Citations for
1CRX, MEF2D
MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers.
Andzelm MM, Cherry TJ, Harmin DA, Boeke AC, Lee C, Hemberg M, Pawlyk B, Malik AN, Flavell SW, Sandberg MA, Raviola E, Greenberg ME.
Neuron 86(1):247-63. doi: 10.1016/j.neuron.2015.02.038. Epub 2015 Mar 19. 2015
2ARR3, CACNA1S, CRX, GUCA1B, MEF2D, PDE6H
Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells.
Omori Y, Kitamura T, Yoshida S, Kuwahara R, Chaya T, Irie S, Furukawa T.
Genes Cells 20(5):408-26. doi: 10.1111/gtc.12233. Epub 2015 Mar 11. 2015
3CRX, KCNV2, NRL, RCD5
RETINA-specific expression of Kcnv2 is controlled by cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl).
Aslanidis A, Karlstetter M, Walczak Y, Jägle H, Langmann T.
Adv Exp Med Biol 801:31-41. doi: 10.1007/978-1-4614-3209-8_5. 2014
4CORD2, CRX
CRX variants in cone-rod dystrophy and mutation overview.
Huang L, Xiao X, Li S, Jia X, Wang P, Guo X, Zhang Q.
Biochem Biophys Res Commun 426(4):498-503. doi: 10.1016/j.bbrc.2012.08.110. Epub 2012 Aug 30. 2012
5CRX, NRL, OTX2, RORB
Transcriptional regulation of neural retina leucine zipper (Nrl), a photoreceptor cell fate determinant.
Montana CL, Lawrence KA, Williams NL, Tran NM, Peng GH, Chen S, Corbo JC.
J Biol Chem 286(42):36921-31. doi: 10.1074/jbc.M111.279026. Epub 2011 Aug 24. 2011
6BEST1, CRX, OTX2, VMD2
BEST1 expression in the retinal pigment epithelium is modulated by OTX family members.
Esumi N, Kachi S, Hackler L Jr, Masuda T, Yang Z, Campochiaro PA, Zack DJ.
Hum Mol Genet 18(1):128-41. Epub 2008 Oct 10. 2009
7AIPL1, CEP290, CRB1, CRX, GUCY2D, IMPDH1, LRAT, Lebercilin, MERTK, RD3, RDH12, RPE65, RPGRP1, TULP1
Leber congenital amaurosis: genes, proteins and disease mechanisms.
den Hollander AI, Roepman R, Koenekoop RK, Cremers FP
Prog Retin Eye Res. Jul;27(4):391-419 2008
8CRX, RS1
CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene.
Langmann T, Lai CC, Weigelt K, Tam BM, Warneke-Wittstock R, Moritz OL, Weber BH.
Nucleic Acids Res 36(20):6523-34. Epub 2008 Oct 16. 2008
9CORD2, CRX, LCA7
Cone and cone-rod dystrophy segregating in the same pedigree due to the same novel CRX gene mutation.
Kitiratschky VB, Nagy D, Zabel T, Zrenner E, Wissinger B, Kohl S, Jägle H.
Br J Ophthalmol 92(8):1086-91. 2008
10CRX, FIZ1, NRL, PDE6B
FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro.
Mali RS, Zhang X, Hoerauf W, Doyle D, Devitt J, Loffreda-Wren J, Mitton KP.
Exp Eye Res 84(2):349-60. Epub 2006 Dec 4. 2007
11ARR3, CRX, GCAP1, GNB3, GNGT1, GNGT2, IMPDH1, OPN1LW, OPN1MW, PDE6C, RP1L1, TIMP3
Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis.
Liu Y, Fu L, Chen DG, Deeb SS.
Vision Res 47(17):2314-26. Epub 2007 Jul 25. 2007
12CRX, NR2E3
The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes.
Peng GH, Ahmad O, Ahmad F, Liu J, Chen S.
Hum Mol Genet 14(6):747-64. Epub 2005 Feb 2. 2005
13SP1, SP3, SP4, CRX
Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.
Lerner LE, Peng GH, Gribanova YE, Chen S, Farber DB.
J Biol Chem 280(21):20642-50. Epub 2005 Mar 21. 2005
14ATXN7, CRX, KAT2B, SCA7, SUPT3H, TAF9
Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.
Palhan VB, Chen S, Peng GH, Tjernberg A, Gamper AM, Fan Y, Chait BT, La Spada AR, Roeder RG.
Proc Natl Acad Sci U S A 102(24):8472-7. Epub 2005 Jun 2. 2005
15CRX, ATXN7
Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization.
Chen S, Peng GH, Wang X, Smith AC, Grote SK, Sopher BL, La Spada AR.
Hum Mol Genet 13(1):53-67. Epub 2003 Nov 12. 2004
16NR2E3, NR1D1, CRX, NRL
Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors.
Cheng H, Khanna H, Oh EC, Hicks D, Mitton KP, Swaroop A.
Hum Mol Genet 13(15):1563-75. Epub 2004 Jun 09. 2004
17CRX,NRL,PDE6A
Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity.
Pittler SJ, Zhang Y, Chen S, Mears AJ, Zack DJ, Ren Z, Swain PK, Yao S, Swaroop A, White JB.
J Biol Chem 279(19):19800-7. Epub 2004 Mar 4. 2004
18CRX
Functional analysis of cone-rod homeobox (CRX) mutations associated with retinal dystrophy.
Chen S, Wang QL, Xu S, Liu I, Li LY, Wang Y, Zack DJ.
Hum Mol Genet 11(8):873-84. 2002
19CRX
Characterization of the genomic and transcriptional structure of the CRX gene: substantial differences between human and mouse.
Hodges MD, Vieira H, Gregory-Evans K, Gregory-Evans CY.
Genomics 80(5):531-42. 2002
20CRX, LCA7
Screening for CRX gene mutations in Chinese patients with Leber congenital amaurosis and mutational phenotype.
Zhang Q, Li S, Guo X, Guo L, Xiao X, Jia X, Kuang Z.
Ophthalmic Genet 22(2):89-96. 2001
21CRX, RAX
Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression.
Kimura A, Singh D, Wawrousek EF, Kikuchi M, Nakamura M, Shinohara T.
J Biol Chem 275(2):1152-60. 2000
22CRX, LCA7
Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX : direct evidence for the involvement of CRX in the development of photoreceptor function.
Swaroop A, et al.
Hum Mol Genet 8 : 299-305. 1999
23CRX, LCA7
De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis.
Freund CL, et al.
Nat Genet 18 : 311-312. 1998
24CORD2, CRX, LCA7
A range of clinical phenotypes associated with mutations in CRX, a photoreceptor transcription-factor gene.
Sohocki MM, et al.
Am J Hum Genet 63 : 1307-1315. 1998
25CORD2, CRX
Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor.
Freund CL, Gregory-Evans CY, Furukawa T, Papaioannou M, Looser J, Ploder L, Bellingham J, Ng D, Herbrick JA, Duncan A, Scherer SW, Tsui LC, Loutradis-Anagnostou A, Jacobson SG, Cepko CL, Bhattacharya SS, McInnes RR.
Cell 91(4):543-53. 1997
26CRX
Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation.
Furukawa T, Morrow EM, Cepko CL.
Cell 91(4):531-41. 1997
27CRX
Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes.
Chen S, Wang QL, Nie Z, Sun H, Lennon G, Copeland NG, Gilbert DJ, Jenkins NA, Zack DJ.
Neuron 19(5):1017-30. 1997
28CORD2, CRX
Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration.
Swain PK, Chen S, Wang QL, Affatigato LM, Coats CL, Brady KD, Fishman GA, Jacobson SG, Swaroop A, Stone E, Sieving PA, Zack DJ.
Neuron 19(6):1329-36. 1997