| 1 | CNR1, CNR2
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| Combined deficiency of the Cnr1 and Cnr2 receptors protects against age-related bone loss by osteoclast inhibition
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| Sophocleous A, Marino S, Kabir D, Ralston SH, Idris AI.
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| Aging Cell. Oct;16(5):1051-1061. doi: 10.1111/acel.12638. Epub 2017 Jul 28 2017
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| 2 | CNR1
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| Impact of CB1 Receptor Deletion on Visual Responses and Organization of Primary Visual Cortex in Adult Mice.
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| Abbas Farishta R, Robert C, Turcot O, Thomas S, Vanni MP, Bouchard JF, Casanova C.
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| Invest Ophthalmol Vis Sci 56(13):7697-707. doi: 10.1167/iovs.15-17690.
2015
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| 3 | CNR1, RAC1
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| The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons.
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| Njoo C, Agarwal N, Lutz B, Kuner R.
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| PLoS Biol 13(10):e1002286. doi: 10.1371/journal.pbio.1002286. eCollection 2015 Oct.
2015
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| 4 | CNR1
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| Type 1 cannabinoid receptor modulates water deprivation-induced homeostatic responses.
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| Ruginsk SG, Vechiato FM, Uchoa ET, Elias LL, Antunes-Rodrigues J.
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| Am J Physiol Regul Integr Comp Physiol 309(11):R1358-68. doi: 10.1152/ajpregu.00536.2014. Epub 2015 Oct 14.
2015
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| 5 | CNR1, SST
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| Colocalization of cannabinoid receptor 1 with somatostatin and neuronal nitric oxide synthase in rat brain hippocampus.
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| Zou S, Kumar U.
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| Brain Res 1622:114-26. doi: 10.1016/j.brainres.2015.06.021. Epub 2015 Jun 23.
2015
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| 6 | CNR1
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| The interactive role of cannabinoid and vanilloid systems in hippocampal synaptic plasticity in rats.
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| Tahmasebi L, Komaki A, Karamian R, Shahidi S, Sarihi A, Salehi I, Nikkhah A.
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| Eur J Pharmacol 757:68-73. doi: 10.1016/j.ejphar.2015.03.063. Epub 2015 Apr 2.
2015
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| 7 | CNR1
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| Cannabinoid receptor 1 is a major mediator of renal fibrosis.
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| Lecru L, Desterke C, Grassin-Delyle S, Chatziantoniou C, Vandermeersch S, Devocelle A, Vernochet A, Ivanovski N, Ledent C, Ferlicot S, Dalia M, Saďd M, Beaudreuil S, Charpentier B, Vazquez A, Giron-Michel J, Azzarone B, Durrbach A, François H.
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| Kidney Int 88(1):72-84. doi: 10.1038/ki.2015.63. Epub 2015 Mar 11.
2015
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| 8 | CNR1
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| Upstream open reading frames regulate cannabinoid receptor 1 expression under baseline conditions and during cellular stress.
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| Eggert M, Pfob M, Jurinovic V, Schelling G, Steinlein OK.
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| Mol Cell Endocrinol 399:103-9. doi: 10.1016/j.mce.2014.09.019. Epub 2014 Sep 26.
2015
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| 9 | CNR1
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| Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study.
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| Fügedi G, Molnár M, Rigó J Jr, Schönléber J, Kovalszky I, Molvarec A.
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| BMC Pregnancy Childbirth 14:395. doi: 10.1186/s12884-014-0395-x.
2014
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| 10 | CNR1
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| Cardiorespiratory anomalies in mice lacking CB1 cannabinoid receptors.
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| Silvani A, Berteotti C, Bastianini S, Cohen G, Lo Martire V, Mazza R, Pagotto U, Quarta C, Zoccoli G.
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| PLoS One 9(6):e100536. doi: 10.1371/journal.pone.0100536. eCollection 2014.
2014
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| 11 | CNR1
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| Cannabinoid receptor 1 disturbance of PPARγ2 augments hyperglycemia induction of mesangial inflammation and fibrosis in renal glomeruli.
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| Lin CL, Hsu YC, Lee PH, Lei CC, Wang JY, Huang YT, Wang SY, Wang FS.
|
| J Mol Med (Berl) 92(7):779-92. doi: 10.1007/s00109-014-1125-6. Epub 2014 Apr 11.
2014
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| 12 | CNR1
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| The endocannabinoid system controls food intake via olfactory processes.
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| Soria-Gómez E, Bellocchio L, Reguero L, Lepousez G, Martin C, Bendahmane M, Ruehle S, Remmers F, Desprez T, Matias I, Wiesner T, Cannich A, Nissant A, Wadleigh A, Pape HC, Chiarlone AP, Quarta C, Verrier D, Vincent P, Massa F, Lutz B, Guzmán M, Gurden H, Ferreira G, Lledo PM, Grandes P, Marsicano G.
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| Nat Neurosci 17(3):407-15. doi: 10.1038/nn.3647. Epub 2014 Feb 9.
2014
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| 13 | CNR1
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| Common polymorphism in the cannabinoid type 1 receptor gene (CNR1) is associated with microvascular complications in type 2 diabetes.
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| Buraczynska M, Wacinski P, Zukowski P, Dragan M, Ksiazek A.
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| J Diabetes Complications 28(1):35-9. doi: 10.1016/j.jdiacomp.2013.08.005. Epub 2013 Sep 24.
2014
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| 14 | CNR1, HINT1
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| HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
|
| Vicente-Sánchez A, Sánchez-Blázquez P, Rodríguez-Muńoz M, Garzón J.
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| Mol Brain 6:42. doi: 10.1186/1756-6606-6-42.
2013
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| 15 | CNR1
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| A common functional promoter variant links CNR1 gene expression to HDL cholesterol level.
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| Feng Q, Vickers KC, Anderson MP, Levin MG, Chen W, Harrison DG, Wilke RA.
|
| Nat Commun 4:1973. doi: 10.1038/ncomms2973.
2013
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| 16 | CNR1
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| Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation.
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| Duncan M, Galic MA, Wang A, Chambers AP, McCafferty DM, McKay DM, Sharkey KA, Pittman QJ.
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| Am J Physiol Regul Integr Comp Physiol 305(3):R224-31. doi: 10.1152/ajpregu.00104.2013. Epub 2013 Jun 5.
2013
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| 17 | CNR1
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| Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation.
|
| Molica F, Burger F, Thomas A, Staub C, Tailleux A, Staels B, Pelli G, Zimmer A, Cravatt B, Matter CM, Pacher P, Steffens S.
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| J Lipid Res 54(5):1360-8. doi: 10.1194/jlr.M035147. Epub 2013 Mar 11.
2013
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| 18 | CNR1
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| Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells.
|
| Compagnucci C, Di Siena S, Bustamante MB, Di Giacomo D, Di Tommaso M, Maccarrone M, Grimaldi P, Sette C.
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| PLoS One 8(1):e54271. doi: 10.1371/journal.pone.0054271. Epub 2013 Jan 23.
2013
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| 19 | ADORA2A, CNR1
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| Adenosine A2A receptor activation stimulates collagen production in sclerodermic dermal fibroblasts either directly and through a cross-talk with the cannabinoid system.
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| Lazzerini PE, Natale M, Gianchecchi E, Capecchi PL, Montilli C, Zimbone S, Castrichini M, Balistreri E, Ricci G, Selvi E, Garcia-Gonzalez E, Galeazzi M, Laghi-Pasini F.
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| J Mol Med (Berl) 90(3):331-42. doi: 10.1007/s00109-011-0824-5. Epub 2011 Oct 28.
2012
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| 20 | CNR1, MC1R, POMC
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| Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor.
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| Pucci M, Pasquariello N, Battista N, Di Tommaso M, Rapino C, Fezza F, Zuccolo M, Jourdain R, Finazzi Agrň A, Breton L, Maccarrone M.
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| J Biol Chem 287(19):15466-78. doi: 10.1074/jbc.M111.314880. Epub 2012 Mar 19.
2012
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| 21 | ARRB2, CNR1
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| Binding between a distal C-terminus fragment of cannabinoid receptor 1 and arrestin-2.
|
| Singh SN, Bakshi K, Mercier RW, Makriyannis A, Pavlopoulos S.
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| Biochemistry 50(12):2223-34. Epub 2011 Feb 28.
2011
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| 22 | CNR1
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| Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging.
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| Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A.
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| Proc Natl Acad Sci U S A 108(27):11256-61. Epub 2011 Jun 20.
2011
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| 23 | CNR1
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| Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential.
|
| Stadelmann AM, Juckel G, Arning L, Gallinat J, Epplen JT, Roser P.
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| Neurosci Lett 496(1):60-4. Epub 2011 Apr 12.
2011
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| 24 | CNR1
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| Cannabinoid receptor type 1 expression during postnatal development of the rat retina.
|
| Zabouri N, Bouchard JF, Casanova C.
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| J Comp Neurol 519(7):1258-80. doi: 10.1002/cne.22534.
2011
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| 25 | CNR1
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| Cannabinoid 1 receptor activation contributes to vascular inflammation and cell death in a mouse model of diabetic retinopathy and a human retinal cell line.
|
| El-Remessy AB, Rajesh M, Mukhopadhyay P, Horváth B, Patel V, Al-Gayyar MM, Pillai BA, Pacher P.
|
| Diabetologia 54(6):1567-78. Epub 2011 Mar 4.
2011
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| 26 | CNR1
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| The cannabinoid type-1 receptor carboxyl-terminus, more than just a tail.
|
| Stadel R, Ahn KH, Kendall DA.
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| J Neurochem 117(1):1-18. doi: 10.1111/j.1471-4159.2011.07186.x. Epub 2011 Feb 11. Review.
2011
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| 27 | ADORA2A, CNR1
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| Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission.
|
| Martire A, Tebano MT, Chiodi V, Ferreira SG, Cunha RA, Köfalvi A, Popoli P.
|
| J Neurochem 116(2):273-80. doi: 10.1111/j.1471-4159.2010.07101.x. Epub 2010 Dec 2.
2011
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| 28 | CNR1
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| Hydrophobic residues in helix 8 of cannabinoid receptor 1 are critical for structural and functional properties.
|
| Ahn KH, Nishiyama A, Mierke DF, Kendall DA.
|
| Biochemistry 49(3):502-11.
2010
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| 29 | CNR1, RARG
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| Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-gamma.
|
| Mukhopadhyay B, Liu J, Osei-Hyiaman D, Godlewski G, Mukhopadhyay P, Wang L, Jeong WI, Gao B, Duester G, Mackie K, Kojima S, Kunos G.
|
| J Biol Chem 285(25):19002-11. Epub 2010 Apr 21.
2010
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| 30 | CNR1
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| Cannabinoid CB₁ receptor is downregulated in clear cell renal cell carcinoma.
|
| Larrinaga G, Sanz B, Pérez I, Blanco L, Cándenas ML, Pinto FM, Gil J, López JI.
|
| J Histochem Cytochem 58(12):1129-34. Epub 2010 Sep 17.
2010
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| 31 | CNR1
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| CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies.
|
| Zurolo E, Iyer AM, Spliet WG, Van Rijen PC, Troost D, Gorter JA, Aronica E.
|
| Neuroscience 170(1):28-41. Epub 2010 Jul 13.
2010
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| 32 | CNR1
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| Expression of cannabinoid receptors in human kidney.
|
| Larrinaga G, Varona A, Pérez I, Sanz B, Ugalde A, Cándenas ML, Pinto FM, Gil J, López JI.
|
| Histol Histopathol 25(9):1133-8.
2010
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| 33 | CNR1
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| Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes.
|
| De Gottardi A, Spahr L, Ravier-Dall'Antonia F, Hadengue A.
|
| Liver Int 30(10):1482-9. doi: 10.1111/j.1478-3231.2010.02298.x.
2010
|
| 34 | CNR1
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| Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.
|
| Pernía-Andrade AJ, Kato A, Witschi R, Nyilas R, Katona I, Freund TF, Watanabe M, Filitz J, Koppert W, Schüttler J, Ji G, Neugebauer V, Marsicano G, Lutz B, Vanegas H, Zeilhofer HU.
|
| Science 325(5941):760-4.
2009
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| 35 | CNR1
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| Cannabinoid receptor 1 gene (CNR1) and susceptibility to a quantitative phenotype for hebephrenic schizophrenia.
|
| Chavarr’a-Siles I, Contreras-Rojas J, Hare E, Walss-Bass C, Quezada P, Dassori A, Contreras S, Medina R, Ram’rez M, Salazar R, Raventos H, Escamilla MA.
|
| Am J Med Genet B Neuropsychiatr Genet 147(3):279-84. 2008
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| 36 | CNR1
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| Cannabinoid CB1 receptors are expressed by parietal cells of the human gastric mucosa.
|
| Pazos MR, Tol—n RM, Benito C, Rodr’guez CF, Gorgojo JJ, Nevado M, Alvarez M, Arias F, Almod—var F, Fern‡ndez MT, Lled— JL, Gonz‡lez S, Fern‡ndez-Ruiz JJ, Romero J.
|
| J Histochem Cytochem 56(5):511-6. Epub 2008 Feb 18. 2008
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| 37 | CNR1
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| Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations.
|
| Benzinou M, Chèvre JC, Ward KJ, Lecoeur C, Dina C, Lobbens S, Durand E, Delplanque J, Horber FF, Heude B, Balkau B, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O, Meyre D, Froguel P.
|
| Hum Mol Genet 17(13):1916-21. Epub 2008 Mar 28.
2008
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| 38 | CNR1
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| Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men.
|
| Russo P, Strazzullo P, Cappuccio FP, Tregouet DA, Lauria F, Loguercio M, Barba G, Versiero M, Siani A.
|
| J Clin Endocrinol Metab 92(6):2382-6. Epub 2007 Apr 3. 2007
|
| 39 | CNR1, CNR2
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| Peripheral cannabinoid receptor, CB2, regulates bone mass.
|
| Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, Wright K, Tam J, Attar-Namdar M, Kram V, Shohami E, Mechoulam R, Zimmer A, Bab I.
|
| Proc Natl Acad Sci U S A 103(3):696-701. Epub 2006 Jan 9. 2006
|
| 40 | CNR1, CNR2
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| Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors.
|
| Idris AI, van 't Hof RJ, Greig IR, Ridge SA, Baker D, Ross RA, Ralston SH.
|
| Nat Med 11(7):774-9. Epub 2005 May 22. 2005
|
| 41 | CNR1, CNR2
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| Cannabinoid receptor type 2 gene is associated with human osteoporosis.
|
| Karsak M, Cohen-Solal M, Freudenberg J, Ostertag A, Morieux C, Kornak U, Essig J, Erxlebe E, Bab I, Kubisch C, de Vernejoul MC, Zimmer A.
|
| Hum Mol Genet 14(22):3389-96. Epub 2005 Oct 4. 2005
|
| 42 | CNR1
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| Identification and characterisation of a novel splice variant of the human CB1 receptor.
|
| Ryberg E, Vu HK, Larsson N, Groblewski T, Hjorth S, Elebring T, Sjogren S, Greasley PJ.
|
| FEBS Lett 579(1):259-64. 2005
|
| 43 | CNR1
|
| Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: differences between restricting and binging/purging subtypes.
|
| Siegfried Z, Kanyas K, Latzer Y, Karni O, Bloch M, Lerer B, Berry EM.
|
| Am J Med Genet 125B(1):126-30. 2004
|
| 44 | CNR1
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| A frequent polymorphism in the coding exon of the human cannabinoid receptor (CNR1) gene.
|
| Gadzicki D, Muller-Vahl K, Stuhrmann M.
|
| Mol Cell Probes 13(4):321-3 1999
|
| 45 | CNR1
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| Localization of cannabinoid CB1 receptors in the human anterior eye and retina.
|
| Straiker AJ, Maguire G, Mackie K, Lindsey J.
|
| Invest Ophthalmol Vis Sci 40(10):2442-8 1999
|
| 46 | CNR1
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| Cannabinoid CB1 receptors and ligands in vertebrate retina: localization and function of an endogenous signaling system.
|
| Straiker A, Stella N, Piomelli D, Mackie K, Karten HJ, Maguire G.
|
| Proc Natl Acad Sci U S A 96(25):14565-70 1999
|
| 47 | CNR1
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| HindIII identifies a two allele DNA polymorphism of the human cannabinoid receptor gene (CNR).
|
| Caenazzo L, et al.
|
| Nucleic Acids Res 19 : 4798. 1991
|
| 48 | CNR1
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| Localization of the cannabanoid receptor locus using non-isotopic in situ hybridization.
|
| Modi WS, et al.
|
| (HGM11) Cytogenet Cell Genet 58 : 1915. 1991
|
| 49 | CNR1
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| Molecular cloning of a human cannabinoid receptor which is also expressed in testis.
|
| GŽrard CM, et al.
|
| Biochem J 279 : 129-134. 1991
|