Citations for
1CRTC2, CRTC3
CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.
Kim JH, Hedrick S, Tsai WW, Wiater E, Le Lay J, Kaestner KH, Leblanc M, Loar A, Montminy M.
Proc Natl Acad Sci U S A 114(44):11739-11744. doi: 10.1073/pnas.1712616114. Epub 2017 Oct 16. 2017
2CRTC2
Glucagon-CREB/CRTC2 signaling cascade regulates hepatic BMAL1 protein.
Sun X, Dang F, Zhang D, Yuan Y, Zhang C, Wu Y, Wang Y, Liu Y.
J Biol Chem 290(4):2189-97. doi: 10.1074/jbc.M114.612358. Epub 2014 Dec 5. 2015
3CRTC2, CRTC3, HDAC4, SIK2, SLC2A4
SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes.
Henriksson E, Säll J, Gormand A, Wasserstrom S, Morrice NA, Fritzen AM, Foretz M, Campbell DG, Sakamoto K, Ekelund M, Degerman E, Stenkula KG, Göransson O.
J Cell Sci 128(3):472-86. 2015
4CRTC2, PROM1
CRTC2 and PROM1 expression in non-small cell lung cancer: analysis by Western blot and immunohistochemistry.
Li Y, He Y, Qiu Z, Zhou B, Shi S, Zhang K, Luo Y, Huang Q, Li W.
Tumour Biol 35(12):11719-26. doi: 10.1007/s13277-014-2011-0. Epub 2014 Sep 26. 2014
5CRTC2
CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure.
Highland JA, Weiser MJ, Hinds LR, Spencer RL.
Am J Physiol Cell Physiol 307(7):C611-21. doi: 10.1152/ajpcell.00319.2013. Epub 2014 Jul 30. 2014
6CRTC2, PRMT6
Arginine methylation of CRTC2 is critical in the transcriptional control of hepatic glucose metabolism.
Han HS, Jung CY, Yoon YS, Choi S, Choi D, Kang G, Park KG, Kim ST, Koo SH.
Sci Signal 7(314):ra19. doi: 10.1126/scisignal.2004479. 2014
7CRTC2, SIK2
SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo.
Park J, Yoon YS, Han HS, Kim YH, Ogawa Y, Park KG, Lee CH, Kim ST, Koo SH.
Diabetes 63(11):3659-73. doi: 10.2337/db13-1423. Epub 2014 Jun 4. 2014
8CRTC2, CRTC3
Creb coactivators direct anabolic responses and enhance performance of skeletal muscle.
Bruno NE, Kelly KA, Hawkins R, Bramah-Lawani M, Amelio AL, Nwachukwu JC, Nettles KW, Conkright MD.
EMBO J 33(9):1027-43. doi: 10.1002/embj.201386145. Epub 2014 Mar 27. 2014
9CRTC2, RPS6
Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling.
Yano T, Ferlito M, Aponte A, Kuno A, Miura T, Murphy E, Steenbergen C.
Circ Res 114(8):1268-80. doi: 10.1161/CIRCRESAHA.114.303562. Epub 2014 Feb 20. 2014
10AKT1, ARHGEF3, CRTC2
XPLN is an endogenous inhibitor of mTORC2.
Khanna N, Fang Y, Yoon MS, Chen J.
Proc Natl Acad Sci U S A 110(40):15979-84. doi: 10.1073/pnas.1310434110. Epub 2013 Sep 16. 2013
11CCDC28B, CRTC2, MAPKAP1
The Bardet-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex.
Cardenas-Rodriguez M, Irigoín F, Osborn DP, Gascue C, Katsanis N, Beales PL, Badano JL.
Hum Mol Genet 22(20):4031-42. doi: 10.1093/hmg/ddt253. Epub 2013 May 31. 2013
12CRTC2, MTOR, UCHL1
Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.
Hussain S, Feldman AL, Das C, Ziesmer SC, Ansell SM, Galardy PJ.
Mol Cell Biol 33(6):1188-97. doi: 10.1128/MCB.01389-12. Epub 2013 Jan 7. 2013
13CRTC2
CRTC2 is required for β-cell function and proliferation.
Eberhard CE, Fu A, Reeks C, Screaton RA.
Endocrinology 154(7):2308-17. doi: 10.1210/en.2012-2088. Epub 2013 May 15. 2013
14CRTC2, MAPKAP1
Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation.
Chang X, Lazorchak AS, Liu D, Su B.
Eur J Immunol 42(6):1639-47. doi: 10.1002/eji.201142066. 2012
15CRTC2
Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2.
Yuan M, Pino E, Wu L, Kacergis M, Soukas AA.
J Biol Chem 287(35):29579-88. doi: 10.1074/jbc.M112.386854. Epub 2012 Jul 7. 2012
16CRTC2
Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses.
Kaur S, Sassano A, Majchrzak-Kita B, Baker DP, Su B, Fish EN, Platanias LC.
Proc Natl Acad Sci U S A 109(20):7723-8. doi: 10.1073/pnas.1118122109. Epub 2012 May 1. 2012
17CRTC2
Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.
Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M.
J Exp Med 209(4):713-28. doi: 10.1084/jem.20111470. Epub 2012 Apr 2. 2012
18CRTC2, DEPTOR
An in vitro assay for the kinase activity of mTOR complex 2.
Huang J.
Methods Mol Biol 821:75-86. doi: 10.1007/978-1-61779-430-8_6. 2012
19CRTC2, MTOR
Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons.
Urbanska M, Gozdz A, Swiech LJ, Jaworski J.
J Biol Chem 287(36):30240-56. doi: 10.1074/jbc.M112.374405. Epub 2012 Jul 18. 2012
20CRTC2, ITPR1, ITPR2
Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.
Wang Y, Li G, Goode J, Paz JC, Ouyang K, Screaton R, Fischer WH, Chen J, Tabas I, Montminy M.
Nature 485(7396):128-32. doi: 10.1038/nature10988. 2012
21CRTC2, FBXW8, IRS1
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E.
Mol Cell 48(6):875-87. doi: 10.1016/j.molcel.2012.09.029. Epub 2012 Nov 8. 2012
22CRTC2, PINK1, RICTOR
A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2.
Murata H, Sakaguchi M, Jin Y, Sakaguchi Y, Futami J, Yamada H, Kataoka K, Huh NH.
J Biol Chem 286(9):7182-9. Epub 2010 Dec 21. 2011
23CRTC2, NIP7
Activation of mTORC2 by association with the ribosome.
Zinzalla V, Stracka D, Oppliger W, Hall MN.
Cell 144(5):757-68. 2011
24CRTC2, MTOR, RAC1
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.
Saci A, Cantley LC, Carpenter CL.
Mol Cell 42(1):50-61. 2011
25AKT1, CRTC2, PREX1
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.
Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Yun J, Shin HK, Song SH, Kim JH, Lee JS, Kim CD, Bae SS.
Oncogene 30(26):2954-63. doi: 10.1038/onc.2011.22. Epub 2011 Feb 21. 2011
26CRTC2, RICTOR
Endoplasmic reticulum is a main localization site of mTORC2.
Boulbés DR, Shaiken T, Sarbassov dos D.
Biochem Biophys Res Commun 413(1):46-52. Epub 2011 Aug 16. 2011
27CRTC2, MAPKAP1, SGK1
mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
Lu M, Wang J, Ives HE, Pearce D.
J Biol Chem 286(35):30647-54. doi: 10.1074/jbc.M111.257592. Epub 2011 Jul 11. 2011
28CRTC2, MAPKAP1
mTORC2 targets AGC kinases through Sin1-dependent recruitment.
Cameron AJ, Linch MD, Saurin AT, Escribano C, Parker PJ.
Biochem J 439(2):287-97. doi: 10.1042/BJ20110678. 2011
29CRTC1, CRTC2, PIN1
Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.
Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi S, Kurihara H, Uchida T, Asano T.
J Biol Chem 285(43):33018-27. Epub 2010 Jul 30. 2010
30CRTC1, CRTC2
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion.
Liu L, Das S, Losert W, Parent CA.
Dev Cell 19(6):845-57. 2010
31CRTC1, CRTC2
Dysregulation of epithelial Na+ absorption induced by inhibition of the kinases TORC1 and TORC2.
Mansley MK, Wilson SM.
Br J Pharmacol 161(8):1778-92. doi: 10.1111/j.1476-5381.2010.01003.x. 2010
32CRTC2
Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity.
Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller N, Liu Y, Hedrick S, Vera L, Montminy M.
Proc Natl Acad Sci U S A 107(7):3087-92. Epub 2010 Jan 26. 2010
33CRTC2
Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.
Hoang B, Frost P, Shi Y, Belanger E, Benavides A, Pezeshkpour G, Cappia S, Guglielmelli T, Gera J, Lichtenstein A.
Blood 116(22):4560-8. Epub 2010 Aug 4. 2010
34CRTC2, MTOR, RICTOR, RPL23A
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.
Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E.
EMBO J 29(23):3939-51. Epub 2010 Nov 2. 2010
35AKT2, CRTC2, MAPKAP1
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B.
Mol Cell 39(3):433-43. doi: 10.1016/j.molcel.2010.07.031. 2010
36CRTC2
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis.
Wang Y, Vera L, Fischer WH, Montminy M.
Nature 460(7254):534-7. Epub 2009 Jun 21. 2009
37CRTC1, CRTC2
TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.
Schonbrun M, Laor D, López-Maury L, Bähler J, Kupiec M, Weisman R.
Mol Cell Biol 29(16):4584-94. Epub 2009 Jun 22.PMID: 19546237 2009
38CRTC2
CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis.
Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH.
Cell Metab 10(1):55-62. 2009
39CRTC2, LPIN1
TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.
Ryu D, Oh KJ, Jo HY, Hedrick S, Kim YN, Hwang YJ, Park TS, Han JS, Choi CS, Montminy M, Koo SH.
Cell Metab 9(3):240-51. 2009
40CRTC2, SIK2
Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes.
Muraoka M, Fukushima A, Viengchareun S, Lombès M, Kishi F, Miyauchi A, Kanematsu M, Doi J, Kajimura J, Nakai R, Uebi T, Okamoto M, Takemori H.
Am J Physiol Endocrinol Metab 296(6):E1430-9. doi: 10.1152/ajpendo.00024.2009. Epub 2009 Apr 7. 2009
41CRTC2
Hepatic glucose sensing via the CREB coactivator CRTC2.
Dentin R, Hedrick S, Xie J, Yates J 3rd, Montminy M.
Science 319(5868):1402-5. 2008
42CRTC2, RICTOR, MAPKAP1
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.
Yang Q, Inoki K, Ikenoue T, Guan KL.
Genes Dev 20(20):2820-32. 2006
43STK11, CRTC2
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC.
Science 310(5754):1642-6. Epub 2005 Nov 24. 2005
44CRTC1, CRTC2
Molecular organization of target of rapamycin complex 2.
Wullschleger S, Loewith R, Oppliger W, Hall MN.
J Biol Chem 280(35):30697-704. Epub 2005 Jul 7. 2005
45CRTC2, SIK2
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.
Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR 3rd, Takemori H, Okamoto M, Montminy M.
Cell 119(1):61-74. 2004
46CRTC1, CRTC2, CRTC3, SIK2
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.
Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA.
Proc Natl Acad Sci U S A 100(21):12147-52. Epub 2003 Sep 23. 2003