Citations for
1CLOCK, NLGN1
Regulation of the Neuroligin-1 Gene by Clock Transcription Factors.
Hannou L, Bélanger-Nelson E, O'Callaghan EK, Dufort-Gervais J, Ballester Roig MN, Roy PG, Beaulieu JM, Cermakian N, Mongrain V.
J Biol Rhythms. Apr;33(2):166-178. doi: 10.1177/0748730418761236. 2018
2CLOCK, NPAS2
NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.
Landgraf D, Wang LL, Diemer T, Welsh DK.
PLoS Genet 12(2):e1005882. doi: 10.1371/journal.pgen.1005882. 2016
3ARNTL, CLOCK, FABP7, NPAS2, NR1D1
Altered Sleep Homeostasis in Rev-erbα Knockout Mice.
Mang GM, La Spada F, Emmenegger Y, Chappuis S, Ripperger JA, Albrecht U, Franken P.
Sleep 39(3):589-601. doi: 10.5665/sleep.5534. 2016
4CLOCK, PTGS2
Circadian CLOCK Mediates Activation of Transforming Growth Factor-β Signaling and Renal Fibrosis through Cyclooxygenase 2.
Chen WD, Yeh JK, Peng MT, Shie SS, Lin SL, Yang CH, Chen TH, Hung KC, Wang CC, Hsieh IC, Wen MS, Wang CY.
Am J Pathol 185(12):3152-63. doi: 10.1016/j.ajpath.2015.08.003. 2015
5CLOCK
Circadian clock gene plays a key role on ovarian cycle and spontaneous abortion.
Li R, Cheng S, Wang Z.
Cell Physiol Biochem 37(3):911-20. doi: 10.1159/000430218. 2015
6ARNTL, CLOCK, FTO
FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription.
Wang CY, Shie SS, Hsieh IC, Tsai ML, Wen MS.
Biochem Biophys Res Commun 464(3):826-32. doi: 10.1016/j.bbrc.2015.07.046. 2015
7ARNTL, CLOCK, PER1
A Positive Role for PERIOD in Mammalian Circadian Gene Expression.
Akashi M, Okamoto A, Tsuchiya Y, Todo T, Nishida E, Node K.
Cell Rep ell Rep. 2014 Apr 30. pii: S2211-1247(14)00282-4. doi: 10.1016/j.celrep.2014.03.072. [Epub ahead of print] 2014
8ARNTL, CLOCK
CLOCK:BMAL1 is a pioneer-like transcription factor.
Menet JS, Pescatore S, Rosbash M.
Genes Dev 28(1):8-13. doi: 10.1101/gad.228536.113. 2014
9ARNTL, CLOCK
CLOCK-controlled polyphonic regulation of circadian rhythms through canonical and noncanonical E-boxes.
Yoshitane H, Ozaki H, Terajima H, Du NH, Suzuki Y, Fujimori T, Kosaka N, Shimba S, Sugano S, Takagi T, Iwasaki W, Fukada Y.
Mol Cell Biol 34(10):1776-87. doi: 10.1128/MCB.01465-13. 2014
10ARNTL, CLOCK
CLOCK:BMAL1 is a pioneer-like transcription factor.
Menet JS, Pescatore S, Rosbash M.
Genes Dev 28(1):8-13. doi: 10.1101/gad.228536.113. 2014
11ARNTL, CLOCK, THRAP3
A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery.
Lande-Diner L, Boyault C, Kim JY, Weitz CJ.
Proc Natl Acad Sci U S A 110(40):16021-6. doi: 10.1073/pnas.1305980110. Epub 2013 Sep 16. 2013
12CLOCK
CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α.
Li S, Wang M, Ao X, Chang AK, Yang C, Zhao F, Bi H, Liu Y, Xiao L, Wu H.
Oncogene 32(41):4883-91. doi: 10.1038/onc.2012.518. Epub 2012 Nov 19. 2013
13ARNTL, CLOCK, NPAS2
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.
Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, Fitzgerald GA.
J Clin Invest 123(12):5389-400. doi: 10.1172/JCI70317. 2013
14CLOCK, SUMO1
CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α.
Li S, Wang M, Ao X, Chang AK, Yang C, Zhao F, Bi H, Liu Y, Xiao L, Wu H.
Oncogene 32(41):4883-91. doi: 10.1038/onc.2012.518. 2013
15APOA4, CLOCK, MTTP, NOCT
Circadian regulation of intestinal lipid absorption by apolipoprotein AIV involves forkhead transcription factors A2 and O1 and microsomal triglyceride transfer protein.
Pan X, Munshi MK, Iqbal J, Queiroz J, Sirwi AA, Shah S, Younus A, Hussain MM.
J Biol Chem 288(28):20464-76. doi: 10.1074/jbc.M113.473454. 2013
16CLOCK, RAI1, SMS
Smith-Magenis Syndrome Results in Disruption of CLOCK Gene Transcription and Reveals an Integral Role for RAI1 in the Maintenance of Circadian Rhythmicity.
Williams SR, Zies D, Mullegama SV, Grotewiel MS, Elsea SH.
Am J Hum Genet 90(6):941-9. Epub 2012 May 10. 2012
17ARNTL, CLOCK, DBP
Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome.
Stratmann M, Suter DM, Molina N, Naef F, Schibler U.
Mol Cell 48(2):277-87. doi: 10.1016/j.molcel.2012.08.012. Epub 2012 Sep 13. 2012
18ARNTL, CLOCK
Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells.
Peruquetti RL, de Mateo S, Sassone-Corsi P.
PLoS One 7(8):e42695. doi: 10.1371/journal.pone.0042695. Epub 2012 Aug 10. 2012
19ARNTL, CLOCK, NFKB1
Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription.
Spengler ML, Kuropatwinski KK, Comas M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP.
Proc Natl Acad Sci U S A 109(37):E2457-65. doi: 10.1073/pnas.1206274109. 2012
20ARNTL, CLOCK
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J.
Nature 466(7306):627-31. 2010
21CLOCK
Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder.
Xu X, Breen G, Chen CK, Huang YS, Wu YY, Asherson P.
Behav Brain Funct 6:48.PMID: 20704703 2010
22CLOCK, GYS2
CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2.
Doi R, Oishi K, Ishida N.
J Biol Chem 285(29):22114-21. Epub 2010 Apr 29.PMID: 20430893 2010
23ARNTL, CLOCK
Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway.
Shimomura K, Lowrey PL, Vitaterna MH, Buhr ED, Kumar V, Hanna P, Omura C, Izumo M, Low SS, Barrett RK, LaRue SI, Green CB, Takahashi JS.
Proc Natl Acad Sci U S A 107(18):8399-403. Epub 2010 Apr 19.PMID: 20404168 2010
24ARNTL, CLOCK
Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain.
Wyse CA, Coogan AN.
Brain Res 1337:21-31. Epub 2010 Apr 9.PMID: 20382135 2010
25CLOCK
Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population).
Garaulet M, Lee YC, Shen J, Parnell LD, Arnett DK, Tsai MY, Lai CQ, Ordovas JM.
Eur J Hum Genet 18(3):364-9. Epub 2009 Nov 4.PMID: 19888304 2010
26ARNTL, CLOCK, MYOD1
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function.
Andrews JL, Zhang X, McCarthy JJ, McDearmon EL, Hornberger TA, Russell B, Campbell KS, Arbogast S, Reid MB, Walker JR, Hogenesch JB, Takahashi JS, Esser KA.
Proc Natl Acad Sci U S A 107(44):19090-5. Epub 2010 Oct 18. 2010
27ARNTL2, CLOCK, ID2
The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.
Ward SM, Fernando SJ, Hou TY, Duffield GE.
J Biol Chem 285(50):38987-9000. Epub 2010 Sep 22. 2010
28CLOCK
A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation.
Spengler ML, Kuropatwinski KK, Schumer M, Antoch MP.
Cell Cycle 8(24):4138-46. Epub 2009 Dec 8.PMID: 19946213 2009
29CLOCK
Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription.
Yoshitane H, Takao T, Satomi Y, Du NH, Okano T, Fukada Y.
Mol Cell Biol 29(13):3675-86. Epub 2009 May 4.PMID: 19414601 2009
30CLOCK
Clock is important for food and circadian regulation of macronutrient absorption in mice.
Pan X, Hussain MM.
J Lipid Res 50(9):1800-13. Epub 2009 Apr 22.PMID: 19387090 2009
31ARNTL, CLOCK
Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cells.
Kimiwada T, Sakurai M, Ohashi H, Aoki S, Tominaga T, Wada K.
Neurochem Int 54(5-6):277-85. Epub 2008 Dec 11.PMID: 19121353 2009
32CLOCK
A polymorphism at the 3'-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorder.
Kissling C, Retz W, Wiemann S, Coogan AN, Clement RM, HŸnnerkopf R, Conner AC, Freitag CM, Ršsler M, Thome J.
Am J Med Genet B Neuropsychiatr Genet 147(3):333-8. 2008
33KAT5, CLOCK
Tip60 is regulated by circadian transcription factor clock and is involved in Cisplatin resistance.
Miyamoto N, Izumi H, Noguchi T, Nakajima Y, Ohmiya Y, Shiota M, Kidani A, Tawara A, Kohno K.
J Biol Chem 283(26):18218-26. Epub 2008 May 5. 2008
34CLOCK
CLOCK is required for maintaining the circadian rhythms of Opsin mRNA expression in photoreceptor cells.
Li P, Chaurasia SS, Gao Y, Carr AL, Iuvone PM, Li L.
J Biol Chem 283(46):31673-8. Epub 2008 Aug 7. 2008
35CLOCK, NPAS2
Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators.
Bertolucci C, Cavallari N, Colognesi I, Aguzzi J, Chen Z, Caruso P, Foá A, Tosini G, Bernardi F, Pinotti M.
Mol Cell Biol 28(9):3070-5. Epub 2008 Mar 3.PMID: 18316400 2008
36ARNTL, CLOCK, NOCT
CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter.
Li R, Yue J, Zhang Y, Zhou L, Hao W, Yuan J, Qiang B, Ding JM, Peng X, Cao JM.
Mol Cell Biochem 317(1-2):169-77. Epub 2008 Jun 28. 2008
37ARNTL, ARNTL2, CLOCK
Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.
Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C.
Am J Med Genet B Neuropsychiatr Genet 147B(7):1047-55. 2008
38ARNTL, CLOCK, NPAS2
CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.
DeBruyne JP, Weaver DR, Reppert SM.
Nat Neurosci 10(5):543-5. Epub 2007 Apr 8. 2007
39CLOCK
Inter-subject differences in constitutive expression levels of the clock gene in man.
Balmforth AJ, Grant PJ, Scott EM, Wheatcroft SB, Kearney MT, Staels B, Marx N.
Diab Vasc Dis Res 4(1):39-43. 2007
40CLOCK
The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: a preliminary study.
Tortorella A, Monteleone P, Martiadis V, Perris F, Maj M.
Am J Med Genet B Neuropsychiatr Genet 144(8):992-5. 2007
41ARNTL, CLOCK
Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions.
Ripperger JA, Schibler U.
Nat Genet 38(3):369-74. Epub 2006 Feb 12. 2006
42CLOCK
Circadian regulator CLOCK is a histone acetyltransferase.
Doi M, Hirayama J, Sassone-Corsi P.
Cell 125(3):497-508. 2006
43ARNTL,ARNTL2,CLOCK,SERPINE1
Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference.
Chong NW, Codd V, Chan D, Samani NJ.
FEBS Lett 580(18):4469-72. Epub 2006 Jul 14. 2006
44ARNTL,CLOCK
Feedback repression is required for mammalian circadian clock function.
Sato TK, Yamada RG, Ukai H, Baggs JE, Miraglia LJ, Kobayashi TJ, Welsh DK, Kay SA, Ueda HR, Hogenesch JB.
Nat Genet 38(3):312-9. Epub 2006 Feb 12. 2006
45CSNK1E, CNSK1G2, PER1, CLOCK, BTRC
SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
Shirogane T, Jin J, Ang XL, Harper JW.
J Biol Chem 280(29):26863-72. Epub 2005 May 24. 2005
46CLOCK
Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism.
Serretti A, Benedetti F, Mandelli L, Lorenzi C, Pirovano A, Colombo C, Smeraldi E.
Am J Med Genet 121B(1):35-8. 2003
47ARNTL, CLOCK
Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1.
Sanada K, Okano T, Fukada Y.
J Biol Chem 277(1):267-71. Epub 2001 Oct 30. 2002
48CLOCK, NPAS2
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors.
Rutter J, Reick M, Wu LC, McKnight SL.
Science 293(5529):510-4. 2001
49CLOCK
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock.
McNamara P, Seo SP, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA.
Cell 105(7):877-89. 2001
50CLOCK
Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei.
Steeves TD, et al.
Genomics 57(2):189-200. 1999
51ADAMTS3, AKAP6, ALMS1, ANKRD28, AREL1, ARHGEF10, ARHGEF11, ARHGEF17, ARNT2, BAZ2A, CABIN1, CAST, CHD9, CIC, CLEC16A, CLOCK, CTNND1, DCLK1, DDX46, DIDO1, DNAH9, DNM3, DOCK3, DYNC1H1, ECM29, ENTPD4, EPB41L1, EZH1, FAM65B, FRMPD4, GCC2, HECW1, HERC2, HISPPD1, HUWE1, IGSF1, KAT6B, KIAA0319, KIAA0323, KIAA0355, KIAA0379, KIF3B, KMT2B, LBA1, MADD, MAST4, MCF2L, MDN1, MTMR3, MYO6, N4BP3, NACAD, NRCAM, PCDH9, PCDHGA8, PCDHGC3, PDZD2, PER2, PFAS, PLEKHM1, PLXNB2, PRORP, PRUNE2, PTPRN2, RAPGEF2, RIMBP2, RIMS1, RUSC2, SALL2, SEC16A, SEMA3C, SEMA3E, SETD1A, SFRS14, SNPH, SPECC1L, SPTBN2, SR140, SRCAP, SRRM2, SYNJ2, TECPR2, TLN2, TRIM66, TTC37, UBR2, WNK1, XPO6, ZBTB39, ZBTB5, ZFYVE16, ZFYVE26, ZMYM3, ZNF518A, ZNF609, ZNF629, ZNF646
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A,Kotani H, Nomura N, Ohara O.
DNA Res 4(2):141-50. 1997