| 1 | AIFM3, CRKL, UBASH3A
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| CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development.
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| Lozic M, Minarik L, Racetin A, Filipovic N, Saraga Babic M, Vukojevic K.
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| Int J Mol Sci. Aug 25;22(17):9183. doi: 10.3390/ijms22179183. 2021
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| 2 | CRKL, DEL22Q11, LCR22
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| Complete Sequence of the 22q11.2 Allele in 1,053 Subjects with 22q11.2 Deletion Syndrome Reveals Modifiers of Conotruncal Heart Defects.
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| Zhao Y, Diacou A, Johnston HR, Musfee FI, McDonald-McGinn DM, McGinn D, Crowley TB, Repetto GM, Swillen A, Breckpot J, Vermeesch JR, Kates WR, Digilio MC, Unolt M, Marino B, Pontillo M, Armando M, Di Fabio F, Vicari S, van den Bree M, Moss H, Owen MJ, Murphy KC, Murphy CM, Murphy D, Schoch K, Shashi V, Tassone F, Simon TJ, Shprintzen RJ, Campbell L, Philip N, Heine-Suñer D, García-Miñaúr S, Fernández L; International 22q11.
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| Am J Hum Genet 106(1):26-40. doi: 10.1016/j.ajhg.2019.11.010. Epub 2019 Dec 20. 2020
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| 3 | CRKL, GRB2, PIK3AP1
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| Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2.
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| Lauenstein JU, Udgata A, Bartram A, De Sutter D, Fisher DI, Halabi S, Eyckerman S, Gay NJ.
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| J Biol Chem 294(52):19852-19861. doi: 10.1074/jbc.RA119.009931. Epub 2019 Sep 16.
2019
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| 4 | CRKL
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| Overexpression of CrkL as a novel biomarker for poor prognosis in gastric cancer.
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| Feng R, Li J, Sah BK, Yuan F, Jin X, Yan M, Liu B, Li C, Zhu Z.
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| Cancer Biomark 26(2):131-138. doi: 10.3233/CBM-192435.
2019
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| 5 | CRKL
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| CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.
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| Song Q, Yi F, Zhang Y, Jun Li DK, Wei Y, Yu H, Zhang Y.
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| BMC Cancer 19(1):499. doi: 10.1186/s12885-019-5671-8.
2019
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| 6 | CRK, CRKL
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| Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
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| Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X.
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| Elife 7. pii: e32586. doi: 10.7554/eLife.32586.
2018
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| 7 | ATIC, CRKL, HNRNPH1, IL7, STIP1
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| IL-7-induced phosphorylation of the adaptor Crk-like and other targets.
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| Aiello FB, Guszczynski T, Li W, Hixon JA, Jiang Q, Hodge DL, Massignan T, Di Lisio C, Merchant A, Procopio AD, Bonetto V, Durum SK.
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| Cell Signal 47:131-141. doi: 10.1016/j.cellsig.2018.03.008. Epub 2018 Mar 24.
2018
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| 8 | CRKL, PIK3CB
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| CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.
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| Zhang J, Gao X, Schmit F, Adelmant G, Eck MJ, Marto JA, Zhao JJ, Roberts TM.
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| Cell Rep 20(3):549-557. doi: 10.1016/j.celrep.2017.06.054.
2017
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| 9 | CRK, CRKL
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| Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL).
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| Park T, Koptyra M, Curran T.
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| J Biol Chem 291(51):26273-26290. Epub 2016 Nov 2.
2016
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| 10 | CRKL
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| Reduction of CRKL expression in patients with partial DiGeorge syndrome is associated with impairment of T-cell functions.
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| Giacomelli M, Kumar R, Soresina A, Tamassia N, Lorenzini T, Moratto D, Gasperini S, Cassatella M, Plebani A, Lougaris V, Badolato R.
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| J Allergy Clin Immunol 138(1):229-240.e3. doi: 10.1016/j.jaci.2015.10.051. Epub 2016 Feb 11.
2016
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| 11 | CRKL
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| Mouse and Human CRKL Is Dosage Sensitive for Cardiac Outflow Tract Formation.
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| Racedo SE, McDonald-McGinn DM, Chung JH, Goldmuntz E, Zackai E, Emanuel BS, Zhou B, Funke B, Morrow BE.
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| Am J Hum Genet 96(2):235-44. doi: 10.1016/j.ajhg.2014.12.025.
2015
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| 12 | CRKL
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| Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation.
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| Racedo SE, McDonald-McGinn DM, Chung JH, Goldmuntz E, Zackai E, Emanuel BS, Zhou B, Funke B, Morrow BE.
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| Am J Hum Genet 96(2):235-44. doi: 10.1016/j.ajhg.2014.12.025.
2015
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| 13 | CRK, CRKL
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| CRK proteins selectively regulate T cell migration into inflamed tissues.
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| Huang Y, Clarke F, Karimi M, Roy NH, Williamson EK, Okumura M, Mochizuki K, Chen EJ, Park TJ, Debes GF, Zhang Y, Curran T, Kambayashi T, Burkhardt JK.
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| J Clin Invest 125(3):1019-32. doi: 10.1172/JCI77278. Epub 2015 Jan 26.
2015
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| 14 | CRKL
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| CRKL protein overexpression enhances cell proliferation and invasion in pancreatic cancer.
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| Fu L, Dong Q, Xie C, Wang Y, Li Q.
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| Tumour Biol 36(2):1015-22. doi: 10.1007/s13277-014-2706-2. Epub 2014 Oct 16.
2015
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| 15 | CRKL, DOK1
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| Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity.
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| Ng KY, Yin T, Machida K, Wu YI, Mayer BJ.
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| Oncogene ncogene. 2014 Jul 21. doi: 10.1038/onc.2014.210. [Epub ahead of print]
2014
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| 16 | CRKL
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| Downregulation of CRKL expression can inhibit tumorigenesis in colon cancer.
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| Lan B, Zhang J, Shan J, Zhang P, Zhang W, Chen Y, Zhen W, Yan S.
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| Front Biosci (Landmark Ed) 19:528-34.
2014
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| 17 | CRK, CRKL
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| Essential roles of Crk and CrkL in fibroblast structure and motility.
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| Park TJ, Curran T.
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| Oncogene 33(43):5121-32. doi: 10.1038/onc.2013.453. Epub 2013 Oct 28.
2014
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| 18 | CRKL
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| Src-inducible association of CrkL with procaspase-8 promotes cell migration.
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| Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, Stupack D.
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| Cell Adh Migr 7(4):362-9. doi: 10.4161/cam.25284. Epub 2013 Jun 10.
2013
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| 19 | CRKL
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| Overexpression of CRKL correlates with malignant cell proliferation in breast cancer.
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| Zhao T, Miao Z, Wang Z, Xu Y, Wu J, Liu X, You Y, Li J.
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| Tumour Biol umour Biol. 2013 May 19. [Epub ahead of print]
2013
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| 20 | CRKL, YES1
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| Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth.
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| Yeung CL, Ngo VN, Grohar PJ, Arnaldez FI, Asante A, Wan X, Khan J, Hewitt SM, Khanna C, Staudt LM, Helman LJ.
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| Oncogene ncogene. 2013 Jan 14. doi: 10.1038/onc.2012.590. [Epub ahead of print]
2013
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| 21 | CRKL, DEL22Q11D, MAPK1
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| Congenital heart defects in a novel recurrent 22q11.2 deletion harboring the genes CRKL and MAPK1.
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| Breckpot J, Thienpont B, Bauters M, Tranchevent LC, Gewillig M, Allegaert K, Vermeesch JR, Moreau Y, Devriendt K.
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| Am J Med Genet A 158A(3):574-80. doi: 10.1002/ajmg.a.35217. Epub 2012 Feb 8.
2012
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| 22 | CRKL, PRPN6
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| SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL.
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| Evren S, Ma XZ, Sakac D, Branch DR.
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| Exp Hematol 40(12):1055-9. doi: 10.1016/j.exphem.2012.08.007. Epub 2012 Sep 5.
2012
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| 23 | CRKL
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| CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion.
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| Yanagi H, Wang L, Nishihara H, Kimura T, Tanino M, Yanagi T, Fukuda S, Tanaka S.
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| Biochem Biophys Res Commun 418(1):104-9. doi: 10.1016/j.bbrc.2011.12.142. Epub 2012 Jan 5.
2012
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| 24 | CRKL
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| The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer.
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| Natsume H, Shinmura K, Tao H, Igarashi H, Suzuki M, Nagura K, Goto M, Yamada H, Maeda M, Konno H, Nakamura S, Sugimura H.
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| J Transl Med 10:97. doi: 10.1186/1479-5876-10-97.
2012
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| 25 | CRK, CRKL
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| Identification of CrkL-SH3 binding proteins from embryonic murine brain: implications for Reelin signaling during brain development.
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| Cheerathodi M, Ballif BA.
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| J Proteome Res 10(10):4453-62. doi: 10.1021/pr200229a. Epub 2011 Sep 15.
2011
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| 26 | CRKL, ESR1
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| CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer.
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| Padmanabhan RA, Nirmala L, Murali M, Laloraya M.
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| Mol Endocrinol 25(9):1499-512. doi: 10.1210/me.2011-0008. Epub 2011 Jun 23.
2011
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| 27 | CRKL
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| Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer.
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| Kim YH, Kwei KA, Girard L, Salari K, Kao J, Pacyna-Gengelbach M, Wang P, Hernandez-Boussard T, Gazdar AF, Petersen I, Minna JD, Pollack JR.
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| Oncogene 29(10):1421-30. Epub 2009 Dec 7.
2010
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| 28 | CRKL, SPRY1, SPRY2
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| CrkL is a novel target of Sprouty2 in fibroblast growth factor signaling.
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| Satoh T, Torii S, Nakayama K, Nishida E.
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| Genes Cells enes Cells. 2010 Feb 3. [Epub ahead of print]PMID: 20136656 2010
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| 29 | AGRN, CRK, CRKL, DOK7, MUSK
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| Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
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| Hallock PT, Xu CF, Park TJ, Neubert TA, Curran T, Burden SJ.
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| Genes Dev 24(21):2451-61.
2010
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| 30 | CRKL, FGFR1
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| Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop.
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| Seo JH, Suenaga A, Hatakeyama M, Taiji M, Imamoto A.
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| Mol Cell Biol 29(11):3076-87. Epub 2009 Mar 23. 2009
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| 31 | CRK, CRKL
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| Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.
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| Park TJ, Curran T.
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| J Neurosci 28(50):13551-62.PMID: 19074029 2008
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| 32 | CRK, CRKL
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| Proapoptotic function of the nuclear Crk II adaptor protein.
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| Kar B, Reichman CT, Singh S, O'Connor JP, Birge RB.
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| Biochemistry 46(38):10828-40. Epub 2007 Sep 1.PMID: 1776415 2007
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| 33 | CRKL
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| The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal.
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| Harkiolaki M, Gilbert RJ, Jones EY, Feller SM.
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| Structure 14(12):1741-53. 2006
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| 34 | CRKL
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| Translocation of CrkL to focal adhesions mediates integrin-induced migration downstream of Src family kinases.
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| Li L, Guris DL, Okura M, Imamoto A.
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| Mol Cell Biol 23(8):2883-92. 2003
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| 35 | CRKL, DEL22Q11
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| Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome.
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| Guris DL, Fantes J, Tara D, Druker BJ, Imamoto A.
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| Nat Genet 27(3):293-8. 2001
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| 36 | CRKL
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| The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene.
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| Senechal K, Halpern J, Sawyers CL.
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| J Biol Chem 271(38):23255-61. 1996
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| 37 | CRKL
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| Isolation and chromosomal localization of CRKL, a human crk-like gene.
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| Ten Hoeve J, et al.
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| Oncogene 8 : 2469-2474. 1993
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