1 | BTG4, CNOT7, CNOT8, ZCF1
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| Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility
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| Zheng W, Zhou Z, Sha Q, Niu X, Sun X, Shi J, Zhao L, Zhang S, Dai J, Cai S, Meng F, Hu L, Gong F, Li X, Fu J, Shi R, Lu G, Chen B, Fan H, Wang L, Lin G, Sang Q.
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| Am J Hum Genet. Jul 2;107(1):24-33. doi: 10.1016/j.ajhg.2020.05.010. Epub 2020 Jun 4. 2020
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2 | CNOT6, CNOT6L, CNOT7, CNOT8
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| Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
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| Mostafa D, Takahashi A, Yanagiya A, Yamaguchi T, Abe T, Kureha T, Kuba K, Kanegae Y, Furuta Y, Yamamoto T, Suzuki T.
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| RNA Biol. Mar;17(3):403-416. doi: 10.1080/15476286.2019.1709747. Epub 2020 Jan 10 2020
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3 | CNOT7, EIF4A2
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| DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.
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| Meijer HA, Schmidt T, Gillen SL, Langlais C, Jukes-Jones R, de Moor CH, Cain K, Wilczynska A, Bushell M.
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| Nucleic Acids Res. Sep 5;47(15):8224-8238. doi: 10.1093/nar/gkz509 2019
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4 | CNOT1, CNOT7, ICAM1, IL8
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| CNOT1 is involved in TTP‑mediated ICAM‑1 and IL‑8 mRNA decay.
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| Shi JX, Li JS, Hu R, Zhao XC, Liang CC, Li XM, Wang H, Shi Y, Su X.
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| Mol Med Rep 18(2):2321-2327. doi: 10.3892/mmr.2018.9213. Epub 2018 Jun 22.
2018
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5 | CNOT7
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| Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
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| Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.
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| Nucleic Acids Res. Aug 21;45(14):8508-8523. doi: 10.1093/nar/gkx506 2017
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6 | CNOT7
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| Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function.
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| McFleder RL, Mansur F, Richter JD.
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| Cell Rep. Jul 18;20(3):683-696. doi: 10.1016/j.celrep.2017.06.078 2017
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7 | BTG2, CNOT7, CNOT8, PABPC1
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| BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation.
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| Stupfler B, Birck C, Séraphin B, Mauxion F.
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| Nat Commun 7:10811. doi: 10.1038/ncomms10811. 2016
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8 | BTG4, CNOT7, CNOT8
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| The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs.
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| Pasternak M, Pfender S, Santhanam B, Schuh M.
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| Open Biol. Sep;6(9):160184. doi: 10.1098/rsob.160184 2016
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9 | BTG4, CNOT7
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| BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes.
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| Yu C, Ji SY, Sha QQ, Dang Y, Zhou JJ, Zhang YL, Liu Y, Wang ZW, Hu B, Sun QY, Sun SC, Tang F, Fan HY.
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| Nat Struct Mol Biol. May;23(5):387-94. doi: 10.1038/nsmb.3204. Epub 2016 Apr 1 2016
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10 | CNOT6, CNOT6L, CNOT7, CNOT8
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| The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.
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| Maryati M, Airhihen B, Winkler GS.
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| Biochem J. Jul 1;469(1):169-76. doi: 10.1042/BJ20150304. Epub 2015 May 6 2015
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11 | BTG1, BTG2, BTG3, BTG4, CNOT7, CNOT8, TOB1, TOB2
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| The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
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| Doidge R, Mittal S, Aslam A, Winkler GS.
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| PLoS One. ;7(12):e51331. doi: 10.1371/journal.pone.0051331. Epub 2012 Dec 7 2012
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12 | BTG1, BTG2, BTG3, BTG4, CNOT7, CNOT8, TOB1, TOB2
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| The mammalian anti-proliferative BTG/Tob protein family.
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| Winkler GS.
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| J Cell Physiol 222(1):66-72. Review.PMID: 19746446 2010
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13 | BTG2, CNOT7, CNOT8
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| Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity.
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| Yang X, Morita M, Wang H, Suzuki T, Yang W, Luo Y, Zhao C, Yu Y, Bartlam M, Yamamoto T, Rao Z.
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| Nucleic Acids Res 36(21):6872-81. Epub 2008 Oct 30.
2008
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14 | CNOT7, PRMT1
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| hCAF1, a new regulator of PRMT1-dependent arginine methylation.
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| Robin-Lespinasse Y, Sentis S, Kolytcheff C, Rostan MC, Corbo L, Le Romancer M.
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| J Cell Sci 120(Pt 4):638-47. Epub 2007 Jan 30.
2007
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15 | CNOT7
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| Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer.
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| Flanagan J, Healey S, Young J, Whitehall V, Chenevix-Trench G.
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| Int J Cancer 106(4):505-9. 2003
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16 | BTG4, CNOT7, BTG3, TOB1, TOB2
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| Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.
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| Yoshida Y, Hosoda E, Nakamura T, Yamamoto T.
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| Jpn J Cancer Res 92(6):592-6. 2001
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17 | CNOT2, CNOT3, CNOT4, CNOT6L, CNOT7, CNOT8
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| Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.
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| Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT.
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| Nucleic Acids Res 28(3):809-17. 2000
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18 | CNOT7, FGL1, MTMR7, PCM1, PDGFRL, SLC7A2
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| Sequence analysis of a total of three megabases of DNA in two regions of chromosome 8p.
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| Isomura M, Ikegawa S, Kinjo T, Takeuchi K, Yamane-Tanaka Y, Kitami K, Nakamura Y.
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| DNA Res 6(6):387-400. 1999
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19 | BTG1, CNOT7, CNOT8
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| Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.
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| Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB.
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| Biochem J 336 ( Pt 2):471-81. 1998
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20 | CNOT7
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| Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex.
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| Draper MP, Salvadore C, Denis CL.
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| Mol Cell Biol 15(7):3487-95. 1995
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21 | CNOT7, PGS1, EXOSC2
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| Sequence identification of 2,375 human brain genes.
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| Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR,Nagle JW, Fields C, Venter JC.
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| Nature 355(6361):632-4. 1992
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