modulates cell motility by altering the acetylation level of cortactin.
Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang XJ, Dent SR, Yao TP, Lane WS, Seto E.
Mol Cell 27(2):197-213. 2007
33CCND1, ORAOV1, CTTN, SHANK2, FGF3
Recurrent coamplification of cytoskeleton-associated genes EMS1 and SHANK2 with CCND1 in oral squamous cell carcinoma.
Freier K, Sticht C, Hofele C, Flechtenmacher C, Stange D, Puccio L, Toedt G, Radlwimmer B, Lichter P, Joos S.
Genes Chromosomes Cancer 45(2):118-25. 2006
34CXCR4, CXCL12, CTTN
CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis.
Luo C, Pan H, Mines M, Watson K, Zhang J, Fan GH.
J Biol Chem 281(40):30081-93. Epub 2006 Aug 11. 2006
35CTTN
Roles of cortactin in tumor pathogenesis
Buday L, Downward J.
Biochim Biophys Acta. 1775(2):263-73 2006
36CTTN
Cortactin phosphorylation sites mapped by mass spectrometry.
Martin KH, Jeffery ED, Grigera PR, Shabanowitz J, Hunt DF, Parsons JT.
J Cell Sci 119: 2851–2853 2006
37WASL, CTTN
A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin.
Kempiak SJ, Yamaguchi H, Sarmiento C, Sidani M, Ghosh M, Eddy RJ, Desmarais V, Way M, Condeelis J, Segall JE.
J Biol Chem 280(7):5836-42. Epub 2004 Dec 4. 2005
38CTTN
Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport.
Cao H, Weller S, Orth JD, Chen J, Huang B, Chen JL, Stamnes M, McNiven MA.
Nat Cell Biol. 7(5):483-92 2005
39CTTN, FGD1
Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.
Hou P, Estrada L, Kinley AW, Parsons JT, Vojtek AB, Gorski JL.
Hum Mol Genet 12(16):1981-93. 2003
40CTTN
Alternative splicing of the actin binding domain of human cortactin affects cell migration.
van Rossum AG, de Graaf JH, Schuuring-Scholtes E, Kluin PM, Fan YX, Zhan X, Moolenaar WH, Schuuring E.
J Biol Chem 278(46):45672-9. Epub 2003 Sep 2. 2003
41CTNND2, CTTN, MYC
Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho
Martinez MC, Ochiishi T, Majewski M, Kosik KS.
J Cell Biol. 162(1):99-111 2003
42CTTN
Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion
Kinley AW, Weed SA, Weaver AM, Karginov AV, Bissonette E, Cooper JA, Parsons JT.
Curr Biol. 13(5):384-93 2003
43PFN1, DNM1, DNM2, CTTN
Dynamin2 and cortactin regulate actin assembly and filament organization.
Schafer DA, Weed SA, Binns D, Karginov AV, Parsons JT, Cooper JA.
Curr Biol 12(21):1852-7. 2002
44CTTN
Novel interaction of cortactin with endothelial cell myosin light chain kinase.
Dudek SM, Birukov KG, Zhan X, Garcia JG.
Biochem Biophys Res Commun. 8;298(4):511-9 2002
45CTTN
Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts
Mizutani K, Miki H, He H, Maruta H, Takenawa T.
Cancer Res. 62(3):669-74 2002
46CTTN
Hepatocyte Growth Factor/scatter factor-induces phosphorylation of cortactin in A431 cells in a Src kinase-independent manner
Crostella L, Lidder S, Williams R, Skouteris GG.
Oncogene. 20(28):3735-45 2001
47CTTN
Human cortactin as putative cancer antigen.
Lagarkova MA, Boitchenko VE, Mescheryakov AA, Kashkarova UA, Nedospasov SA.
Oncogene 19(45):5204-7. 2000
48CTTN
Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex
Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT.
J Cell Biol. 151(1):29-40 2000
49CTTN
Clinical application of fluorescence in situ hybridization for chromosome 11q13 analysis in head and neck cancer.
Alavi S, et al.
Laryngoscope 109(6):874-9. 1999
50CTTN
Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin.
Campbell DH, Sutherland RL, Daly RJ.
Cancer Res 59(20):5376-85 1999
51CTTN
Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER
Kim L, Wong TW.
J Biol Chem. 273(36):23542-8 1998
52CTTN
Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth
Kinnunen T, Kaksonen M, Saarinen J, Kalkkinen N, Peng HB, Rauvala H.
J Biol Chem. 273(17):10702-8 1998
53CTTN
Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons
Du Y, Weed SA, Xiong WC, Marshall TD, Parsons JT.
Mol Cell Biol. 18(10):5838-51 1998
54CTTN
Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90
Ohoka Y, Takai Y.
Genes Cells. 3(9):603-12 1998
55CTTN
The redistribution of cortactin into cell-matrix contact sites in human carcinoma cells with 11q13 amplification is associated with both overexpression and post-translational modification.
Van Damme H, et al.
J Biol Chem 272 : 7374-7380. 1997
56CCND1, CTTN, FGF3
EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer.
Hui R, Campbell DH, Lee CS, McCaul K, Horsfall DJ, Musgrove EA, Daly RJ, Seshadri R, Sutherland RL.
Oncogene 15(13):1617-23. 1997
57CTTN
Physical and functional association of cortactin with Syk in human leukemic cell line K562
Maruyama S, Kurosaki T, Sada K, Yamanashi Y, Yamamoto T, Yamamura H.
J Biol Chem. 271(12):6631-5 1996
58CCND1, CTTN
The involvement of the chromosome 11q13 region in human malignancies : cyclin D1 and EMS1 are two new candidate oncogenes-a review.
Schuuring E.
Gene 159 : 83-96. 1995
59TOF1, TOF2, CTTN
Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMSI.
Brookes S, et al.
Genes Chromosomes Cancer 6 : 222-231. 1993
60CTTN, CCND1
Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.
Schuuring E, et al.
Oncogene 7 : 355-361. 1992