Citations for
1CRKL
Mouse and Human CRKL Is Dosage Sensitive for Cardiac Outflow Tract Formation.
Racedo SE, McDonald-McGinn DM, Chung JH, Goldmuntz E, Zackai E, Emanuel BS, Zhou B, Funke B, Morrow BE.
Am J Hum Genet 96(2):235-44. doi: 10.1016/j.ajhg.2014.12.025. 2015
2CRKL, DOK1
Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity.
Ng KY, Yin T, Machida K, Wu YI, Mayer BJ.
Oncogene ncogene. 2014 Jul 21. doi: 10.1038/onc.2014.210. [Epub ahead of print] 2014
3CRKL
Src-inducible association of CrkL with procaspase-8 promotes cell migration.
Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, Stupack D.
Cell Adh Migr 7(4):362-9. doi: 10.4161/cam.25284. Epub 2013 Jun 10. 2013
4CRKL
Overexpression of CRKL correlates with malignant cell proliferation in breast cancer.
Zhao T, Miao Z, Wang Z, Xu Y, Wu J, Liu X, You Y, Li J.
Tumour Biol umour Biol. 2013 May 19. [Epub ahead of print] 2013
5CRKL, YES1
Loss-of-function screen in rhabdomyosarcoma identifies CRKL-YES as a critical signal for tumor growth.
Yeung CL, Ngo VN, Grohar PJ, Arnaldez FI, Asante A, Wan X, Khan J, Hewitt SM, Khanna C, Staudt LM, Helman LJ.
Oncogene ncogene. 2013 Jan 14. doi: 10.1038/onc.2012.590. [Epub ahead of print] 2013
6CRKL, DEL22Q11D, MAPK1
Congenital heart defects in a novel recurrent 22q11.2 deletion harboring the genes CRKL and MAPK1.
Breckpot J, Thienpont B, Bauters M, Tranchevent LC, Gewillig M, Allegaert K, Vermeesch JR, Moreau Y, Devriendt K.
Am J Med Genet A 158A(3):574-80. doi: 10.1002/ajmg.a.35217. Epub 2012 Feb 8. 2012
7CRKL, PRPN6
SHP-1 protein tyrosine phosphatase associates with the adaptor protein CrkL.
Evren S, Ma XZ, Sakac D, Branch DR.
Exp Hematol 40(12):1055-9. doi: 10.1016/j.exphem.2012.08.007. Epub 2012 Sep 5. 2012
8CRKL
CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion.
Yanagi H, Wang L, Nishihara H, Kimura T, Tanino M, Yanagi T, Fukuda S, Tanaka S.
Biochem Biophys Res Commun 418(1):104-9. doi: 10.1016/j.bbrc.2011.12.142. Epub 2012 Jan 5. 2012
9CRKL
The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer.
Natsume H, Shinmura K, Tao H, Igarashi H, Suzuki M, Nagura K, Goto M, Yamada H, Maeda M, Konno H, Nakamura S, Sugimura H.
J Transl Med 10:97. doi: 10.1186/1479-5876-10-97. 2012
10CRK, CRKL
Identification of CrkL-SH3 binding proteins from embryonic murine brain: implications for Reelin signaling during brain development.
Cheerathodi M, Ballif BA.
J Proteome Res 10(10):4453-62. doi: 10.1021/pr200229a. Epub 2011 Sep 15. 2011
11CRKL, ESR1
CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer.
Padmanabhan RA, Nirmala L, Murali M, Laloraya M.
Mol Endocrinol 25(9):1499-512. doi: 10.1210/me.2011-0008. Epub 2011 Jun 23. 2011
12CRKL
Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer.
Kim YH, Kwei KA, Girard L, Salari K, Kao J, Pacyna-Gengelbach M, Wang P, Hernandez-Boussard T, Gazdar AF, Petersen I, Minna JD, Pollack JR.
Oncogene 29(10):1421-30. Epub 2009 Dec 7. 2010
13CRKL, SPRY1, SPRY2
CrkL is a novel target of Sprouty2 in fibroblast growth factor signaling.
Satoh T, Torii S, Nakayama K, Nishida E.
Genes Cells enes Cells. 2010 Feb 3. [Epub ahead of print]PMID: 20136656 2010
14AGRN, CRK, CRKL, DOK7, MUSK
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
Hallock PT, Xu CF, Park TJ, Neubert TA, Curran T, Burden SJ.
Genes Dev 24(21):2451-61. 2010
15CRKL, FGFR1
Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop.
Seo JH, Suenaga A, Hatakeyama M, Taiji M, Imamoto A.
Mol Cell Biol 29(11):3076-87. Epub 2009 Mar 23. 2009
16CRK, CRKL
Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.
Park TJ, Curran T.
J Neurosci 28(50):13551-62.PMID: 19074029 2008
17CRK, CRKL
Proapoptotic function of the nuclear Crk II adaptor protein.
Kar B, Reichman CT, Singh S, O'Connor JP, Birge RB.
Biochemistry 46(38):10828-40. Epub 2007 Sep 1.PMID: 1776415 2007
18CRKL
The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal.
Harkiolaki M, Gilbert RJ, Jones EY, Feller SM.
Structure 14(12):1741-53. 2006
19CRKL
Translocation of CrkL to focal adhesions mediates integrin-induced migration downstream of Src family kinases.
Li L, Guris DL, Okura M, Imamoto A.
Mol Cell Biol 23(8):2883-92. 2003
20CRKL, DEL22Q11
Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome.
Guris DL, Fantes J, Tara D, Druker BJ, Imamoto A.
Nat Genet 27(3):293-8. 2001
21CRKL
The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene.
Senechal K, Halpern J, Sawyers CL.
J Biol Chem 271(38):23255-61. 1996
22CRKL
Isolation and chromosomal localization of CRKL, a human crk-like gene.
Ten Hoeve J, et al.
Oncogene 8 : 2469-2474. 1993