| 1 | CTSD, FIGF, KLK3, VEGFC
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| KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D.
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| Jha SK, Rauniyar K, Chronowska E, Mattonet K, Maina EW, Koistinen H, Stenman UH, Alitalo K, Jeltsch M.
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| Elife 8. pii: e44478. doi: 10.7554/eLife.44478.
2019
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| 2 | CTSD
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| Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.
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| Koike M, Shibata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, Tanaka K, Uchiyama Y.
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| Am J Pathol 187(7):1586-1600. doi: 10.1016/j.ajpath.2017.02.020. Epub 2017 May 11.
2017
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| 3 | CTSD, GRN
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| Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
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| Beel S, Moisse M, Damme M, De Muynck L, Robberecht W, Van Den Bosch L, Saftig P, Van Damme P.
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| Hum Mol Genet 26(15):2850-2863. doi: 10.1093/hmg/ddx162.
2017
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| 4 | CLN3, CTSD, PSAP
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| Role of the Lysosomal Membrane Protein, CLN3, in the Regulation of Cathepsin D Activity.
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| Cárcel-Trullols J, Kovács AD, Pearce DA.
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| J Cell Biochem 118(11):3883-3890. doi: 10.1002/jcb.26039. Epub 2017 May 23.
2017
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| 5 | CTSD, GRN
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| Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
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| Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.
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| Hum Mol Genet 26(5):969-988. doi: 10.1093/hmg/ddx011.
2017
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| 6 | CTSD, TNFSF10
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| Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL.
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| Jancekova B, Ondrouskova E, Knopfova L, Smarda J, Benes P.
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| Tumour Biol 37(8):10685-96. doi: 10.1007/s13277-016-4958-5. Epub 2016 Feb 11.
2016
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| 7 | CTSD, NPC1
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| Identification of lysosomal Npc1-binding proteins: Cathepsin D activity is regulated by NPC1.
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| Macías-Vidal J, Guerrero-Hernández M, Estanyol JM, Aguado C, Knecht E, Coll MJ, Bachs O.
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| Proteomics 16(1):150-8. doi: 10.1002/pmic.201500110. Epub 2015 Dec 15.
2016
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| 8 | CTSD, SNCA
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| Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates.
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| Bae EJ, Yang NY, Lee C, Kim S, Lee HJ, Lee SJ.
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| Cell Death Dis 6:e1901. doi: 10.1038/cddis.2015.283.
2015
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| 9 | CTSD
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| Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier.
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| Okada R, Wu Z, Zhu A, Ni J, Zhang J, Yoshimine Y, Peters C, Saftig P, Nakanishi H.
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| Mol Cell Neurosci 64:51-60. doi: 10.1016/j.mcn.2014.12.002. Epub 2014 Dec 10.
2015
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| 10 | CTSB, CTSD, SNCA
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| Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells.
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| Crabtree D, Dodson M, Ouyang X, Boyer-Guittaut M, Liang Q, Ballestas ME, Fineberg N, Zhang J.
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| J Neurochem 128(6):950-61. doi: 10.1111/jnc.12497. Epub 2013 Nov 13.
2014
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| 11 | CTSD, MREG
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| Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium.
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| Frost LS, Lopes VS, Stefano FP, Bragin A, Williams DS, Mitchell CH, Boesze-Battaglia K.
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| Vis Neurosci 30(3):55-64. doi: 10.1017/S0952523813000096.
2013
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| 12 | CTSD
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| Cathepsin D levels are reduced in patients with preeclampsia in Korean population.
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| Kim HY, Lee M, Kang HW, Moon C.
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| Clin Biochem 46(18):1808-11. doi: 10.1016/j.clinbiochem.2013.07.022. Epub 2013 Aug 15.
2013
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| 13 | CTSD
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| Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium.
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| Pruitt FL, He Y, Franco OE, Jiang M, Cates JM, Hayward SW.
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| Prostate 73(5):476-88. doi: 10.1002/pros.22589. Epub 2012 Sep 19.
2013
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| 14 | CTSD, LRP1
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| Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis.
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| Derocq D, Prébois C, Beaujouin M, Laurent-Matha V, Pattingre S, Smith GK, Liaudet-Coopman E.
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| Oncogene 31(26):3202-12. doi: 10.1038/onc.2011.501. Epub 2011 Nov 14.
2012
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| 15 | CTSD
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| Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells.
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| Hah YS, Noh HS, Ha JH, Ahn JS, Hahm JR, Cho HY, Kim DR.
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| Cancer Lett 323(2):208-14. doi: 10.1016/j.canlet.2012.04.012. Epub 2012 Apr 24.
2012
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| 16 | CLN10, CTSD
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| Therapeutic Approaches to the Challenge of Neuronal Ceroid Lipofuscinoses.
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| Kohan R, Cismondi IA, Oller-Ramirez AM, Guelbert N, Anzolini TV, Alonso G, Mole SE, de Kremer DR, de Halac NI.
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| Curr Pharm Biotechnol urr Pharm Biotechnol. 2011 Jan 11. [Epub ahead of print]
2011
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| 17 | CST3, CTSD
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| Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells.
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| Martino S, Tiribuzi R, Ciraci E, Makrypidi G, D'Angelo F, di Girolamo I, Gritti A, de Angelis GM, Papaccio G, Sampaolesi M, Berardi AC, Datti A, Orlacchio A.
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| Int J Biochem Cell Biol 43(5):775-83. Epub 2011 Feb 17.
2011
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| 18 | CTSD
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| CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.
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| Shevtsova Z, Garrido M, Weishaupt J, Saftig P, Bähr M, Lühder F, Kügler S.
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| Am J Pathol 177(1):271-9. Epub 2010 May 20.
2010
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| 19 | CTSD
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| The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men.
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| Albayrak O, Tirniceriu A, Riemenschneider M, Kurz A, Scherag A, Egensperger R.
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| J Gerontol A Biol Sci Med Sci 65(3):219-24. Epub 2010 Jan 18.
2010
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| 20 | CTSD
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| Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins.
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| Grimm S, Ernst L, Grötzinger N, Höhn A, Breusing N, Reinheckel T, Grune T.
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| Free Radic Res 44(9):1013-26.
2010
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| 21 | CTSD
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| Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects.
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| Sheikh AM, Li X, Wen G, Tauqeer Z, Brown WT, Malik M.
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| Neuroscience 165(2):363-70. Epub .
2010
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| 22 | CTSD
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| Cathepsin D gene and the risk of Alzheimer's disease: A population-based study and meta-analysis.
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| Schuur M, Ikram MA, van Swieten JC, Isaacs A, Vergeer-Drop JM, Hofman A, Oostra BA, Breteler MM, van Duijn CM.
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| Neurobiol Aging eurobiol Aging. 2009 Nov 18. [Epub ahead of print]
2009
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| 23 | CTSD
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| Activation of cathepsin D by glycosaminoglycans.
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| Beckman M, Freeman C, Parish CR, Small DH.
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| FEBS J 276(24):7343-52. Epub .
2009
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| 24 | CTSD
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| Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence.
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| Byun HO, Han NK, Lee HJ, Kim KB, Ko YG, Yoon G, Lee YS, Hong SI, Lee JS.
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| Cancer Res 69(11):4638-47.
2009
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| 25 | CTSD, CTSH, SORT1
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| Sortilin mediates the lysosomal targeting of cathepsins D and H.
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| Canuel M, Korkidakis A, Konnyu K, Morales CR.
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| Biochem Biophys Res Commun 373(2):292-7. Epub 2008 Jun 16.
2008
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| 26 | CTSD
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| E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements.
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| Bretschneider N, Kangaspeska S, Seifert M, Reid G, Gannon F, Denger S.
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| Mol Oncol 2(2):182-90. Epub 2008 May 29.
2008
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| 27 | CTSD
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| Immunohistochemical study of cathepsin D in the spinal cords of rats with clip compression injury.
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| Moon C, Lee TK, Kim H, Ahn M, Lee Y, Kim MD, Sim KB, Shin T.
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| J Vet Med Sci 70(9):937-41.
2008
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| 28 | CTSD
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| Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.
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| Sevlever D, Jiang P, Yen SH.
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| Biochemistry 47(36):9678-87. Epub 2008 Aug 15.
2008
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| 29 | STAT3, CTSD, PRL
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| A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy.
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| Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H.
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| Cell 128(3):589-600. 2007
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| 30 | CTSD, CLN10
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| Cathepsin d deficiency is associated with a human neurodegenerative disorder.
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| Steinfeld R, Reinhardt K, Schreiber K, Hillebrand M, Kraetzner R, Bruck W, Saftig P, Gartner J.
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| Am J Hum Genet 78(6):988-98. Epub 2006 Mar 29. 2006
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| 31 | CTSD, CLN10
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| Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.
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| Siintola E, Partanen S, Stršmme P, Haapanen A, Haltia M, Maehlen J, Lehesjoki AE, TyynelŠ J.
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| Brain 129(Pt 6):1438-45. Epub 2006 May 2. 2006
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| 32 | CTSD
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| Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux.
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| Haidar B, Kiss RS, Sarov-Blat L, Brunet R, Harder C, McPherson R, Marcel YL.
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| J Biol Chem 281(52):39971-81. Epub 2006 Oct 10. 2006
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| 33 | CTSD, PRL
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| Cathepsin D processes human prolactin into multiple 16K-like N-terminal fragments: study of their antiangiogenic properties and physiological relevance.
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| Piwnica D, Touraine P, Struman I, Tabruyn S, Bolbach G, Clapp C, Martial JA, Kelly PA, Goffin V.
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| Mol Endocrinol 18(10):2522-42. Epub 2004 Jun 10. 2004
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| 34 | CTSD
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| Non-replication of association between cathepsin D genotype and late onset Alzheimer disease.
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| Menzer G, Muller-Thomsen T, Meins W, Alberici A, Binetti G, Hock C, Nitsch RM, Stoppe G, Reiss J, Finckh U.
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| Am J Med Genet 105(2):179-82. 2001
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| 35 | CTSD
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| A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.
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| Papassotiropoulos A, Bagli M, Kurz A, Kornhuber J, Forstl H, Maier W, Pauls J, Lautenschlager N, Heun R.
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| Ann Neurol 47(3):399-403. 2000
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| 36 | CTSD
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| Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus.
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| Bi X, Haque TS, Zhou J, Skillman AG, Lin B, Lee CE, Kuntz ID, Ellman JA, Lynch G.
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| J Neurochem 74(4):1469-77. 2000
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| 37 | CTSD
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| The genetic association between Cathepsin D and Alzheimer's disease.
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| Crawford FC, Freeman MJ, Schinka J, Abdullah LI, Richards D, Sevush S, Duara R, Mullan MJ.
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| Neurosci Lett 289(1):61-5. 2000
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| 38 | CTSD
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| Cloning of a major human retinal pigment epithelial lysosomal aspartic protease and mapping its transcriptional start sites.
|
| Cavaney-Brooker DM, et al.
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| Curr Eye Res 18(4):310-8. 1999
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| 39 | CTSD
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| Cathepsin D targeted by acid sphingomyelinase-derived ceramide.
|
| Heinrich M, et al.
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| EMBO J 18(19):5252-5263 1999
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| 40 | CTSD
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| Cathepsin D gene exon 2 polymorphism and sporadic Alzheimer's disease.
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| McIlroy SP, Dynan KB, McGleenon BM, Lawson JT, Passmore AP.
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| Neurosci Lett 273(2):140-1 1999
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| 41 | CTSD
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| Distribution of cathepsin D in human eyes with or without age-related maculopathy.
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| Rakoczy PE, Sarks SH, Daw N, Constable IJ.
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| Exp Eye Res 69(4):367-74 1999
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| 42 | CTSD
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| Isoforms of cathepsin D and human epidermal differentiation.
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| Horikoshi T, Arany I, Rajaraman S, Chen SH, Brysk H, Lei G, Tyring SK, Brysk MM.
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| Biochimie 80 : 605-612. 1998
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| 43 | CTSD, DAP, DAP3, DAPK1, EIF4G2
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| Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions.
|
| Levy-Strumpf N, et al.
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| Oncogene 17(25):3331-40. Review. 1998
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| 44 | CTSB, CTSD
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| Partial deficiency of cathepsins B and H in two human fibroblast cell lines with chromosome 11 abnormalities.
|
| Murnane MJ, et al.
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| Genetics 110 : s35. 1985
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| 45 | CTSD
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| Assignment of a gene for human cathepsin D to chromosome 11.
|
| Hasilik A, et al.
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| Cytogenet Cell Genet 32 : 284. 1982
|