1 | CRX, MEF2D
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| MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers.
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| Andzelm MM, Cherry TJ, Harmin DA, Boeke AC, Lee C, Hemberg M, Pawlyk B, Malik AN, Flavell SW, Sandberg MA, Raviola E, Greenberg ME.
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| Neuron 86(1):247-63. doi: 10.1016/j.neuron.2015.02.038. Epub 2015 Mar 19.
2015
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2 | ARR3, CACNA1S, CRX, GUCA1B, MEF2D, PDE6H
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| Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells.
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| Omori Y, Kitamura T, Yoshida S, Kuwahara R, Chaya T, Irie S, Furukawa T.
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| Genes Cells 20(5):408-26. doi: 10.1111/gtc.12233. Epub 2015 Mar 11. 2015
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3 | CRX, KCNV2, NRL, RCD5
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| RETINA-specific expression of Kcnv2 is controlled by cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl).
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| Aslanidis A, Karlstetter M, Walczak Y, Jägle H, Langmann T.
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| Adv Exp Med Biol 801:31-41. doi: 10.1007/978-1-4614-3209-8_5.
2014
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4 | CORD2, CRX
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| CRX variants in cone-rod dystrophy and mutation overview.
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| Huang L, Xiao X, Li S, Jia X, Wang P, Guo X, Zhang Q.
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| Biochem Biophys Res Commun 426(4):498-503. doi: 10.1016/j.bbrc.2012.08.110. Epub 2012 Aug 30.
2012
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5 | CRX, NRL, OTX2, RORB
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| Transcriptional regulation of neural retina leucine zipper (Nrl), a photoreceptor cell fate determinant.
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| Montana CL, Lawrence KA, Williams NL, Tran NM, Peng GH, Chen S, Corbo JC.
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| J Biol Chem 286(42):36921-31. doi: 10.1074/jbc.M111.279026. Epub 2011 Aug 24.
2011
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6 | BEST1, CRX, OTX2, VMD2
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| BEST1 expression in the retinal pigment epithelium is modulated by OTX family members.
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| Esumi N, Kachi S, Hackler L Jr, Masuda T, Yang Z, Campochiaro PA, Zack DJ.
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| Hum Mol Genet 18(1):128-41. Epub 2008 Oct 10.
2009
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7 | AIPL1, CEP290, CRB1, CRX, GUCY2D, IMPDH1, LRAT, Lebercilin, MERTK, RD3, RDH12, RPE65, RPGRP1, TULP1
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| Leber congenital amaurosis: genes, proteins and disease mechanisms.
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| den Hollander AI, Roepman R, Koenekoop RK, Cremers FP
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| Prog Retin Eye Res. Jul;27(4):391-419 2008
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8 | CRX, RS1
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| CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene.
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| Langmann T, Lai CC, Weigelt K, Tam BM, Warneke-Wittstock R, Moritz OL, Weber BH.
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| Nucleic Acids Res 36(20):6523-34. Epub 2008 Oct 16.
2008
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9 | CORD2, CRX, LCA7
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| Cone and cone-rod dystrophy segregating in the same pedigree due to the same novel CRX gene mutation.
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| Kitiratschky VB, Nagy D, Zabel T, Zrenner E, Wissinger B, Kohl S, Jägle H.
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| Br J Ophthalmol 92(8):1086-91.
2008
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10 | CRX, FIZ1, NRL, PDE6B
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| FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro.
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| Mali RS, Zhang X, Hoerauf W, Doyle D, Devitt J, Loffreda-Wren J, Mitton KP.
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| Exp Eye Res 84(2):349-60. Epub 2006 Dec 4.
2007
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11 | ARR3, CRX, GCAP1, GNB3, GNGT1, GNGT2, IMPDH1, OPN1LW, OPN1MW, PDE6C, RP1L1, TIMP3
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| Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis.
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| Liu Y, Fu L, Chen DG, Deeb SS.
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| Vision Res 47(17):2314-26. Epub 2007 Jul 25.
2007
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12 | CRX, NR2E3
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| The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes.
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| Peng GH, Ahmad O, Ahmad F, Liu J, Chen S.
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| Hum Mol Genet 14(6):747-64. Epub 2005 Feb 2. 2005
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13 | SP1, SP3, SP4, CRX
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| Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.
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| Lerner LE, Peng GH, Gribanova YE, Chen S, Farber DB.
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| J Biol Chem 280(21):20642-50. Epub 2005 Mar 21. 2005
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14 | ATXN7, CRX, KAT2B, SCA7, SUPT3H, TAF9
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| Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.
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| Palhan VB, Chen S, Peng GH, Tjernberg A, Gamper AM, Fan Y, Chait BT, La Spada AR, Roeder RG.
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| Proc Natl Acad Sci U S A 102(24):8472-7. Epub 2005 Jun 2. 2005
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15 | CRX, ATXN7
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| Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization.
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| Chen S, Peng GH, Wang X, Smith AC, Grote SK, Sopher BL, La Spada AR.
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| Hum Mol Genet 13(1):53-67. Epub 2003 Nov 12. 2004
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16 | NR2E3, NR1D1, CRX, NRL
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| Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors.
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| Cheng H, Khanna H, Oh EC, Hicks D, Mitton KP, Swaroop A.
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| Hum Mol Genet 13(15):1563-75. Epub 2004 Jun 09. 2004
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17 | CRX,NRL,PDE6A
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| Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity.
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| Pittler SJ, Zhang Y, Chen S, Mears AJ, Zack DJ, Ren Z, Swain PK, Yao S, Swaroop A, White JB.
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| J Biol Chem 279(19):19800-7. Epub 2004 Mar 4. 2004
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18 | CRX
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| Functional analysis of cone-rod homeobox (CRX) mutations associated with retinal dystrophy.
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| Chen S, Wang QL, Xu S, Liu I, Li LY, Wang Y, Zack DJ.
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| Hum Mol Genet 11(8):873-84. 2002
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19 | CRX
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| Characterization of the genomic and transcriptional structure of the CRX gene: substantial differences between human and mouse.
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| Hodges MD, Vieira H, Gregory-Evans K, Gregory-Evans CY.
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| Genomics 80(5):531-42. 2002
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20 | CRX, LCA7
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| Screening for CRX gene mutations in Chinese patients with Leber congenital amaurosis and mutational phenotype.
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| Zhang Q, Li S, Guo X, Guo L, Xiao X, Jia X, Kuang Z.
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| Ophthalmic Genet 22(2):89-96. 2001
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21 | CRX, RAX
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| Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression.
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| Kimura A, Singh D, Wawrousek EF, Kikuchi M, Nakamura M, Shinohara T.
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| J Biol Chem 275(2):1152-60. 2000
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22 | CRX, LCA7
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| Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX : direct evidence for the involvement of CRX in the development of photoreceptor function.
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| Swaroop A, et al.
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| Hum Mol Genet 8 : 299-305. 1999
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23 | CRX, LCA7
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| De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis.
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| Freund CL, et al.
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| Nat Genet 18 : 311-312. 1998
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24 | CORD2, CRX, LCA7
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| A range of clinical phenotypes associated with mutations in CRX, a photoreceptor transcription-factor gene.
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| Sohocki MM, et al.
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| Am J Hum Genet 63 : 1307-1315. 1998
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25 | CORD2, CRX
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| Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor.
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| Freund CL, Gregory-Evans CY, Furukawa T, Papaioannou M, Looser J, Ploder L, Bellingham J, Ng D, Herbrick JA, Duncan A, Scherer SW, Tsui LC, Loutradis-Anagnostou A, Jacobson SG, Cepko CL, Bhattacharya SS, McInnes RR.
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| Cell 91(4):543-53. 1997
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26 | CRX
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| Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation.
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| Furukawa T, Morrow EM, Cepko CL.
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| Cell 91(4):531-41. 1997
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27 | CRX
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| Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes.
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| Chen S, Wang QL, Nie Z, Sun H, Lennon G, Copeland NG, Gilbert DJ, Jenkins NA, Zack DJ.
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| Neuron 19(5):1017-30. 1997
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28 | CORD2, CRX
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| Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration.
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| Swain PK, Chen S, Wang QL, Affatigato LM, Coats CL, Brady KD, Fishman GA, Jacobson SG, Swaroop A, Stone E, Sieving PA, Zack DJ.
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| Neuron 19(6):1329-36. 1997
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