1 | CTSK
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| Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis.
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| Kubler A, Larsson C, Luna B, Andrade BB, Amaral EP, Urbanowski M, Orandle M, Bock K, Ammerman NC, Cheung LS, Winglee K, Halushka M, Park JK, Sher A, Friedland JS, Elkington PT, Bishai WR.
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| J Infect Dis Infect Dis. 2015 Sep 27. pii: jiv458. [Epub ahead of print]
2015
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2 | CTSK, MMP9
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| Matrix-metalloproteinase-9 is cleaved and activated by cathepsin K.
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| Christensen J, Shastri VP.
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| BMC Res Notes 8:322. doi: 10.1186/s13104-015-1284-8.
2015
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3 | CTSK
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| Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role.
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| Hao L, Zhu G, Lu Y, Wang M, Jules J, Zhou X, Chen W.
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| FEBS Lett 589(12):1331-9. doi: 10.1016/j.febslet.2015.04.008. Epub 2015 Apr 17.
2015
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4 | CTSK
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| Structural basis of collagen fiber degradation by cathepsin K.
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| Aguda AH, Panwar P, Du X, Nguyen NT, Brayer GD, Brömme D.
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| Proc Natl Acad Sci U S A 111(49):17474-9. doi: 10.1073/pnas.1414126111. Epub 2014 Nov 24.
2014
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5 | CTSK
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| Increased fracture callus mineralization and strength in cathepsin K knockout mice.
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| Gentile MA, Soung do Y, Horrell C, Samadfam R, Drissi H, Duong LT.
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| Bone 66:72-81. doi: 10.1016/j.bone.2014.04.032. Epub 2014 Jun 10. Erratum in: Bone. 2015 Feb;71:264.
2014
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6 | CTSK, PYCD
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| Cathepsin K analysis in a pycnodysostosis cohort: demographic, genotypic and phenotypic features.
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| Arman A, Bereket A, Coker A, Kiper PÖ, Güran T, Ozkan B, Atay Z, Akçay T, Haliloglu B, Boduroglu K, Alanay Y, Turan S.
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| Orphanet J Rare Dis 9:60. doi: 10.1186/1750-1172-9-60.
2014
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7 | CTSK
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| Exome sequencing identifies CTSK mutations in patients originally diagnosed as intermediate osteopetrosis.
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| Pangrazio A, Puddu A, Oppo M, Valentini M, Zammataro L, Vellodi A, Gener B, Llano-Rivas I, Raza J, Atta I, Vezzoni P, Superti-Furga A, Villa A, Sobacchi C.
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| Bone 59:122-6. doi: 10.1016/j.bone.2013.11.014. Epub 2013 Nov 20.
2014
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8 | CTSK
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| Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy.
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| Hua Y, Xu X, Shi GP, Chicco AJ, Ren J, Nair S.
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| Hypertension 61(6):1184-92. doi: 10.1161/HYPERTENSIONAHA.111.00947. Epub 2013 Mar 25.
2013
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9 | CTSK
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| Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation.
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| Lotinun S, Kiviranta R, Matsubara T, Alzate JA, Neff L, Lüth A, Koskivirta I, Kleuser B, Vacher J, Vuorio E, Horne WC, Baron R.
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| J Clin Invest 123(2):666-81. doi: 10.1172/JCI64840. Epub 2013 Jan 16.
2013
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10 | CTSK, MARCKS, PRKCD
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| Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts.
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| Cremasco V, Decker CE, Stumpo D, Blackshear PJ, Nakayama KI, Nakayama K, Lupu TS, Graham DB, Novack DV, Faccio R.
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| J Bone Miner Res 27(12):2452-63. doi: 10.1002/jbmr.1701.
2012
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11 | CTSK, CTSS
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| Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation.
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| Barry ZT, Platt MO.
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| J Biol Chem 287(33):27723-30. doi: 10.1074/jbc.M111.332684. Epub 2012 Jun 22.
2012
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12 | CLU, CTSK
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| Clusterin is a specific stabilizer and liberator of extracellular cathepsin K.
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| Novinec M, Lenarčič B, Baici A.
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| FEBS Lett 586(7):1062-6. doi: 10.1016/j.febslet.2012.03.004. Epub 2012 Mar 10.
2012
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13 | CTSK
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| Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice.
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| Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xia M, Xiong N, Gelb BD, Shi GP.
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| Arterioscler Thromb Vasc Biol 32(1):15-23. doi: 10.1161/ATVBAHA.111.235002. Epub 2011 Aug 4.
2012
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14 | CTSB, CTSK, CTSL, CTSS
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| Cysteine cathepsin S processes leptin, inactivating its biological activity.
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| Oliveira M, Assis DM, Paschoalin T, Miranda A, Ribeiro EB, Juliano MA, Brömme D, Christoffolete MA, Barros NM, Carmona AK.
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| J Endocrinol 214(2):217-24. doi: 10.1530/JOE-12-0108. Epub 2012 May 31.
2012
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15 | CTSK
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| Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions.
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| Cherney MM, Lecaille F, Kienitz M, Nallaseth FS, Li Z, James MN, Brömme D.
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| J Biol Chem 286(11):8988-98. Epub 2010 Dec 30.
2011
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16 | CTSK, SIGLEC15
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| Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation.
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| Hiruma Y, Hirai T, Tsuda E.
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| Biochem Biophys Res Commun 409(3):424-9. Epub 2011 May 8.
2011
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17 | CTSK, CTSL, CTSS
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| Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation.
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| Naour N, Rouault C, Fellahi S, Lavoie ME, Poitou C, Keophiphath M, Eberlé D, Shoelson S, Rizkalla S, Bastard JP, Rabasa-Lhoret R, Clément K, Guerre-Millo M.
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| J Clin Endocrinol Metab 95(4):1861-8. Epub 2010 Feb 17. 2010
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18 | CTSK
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| Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption.
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| Wilson SR, Peters C, Saftig P, Brömme D.
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| J Biol Chem 284(4):2584-92. Epub 2008 Nov 21.
2009
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19 | CTSK, PYCD
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| Cathepsin K: a therapeutic target for bone diseases.
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| Zhao Q, Jia Y, Xiao Y.
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| Biochem Biophys Res Commun 380(4):721-3. Epub 2009 Jan 27. Review.
2009
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20 | CTSK, NFATC1, TNFSF11
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| Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand.
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| Balkan W, Martinez AF, Fernandez I, Rodriguez MA, Pang M, Troen BR.
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| Gene 446(2):90-8. Epub 2009 Jun 27.
2009
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21 | CTSK
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| Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts.
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| Fuller K, Lawrence KM, Ross JL, Grabowska UB, Shiroo M, Samuelsson B, Chambers TJ.
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| Bone 42(1):200-11. Epub 2007 Sep 26.PMID: 17962093 2008
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22 | CTSK
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| Cathepsin K in melanoma invasion.
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| Quintanilla-Dieck MJ, Codriansky K, Keady M, Bhawan J, Rünger TM.
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| J Invest Dermatol 128(9):2281-8. Epub 2008 Mar 27.
2008
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23 | CTSK, PYCD
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| Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence.
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| Chen W, Yang S, Abe Y, Li M, Wang Y, Shao J, Li E, Li YP.
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| Hum Mol Genet 16(4):410-23. Epub 2007 Jan 8. 2007
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24 | CTSK
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| Role of cathepsin K in the turnover of the dermal extracellular matrix during scar formation.
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| Runger TM, Quintanilla-Dieck MJ, Bhawan J.
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| J Invest Dermatol 127(2):293-7. Epub 2006 Aug 31. 2007
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25 | CTSK
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| The regulation of cathepsin K gene expression.
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| Troen BR.
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| Ann N Y Acad Sci 1068:165-72. Review. 2006
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26 | CTSK
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| Human osteoblasts produce cathepsin K.
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| Mandelin J, Hukkanen M, Li TF, Korhonen M, Liljestrom M, Sillat T, Hanemaaijer R, Salo J, Santavirta S, Konttinen YT.
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| Bone 38(6):769-77. Epub 2005 Dec 5. 2006
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27 | NFATC1, TNFSF11, CTSK
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| NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K.
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| Lange AW, Yutzey KE.
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| Dev Biol 292(2):407-17. 2006
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28 | CTSK
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| Cathepsin K mRNA and protein expression in prostate cancer progression.
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| Brubaker KD, Vessella RL, True LD, Thomas R, Corey E.
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| J Bone Miner Res 18(2):222-30. 2003
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29 | CTSK
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| Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation.
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| Hou WS, Li Z, Gordon RE, Chan K, Klein MJ, Levy R, Keysser M, Keyszer G, Bromme D.
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| Am J Pathol 159(6):2167-77. 2001
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30 | CTSK
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| Novel mutations of the cathepsin K gene in patients with pycnodysostosis and their characterization.
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| Fujita Y, Nakata K, Yasui N, Matsui Y, Kataoka E, Hiroshima K, Shiba RI, Ochi T.
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| J Clin Endocrinol Metab 85(1):425-31. 2000
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31 | CTSK, PYCD
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| Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis.
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| Hou WS, et al.
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| J Clin Invest 103(5):731-8. 1999
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32 | CTSB, CTSH, CTSK, CTSL
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| Cathepsin expression during skeletal development.
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| Soderstrom M, et al.
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| Biochim Biophys Acta 1446(1-2):35-46 1999
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33 | CTSK, PYCD
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| Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein.
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| Ho N, Punturieri A, Wilkin D, Szabo J, Johnson M, Whaley J, Davis J, Clark A, Weiss S, Francomano C.
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| J Bone Miner Res 14(10):1649-53 1999
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34 | CTSK
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| Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.
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| Saftig P, et al.
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| Proc Natl Acad Sci U S A 95 : 13453-13458. 1998
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35 | CTSK
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| Genomic organization and chromosome localization of the human cathepsin K gene (CTSK).
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| Rood JA, Van Horn S, Drake FH, Gowen M, Debouck C.
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| Genomics 41 : 169-176. 1997
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36 | CTSK
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| Structure and chromosomal assignment of the human cathepsin K gene.
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| Gelb BD, Shi GP, Heller M, Weremowicz S, Morton C, Desnick RJ, Chapman HA.
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| Genomics 41 : 258-262. 1997
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37 | PYCD, CTSK
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| Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.
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| Gelb BD, Shi GP, Chapman HA, Desnick RJ.
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| Science 273 : 1236-1238. 1996
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38 | CTSK, PYCD
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| A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis.
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| Johnson MR, Polymeropoulos MH, Vos HL, Ortiz de Luna RI, Francomano CA.
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| Genome Res 6 : 1050 -1055. 1996
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39 | CTSK
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| Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution.
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| Bromme D, Okamoto K.
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| Biol Chem Hoppe Seyler 376(6):379-84. 1995
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40 | CTSK
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| Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas.
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| Li YP, Alexander M, Wucherpfennig AL, Yelick P, Chen W, Stashenko P.
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| J Bone Miner Res 10(8):1197-202. 1995
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41 | CTSK
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| Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.
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| Inaoka T, Bilbe G, Ishibashi O, Tezuka K, Kumegawa M, Kokubo T.
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| Biochem Biophys Res Commun 206(1):89-96. 1995
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