1 | AKT1S1, CHEK2
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| CHK2 Promotes Anoikis and is Associated with the Progression of Papillary Thyroid Cancer.
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| Zhao W, Chen S, Hou X, Chen G, Zhao Y.
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| Cell Physiol Biochem. 45(4):1590-1602. doi: 10.1159/000487724. Epub 2018 Feb 21 2018
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2 | BRCA1, CEP72, CHEK2
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| The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability.
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| Lüddecke S, Ertych N, Stenzinger A, Weichert W, Beissbarth T, Dyczkowski J, Gaedcke J, Valerius O, Braus GH, Kschischo M, Bastians H.
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| Oncogene 35(18):2398-406. doi: 10.1038/onc.2015.290. 2016
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3 | CHEK2, LFS2
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| Case report of a Li-Fraumeni syndrome-like phenotype with a de novo mutation in CHEK2.
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| Zhuang X, Li Y, Cao H, Wang T, Chen J, Liu J, Lin L, Ye R, Li X, Liu S, Li W, Lv Y, Zhang J, He C, Xu X, Wang Z, Huang C, Liu X, Wang L.
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| Medicine (Baltimore) 95(29):e4251. doi: 10.1097/MD.0000000000004251.
2016
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4 | AURKA, BRCA1, CHEK2
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| CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.
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| Ertych N, Stolz A, Valerius O, Braus GH, Bastians H.
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| Proc Natl Acad Sci U S A 113(7):1817-22. doi: 10.1073/pnas.1525129113. Epub 2016 Feb 1.
2016
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5 | ATM, CHEK2
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| Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.
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| Chou WC, Hu LY, Hsiung CN, Shen CY.
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| Carcinogenesis 36(8):832-40. doi: 10.1093/carcin/bgv079. Epub 2015 May 29.
2015
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6 | CHEK1, CHEK2
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| Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
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| Davari K, Frankenberger S, Schmidt A, Tomi NS, Jungnickel B.
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| Cell Cycle 13(23):3659-69. doi: 10.4161/15384101.2014.964112.
2014
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7 | CHEK2
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| CHK2 kinase in the DNA damage response and beyond.
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| Zannini L, Delia D, Buscemi G.
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| J Mol Cell Biol 6(6):442-57. doi: 10.1093/jmcb/mju045. Epub 2014 Nov 17. Review.
2014
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8 | CCAR2, CHEK2, SIRT1
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| Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis.
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| Magni M, Ruscica V, Buscemi G, Kim JE, Nachimuthu BT, Fontanella E, Delia D, Zannini L.
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| Nucleic Acids Res 42(21):13150-60. doi: 10.1093/nar/gku1065. Epub 2014 Oct 31.
2014
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9 | CHEK2
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| In vivo role of checkpoint kinase 2 in signaling telomere dysfunction.
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| García-Beccaria M, Martínez P, Flores JM, Blasco MA.
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| Aging Cell 13(5):810-6. doi: 10.1111/acel.12237. Epub 2014 Jun 12.
2014
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10 | AURKB, CHEK2, TTK
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| Chk2 prevents mitotic exit when the majority of kinetochores are unattached.
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| Petsalaki E, Zachos G.
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| J Cell Biol 205(3):339-56. doi: 10.1083/jcb.201310071. Epub 2014 May 5.
2014
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11 | CHEK2, TTK
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| Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.
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| Yeh CW, Yu ZC, Chen PH, Cheng YC, Shieh SY.
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| J Biol Chem 289(22):15319-27. doi: 10.1074/jbc.M114.552273. Epub 2014 Apr 24.
2014
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12 | CHEK2
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| Chk2 regulates cell cycle progression during mouse oocyte maturation and early embryo development.
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| Dai XX, Duan X, Liu HL, Cui XS, Kim NH, Sun SC.
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| Mol Cells 37(2):126-32. doi: 10.14348/molcells.2014.2259. Epub 2014 Feb 19.
2014
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13 | CHEK2
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| Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway.
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| Bolcun-Filas E, Rinaldi VD, White ME, Schimenti JC.
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| Science 343(6170):533-6. doi: 10.1126/science.1247671.
2014
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14 | CDK11A, CHEK2
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| CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).
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| Choi HH, Choi HK, Jung SY, Hyle J, Kim BJ, Yoon K, Cho EJ, Youn HD, Lahti JM, Qin J, Kim ST.
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| Oncogene 33(1):108-15. doi: 10.1038/onc.2012.535. Epub 2012 Nov 26.
2014
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15 | CHEK2, RAD9A, SLX4
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| DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9.
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| Ohouo PY, Bastos de Oliveira FM, Liu Y, Ma CJ, Smolka MB.
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| Nature 493(7430):120-4. doi: 10.1038/nature11658. Epub 2012 Nov 18. 2013
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16 | CHEK2, NCOR2, PPM1D
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| The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation.
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| Scafoglio C, Smolka M, Zhou H, Perissi V, Rosenfeld MG.
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| PLoS One 8(5):e59986. doi: 10.1371/journal.pone.0059986. Print 2013.
2013
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17 | CHEK2, RCHY1
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| The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover.
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| Bohgaki M, Hakem A, Halaby MJ, Bohgaki T, Li Q, Bissey PA, Shloush J, Kislinger T, Sanchez O, Sheng Y, Hakem R.
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| Cell Death Differ 20(6):812-22. doi: 10.1038/cdd.2013.7. Epub 2013 Mar 1.
2013
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18 | CHEK2
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| Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
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| Roeb W, Higgins J, King MC.
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| Hum Mol Genet 21(12):2738-44. doi: 10.1093/hmg/dds101. Epub 2012 Mar 13.
2012
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19 | CHEK2
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| Chk2 mediates RITA-induced apoptosis.
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| de Lange J, Verlaan-de Vries M, Teunisse AF, Jochemsen AG.
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| Cell Death Differ 19(6):980-9. doi: 10.1038/cdd.2011.182. Epub 2011 Dec 9.
2012
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20 | CHEK2, MUS81
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| Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
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| El Ghamrasni S, Pamidi A, Halaby MJ, Bohgaki M, Cardoso R, Li L, Venkatesan S, Sethu S, Hirao A, Mak TW, Hande MP, Hakem A, Hakem R.
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| PLoS Genet 7(5):e1001385. Epub 2011 May 19.
2011
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21 | BARD1, BRCA1, BRCA2, BRIP1, CHEK2, MRE11A, MSH6, NBN, PALB2, RAD50, RAD51c, TP53
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| Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
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| Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ, Stray SM, Wickramanayake A, Norquist B, Pennington KP, Garcia RL, King MC, Swisher EM.
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| Proc Natl Acad Sci U S A 108(44):18032-7. doi: 10.1073/pnas.1115052108. Epub 2011 Oct 17.
2011
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22 | ABL1, CHEK2, EWSR1, MAP4K2
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| The Ewing sarcoma protein regulates DNA damage-induced alternative splicing.
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| Paronetto MP, Miñana B, Valcárcel J.
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| Mol Cell 43(3):353-68. doi: 10.1016/j.molcel.2011.05.035.
2011
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23 | CHEK2, PER3
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| Per3, a circadian gene, is required for Chk2 activation in human cells.
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| Im JS, Jung BH, Kim SE, Lee KH, Lee JK.
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| FEBS Lett 584(23):4731-4. Epub 2010 Nov 9.
2010
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24 | CHEK1, CHEK2
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| Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo.
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| Niida H, Murata K, Shimada M, Ogawa K, Ohta K, Suzuki K, Fujigaki H, Khaw AK, Banerjee B, Hande MP, Miyamoto T, Miyoshi I, Shirai T, Motoyama N, Delhase M, Appella E, Nakanishi M.
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| EMBO J 29(20):3558-70. Epub 2010 Sep 10.
2010
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25 | CHEK2
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| Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activity.
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| Guo X, Ward MD, Tiedebohl JB, Oden YM, Nyalwidhe JO, Semmes OJ.
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| J Biol Chem 285(43):33348-57. Epub 2010 Aug 16.
2010
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26 | CHEK2
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| A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.
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| Carlessi L, Buscemi G, Fontanella E, Delia D.
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| Biochim Biophys Acta 1803(10):1213-23. Epub 2010 Jun 22.
2010
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27 | CHEK2
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| Centrosomal Chk2 in DNA damage responses and cell cycle progression.
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| Golan A, Pick E, Tsvetkov L, Nadler Y, Kluger H, Stern DF.
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| Cell Cycle 9(13):2647-56.
2010
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28 | CHEK2
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| CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells.
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| Nalapareddy K, Choudhury AR, Gompf A, Ju Z, Ravipati S, Leucht T, Lechel A, Rudolph KL.
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| EMBO Rep 11(8):619-25. Epub 2010 Jun 25.
2010
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29 | CHEK2
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| A mitotic role for the DNA damage-responsive CHK2 kinase.
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| Sato K, Ohta T, Venkitaraman AR.
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| Nat Cell Biol 12(5):424-5. No abstract available.
2010
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30 | CHEK2
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| Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity.
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| Berge EO, Staalesen V, Straume AH, Lillehaug JR, Lønning PE.
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| Biochim Biophys Acta 1803(3):386-95. Epub 2010 Jan 15.
2010
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31 | CHEK2
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| Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.
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| Cai Z, Chehab NH, Pavletich NP.
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| Mol Cell 35(6):818-29.
2009
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32 | CHEK2
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| Chk2 protects against radiation-induced genomic instability.
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| MacLaren A, Slavin D, McGowan CH.
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| Radiat Res 172(4):463-72.
2009
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33 | ATML, CHEK2, STRAP, TTC5
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| ATM and Chk2 kinase target the p53 cofactor Strap.
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| Adams CJ, Graham AL, Jansson M, Coutts AS, Edelmann M, Smith L, Kessler B, La Thangue NB.
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| EMBO Rep 9(12):1222-9. Epub 2008 Oct 3. 2008
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34 | CHEK2
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| Germline CHEK2 mutations and colorectal cancer risk: different effects of a missense and truncating mutations?
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| Cybulski C, Wokolorczyk D, Kladny J, Kurzwaski G, Suchy J, Grabowska E, Gronwald J, Huzarski T, Byrski T, Gorski B, D Ecedil Bniak T, Narod SA, Lubinski J.
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| Eur J Hum Genet 15(2):237-41. Epub 2006 Nov 15. 2007
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35 | CHEK2
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| Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.
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| Brennan P, McKay J, Moore L, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Chow WH, Rothman N, Chabrier A, Gaborieau V, Odefrey F, Southey M, Hashibe M, Hall J, Boffetta P, Peto J, Peto R, Hung RJ.
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| Hum Mol Genet 16(15):1794-801. Epub 2007 May 21. 2007
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36 | CHEK2
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| Inherited association of breast and colorectal cancer: limited role of CHEK2 compared with high-penetrance genes.
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| Naseem H, Boylan J, Speake D, Leask K, Shenton A, Lalloo F, Hill J, Trump D, Evans DG.
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| Clin Genet 70(5):388-95. 2006
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37 | CHEK2
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| A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer.
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| Cybulski C, Wokolorczyk D, Huzarski T, Byrski T, Gronwald J, Gorski B, Debniak T, Masojc B, Jakubowska A, Gliniewicz B, Sikorski A, Stawicka M, Godlewski D, Kwias Z, Antczak A, Krajka K, Lauer W, Sosnowski M, Sikorska-Radek P, Bar K, Klijer R, Zdrojowy R, Malkiewicz B, Borkowski A, Borkowski T, Szwiec M, Narod SA, Lubinski J.
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| J Med Genet 43(11):863-6. 2006
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38 | CHEK2, PPP2R2A
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| Fusion of the tumor-suppressor gene CHEK2 and the gene for the regulatory subunit B of protein phosphatase 2 PPP2R2A in childhood teratoma.
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| Jin Y, Mertens F, Kullendorff CM, Panagopoulos I.
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| Neoplasia 8(5):413-8. 2006
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39 | CHEK2
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| CHEK2 is a multiorgan cancer susceptibility gene.
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| Cybulski C, Gorski B, Huzarski T, Masojc B, Mierzejewski M, Debniak T, Teodorczyk U, Byrski T, Gronwald J, Matyjasik J, Zlowocka E, Lenner M, Grabowska E, Nej K, Castaneda J, Medrek K, Szymanska A, Szymanska J, Kurzawski G, Suchy J, Oszurek O, Witek A, Narod SA, Lubinski J.
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| Am J Hum Genet 75(6):1131-5. Epub 2004 Oct 18. 2004
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40 | CHEK2
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| Mutations in CHEK2 associated with prostate cancer risk
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| Dong X, Wang L, Taniguchi K, Wang X, Cunningham JM, McDonnell SK, Qian C, Marks AF, Slager SL, Peterson BJ, Smith DI, Cheville JC, Blute ML, Jacobsen SJ, Schaid DJ, Tindall DJ, Thibodeau SN, Liu W.
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| Am J Hum Genet 72(2):270-80. 2003
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41 | CHEK2
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| Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.
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| Schutte M, Seal S, Barfoot R, Meijers-Heijboer H, Wasielewski M, Evans DG, Eccles D, Meijers C, Lohman F, Klijn J, van den Ouweland A, Futreal PA, Nathanson KL, Weber BL, Easton DF, Stratton MR, Rahman N; Breast Cancer Linkage Consortium.
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| Am J Hum Genet 72(4):1023-8. Epub 2003 Feb 27. 2003
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42 | CHEK2
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| The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype.
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| Meijers-Heijboer H, Wijnen J, Vasen H, Wasielewski M, Wagner A, Hollestelle A, Elstrodt F, van den Bos R, de Snoo A, Fat GT, Brekelmans C, Jagmohan S, Franken P, Verkuijlen P, van den Ouweland A, Chapman P, Tops C, Moslein G, Burn J, Lynch H, Klijn J, Fodde R, Schutte M.
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| Am J Hum Genet 72(5):1308-14. Epub 2003 Apr 10. 2003
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43 | ATM, CHEK2, TP53
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| Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.
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| Keramaris E, Hirao A, Slack RS, Mak TW, Park DS.
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| J Biol Chem 278(39):37782-9. Epub 2003 Jul 11. 2003
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44 | CHEK2
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| Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies.
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| Qin D, Lee H, Yuan C, Ju Y, Tsai MD.
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| Biochem Biophys Res Commun 311(4):803-8. 2003
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45 | CHEK2
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| Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.
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| Miller CW, Ikezoe T, Krug U, Hofmann WK, Tavor S, Vegesna V, Tsukasaki K, Takeuchi S, Koeffler HP.
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| Genes Chromosomes Cancer 33(1):17-21. 2002
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46 | CHEK2
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| A robust method for detecting CHK2/RAD53 mutations in genomic DNA.
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| Sodha N, Houlston RS, Williams R, Yuille MA, Mangion J, Eeles RA.
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| Hum Mutat 19(2):173-7. 2002
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47 | CHEK2
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| Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.
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| Meijers-Heijboer H, van den Ouweland A, Klijn J, Wasielewski M, de Snoo A, Oldenburg R, Hollestelle A, Houben M, Crepin E, van Veghel-Plandsoen M, Elstrodt F, van Duijn C, Bartels C, Meijers C, Schutte M, McGuffog L, Thompson D, Easton D, Sodha N, Seal S, Barfoot R, Mangion J, Chang-Claude J, Eccles D, Eeles R, Evans DG, Houlston R, Murday V, Narod S, Peretz T, Peto J, Phelan C, Zhang HX, Szabo C, Devilee P, Goldgar D, Futreal PA, Nathanson KL, Weber B, Rahman N, Stratton MR.
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| Nat Genet 31(1):55-9. 2002
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48 | CHEK2
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| A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer.
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| Vahteristo P, Bartkova J, Eerola H, Syrjakoski K, Ojala S, Kilpivaara O, Tamminen A, Kononen J, Aittomaki K, Heikkila P, Holli K, Blomqvist C, Bartek J, Kallioniemi OP, Nevanlinna H.
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| Am J Hum Genet 71(2):432-8. 2002
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49 | CHEK2, PLK3, TP53
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| Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.
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| Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ.
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| Oncogene 21(43):6633-40. 2002
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50 | CHEK2
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| CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas.
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| Tort F, Hernandez S, Bea S, Martinez A, Esteller M, Herman JG, Puig X, Camacho E, Sanchez M, Nayach I, Lopez-Guillermo A, Fernandez PL, Colomer D, Hernandez L, Campo E.
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| Blood 100(13):4602-8. Epub 2002 Aug 01. 2002
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51 | ATM, CDC25A, CHEK2
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| The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
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| Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J.
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| Nature 410(6830):842-7. 2001
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52 | CHEK2, LFS2
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| Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome.
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| Lee SB, Kim SH, Bell DW, Wahrer DC, Schiripo TA, Jorczak MM, Sgroi DC, Garber JE, Li FP, Nichols KE, Varley JM, Godwin AK, Shannon KM, Harlow E, Haber DA.
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| Cancer Res 61(22):8062-7. 2001
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53 | TP53, CHEK2, LFS1, LFS2
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| p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition.
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| Vahteristo P, Tamminen A, Karvinen P, Eerola H, Eklund C, Aaltonen LA, Blomqvist C, Aittomaki K, Nevanlinna H.
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| Cancer Res 61(15):5718-22. 2001
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54 | CHEK2
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| Mutation analysis of the CHK2 gene in families with hereditary breast cancer.
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| Allinen M, Huusko P, Mantyniemi S, Launonen V, Winqvist R.
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| Br J Cancer 85(2):209-12. 2001
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55 | CHEK2
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| DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
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| Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW.
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| Science 287(5459):1824-7. 2000
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56 | CHEK2
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| Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.
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| Chaturvedi P, Eng WK, Zhu Y, Mattern MR, Mishra R, Hurle MR, Zhang X, Annan RS, Lu Q, Faucette LF, Scott GF, Li X, Carr SA, Johnson RK, Winkler JD, Zhou BB.
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| Oncogene 18(28):4047-54 1999
|
57 | CHEK2
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| A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage.
|
| Brown AL, Lee CH, Schwarz JK, Mitiku N, Piwnica-Worms H, Chung JH.
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| Proc Natl Acad Sci U S A 96(7):3745-50 1999
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58 | CHEK2
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| A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase.
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| Blasina A, de Weyer IV, Laus MC, Luyten WH, Parker AE, McGowan CH.
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| Curr Biol 9(1):1-10 1999
|
59 | LFS2, CHEK2
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| Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.
|
| Bell DW, Varley JM, Szydlo TE, Kang DH, Wahrer DC, Shannon KE, Lubratovich M, Verselis SJ, Isselbacher KJ, Fraumeni JF, Birch JM, Li FP, Garber JE, Haber DA.
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| Science 286(5449):2528-31 1999
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60 | CHEK2
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| Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
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| Matsuoka S, Huang M, Elledge SJ.
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| Science 282(5395):1893-7 1998
|