1 | CTLA4, HAVCR2, LAG3, PDCD1
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| Inhibitory immune checkpoint molecules and exhaustion of T cells in COVID-19. . 2021. PMID:
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| Barnova M, Bobcakova A, Urdova V, Kosturiak R, Kapustova L, Dobrota D, Jesenak M.
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| Physiol Res Dec 16;70(S2):S227-S247. doi: 10.33549/physiolres.934757 2021
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2 | CTLA4, RGMB
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| RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4.
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| Sekiya T, Takaki S.
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| Sci Rep. May 6;9(1):6984. doi: 10.1038/s41598-019-43068-y. 2019
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3 | CTLA4, ID3
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| Aberrant expressions of endometrial Id3 and CTLA-4 are associated with unexplained repeated implantation failure and recurrent miscarriage.
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| Ding JL, Diao LH, Yin TL, Huang CY, Yin B, Chen C, Zhang Y, Li J, Cheng YX, Zeng Y, Yang J.
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| Am J Reprod Immunol 78(2). doi: 10.1111/aji.12632. Epub 2017 Feb 21.
2017
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4 | CTLA4
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| CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.
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| Verhagen J, Genolet R, Britton GJ, Stevenson BJ, Sabatos-Peyton CA, Dyson J, Luescher IF, Wraith DC.
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| Proc Natl Acad Sci U S A 110(3):E221-30. doi: 10.1073/pnas.1208573110. Epub 2012 Dec 24.
2013
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5 | CTLA4
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| Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
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| Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM.
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| Science. 332(6029):600-3. 2011
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6 | CTLA4, ICOSLG
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| B7-h2 is a costimulatory ligand for CD28 in human.
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| Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L.
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| Immunity 34(5):729-40. doi: 10.1016/j.immuni.2011.03.014.
2011
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7 | CTLA4
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| Evidence for CTLA4 as a susceptibility gene for dilated cardiomyopathy.
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| Ruppert V, Meyer T, Struwe C, Petersen J, Perrot A, Posch MG, Ozcelik C, Richter A, Maisch B, Pankuweit S; German Heart Failure Network.
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| Eur J Hum Genet 18(6):694-9. Epub 2010 Feb 10.PMID: 20145677 2010
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8 | CTLA4, PTPN22
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| Meta-analysis of genome-wide linkage studies across autoimmune diseases.
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| Forabosco P, Bouzigon E, Ng MY, Hermanowski J, Fisher SA, Criswell LA, Lewis CM.
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| Eur J Hum Genet 17(2):236-43. Epub 2008 Sep 10.
2009
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9 | CTLA4, PPP2R4
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| Structure-Function analysis of the CTLA-4 interaction with PP2A.
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| Teft WA, Chau TA, Madrenas J.
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| BMC Immunol 10:23.PMID: 19405949 2009
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10 | CLEC16A, CTLA4, IFIH1, IL2RA, INS, MODY10, PTPN2, PTPN22
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| The molecular genetics of type 1 diabetes: new genes and emerging mechanisms.
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| Ounissi-Benkalha H, Polychronakos C.
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| Trends Mol Med 14(6):268-75. Epub 2008 May 14. 2008
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11 | CTLA4
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| Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis.
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| Gu M, Kakoulidou M, Giscombe R, Pirskanen R, Lefvert AK, Klareskog L, Wang X.
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| Clin Immunol 128(3):374-81. Epub 2008 Jul 2.
2008
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12 | CTLA4, VKH
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| Association of the CTLA-4 gene with Vogt-Koyanagi-Harada syndrome.
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| Du L, Yang P, Hou S, Lin X, Zhou H, Huang X, Wang L, Kijlstra A.
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| Clin Immunol 127(1):43-8. Epub 2008 Feb 20.
2008
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13 | CTLA4
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| CTLA-4 control over Foxp3+ regulatory T cell function.
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| Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S.
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| Science. 322(5899):271-5. 2008
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14 | CD28, CTLA4, ICOS
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| Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.
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| Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D.
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| Proc Natl Acad Sci U S A 104(2):570-5. Epub 2006 Dec 29. 2007
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15 | CTLA4
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| Allelic variant in CTLA4 alters T cell phosphorylation patterns.
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| Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA.
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| Proc Natl Acad Sci U S A 104(47):18607-12. Epub 2007 Nov 13. 2007
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16 | CTLA4, CD28
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| Expression of CD28 and cytotoxic T lymphocyte antigen 4 at the maternal-fetal interface in women with unexplained pregnancy loss.
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| Wang X, Ma Z, Hong Y, Lu P, Lin Q.
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| Int J Gynaecol Obstet 93(2):123-9. Epub 2006 Mar 6. 2006
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17 | CTLA4, TCIRG1
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| TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.
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| Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Wälter S, Sabat R, Schülein R, Wiesner B, Veh RW, Löhler J, Blumberg RS, Volk HD, Utku N.
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| J Immunol 177(10):6833-41.
2006
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18 | CTLA4
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| CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription.
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| Srahna M, Van Grunsven LA, Remacle JE, Vandenberghe P.
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| Immunology. 117(3):396-401. 2006
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19 | CTLA4
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| Association of the CTLA-4 gene with rheumatoid arthritis in Chinese Han population.
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| Lei C, Dongqing Z, Yeqing S, Oaks MK, Lishan C, Jianzhong J, Jie Q, Fang D, Ningli L, Xinghai H, Daming R.
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| Eur J Hum Genet 13(7):823-8. 2005
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20 | PTPN22, CTLA4, PADI4
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| Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
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| Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, Wolfe F, Kastner DL, Alfredsson L, Altshuler D, Gregersen PK, Klareskog L, Rioux JD.
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| Am J Hum Genet 77(6):1044-60. Epub 2005 Nov 1. 2005
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21 | CD28, CTLA4, ICOS
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| Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma.
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| Piras G, Monne M, Uras A, Palmas A, Murineddu M, Arru L, Bianchi A, Calvisi A, Curreli L, Gaviano E, Lai P, Murgia A, Latte GC, Noli A, Gabbas A.
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| Br J Haematol 129(6):784-90. 2005
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22 | CTLA4
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| Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.
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| Barreto M, Santos E, Ferreira R, Fesel C, Fontes MF, Pereira C, Martins B, Andreia R, Viana JF, Crespo F, Vasconcelos C, Ferreira C, Vicente AM.
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| Eur J Hum Genet 12(8):620-6. 2004
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23 | CTLA4, HLA-DQA1, HLA-DQB1
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| Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.
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| Rioux JD, Karinen H, Kocher K, McMahon SG, Karkkainen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamaki J, Naukkarinen A, Kosma VM, Daly MJ, Lander ES, Laakso M.
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| Am J Med Genet 130A(4):345-50. 2004
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24 | CTLA4
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| Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism.
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| Bilinska M, Frydecka I, Noga L, Dobosz T, Zoledziewska M, Suwalska K, Tutak A, Pokryszko-Dragan A.
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| Acta Neurol Scand 110(1):67-71. 2004
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25 | CTLA4
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| Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease.
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| Blomhoff A, Lie BA, Myhre AG, Kemp EH, Weetman AP, Akselsen HE, Huseby ES, Undlien DE.
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| J Clin Endocrinol Metab 89(7):3474-6. 2004
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26 | CTLA4
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| High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.
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| Huxley P, Sutton DH, Debnam P, Matthews IR, Brewer JE, Rose J, Trickett M, Williams DD, Andersen TB, Classon BJ.
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| Chem Biol. 11(12):1651-8. 2004
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27 | CTLA4, GD5S
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| The CTLA4 region as a general autoimmunity factor: An extended pedigree provides evidence for synergy with the HLA locus in the etiology of type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' disease.
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| Einarsdottir E, Soderstrom I, Lofgren-Burstrom A, Haraldsson S, Nilsson-Ardnor S, Penha-Goncalves C, Lind L, Holmgren G, Holmberg M, Asplund K, Holmberg D.
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| Eur J Hum Genet 11(1):81-4. 2003
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28 | CTLA4, GD5S
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| Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
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| Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC.
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| Nature 423(6939):506-11. 2003
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29 | AITD1, AITD2, AITD3, AITD4, CTLA4, GD1S, GD2S, GD4S, GDSX, GDSX2, HTD1, HTD2, TG
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| Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families.
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| Tomer Y, Ban Y, Concepcion E, Barbesino G, Villanueva R, Greenberg DA, Davies TF.
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| Am J Hum Genet 73(4):736-47. Epub 2003 Sep 12. 2003
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30 | CTLA4
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| CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
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| Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA.
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| Nat Immunol. 4(2):182-8. 2003
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31 | CD28, CTLA4
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| CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families.
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| King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ellis HJ, Ciclitira PJ.
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| J Med Genet 39(1):51-4. No abstract available. 2002
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32 | CD28, CTLA4
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| Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease.
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| Popat S, Hearle N, Hogberg L, Braegger CP, O'Donoghue D, Falth-Magnusson K, Holmes GK, Howdle PD, Jenkins H, Johnston S, Kennedy NP, Kumar PJ, Logan RF, Marsh MN, Mulder CJ, Torinsson Naluai A, Sjoberg K, Stenhammar L, Walters JR, Jewell DP, Houlston RS.
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| Ann Hum Genet 66(Pt 2):125-37. 2002
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33 | CTLA4
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| Association of the CTLA4 3' untranslated region polymorphism with the susceptibility to rheumatoid arthritis.
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| Rodriguez MR, Nunez-Roldan A, Aguilar F, Valenzuela A, Garcia A, Gonzalez-Escribano MF.
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| Hum Immunol 63(1):76-81. 2002
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34 | CTLA4
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| Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A.
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| Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK.
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| J Immunol. 168(10):5070-8. 2002
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35 | CD86, CTLA4
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| Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
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| Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC.
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| Nature 410(6828):604-608. 2001
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36 | CD28, CTLA4, ICOS
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| Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.
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| Ling V, Wu PW, Finnerty HF, Agostino MJ, Graham JR, Chen S, Jussiff JM, Fisk GJ, Miller CP, Collins M.
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| Genomics 78(3):155-68. 2001
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37 | CTLA4
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| CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.
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| Hadj Kacem H, Bellassoued M, Bougacha-Elleuch N, Abid M, Ayadi H.
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| Clin Immunol 101(3):361-5. 2001
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38 | CTLA4
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| Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28.
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| Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, Rowsell S, Stacey CL, Stanway JJ, Taylor IW, Abbott WM.
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| Biochem J. 359(Pt 2):427-34. 2001
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39 | CTLA4
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| Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice.
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| Gozalo-Sanmillan S, McNally JM, Lin MY, Chambers CA, Berg LJ.
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| J Immunol. 166(2):727-30. 2001
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40 | ABI2, AOX1, BMPR2, CASP10, CASP8, CD28, CFLAR, CLK1, CTLA4, DAZAP2, MAGI2, ORC2, PPH1, PSMA2, SATB2, SUMO1, TRAK2
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| A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension.
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| Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC.
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| Genomics 68(2):220-8. 2000
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41 | CTLA4
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| CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis.
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| Agarwal K, Jones DE, Daly AK, James OF, Vaidya B, Pearce S, Bassendine MF.
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| J Hepatol 32(4):538-41. 2000
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42 | CD28, CTLA4
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| Common polymorphisms in the CTLA-4 and CD28 genes at 2q33 are not associated with asthma or atopy.
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| Heinzmann A, Plesnar C, Kuehr J, Forster J, Deichmann KA.
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| Eur J Immunogenet 27(2):57-61. 2000
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43 | CD28, CDIG3, CTLA4
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| The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders.
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| Naluai AT, Nilsson S, Samuelsson L, Gudjonsdottir AH, Ascher H, Ek J, Hallberg B, Kristiansson B, Martinsson T, Nerman O, Sollid LM, Wahlstrom J.
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| Tissue Antigens 56(4):350-5. 2000
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44 | CTLA4, JAK2
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| Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.
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| Chikuma S, Murakami M, Tanaka K, Uede T.
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| J Cell Biochem. 78(2):241-50. 2000
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45 | CTLA4
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| Analysis of a microsatellite polymorphism of the cytotoxic T-lymphocyte antigen-4 gene in patients with vitiligo.
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| Kemp EH, et al.
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| Br J Dermatol 140(1):73-78. 1999
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46 | CTLA4, GD4S
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| The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus.
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| Vaidya B, et al.
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| Hum Mol Genet 8(7):1195-1199. 1999
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47 | CD28, CDIG3, CTLA4
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| CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family-based association study.
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| Holopainen P, et al.
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| Tissue Antigens 53(5):470-5. 1999
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48 | CTLA4
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| Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy.
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| Vaidya B, et al.
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| Lancet 354(9180):743-4. 1999
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49 | CTLA4
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| The CTLA-4 gene is associated with multiple sclerosis.
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| Ligers A, et al.
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| J Neuroimmunol 97(1-2):182-90. 1999
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50 | CTLA4, GD5S
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| The development of Graves' disease and the CTLA-4 gene on chromosome 2q33.
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| Heward JM, et al.
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| J Clin Endocrinol Metab 84(7):2398-401 1999
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51 | CTLA4
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| Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.
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| Ling V, et al.
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| Genomics 60(3):341-55 1999
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52 | CTLA4, GD5S
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| CTLA-4 gene polymorphism may modulate disease in Japanese multiple sclerosis patients.
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| Fukazawa T, Yanagawa T, Kikuchi S, Yabe I, Sasaki H, Hamada T, Miyasaka K, Gomi K, Tashiro K.
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| J Neurol Sci 171(1):49-55. 1999
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53 | CTLA4
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| Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).
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| Miyatake S, Nakaseko C, Umemori H, Yamamoto T, Saito T.
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| Biochem Biophys Res Commun. 249(2):444-8. 1998
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54 | CTLA4, IDDM12
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| Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups.
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| Marron MP, Raffel LJ, Garchon HJ, Jacob CO, Serrano-Rios M, Martinez Larrad MT, Teng WP, Park Y, Zhang ZX, Goldstein DR, Tao YW, Beaurain G, Bach JF, Huang HS, Luo DF, Zeidler A, Rotter JI, Yang MC, Modilevsky T, Maclaren NK, She JX.
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| Hum Mol Genet 6(8):1275-82. 1997
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55 | AP2M1, CTLA4
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| Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein.
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| Zhang Y, Allison JP.
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| Proc Natl Acad Sci U S A 94(17):9273-8. 1997
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56 | AP2M1, CTLA4
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| Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
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| Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB.
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| J Immunol 159(1):144-51. 1997
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57 | IDDM12, CTLA4
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| The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes.
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| Nistico L, et al.
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| Hum Mol Genet 5 : 1075-1080. 1996
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58 | CD28, CTLA4
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| CTLA-4 ligation blocks CD28-dependent T cell activation.
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| Walunas TL, et al.
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| J Exp Med 183(6):2541-50. 1996
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59 | CTLA4
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| Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.
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| Marengère LE, Waterhouse P, Duncan GS, Mittrücker HW, Feng GS, Mak TW.
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| Science. 272(5265):1170-3. 1996
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60 | CTLA4
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| CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.
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| Schneider H, Prasad KV, Shoelson SE, Rudd CE.
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| J Exp Med. 181(1):351-5. 1995
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61 | CTLA4
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| Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
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| Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW.
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| Science. 270(5238):985-8. 1995
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62 | CTLA4
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| Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.
|
| Chen C, Gault A, Shen L, Nabavi N.
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| J Immunol. 152(10):4929-36. 1994
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63 | CTLA4, CD28
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| Molecular linkage of the human CTLA4 and CD28 Ig-superfamily genes in yeast artificial chromosomes.
|
| Buonavista N, et al.
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| Genomics 13 : 856-861. 1992
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64 | CTLA4
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| Dinucleotide repeat polymorphism at the human CTLA4 gene.
|
| Polymeropoulos MH, et al.
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| Nucleic Acids Res 19 : 4018. 1991
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65 | CD28, CTLA4
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| CTLA-4 and CD2S activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
|
| Harper K, et al.
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| J Immunol 147 : 1037-1044. 1991
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66 | CD80, CD86, CTLA4
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| CTLA-4 is a second receptor for the B cell activation antigen B7.
|
| Linsley PS, et al.
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| J Exp Med 174(3):561-9. 1991
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67 | CD28, CTLA4
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| Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34.
|
| Lafage-Pochitaloff M, et al.
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| Immunogenetics 31 : 198-201. 1990
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68 | GZMB, CTLA4
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| Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes.
|
| Klein JL, et al.
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| Genomics 5 : 110-117. 1989
|
69 | CTLA4
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| Human Ig superfamily CTLA-4 gene localization and organization.
|
| Dariavach P, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 983. 1989
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70 | CTLA4
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| Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains.
|
| Dariavach P, Mattei MG, Golstein P, Lefranc MP.
|
| Eur J Immunol 18 : 1901-1905. 1988
|
71 | CTLA4
|
| A new member of the immunoglobulin superfamily : CTLA-4.
|
| Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG, Golstein P.
|
| Nature 328 : 267-270. 1987
|