| 1 | CGAS, MARCHF8
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| MARCH8 attenuates cGAS-mediated innate immune responses through ubiquitylation
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| Yang X, Shi C, Li H, Shen S, Su C, Yin H.
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| Sci Signal. May 3;15(732):eabk3067. doi: 10.1126/scisignal.abk3067. Epub 2022 May 3. 2022
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| 2 | CGAS, STING1
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| Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway.
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| Chen YA, Shen YL, Hsia HY, Tiang YP, Sung TL, Chen LY.
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| Nat Struct Mol Biol at Struct Mol Biol. 2017 Nov 6. doi: 10.1038/nsmb.3498. [Epub ahead of print] 2017
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| 3 | CGAS, IKBKB, STING1, TBK1
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| NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway.
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| Fang R, Wang C, Jiang Q, Lv M, Gao P, Yu X, Mu P, Zhang R, Bi S, Feng JM, Jiang Z.
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| J Immunol 199(9):3222-3233. doi: 10.4049/jimmunol.1700699. Epub 2017 Sep 22. 2017
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| 4 | CGAS
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| Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.
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| Glück S, Guey B, Gulen MF, Wolter K, Kang TW, Schmacke NA, Bridgeman A, Rehwinkel J, Zender L, Ablasser A.
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| Nat Cell Biol 19(9):1061-1070. doi: 10.1038/ncb3586. Epub 2017 Jul 31.
2017
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| 5 | CGAS, STING1
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| Intracellular DNA sensing pathway of cGAS-cGAMP is decreased in human newborns and young children.
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| Wang ZS, Liu YL, Mi N, Duan DY.
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| Mol Immunol 87:76-85. doi: 10.1016/j.molimm.2017.04.007. Epub 2017 Apr 13. 2017
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| 6 | CGAS
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| Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.
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| Tao J, Zhang XW, Jin J, Du XX, Lian T, Yang J, Zhou X, Jiang Z, Su XD.
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| J Immunol 198(9):3627-3636. doi: 10.4049/jimmunol.1601909. Epub 2017 Mar 31.
2017
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| 7 | CGAS
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| The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity.
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| Lee A, Park EB, Lee J, Choi BS, Kang SJ.
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| FEBS Lett 591(6):954-961. doi: 10.1002/1873-3468.12598. Epub 2017 Mar 7.
2017
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| 8 | CGAS, SENP7
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| SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing.
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| Cui Y, Yu H, Zheng X, Peng R, Wang Q, Zhou Y, Wang R, Wang J, Qu B, Shen N, Guo Q, Liu X, Wang C.
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| PLoS Pathog 13(1):e1006156. doi: 10.1371/journal.ppat.1006156. eCollection 2017 Jan.
2017
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| 9 | CGAS
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| DNA sensor cGAS-mediated immune recognition.
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| Xia P, Wang S, Gao P, Gao G, Fan Z.
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| Protein Cell 7(11):777-791. Epub 2016 Sep 30. Review.
2016
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| 10 | CGAS, TRIM14
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| TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses.
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| Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J, Wang RF, Cui J.
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| Mol Cell 64(1):105-119. doi: 10.1016/j.molcel.2016.08.025. Epub 2016 Sep 22.
2016
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| 11 | CGAS, RNASEH2B
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| Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.
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| Mackenzie KJ, Carroll P, Lettice L, Tarnauskaitė Ž, Reddy K, Dix F, Revuelta A, Abbondati E, Rigby RE, Rabe B, Kilanowski F, Grimes G, Fluteau A, Devenney PS, Hill RE, Reijns MA, Jackson AP.
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| EMBO J 35(8):831-44. doi: 10.15252/embj.201593339. Epub 2016 Feb 22.
2016
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| 12 | CGAS, DDX58, MAVS, STING1
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| Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
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| Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu YT, Grishin NV, Chen ZJ.
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| Science 347(6227):aaa2630. doi: 10.1126/science.aaa2630. Epub 2015 Jan 29. 2015
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| 13 | CGAS
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| Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.
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| Gao D, Li T, Li XD, Chen X, Li QZ, Wight-Carter M, Chen ZJ.
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| Proc Natl Acad Sci U S A 112(42):E5699-705. doi: 10.1073/pnas.1516465112. Epub 2015 Sep 14.
2015
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| 14 | CGAS
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| Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.
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| Collins AC, Cai H, Li T, Franco LH, Li XD, Nair VR, Scharn CR, Stamm CE, Levine B, Chen ZJ, Shiloh MU.
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| Cell Host Microbe 17(6):820-8. doi: 10.1016/j.chom.2015.05.005. Epub 2015 Jun 2.
2015
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| 15 | CGAS, PQBP1
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| PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.
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| Yoh SM, Schneider M, Seifried J, Soonthornvacharin S, Akleh RE, Olivieri KC, De Jesus PD, Ruan C, de Castro E, Ruiz PA, Germanaud D, des Portes V, García-Sastre A, König R, Chanda SK.
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| Cell 161(6):1293-1305. doi: 10.1016/j.cell.2015.04.050.
2015
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| 16 | CGAS
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| The mechanism of double-stranded DNA sensing through the cGAS-STING pathway.
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| Shu C, Li X, Li P.
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| Cytokine Growth Factor Rev 25(6):641-8. doi: 10.1016/j.cytogfr.2014.06.006. Epub 2014 Jun 22. Review.
2014
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| 17 | CGAS, IRF3, STING1
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| Structural and functional analyses of DNA-sensing and immune activation by human cGAS.
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| Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O.
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| PLoS One 8(10):e76983. doi: 10.1371/journal.pone.0076983. eCollection 2013. 2013
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| 18 | CGAS
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| Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.
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| Kranzusch PJ, Lee AS, Berger JM, Doudna JA.
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| Cell Rep 3(5):1362-8. doi: 10.1016/j.celrep.2013.05.008. Epub 2013 May 23.
2013
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| 19 | CGAS
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| Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.
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| Kranzusch PJ, Lee AS, Berger JM, Doudna JA.
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| Cell Rep 3(5):1362-8. doi: 10.1016/j.celrep.2013.05.008. Epub 2013 May 23.
2013
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