Citations for
1CTLA4, HAVCR2, LAG3, PDCD1
Inhibitory immune checkpoint molecules and exhaustion of T cells in COVID-19. . 2021. PMID:
Barnova M, Bobcakova A, Urdova V, Kosturiak R, Kapustova L, Dobrota D, Jesenak M.
Physiol Res Dec 16;70(S2):S227-S247. doi: 10.33549/physiolres.934757 2021
2CTLA4, RGMB
RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4.
Sekiya T, Takaki S.
Sci Rep. May 6;9(1):6984. doi: 10.1038/s41598-019-43068-y. 2019
3CTLA4, ID3
Aberrant expressions of endometrial Id3 and CTLA-4 are associated with unexplained repeated implantation failure and recurrent miscarriage.
Ding JL, Diao LH, Yin TL, Huang CY, Yin B, Chen C, Zhang Y, Li J, Cheng YX, Zeng Y, Yang J.
Am J Reprod Immunol 78(2). doi: 10.1111/aji.12632. Epub 2017 Feb 21. 2017
4CTLA4
CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.
Verhagen J, Genolet R, Britton GJ, Stevenson BJ, Sabatos-Peyton CA, Dyson J, Luescher IF, Wraith DC.
Proc Natl Acad Sci U S A 110(3):E221-30. doi: 10.1073/pnas.1208573110. Epub 2012 Dec 24. 2013
5CTLA4
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM.
Science. 332(6029):600-3. 2011
6CTLA4, ICOSLG
B7-h2 is a costimulatory ligand for CD28 in human.
Yao S, Zhu Y, Zhu G, Augustine M, Zheng L, Goode DJ, Broadwater M, Ruff W, Flies S, Xu H, Flies D, Luo L, Wang S, Chen L.
Immunity 34(5):729-40. doi: 10.1016/j.immuni.2011.03.014. 2011
7CTLA4
Evidence for CTLA4 as a susceptibility gene for dilated cardiomyopathy.
Ruppert V, Meyer T, Struwe C, Petersen J, Perrot A, Posch MG, Ozcelik C, Richter A, Maisch B, Pankuweit S; German Heart Failure Network.
Eur J Hum Genet 18(6):694-9. Epub 2010 Feb 10.PMID: 20145677 2010
8CTLA4, PTPN22
Meta-analysis of genome-wide linkage studies across autoimmune diseases.
Forabosco P, Bouzigon E, Ng MY, Hermanowski J, Fisher SA, Criswell LA, Lewis CM.
Eur J Hum Genet 17(2):236-43. Epub 2008 Sep 10. 2009
9CTLA4, PPP2R4
Structure-Function analysis of the CTLA-4 interaction with PP2A.
Teft WA, Chau TA, Madrenas J.
BMC Immunol 10:23.PMID: 19405949 2009
10CLEC16A, CTLA4, IFIH1, IL2RA, INS, MODY10, PTPN2, PTPN22
The molecular genetics of type 1 diabetes: new genes and emerging mechanisms.
Ounissi-Benkalha H, Polychronakos C.
Trends Mol Med 14(6):268-75. Epub 2008 May 14. 2008
11CTLA4
Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis.
Gu M, Kakoulidou M, Giscombe R, Pirskanen R, Lefvert AK, Klareskog L, Wang X.
Clin Immunol 128(3):374-81. Epub 2008 Jul 2. 2008
12CTLA4, VKH
Association of the CTLA-4 gene with Vogt-Koyanagi-Harada syndrome.
Du L, Yang P, Hou S, Lin X, Zhou H, Huang X, Wang L, Kijlstra A.
Clin Immunol 127(1):43-8. Epub 2008 Feb 20. 2008
13CTLA4
CTLA-4 control over Foxp3+ regulatory T cell function.
Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S.
Science. 322(5899):271-5. 2008
14CD28, CTLA4, ICOS
Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.
Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D.
Proc Natl Acad Sci U S A 104(2):570-5. Epub 2006 Dec 29. 2007
15CTLA4
Allelic variant in CTLA4 alters T cell phosphorylation patterns.
Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA.
Proc Natl Acad Sci U S A 104(47):18607-12. Epub 2007 Nov 13. 2007
16CTLA4, CD28
Expression of CD28 and cytotoxic T lymphocyte antigen 4 at the maternal-fetal interface in women with unexplained pregnancy loss.
Wang X, Ma Z, Hong Y, Lu P, Lin Q.
Int J Gynaecol Obstet 93(2):123-9. Epub 2006 Mar 6. 2006
17CTLA4, TCIRG1
TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.
Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Wälter S, Sabat R, Schülein R, Wiesner B, Veh RW, Löhler J, Blumberg RS, Volk HD, Utku N.
J Immunol 177(10):6833-41. 2006
18CTLA4
CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription.
Srahna M, Van Grunsven LA, Remacle JE, Vandenberghe P.
Immunology. 117(3):396-401. 2006
19CTLA4
Association of the CTLA-4 gene with rheumatoid arthritis in Chinese Han population.
Lei C, Dongqing Z, Yeqing S, Oaks MK, Lishan C, Jianzhong J, Jie Q, Fang D, Ningli L, Xinghai H, Daming R.
Eur J Hum Genet 13(7):823-8. 2005
20PTPN22, CTLA4, PADI4
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, Wolfe F, Kastner DL, Alfredsson L, Altshuler D, Gregersen PK, Klareskog L, Rioux JD.
Am J Hum Genet 77(6):1044-60. Epub 2005 Nov 1. 2005
21CD28, CTLA4, ICOS
Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma.
Piras G, Monne M, Uras A, Palmas A, Murineddu M, Arru L, Bianchi A, Calvisi A, Curreli L, Gaviano E, Lai P, Murgia A, Latte GC, Noli A, Gabbas A.
Br J Haematol 129(6):784-90. 2005
22CTLA4
Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.
Barreto M, Santos E, Ferreira R, Fesel C, Fontes MF, Pereira C, Martins B, Andreia R, Viana JF, Crespo F, Vasconcelos C, Ferreira C, Vicente AM.
Eur J Hum Genet 12(8):620-6. 2004
23CTLA4, HLA-DQA1, HLA-DQB1
Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci.
Rioux JD, Karinen H, Kocher K, McMahon SG, Karkkainen P, Janatuinen E, Heikkinen M, Julkunen R, Pihlajamaki J, Naukkarinen A, Kosma VM, Daly MJ, Lander ES, Laakso M.
Am J Med Genet 130A(4):345-50. 2004
24CTLA4
Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism.
Bilinska M, Frydecka I, Noga L, Dobosz T, Zoledziewska M, Suwalska K, Tutak A, Pokryszko-Dragan A.
Acta Neurol Scand 110(1):67-71. 2004
25CTLA4
Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease.
Blomhoff A, Lie BA, Myhre AG, Kemp EH, Weetman AP, Akselsen HE, Huseby ES, Undlien DE.
J Clin Endocrinol Metab 89(7):3474-6. 2004
26CTLA4
High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.
Huxley P, Sutton DH, Debnam P, Matthews IR, Brewer JE, Rose J, Trickett M, Williams DD, Andersen TB, Classon BJ.
Chem Biol. 11(12):1651-8. 2004
27CTLA4, GD5S
The CTLA4 region as a general autoimmunity factor: An extended pedigree provides evidence for synergy with the HLA locus in the etiology of type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' disease.
Einarsdottir E, Soderstrom I, Lofgren-Burstrom A, Haraldsson S, Nilsson-Ardnor S, Penha-Goncalves C, Lind L, Holmgren G, Holmberg M, Asplund K, Holmberg D.
Eur J Hum Genet 11(1):81-4. 2003
28CTLA4, GD5S
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC.
Nature 423(6939):506-11. 2003
29AITD1, AITD2, AITD3, AITD4, CTLA4, GD1S, GD2S, GD4S, GDSX, GDSX2, HTD1, HTD2, TG
Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families.
Tomer Y, Ban Y, Concepcion E, Barbesino G, Villanueva R, Greenberg DA, Davies TF.
Am J Hum Genet 73(4):736-47. Epub 2003 Sep 12. 2003
30CTLA4
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA.
Nat Immunol. 4(2):182-8. 2003
31CD28, CTLA4
CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families.
King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ellis HJ, Ciclitira PJ.
J Med Genet 39(1):51-4. No abstract available. 2002
32CD28, CTLA4
Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease.
Popat S, Hearle N, Hogberg L, Braegger CP, O'Donoghue D, Falth-Magnusson K, Holmes GK, Howdle PD, Jenkins H, Johnston S, Kennedy NP, Kumar PJ, Logan RF, Marsh MN, Mulder CJ, Torinsson Naluai A, Sjoberg K, Stenhammar L, Walters JR, Jewell DP, Houlston RS.
Ann Hum Genet 66(Pt 2):125-37. 2002
33CTLA4
Association of the CTLA4 3' untranslated region polymorphism with the susceptibility to rheumatoid arthritis.
Rodriguez MR, Nunez-Roldan A, Aguilar F, Valenzuela A, Garcia A, Gonzalez-Escribano MF.
Hum Immunol 63(1):76-81. 2002
34CTLA4
Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A.
Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK.
J Immunol. 168(10):5070-8. 2002
35CD86, CTLA4
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC.
Nature 410(6828):604-608. 2001
36CD28, CTLA4, ICOS
Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.
Ling V, Wu PW, Finnerty HF, Agostino MJ, Graham JR, Chen S, Jussiff JM, Fisk GJ, Miller CP, Collins M.
Genomics 78(3):155-68. 2001
37CTLA4
CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.
Hadj Kacem H, Bellassoued M, Bougacha-Elleuch N, Abid M, Ayadi H.
Clin Immunol 101(3):361-5. 2001
38CTLA4
Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28.
Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, Rowsell S, Stacey CL, Stanway JJ, Taylor IW, Abbott WM.
Biochem J. 359(Pt 2):427-34. 2001
39CTLA4
Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice.
Gozalo-Sanmillan S, McNally JM, Lin MY, Chambers CA, Berg LJ.
J Immunol. 166(2):727-30. 2001
40ABI2, AOX1, BMPR2, CASP10, CASP8, CD28, CFLAR, CLK1, CTLA4, DAZAP2, MAGI2, ORC2, PPH1, PSMA2, SATB2, SUMO1, TRAK2
A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension.
Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC.
Genomics 68(2):220-8. 2000
41CTLA4
CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis.
Agarwal K, Jones DE, Daly AK, James OF, Vaidya B, Pearce S, Bassendine MF.
J Hepatol 32(4):538-41. 2000
42CD28, CTLA4
Common polymorphisms in the CTLA-4 and CD28 genes at 2q33 are not associated with asthma or atopy.
Heinzmann A, Plesnar C, Kuehr J, Forster J, Deichmann KA.
Eur J Immunogenet 27(2):57-61. 2000
43CD28, CDIG3, CTLA4
The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders.
Naluai AT, Nilsson S, Samuelsson L, Gudjonsdottir AH, Ascher H, Ek J, Hallberg B, Kristiansson B, Martinsson T, Nerman O, Sollid LM, Wahlstrom J.
Tissue Antigens 56(4):350-5. 2000
44CTLA4, JAK2
Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.
Chikuma S, Murakami M, Tanaka K, Uede T.
J Cell Biochem. 78(2):241-50. 2000
45CTLA4
Analysis of a microsatellite polymorphism of the cytotoxic T-lymphocyte antigen-4 gene in patients with vitiligo.
Kemp EH, et al.
Br J Dermatol 140(1):73-78. 1999
46CTLA4, GD4S
The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus.
Vaidya B, et al.
Hum Mol Genet 8(7):1195-1199. 1999
47CD28, CDIG3, CTLA4
CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family-based association study.
Holopainen P, et al.
Tissue Antigens 53(5):470-5. 1999
48CTLA4
Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy.
Vaidya B, et al.
Lancet 354(9180):743-4. 1999
49CTLA4
The CTLA-4 gene is associated with multiple sclerosis.
Ligers A, et al.
J Neuroimmunol 97(1-2):182-90. 1999
50CTLA4, GD5S
The development of Graves' disease and the CTLA-4 gene on chromosome 2q33.
Heward JM, et al.
J Clin Endocrinol Metab 84(7):2398-401 1999
51CTLA4
Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.
Ling V, et al.
Genomics 60(3):341-55 1999
52CTLA4, GD5S
CTLA-4 gene polymorphism may modulate disease in Japanese multiple sclerosis patients.
Fukazawa T, Yanagawa T, Kikuchi S, Yabe I, Sasaki H, Hamada T, Miyasaka K, Gomi K, Tashiro K.
J Neurol Sci 171(1):49-55. 1999
53CTLA4
Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).
Miyatake S, Nakaseko C, Umemori H, Yamamoto T, Saito T.
Biochem Biophys Res Commun. 249(2):444-8. 1998
54CTLA4, IDDM12
Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups.
Marron MP, Raffel LJ, Garchon HJ, Jacob CO, Serrano-Rios M, Martinez Larrad MT, Teng WP, Park Y, Zhang ZX, Goldstein DR, Tao YW, Beaurain G, Bach JF, Huang HS, Luo DF, Zeidler A, Rotter JI, Yang MC, Modilevsky T, Maclaren NK, She JX.
Hum Mol Genet 6(8):1275-82. 1997
55AP2M1, CTLA4
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein.
Zhang Y, Allison JP.
Proc Natl Acad Sci U S A 94(17):9273-8. 1997
56AP2M1, CTLA4
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB.
J Immunol 159(1):144-51. 1997
57IDDM12, CTLA4
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes.
Nistico L, et al.
Hum Mol Genet 5 : 1075-1080. 1996
58CD28, CTLA4
CTLA-4 ligation blocks CD28-dependent T cell activation.
Walunas TL, et al.
J Exp Med 183(6):2541-50. 1996
59CTLA4
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.
Marengère LE, Waterhouse P, Duncan GS, Mittrücker HW, Feng GS, Mak TW.
Science. 272(5265):1170-3. 1996
60CTLA4
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.
Schneider H, Prasad KV, Shoelson SE, Rudd CE.
J Exp Med. 181(1):351-5. 1995
61CTLA4
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW.
Science. 270(5238):985-8. 1995
62CTLA4
Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.
Chen C, Gault A, Shen L, Nabavi N.
J Immunol. 152(10):4929-36. 1994
63CTLA4, CD28
Molecular linkage of the human CTLA4 and CD28 Ig-superfamily genes in yeast artificial chromosomes.
Buonavista N, et al.
Genomics 13 : 856-861. 1992
64CTLA4
Dinucleotide repeat polymorphism at the human CTLA4 gene.
Polymeropoulos MH, et al.
Nucleic Acids Res 19 : 4018. 1991
65CD28, CTLA4
CTLA-4 and CD2S activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
Harper K, et al.
J Immunol 147 : 1037-1044. 1991
66CD80, CD86, CTLA4
CTLA-4 is a second receptor for the B cell activation antigen B7.
Linsley PS, et al.
J Exp Med 174(3):561-9. 1991
67CD28, CTLA4
Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33-q34.
Lafage-Pochitaloff M, et al.
Immunogenetics 31 : 198-201. 1990
68GZMB, CTLA4
Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes.
Klein JL, et al.
Genomics 5 : 110-117. 1989
69CTLA4
Human Ig superfamily CTLA-4 gene localization and organization.
Dariavach P, et al.
(HGM10) Cytogenet Cell Genet 51 : 983. 1989
70CTLA4
Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains.
Dariavach P, Mattei MG, Golstein P, Lefranc MP.
Eur J Immunol 18 : 1901-1905. 1988
71CTLA4
A new member of the immunoglobulin superfamily : CTLA-4.
Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG, Golstein P.
Nature 328 : 267-270. 1987