Citations for
1CHRNA7, DEL15Q13, DUP15Q13, OTUD7A
Functional Consequences of CHRNA7 Copy-Number Alterations in Induced Pluripotent Stem Cells and Neural Progenitor Cells.
Gillentine MA, Yin J, Bajic A, Zhang P, Cummock S, Kim JJ, Schaaf CP.
Am J Hum Genet 101(6):874-887. doi: 10.1016/j.ajhg.2017.09.024. Epub 2017 Nov 9. 2017
2CHRNA7
Alpha-7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation.
Yamada-Nomoto K, Yoshino O, Akiyama I, Ushijima A, Ono Y, Shima T, Nakashima A, Hayashi S, Kadowaki M, Osuga Y, Saito S.
Am J Reprod Immunol 76(6):491-498. doi: 10.1111/aji.12592. Epub 2016 Oct 21. 2016
3CHRNA7
Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells.
Zanetti SR, Ziblat A, Torres NI, Zwirner NW, Bouzat C.
J Biol Chem 291(32):16541-52. doi: 10.1074/jbc.M115.710574. Epub 2016 Jun 9. 2016
4CHRNA7, RIC3
RIC-3 expression and splicing regulate nAChR functional expression.
Ben-David Y, Mizrachi T, Kagan S, Krisher T, Cohen E, Brenner T, Treinin M.
Mol Brain 9(1):47. doi: 10.1186/s13041-016-0231-5. 2016
5CHRNA7
Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders.
Kalkman HO, Feuerbach D.
Cell Mol Life Sci 73(13):2511-30. doi: 10.1007/s00018-016-2175-4. Epub 2016 Mar 15. Review. 2016
6CHRNA7
Integration of inhibitory and excitatory effects of α7 nicotinic acetylcholine receptor activation in the prelimbic cortex regulates network activity and plasticity.
Udakis M, Wright VL, Wonnacott S, Bailey CP.
Neuropharmacology 105:618-629. doi: 10.1016/j.neuropharm.2016.02.028. Epub 2016 Feb 24. 2016
7CHRNA7
Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.
Dong MW, Li M, Chen J, Fu TT, Lin KZ, Ye GH, Han JG, Feng XP, Li XB, Yu LS, Fan YY.
Inflammation 39(2):687-99. doi: 10.1007/s10753-015-0295-x. 2016
8CHRNA7, RIC3
Functional expression of human α7 nicotinic acetylcholine receptor in human embryonic kidney 293 cells.
Gong Y, Jiang JH, Li ST.
Mol Med Rep 14(3):2257-63. doi: 10.3892/mmr.2016.5493. Epub 2016 Jul 11. 2016
9CHRNA7, RIC3
Evidence of mutations in RIC3 acetylcholine receptor chaperone as a novel cause of autosomal-dominant Parkinson's disease with non-motor phenotypes.
Sudhaman S, Muthane UB, Behari M, Govindappa ST, Juyal RC, Thelma BK.
J Med Genet 53(8):559-66. doi: 10.1136/jmedgenet-2015-103616. Epub 2016 Apr 7. 2016
10CHRNA7
Amyloid-β peptide increases cell surface localization of α7 ACh receptor to protect neurons from amyloid β-induced damage.
Jin Y, Tsuchiya A, Kanno T, Nishizaki T.
Biochem Biophys Res Commun 468(1-2):157-60. doi: 10.1016/j.bbrc.2015.10.141. Epub 2015 Nov 4. 2015
11CHRNA7
Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.
Zhang Q, Du Y, Zhang J, Xu X, Xue F, Guo C, Huang Y, Lukas RJ, Chang Y.
PLoS One 10(9):e0137588. doi: 10.1371/journal.pone.0137588. eCollection 2015. 2015
12CHRNA7
Inflammation decreases the level of alpha7 nicotinic acetylcholine receptors in the brain mitochondria and makes them more susceptible to apoptosis induction.
Lykhmus O, Gergalova G, Zouridakis M, Tzartos S, Komisarenko S, Skok M.
Int Immunopharmacol 29(1):148-51. doi: 10.1016/j.intimp.2015.04.007. Epub 2015 Apr 15. 2015
13CHRNA7
Analysis of CHRNA7 rare variants in autism spectrum disorder susceptibility.
Bacchelli E, Battaglia A, Cameli C, Lomartire S, Tancredi R, Thomson S, Sutcliffe JS, Maestrini E.
Am J Med Genet A 167A(4):715-23. doi: 10.1002/ajmg.a.36847. Epub 2015 Feb 5. 2015
14CHRNA7
Functional alpha7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
John D, Shelukhina I, Yanagawa Y, Deuchars J, Henderson Z.
Brain Res 1601:15-30. doi: 10.1016/j.brainres.2014.12.041. Epub 2014 Dec 29. 2015
15CHRNA7
Nicotinic receptor Alpha7 expression during mouse adrenal gland development.
Gahring LC, Myers E, Palumbos S, Rogers SW.
PLoS One 9(8):e103861. doi: 10.1371/journal.pone.0103861. eCollection 2014. 2014
16CHRNA7
Selective activation of α7 nicotinic acetylcholine receptor (nAChRα7) inhibits muscular degeneration in mdx dystrophic mice.
Leite PE, Gandía L, de Pascual R, Nanclares C, Colmena I, Santos WC, Lagrota-Candido J, Quirico-Santos T.
Brain Res 1573:27-36. doi: 10.1016/j.brainres.2014.05.004. Epub 2014 May 14. 2014
17CHRNA7
α7 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways.
Gergalova G, Lykhmus O, Komisarenko S, Skok M.
Int J Biochem Cell Biol 49:26-31. doi: 10.1016/j.biocel.2014.01.001. Epub 2014 Jan 9. 2014
18CHRNA7
Axon targeting of the alpha 7 nicotinic receptor in developing hippocampal neurons by Gprin1 regulates growth.
Nordman JC, Phillips WS, Kodama N, Clark SG, Del Negro CA, Kabbani N.
J Neurochem 129(4):649-62. doi: 10.1111/jnc.12641. Epub 2014 Jan 10. 2014
19CHRNA7
Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.
Inestrosa NC, Godoy JA, Vargas JY, Arrazola MS, Rios JA, Carvajal FJ, Serrano FG, Farias GG.
Neuromolecular Med 15(3):549-69. doi: 10.1007/s12017-013-8242-1. Epub 2013 Jul 11. 2013
20CHRNA7
Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage.
Gahring LC, Enioutina EY, Myers EJ, Spangrude GJ, Efimova OV, Kelley TW, Tvrdik P, Capecchi MR, Rogers SW.
PLoS One 8(3):e57481. doi: 10.1371/journal.pone.0057481. Epub 2013 Mar 1. 2013
21CHRNA7, RIC3
Chemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRs.
Kuryatov A, Mukherjee J, Lindstrom J.
PLoS One 8(4):e62246. doi: 10.1371/journal.pone.0062246. Print 2013. 2013
22CHRNA7, DEL15Q13
Identification of single gene deletions at 15q13.3: further evidence that CHRNA7 causes the 15q13.3 microdeletion syndrome phenotype.
Hoppman-Chaney N, Wain K, Seger P, Superneau D, Hodge J.
Clin Genet lin Genet. 2012 Jul 9. doi: 10.1111/j.1399-0004.2012.01925.x. [Epub ahead of print] 2012
23CHRNA7
An interaction between α7 nicotinic receptors and a G-protein pathway complex regulates neurite growth in neural cells.
Nordman JC, Kabbani N.
J Cell Sci 125(Pt 22):5502-13. doi: 10.1242/jcs.110379. Epub 2012 Sep 6. 2012
24CHRNA7
Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy.
Rogers SW, Gahring LC.
PLoS One 7(5):e36467. doi: 10.1371/journal.pone.0036467. Epub 2012 May 30. 2012
25CHRNA7, DEL15Q13
Deletions flanked by breakpoints 3 and 4 on 15q13 may contribute to abnormal phenotypes.
Rosenfeld JA, Stephens LE, Coppinger J, Ballif BC, Hoo JJ, French BN, Banks VC, Smith WE, Manchester D, Tsai AC, Merrion K, Mendoza-Londono R, Dupuis L, Schultz R, Torchia B, Sahoo T, Bejjani B, Weaver DD, Shaffer LG.
Eur J Hum Genet 19(5):547-54. Epub 2011 Jan 19. 2011
26CHRNA7, DEl15Q13
Pharmacotherapeutic implications of the association between genomic instability at chromosome 15q13.3 and autism spectrum disorders.
Deutsch SI, Urbano MR, Burket JA, Herndon AL, Winebarger EE.
Clin Neuropharmacol 34(6):203-5. 2011
27CHRNA7
15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain.
Yasui DH, Scoles HA, Horike S, Meguro-Horike M, Dunaway KW, Schroeder DI, Lasalle JM.
Hum Mol Genet. 20(22):4311-23. 2011
28CHRNA7, TFAP2A
Transcriptional repression of the α7 nicotinic acetylcholine receptor subunit gene (CHRNA7) by activating protein-2α (AP-2α).
Finlay-Schultz J, Canastar A, Short M, El Gazzar M, Coughlan C, Leonard S.
J Biol Chem 286(49):42123-32. doi: 10.1074/jbc.M111.276014. Epub 2011 Oct 6. 2011
29CHRNA7, DEL15Q13, TRPM1
A 15q13.3 homozygous microdeletion associated with a severe neurodevelopmental disorder suggests putative functions of the TRPM1, CHRNA7, and other homozygously deleted genes.
Lepichon JB, Bittel DC, Graf WD, Yu S.
Am J Med Genet A 152A(5):1300-4.PMID: 20425840 2010
30CHRNA7, DUP15Q13
Structures and molecular mechanisms for common 15q13.3 microduplications involving CHRNA7: benign or pathological?
Szafranski P, Schaaf CP, Person RE, Gibson IB, Xia Z, Mahadevan S, Wiszniewska J, Bacino CA, Lalani S, Potocki L, Kang SH, Patel A, Cheung SW, Probst FJ, Graham BH, Shinawi M, Beaudet AL, Stankiewicz P.
Hum Mutat 31(7):840-50.PMID: 20506139 2010
31CHRNA7, DEL15Q13
Homozygous loss of CHRNA7 on chromosome 15q13.3 causes severe encephalopathy with seizures and hypotonia.
Endris V, Hackmann K, Neuhann TM, Grasshoff U, Bonin M, Haug U, Hahn G, Schallner JC, Schröck E, Tinschert S, Rappold G, Moog U.
Am J Med Genet A 152A(11):2908-11. No abstract available. PMID: 20979196 2010
32CHRNA7, DEL15Q13
Delineation of 15q13.3 microdeletions.
Masurel-Paulet A, Andrieux J, Callier P, Cuisset JM, Le Caignec C, Holder M, Thauvin-Robinet C, Doray B, Flori E, Alex-Cordier MP, Beri M, Boute O, Delobel B, Dieux A, Vallee L, Jaillard S, Odent S, Isidor B, Beneteau C, Vigneron J, Bilan F, Gilbert-Dussardier B, Dubourg C, Labalme A, Bidon C, Gautier A, Pernes P, Pinoit JM, Huet F, Mugneret F, Aral B, Jonveaux P, Sanlaville D, Faivre L.
Clin Genet 78(2):149-61. Epub 2010 Feb 9. 2010
33CHRNA7, RIC3
Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER subcompartment of dendrites.
Alexander JK, Sagher D, Krivoshein AV, Criado M, Jefford G, Green WN.
J Neurosci 30(30):10112-26. doi: 10.1523/JNEUROSCI.6344-09.2010. 2010
34CHRNA7
Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor.
Wu JC, Chruscinski A, De Jesus Perez VA, Singh H, Pitsiouni M, Rabinovitch M, Utz PJ, Cooke JP.
J Cell Biochem 108(2):433-46.PMID: 19623583 2009
35CHRNA7, DEL15Q13, OTUD7A
A small recurrent deletion within 15q13.3 is associated with a range of neurodevelopmental phenotypes.
Shinawi M, Schaaf CP, Bhatt SS, Xia Z, Patel A, Cheung SW, Lanpher B, Nagl S, Herding HS, Nevinny-Stickel C, Immken LL, Patel GS, German JR, Beaudet AL, Stankiewicz P.
Nat Genet 41(12):1269-71. Epub 2009 Nov 8. 2009
36CHRNA7, DEL15Q13, DUP15Q13
Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders.
Miller DT, Shen Y, Weiss LA, Korn J, Anselm I, Bridgemohan C, Cox GF, Dickinson H, Gentile J, Harris DJ, Hegde V, Hundley R, Khwaja O, Kothare S, Luedke C, Nasir R, Poduri A, Prasad K, Raffalli P, Reinhard A, Smith SE, Sobeih MM, Soul JS, Stoler J, Takeoka M, Tan WH, Thakuria J, Wolff R, Yusupov R, Gusella JF, Daly MJ, Wu BL.
J Med Genet 46(4):242-8. Epub 2008 Sep 19. 2009
37CHRNA7, DEL15Q13
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy.
Helbig I, Mefford HC, Sharp AJ, Guipponi M, Fichera M, Franke A, Muhle H, de Kovel C, Baker C, von Spiczak S, Kron KL, Steinich I, Kleefuss-Lie AA, Leu C, Gaus V, Schmitz B, Klein KM, Reif PS, Rosenow F, Weber Y, Lerche H, Zimprich F, Urak L, Fuchs K, Feucht M, Genton P, Thomas P, Visscher F, de Haan GJ, Møller RS, Hjalgrim H, Luciano D, Wittig M, Nothnagel M, Elger CE, Nürnberg P, Romano C, Malafosse A, Koeleman BP, Lindhout D, Stephani U, Schreiber S, Eichler EE, Sander T.
Nat Genet 41(2):160-2. Epub 2009 Jan 11. 2009
38CHRNA7
Role of alpha7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation.
Paleari L, Catassi A, Ciarlo M, Cavalieri Z, Bruzzo C, Servent D, Cesario A, Chessa L, Cilli M, Piccardi F, Granone P, Russo P.
Cell Prolif 41(6):936-59. Erratum in: Cell Prolif. 2009 Aug;42(4):568. Cell Prolif. 2009 Feb;42(1):122. PMID: 19040571 2008
39CHRNA7
Expression of nicotinic receptors in normal and tumoral pulmonary neuroendocrine cells (PNEC).
Sartelet H, Maouche K, Totobenazara JL, Petit J, Burlet H, Monteau M, Tournier JM, Birembaut P.
Pathol Res Pract 204(12):891-8. Epub 2008 Jul 29.PMID: 18667281 2008
40CHRNA7, DEL15Q13
A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures.
Sharp AJ, Mefford HC, Li K, Baker C, Skinner C, Stevenson RE, Schroer RJ, Novara F, De Gregori M, Ciccone R, Broomer A, Casuga I, Wang Y, Xiao C, Barbacioru C, Gimelli G, Bernardina BD, Torniero C, Giorda R, Regan R, Murday V, Mansour S, Fichera M, Castiglia L, Failla P, Ventura M, Jiang Z, Cooper GM, Knight SJ, Romano C, Zuffardi O, Chen C, Schwartz CE, Eichler EE.
Nat Genet 40(3):322-8. Epub 2008 Feb 17. 2008
41CHRNA7
Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.
Counts SE, He B, Che S, Ikonomovic MD, DeKosky ST, Ginsberg SD, Mufson EJ.
Arch Neurol 64(12):1771-6.PMID: 18071042 2007
42RIC3, CHRNA7
Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors.
Castillo M, Mulet J, Gutierrez LM, Ortiz JA, Castelan F, Gerber S, Sala S, Sala F, Criado M.
J Biol Chem 280(29):27062-8. Epub 2005 May 31. 2005
43CHRNA3,CHRNA7
Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes.
Chernyavsky AI, Arredondo J, Marubio LM, Grando SA.
J Cell Sci 117(Pt 23):5665-79. Epub 2004 Oct 19. 2004
44CHRFAM7A, CHRNA7, FAM7A1, FAM7A3, ARHGAP11A, FAM7A2, FAM7B1
A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14.
Riley B, Williamson M, Collier D, Wilkie H, Makoff A.
Genomics 79(2):197-209. 2002
45CHRNA7, SCZD10
Linkage disequilibrium for Schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7).
Freedman R, Leonard S, Gault JM, Hopkins J, Cloninger CR, Kaufmann CA, Tsuang MT, Farone SV, Malaspina D, Svrakic DM, Sanders A, Gejman P.
Am J Med Genet 105 : 20-22. 2001
46CHRNA7
alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity.
Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A.
J Biol Chem. 276(17):13541-6 2001
47APP, CHRNA7
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.
Wang HY, Lee DH, D'Andrea MR, Peterson PA, Shank RP, Reitz AB.
J Biol Chem. 275(8):5626-32. 2000
48CHRNA7
Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).
Gault J, et al.
Genomics 52 : 173-185. 1998
49CHRNA7, NRG1
A cysteine-rich isoform of neuregulin controls the level of expression of neuronal nicotinic receptor channels during synaptogenesis.
Yang X, Kuo Y, Devay P, Yu C, Role L.
Neuron 20(2):255-70. 1998
50CHRNA7, EJM3, EJM2
Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q.
Elmslie FV, Rees M, Williamson MP, Kerr M, Kjeldsen MJ, Pang KA, Sundqvist A, Friis ML, Chadwick D, Richens A, Covanis A, Santos M, Arzimanoglou A, Panayiotopoulos CP, Curtis D, Whitehouse WP, Gardiner RM.
Hum Mol Genet 6(8):1329-34. 1997
51CHRNA7
Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32.
Groot Kormelink PJ, Luyten WH.
FEBS Lett. 400(3):309-14. 1997
52CHRNA2, CHRNA3, CHRNA4, CHRNA5, CHRNA6, CHRNA7, CHRNB2, CHRNB3, CHRNB4
Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.
Elliott KJ, Ellis SB, Berckhan KJ, Urrutia A, Chavez-Noriega LE, Johnson EC, Veliçelebi G, Harpold MM.
J Mol Neurosci 7(3):217-28. 1996
53CHRNA7
Molecular cloning and chromosomal localization of the human alpha7-nicotinic receptor subunit gene (CHRNA7).
Chini B, et al.
Genomics 19 : 379-381. 1994