1 | CRTC1, HUWE1, WIPI2
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| MTORC1 regulates autophagic membrane growth by targeting WIPI2
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| Wan W, Liu W.
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| Autophagy. Apr;15(4):742-743. doi: 10.1080/15548627.2019.1569949. Epub 2019 Jan 22. 2019
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2 | CRTC1, FGF1
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| CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene.
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| Uchida S, Teubner BJ, Hevi C, Hara K, Kobayashi A, Dave RM, Shintaku T, Jaikhan P, Yamagata H, Suzuki T, Watanabe Y, Zakharenko SS, Shumyatsky GP.
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| Cell Rep 18(2):352-366. doi: 10.1016/j.celrep.2016.12.052.
2017
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3 | CRTC1, CRTC3, MAML2
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| A novel fusion gene CRTC3-MAML2 in hidradenoma: histopathological significance.
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| Kuma Y, Yamada Y, Yamamoto H, Kohashi K, Ito T, Furue M, Oda Y.
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| Hum Pathol 70:55-61. doi: 10.1016/j.humpath.2017.10.004. Epub 2017 Oct 24.
2017
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4 | CRTC1, NR1H3
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| The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation.
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| Kim H.
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| Sci Rep 6:37280. doi: 10.1038/srep37280.
2016
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5 | CRTC1, NPRL2, NPRL3, WDR24
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| The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function.
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| Cai W, Wei Y, Jarnik M, Reich J, Lilly MA.
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| PLoS Genet 12(5):e1006036. doi: 10.1371/journal.pgen.1006036. eCollection 2016 May.
2016
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6 | CRTC1
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| CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy.
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| Dubey D, Porter BE.
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| Neuroscience 320:57-68. doi: 10.1016/j.neuroscience.2016.01.059. Epub 2016 Feb 1.
2016
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7 | CRTC1, MAML2
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| Role of CRTC1/MAML2 Translocation in the Prognosis and Clinical Outcomes of Mucoepidermoid Carcinoma.
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| Saade RE, Bell D, Garcia J, Roberts D, Weber R.
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| JAMA Otolaryngol Head Neck Surg 142(3):234-40. doi: 10.1001/jamaoto.2015.3270. Erratum in: JAMA Otolaryngol Head Neck Surg. 2016 Mar;142(3):300.
2016
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8 | CRTC1, PROM1, PROM2
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| CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer's disease. Alzheimers
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| Mendioroz M, Celarain N, Altuna M, Sánchez-Ruiz de Gordoa J, Zelaya MV, Roldán M, Rubio I, Larumbe R, Erro ME, Méndez I, Echávarri C.
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| Res Ther. Apr 19;8(1):15. doi: 10.1186/s13195-016-0183-0. 2016
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9 | CRTC1, MAML2
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| Gene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma cells.
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| Chen J, Li JL, Chen Z, Griffin JD, Wu L.
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| BMC Cancer 15:803. doi: 10.1186/s12885-015-1827-3.
2015
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10 | CRTC1
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| Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.
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| Burkewitz K, Morantte I, Weir HJ, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB.
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| Cell 160(5):842-55. doi: 10.1016/j.cell.2015.02.004.
2015
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11 | CRTC1
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| Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages.
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| Parra-Damas A, Valero J, Chen M, Espańa J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA.
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| J Neurosci 34(17):5776-87. doi: 10.1523/JNEUROSCI.5288-13.2014.
2014
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12 | CRTC1, SIK1
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| The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.
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| Jagannath A, Butler R, Godinho SI, Couch Y, Brown LA, Vasudevan SR, Flanagan KC, Anthony D, Churchill GC, Wood MJ, Steiner G, Ebeling M, Hossbach M, Wettstein JG, Duffield GE, Gatti S, Hankins MW, Foster RG, Peirson SN.
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| Cell 154(5):1100-11. doi: 10.1016/j.cell.2013.08.004.
2013
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13 | CRTC1
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| Sustained adrenergic stimulation is required for the nuclear retention of TORC1 in male rat pinealocytes.
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| McTague J, Ferguson M, Chik CL, Ho AK.
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| Endocrinology 154(9):3240-50. doi: 10.1210/en.2013-1293. Epub 2013 Jun 10.
2013
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14 | CRTC1
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| Fetal brain lesions in tuberous sclerosis complex: TORC1 activation and inflammation.
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| Prabowo AS, Anink JJ, Lammens M, Nellist M, van den Ouweland AM, Adle-Biassette H, Sarnat HB, Flores-Sarnat L, Crino PB, Aronica E.
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| Brain Pathol 23(1):45-59. doi: 10.1111/j.1750-3639.2012.00616.x. Epub 2012 Aug 30.
2013
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15 | CRTC1, CRTC3, MAML2
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| Clinicopathological significance of MAML2 gene split in mucoepidermoid carcinoma.
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| Noda H, Okumura Y, Nakayama T, Miyabe S, Fujiyoshi Y, Hattori H, Shimozato K, Inagaki H.
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| Cancer Sci 104(1):85-92. doi: 10.1111/cas.12039. Epub 2012 Nov 8.
2013
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16 | CRTC1, STK11
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| Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion.
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| Gu Y, Lin S, Li JL, Nakagawa H, Chen Z, Jin B, Tian L, Ucar DA, Shen H, Lu J, Hochwald SN, Kaye FJ, Wu L.
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| Oncogene 31(4):469-79. doi: 10.1038/onc.2011.247. Epub 2011 Jun 27.
2012
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17 | CRTC1
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| Transient sequestration of TORC1 into stress granules during heat stress.
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| Takahara T, Maeda T.
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| Mol Cell 47(2):242-52. doi: 10.1016/j.molcel.2012.05.019. Epub 2012 Jun 21.
2012
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18 | CRTC1, MTOR, RAB5A
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| Rab5 proteins regulate activation and localization of target of rapamycin complex 1.
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| Bridges D, Fisher K, Zolov SN, Xiong T, Inoki K, Weisman LS, Saltiel AR.
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| J Biol Chem 287(25):20913-21. doi: 10.1074/jbc.M111.334060. Epub 2012 Apr 30.
2012
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19 | CREB1, CRTC1, SIK2
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| SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB.
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| Sasaki T, Takemori H, Yagita Y, Terasaki Y, Uebi T, Horike N, Takagi H, Susumu T, Teraoka H, Kusano K, Hatano O, Oyama N, Sugiyama Y, Sakoda S, Kitagawa K.
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| Neuron 69(1):106-19. doi: 10.1016/j.neuron.2010.12.004.
2011
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20 | CRTC1, WIPI1
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| WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition
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| Ho H, Kapadia R, Al-Tahan S, Ahmad S, Ganesan AK.
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| J Biol Chem. Apr 8;286(14):12509-23. doi: 10.1074/jbc.M110.200543. Epub 2011 Feb 11. 2011
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21 | CRTC1, CRTC2, PIN1
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| Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.
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| Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi S, Kurihara H, Uchida T, Asano T.
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| J Biol Chem 285(43):33018-27. Epub 2010 Jul 30. 2010
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22 | CRTC1, CRTC2
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| mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion.
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| Liu L, Das S, Losert W, Parent CA.
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| Dev Cell 19(6):845-57.
2010
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23 | CRTC1, CRTC2
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| Dysregulation of epithelial Na+ absorption induced by inhibition of the kinases TORC1 and TORC2.
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| Mansley MK, Wilson SM.
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| Br J Pharmacol 161(8):1778-92. doi: 10.1111/j.1476-5381.2010.01003.x.
2010
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24 | CRTC1
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| The coactivator CRTC1 promotes cell proliferation and transformation via AP-1.
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| Canettieri G, Coni S, Della Guardia M, Nocerino V, Antonucci L, Di Magno L, Screaton R, Screpanti I, Giannini G, Gulino A.
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| Proc Natl Acad Sci U S A 106(5):1445-50. Epub 2009 Jan 21.
2009
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25 | CRTC1, CRTC2
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| TOR complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions.
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| Schonbrun M, Laor D, López-Maury L, Bähler J, Kupiec M, Weisman R.
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| Mol Cell Biol 29(16):4584-94. Epub 2009 Jun 22.PMID: 19546237 2009
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26 | CRTC1, MAML2
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| A link between the expression of the stem cell marker HMGA2, grading, and the fusion CRTC1-MAML2 in mucoepidermoid carcinoma.
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| Fehr A, Meyer A, Heidorn K, Röser K, Löning T, Bullerdiek J.
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| Genes Chromosomes Cancer 48(9):777-85.PMID: 19521953 2009
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27 | CREB1, CRTC1
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| The Creb1 coactivator Crtc1 is required for energy balance and fertility.
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| Altarejos JY, Goebel N, Conkright MD, Inoue H, Xie J, Arias CM, Sawchenko PE, Montminy M.
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| Nat Med 14(10):1112-7. Epub 2008 Aug 31.
2008
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28 | CRTC1, MAP3K1
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| Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation.
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| Siu YT, Ching YP, Jin DY.
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| Mol Biol Cell 19(11):4750-61. Epub 2008 Sep 10.
2008
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29 | CRTC1, MAML2
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| Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene.
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| Behboudi A, Enlund F, Winnes M, Andren Y, Nordkvist A, Leivo I, Flaberg E, Szekely L, Makitie A, Grenman R, Mark J, Stenman G.
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| Genes Chromosomes Cancer 45(5):470-81. 2006
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30 | CRTC1, MAML2
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| Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion.
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| Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G.
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| Genes Chromosomes Cancer 43(2):202-5. 2005
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31 | CRTC1, CRTC2
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| Molecular organization of target of rapamycin complex 2.
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| Wullschleger S, Loewith R, Oppliger W, Hall MN.
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| J Biol Chem 280(35):30697-704. Epub 2005 Jul 7. 2005
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32 | CRTC1, MAML2
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| Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors.
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| Enlund F, Behboudi A, Andren Y, Oberg C, Lendahl U, Mark J, Stenman G.
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| Exp Cell Res 292(1):21-8. 2004
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33 | MAML1, MAML2, CRTC1
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| t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway
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| Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ.
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| Nat Genet 33(2):208-13. 2003
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34 | CRTC1, CRTC2, CRTC3, SIK2
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| Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.
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| Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA.
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| Proc Natl Acad Sci U S A 100(21):12147-52. Epub 2003 Sep 23. 2003
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35 | MAML1, MAML2, MAML3, CRTC1
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| Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling
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| Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M.
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| J Biol Chem 277(52):50612-20. 2002
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36 | MAML1, MAML2, MAML3, CRTC1
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| Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors
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| Wu L, Sun T, Kobayashi K, Gao P, Griffin JD.
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| Mol Cell Biol 22(21):7688-700. 2002
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37 | AATK, ACIN1, ACOT11, ACSBG1, ADAMTS4, ADGRV1, AKAP11, ANKLE2, ARHGAP26, ARHGEF2, ASTN2, ATP2C2, ATP9A, BICD2, BZRAP1, C12orf51, CAND2, CEP135, CLASP1, CLASP2, CLUAP1, CLUH, CNOT3, COBL, CPNE3, CRTC1, CRY2, CSTF2T, CUL3, CUL4B, DAAM1, DAGLA, DEPDC5, DNAJC13, DOCK10, DZIP3, FBXW11, FKBP15, G3BP2, HEPH, HIP1R, HIPK1, ICOSLG, KIAA0649, KIAA0652, KIF13B, KIF1C, KIF21A, L3MBTL1, LDB3, MAGI2, MAP4K4, MFAP3L, MGEA5, MRC2, MTMR4, N4BP1, NPHP4, OBSL1, PAN2, PHACTR2, PHF2, PHLDB1, PLXND1, PPFIA3, PTCD1, RAB11FIP3, RBM19, RICH2, RNF40, RNF8, ROCK2, RRP12, SAPS2, SETX, SIN3B, SLC24A1, SMCHD1, SNAP91, SOCS5, SS18L1, SWAP70, TBC1D9B, TELO2, TNRC15, TSC22D2, UBE4B, UHRF1BP1L, ULK2, ZBED4, ZC3H11A, ZNF623
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| Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
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| Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N,Ohara O.
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| DNA Res 5(3):169-76. 1998
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