1 | CNOT1, DDNFA
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| De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay
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| Vissers LELM, Kalvakuri S, de Boer E, Geuer S, Oud M, van Outersterp I, Kwint M, Witmond M, Kersten S, Polla DL, Weijers D, Begtrup A, McWalter K, Ruiz A, Gabau E, Morton JEV, Griffith C, Weiss K, Gamble C, Bartley J, Vernon HJ, Brunet K, Ruivenkamp C, Kant SG, Kruszka P, Larson A, Afenjar A, Billette de Villemeur T, Nugent K; DDD Study, Raymond FL, Venselaar H, Demurger F, Soler-Alfonso C, Li D, Bhoj E, Hayes I, Hamilton NP, Ahmad A, Fisher R, van den Born M, Willems M, Sorlin A, Delanne J, Moutton S, Christophe P, Mau-Them FT, Vitobello A, Goel H, Massingham L, Phornphutkul C, Schwab J, Keren B, Charles P, Vreeburg M, De Simone L, Hoganson G, Iascone M, Milani D, Evenepoel L, Revencu N, Ward DI, Burns K, Krantz I, Raible SE, Murrell JR, Wood K, Cho MT, van Bokhoven H, Muenke M, Kleefstra T, Bodmer R, de Brouwer APM.
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| Am J Hum Genet. Jul 2;107(1):164-172. doi: 10.1016/j.ajhg.2020.05.017. Epub 2020 Jun 17 2020
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2 | CNOT1, HPEAP
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| A Specific CNOT1 Mutation Results in a Novel Syndrome of Pancreatic Agenesis and Holoprosencephaly through Impaired Pancreatic and Neurological Development.
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| De Franco E, Watson RA, Weninger WJ, Wong CC, Flanagan SE, Caswell R, Green A, Tudor C, Lelliott CJ, Geyer SH, Maurer-Gesek B, Reissig LF, Lango Allen H, Caliebe A, Siebert R, Holterhus PM, Deeb A, Prin F, Hilbrands R, Heimberg H, Ellard S, Hattersley AT, Barroso I.
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| Am J Hum Genet 104(5):985-989. doi: 10.1016/j.ajhg.2019.03.018. Epub 2019 Apr 18.
2019
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3 | CNOT1, HPEAP
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| A CCR4-NOT Transcription Complex, Subunit 1, CNOT1, Variant Associated with Holoprosencephaly.
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| Kruszka P, Berger SI, Weiss K, Everson JL, Martinez AF, Hong S, Anyane-Yeboa K, Lipinski RJ, Muenke M.
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| Am J Hum Genet 104(5):990-993. doi: 10.1016/j.ajhg.2019.03.017. Epub 2019 Apr 18.
2019
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4 | ATG7, CNOT1, CNOT3
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| The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function.
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| Yamaguchi T, Suzuki T, Sato T, Takahashi A, Watanabe H, Kadowaki A, Natsui M, Inagaki H, Arakawa S, Nakaoka S, Koizumi Y, Seki S, Adachi S, Fukao A, Fujiwara T, Natsume T, Kimura A, Komatsu M, Shimizu S, Ito H, Suzuki Y, Penninger JM, Yamamoto T, Imai Y, Kuba K.
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| Sci Signal 11(516). pii: eaan3638. doi: 10.1126/scisignal.aan3638.
2018
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5 | CNOT1, CNOT9
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| The central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4-Not nuclease module.
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| Pavanello L, Hall B, Airhihen B, Winkler GS.
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| Biochem J 475(21):3437-3450. doi: 10.1042/BCJ20180456.
2018
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6 | CNOT1, CNOT7, ICAM1, IL8
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| CNOT1 is involved in TTP‑mediated ICAM‑1 and IL‑8 mRNA decay.
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| Shi JX, Li JS, Hu R, Zhao XC, Liang CC, Li XM, Wang H, Shi Y, Su X.
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| Mol Med Rep 18(2):2321-2327. doi: 10.3892/mmr.2018.9213. Epub 2018 Jun 22.
2018
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7 | CNOT1, LMNA
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| CNOT1 cooperates with LMNA to aggravate osteosarcoma tumorigenesis through the Hedgehog signaling pathway.
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| Cheng DD, Li J, Li SJ, Yang QC, Fan CY.
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| Mol Oncol 11(4):388-404. doi: 10.1002/1878-0261.12043. Epub 2017 Mar 6.
2017
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8 | CNOT1, YTHDF2
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| YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex.
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| Du H, Zhao Y, He J, Zhang Y, Xi H, Liu M, Ma J, Wu L.
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| Nat Commun 7:12626. doi: 10.1038/ncomms12626.
2016
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9 | CNOT1, DDX6, EDC3, EIF4ENIF1
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| Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex.
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| Ozgur S, Basquin J, Kamenska A, Filipowicz W, Standart N, Conti E.
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| Cell Rep 13(4):703-11. doi: 10.1016/j.celrep.2015.09.033. Epub 2015 Oct 17.
2015
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10 | CNOT1, DDX6
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| Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.
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| Rouya C, Siddiqui N, Morita M, Duchaine TF, Fabian MR, Sonenberg N.
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| RNA 20(9):1398-409. doi: 10.1261/rna.045302.114. Epub 2014 Jul 17.
2014
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11 | CNOT1, DDX6
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| Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.
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| Mathys H, Basquin J, Ozgur S, Czarnocki-Cieciura M, Bonneau F, Aartse A, Dziembowski A, Nowotny M, Conti E, Filipowicz W.
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| Mol Cell 54(5):751-65. doi: 10.1016/j.molcel.2014.03.036. Epub 2014 Apr 24.
2014
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12 | CNOT1, CNOT2, CNOT3
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| Structure and assembly of the NOT module of the human CCR4-NOT complex.
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| Boland A, Chen Y, Raisch T, Jonas S, Kuzuoğlu-Öztürk D, Wohlbold L, Weichenrieder O, Izaurralde E.
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| Nat Struct Mol Biol 20(11):1289-97. doi: 10.1038/nsmb.2681. Epub 2013 Oct 13.
2013
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13 | CNOT1, ZFP36
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| Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin.
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| Fabian MR, Frank F, Rouya C, Siddiqui N, Lai WS, Karetnikov A, Blackshear PJ, Nagar B, Sonenberg N.
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| Nat Struct Mol Biol 20(6):735-9. doi: 10.1038/nsmb.2572. Epub 2013 May 5.
2013
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14 | CNOT1, CNOT2, CNOT3
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| Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.
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| Zheng X, Dumitru R, Lackford BL, Freudenberg JM, Singh AP, Archer TK, Jothi R, Hu G.
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| Stem Cells 30(5):910-22. doi: 10.1002/stem.1070.
2012
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15 | CNOT1, CNOT2, CNOT3
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| Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.
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| Zheng X, Dumitru R, Lackford BL, Freudenberg JM, Singh AP, Archer TK, Jothi R, Hu G.
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| Stem Cells 30(5):910-22. doi: 10.1002/stem.1070.
2012
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16 | CNOT1
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| The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability.
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| Ito K, Takahashi A, Morita M, Suzuki T, Yamamoto T.
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| Protein Cell 2(9):755-63. doi: 10.1007/s13238-011-1092-4. Epub 2011 Oct 6.
2011
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17 | CNOT1, ESR1
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| Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription.
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| Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT.
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| EMBO J 25(13):3089-99. Epub 2006 Jun 15.
2006
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18 | CNOT1, CNOT2, CNOT3
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| Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.
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| Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT.
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| Nucleic Acids Res 28(3):809-17.
2000
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