| 1 | CFLAR, PRMT1
|
| The Regulatory Impact of CFLAR Methylation Modification on Liver Lipid Metabolism.
|
| Ye C, Jiang W, Hu T, Liang J, Chen Y.
|
| Int J Mol Sci. Jul 19;25(14):7897. doi: 10.3390/ijms25147897. 2024
|
| 2 | BCAR1, CFLAR
|
| The interaction of CFLAR with p130Cas promotes cell migration.
|
| Li H, Li L, Qiu X, Zhang J, Hua Z.
|
| Biochim Biophys Acta Mol Cell Res. Feb;1870(2):119390. doi: 10.1016/j.bbamcr.2022.119390. Epub 2022 Nov 16. 2023
|
| 3 | BCLAF1, CFLAR
|
| Bclaf1 regulates c-FLIP expression and protects cells from TNF-induced apoptosis and tissue injury.
|
| Zhang R, Xue T, Shao A, Lang Y, Qin C, Zhao M, Kuang Y, Yu Z, Geng Y, Zhao C, Tang J.
|
| EMBO Rep. Jan 5;23(1):e52702. doi: 10.15252/embr.202152702. Epub 2021 Oct 25. 2022
|
| 4 | CFLAR, USP27X
|
| The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis
|
| Dold MN, Ng X, Alber C, Gentle IE, Häcker G, Weber A.
|
| Apoptosis. Feb;27(1-2):112-132. doi: 10.1007/s10495-021-01706-9. Epub 2022 Jan 19. 2022
|
| 5 | CFLAR
|
| cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells.
|
| Mora-Molina R, Stöhr D, Rehm M, López-Rivas A
|
| Cell Death Dis. Feb 3;13(2):111. doi: 10.1038/s41419-022-04574-6. 2022
|
| 6 | BECN1, CFLAR
|
| c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability.
|
| Tomaipitinca L, Petrungaro S, D'Acunzo P, Facchiano A, Dubey A, Rizza S, Giulitti F, Gaudio E, Filippini A, Ziparo E, Cecconi F, Giampietri C.
|
| Cell Death Dis. Jul 8;12(7):686. doi: 10.1038/s41419-021-03957-5 2021
|
| 7 | CFLAR, ITCH, PRMT1, PRMT5
|
| The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLARL in human lung cancer cells.
|
| Li M, An W, Xu L, Lin Y, Su L, Liu X.
|
| J Exp Clin Cancer Res. Feb 8;38(1):64. doi: 10.1186/s13046-019-1064-8. 2019
|
| 8 | CASP8, CFLAR
|
| Induction of immunosuppressive functions and NF-κB by FLIP in monocytes.
|
| Fiore A, Ugel S, De Sanctis F, Sandri S, Fracasso G, Trovato R, Sartoris S, Solito S, Mandruzzato S, Vascotto F, Hippen KL, Mondanelli G, Grohmann U, Piro G, Carbone C, Melisi D, Lawlor RT, Scarpa A, Lamolinara A, Iezzi M, Fassan M, Bicciato S, Blazar BR, Sahin U, Murray PJ, Bronte V.
|
| Nat Commun. Dec 5;9(1):5193. doi: 10.1038/s41467-018-07654-4. 2018
|
| 9 | CASP10, CASP8, CFLAR
|
| Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival.
|
| Horn S, Hughes MA, Schilling R, Sticht C, Tenev T, Ploesser M, Meier P, Sprick MR, MacFarlane M, Leverkus M.
|
| Cell Rep 19(4):785-797. doi: 10.1016/j.celrep.2017.04.010.
2017
|
| 10 | CFLAR, RUVBL1
|
| C-FLIPL Modulated Wnt/β-Catenin Activation via Association with TIP49 Protein.
|
| Liu W, Zheng QQ, Hua ZC.
|
| J Biol Chem. Feb 10;292(6):2132-2142. doi: 10.1074/jbc.M116.753251. Epub 2016 Dec 27 2017
|
| 11 | CASP8, CFLAR
|
| Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.
|
| Philip NH, DeLaney A, Peterson LW, Santos-Marrero M, Grier JT, Sun Y, Wynosky-Dolfi MA, Zwack EE, Hu B, Olsen TM, Rongvaux A, Pope SD, López CB, Oberst A, Beiting DP, Henao-Mejia J, Brodsky IE.
|
| PLoS Pathog 12(10):e1005910. doi: 10.1371/journal.ppat.1005910. eCollection 2016 Oct.
2016
|
| 12 | CFLAR, FADD
|
| FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis.
|
| Ranjan K, Pathak C.
|
| Sci Rep. Mar 14;6:22787. doi: 10.1038/srep22787 2016
|
| 13 | CFLAR, RBM10, RBM5
|
| RBM10 regulates alternative splicing
|
| Inoue A, Yamamoto N, Kimura M, Nishio K, Yamane H, Nakajima K.
|
| FEBS Lett. Mar 18;588(6):942-7. doi: 10.1016/j.febslet.2014.01.052. Epub 2014 Feb 11. 2014
|
| 14 | CFLAR
|
| Novel phosphorylation and ubiquitination sites regulate reactive oxygen species-dependent degradation of anti-apoptotic c-FLIP protein.
|
| Wilkie-Grantham RP, Matsuzawa S, Reed JC.
|
| J Biol Chem. May 3;288(18):12777-90. doi: 10.1074/jbc.M112.431320. Epub 2013 Mar 21. 2013
|
| 15 | CFLAR, SART1
|
| A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer.
|
| Allen WL, Stevenson L, Coyle VM, Jithesh PV, Proutski I, Carson G, Gordon MA, Lenz HJ, Van Schaeybroeck S, Longley DB, Johnston PG.
|
| Mol Cancer Ther 11(1):119-31. Epub 2011 Oct 25.
2012
|
| 16 | CFLAR, XRCC6
|
| Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis.
|
| Kerr E, Holohan C, McLaughlin KM, Majkut J, Dolan S, Redmond K, Riley J, McLaughlin K, Stasik I, Crudden M, Van Schaeybroeck S, Fenning C, O'Connor R, Kiely P, Sgobba M, Haigh D, Johnston PG, Longley DB.
|
| Cell Death Differ 19(8):1317-27. doi: 10.1038/cdd.2012.8. Epub 2012 Feb 10.
2012
|
| 17 | CFLAR
|
| Reduced CaM/FLIP binding by a single point mutation in c-FLIP(L) modulates Fas-mediated apoptosis and decreases tumorigenesis.
|
| Jing G, Yuan K, Liang Q, Sun Y, Mao X, McDonald JM, Chen Y.
|
| Lab Invest 92(1):82-90. doi: 10.1038/labinvest.2011.131. Epub 2011 Sep 12.
2012
|
| 18 | CFLAR, TANK
|
| TRAF family member-associated NF-κB activator (TANK) induced by RANKL negatively regulates osteoclasts survival and function.
|
| Wu M, Wang Y, Deng L, Chen W, Li YP.
|
| Int J Biol Sci 8(10):1398-407. doi: 10.7150/ijbs.5079. Epub 2012 Nov 6.
2012
|
| 19 | CFLAR, TANK
|
| TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
|
| Maruyama K, Kawagoe T, Kondo T, Akira S, Takeuchi O.
|
| J Biol Chem 287(34):29114-24. doi: 10.1074/jbc.M112.347799. Epub 2012 Jul 6.
2012
|
| 20 | CFLAR, TRAF7
|
| Tumor necrosis factor (TNF) receptor-associated factor 7 is required for TNFα-induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein.
|
| Scudiero I, Zotti T, Ferravante A, Vessichelli M, Reale C, Masone MC, Leonardi A, Vito P, Stilo R.
|
| J Biol Chem 287(8):6053-61. doi: 10.1074/jbc.M111.300137. Epub 2012 Jan 3.
2012
|
| 21 | CFLAR
|
| The role of c-FLIP splice variants in urothelial tumours.
|
| Ewald F, Ueffing N, Brockmann L, Hader C, Telieps T, Schuster M, Schulz WA, Schmitz I.
|
| Cell Death Dis 2:e245. doi: 10.1038/cddis.2011.131.
2011
|
| 22 | CFLAR
|
| Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo.
|
| Schattenberg JM, Zimmermann T, Wörns M, Sprinzl MF, Kreft A, Kohl T, Nagel M, Siebler J, Bergkamen HS, He YW, Galle PR, Schuchmann M.
|
| J Hepatol 55(6):1272-80. Epub 2011 Apr 15.
2011
|
| 23 | CFLAR
|
| Silencing FLIP(L) modifies TNF-induced apoptotic protein expression.
|
| Zaitseva L, Rushworth SA, MacEwan DJ.
|
| Cell Cycle 10(7):1067-72. Epub 2011 Apr 1.
2011
|
| 24 | CASP8, CFLAR
|
| Caspase-8, c-FLIP, and caspase-9 in c-Myc-induced apoptosis of fibroblasts.
|
| Järvinen K, Hotti A, Santos L, Nummela P, Hölttä E.
|
| Exp Cell Res 317(18):2602-15. doi: 10.1016/j.yexcr.2011.08.014. Epub 2011 Aug 28.
2011
|
| 25 | CFLAR, PML, RARA
|
| PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.
|
| Tao RH, Berkova Z, Wise JF, Rezaeian AH, Daniluk U, Ao X, Hawke DH, Karp JE, Lin HK, Molldrem JJ, Samaniego F.
|
| Blood 118(11):3107-18. doi: 10.1182/blood-2011-04-349670. Epub 2011 Jul 29.
2011
|
| 26 | AKT1, CFLAR
|
| c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity.
|
| Quintavalle C, Incoronato M, Puca L, Acunzo M, Zanca C, Romano G, Garofalo M, Iaboni M, Croce CM, Condorelli G.
|
| Cell Death Differ 17(12):1908-16. Epub 2010 May 28.
2010
|
| 27 | CFLAR
|
| FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis.
|
| Huang QQ, Perlman H, Huang Z, Birkett R, Kan L, Agrawal H, Misharin A, Gurbuxani S, Crispino JD, Pope RM.
|
| Blood 116(23):4968-77. Epub 2010 Aug 19.
2010
|
| 28 | CFLAR, HNRNPK
|
| The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients.
|
| Chen LC, Chung IC, Hsueh C, Tsang NM, Chi LM, Liang Y, Chen CC, Wang LJ, Chang YS.
|
| Cell Death Differ 17(9):1463-73. Epub 2010 Mar 12.
2010
|
| 29 | CFLAR, XIAP
|
| Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells.
|
| Wilson TR, McEwan M, McLaughlin K, Le Clorennec C, Allen WL, Fennell DA, Johnston PG, Longley DB.
|
| Oncogene 28(1):63-72. Epub 2008 Sep 29. 2009
|
| 30 | CFLAR
|
| A role for cFLIP in B cell proliferation and stress MAPK regulation.
|
| Zhang H, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang J.
|
| J Immunol 182(1):207-15.
2009
|
| 31 | CFLAR, MIB1
|
| Mind bomb 1 regulation of cFLIP interactions.
|
| Zhang L, Gallagher PJ.
|
| Am J Physiol Cell Physiol 297(5):C1275-83. Epub 2009 Aug 26. 2009
|
| 32 | CFLAR
|
| Differential responses of FLIPLong and FLIPShort-overexpressing human myeloid leukemia cells to TNF-alpha and TRAIL-initiated apoptotic signals.
|
| Seal S, Hockenbery DM, Spaulding EY, Kiem HP, Abbassi N, Deeg HJ.
|
| Exp Hematol 36(12):1660-72. Epub 2008 Oct 5.
2008
|
| 33 | CFLAR
|
| Overexpression of cFLIP in head and neck squamous cell carcinoma and its clinicopathologic correlations.
|
| Li X, Pan X, Zhang H, Lei D, Liu D, Xu F, Luan X.
|
| J Cancer Res Clin Oncol 134(5):609-15. Epub 2007 Oct 9.
2008
|
| 34 | CFLAR
|
| Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells.
|
| Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I.
|
| Blood 112(3):690-8. Epub 2008 May 28.
2008
|
| 35 | CALM1, CFLAR
|
| Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling.
|
| Pawar PS, Micoli KJ, Ding H, Cook WJ, Kappes JC, Chen Y, McDonald JM.
|
| Biochem J 412(3):459-68.PMID: 18257744 2008
|
| 36 | CFLAR
|
| Impairment of the ubiquitin-proteasome system by cellular FLIP.
|
| Ishioka T, Katayama R, Kikuchi R, Nishimoto M, Takada S, Takada R, Matsuzawa S, Reed JC, Tsuruo T, Naito M.
|
| Genes Cells 12(6):735-44.
2007
|
| 37 | AR, CFLAR, PAWR
|
| Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland.
|
| Gao S, Wang H, Lee P, Melamed J, Li CX, Zhang F, Wu H, Zhou L, Wang Z.
|
| J Mol Endocrinol 36(3):463-83. 2006
|
| 38 | CFLAR
|
| c-FLIPR, a new regulator of death receptor-induced apoptosis.
|
| Golks A, Brenner D, Fritsch C, Krammer PH, Lavrik IN.
|
| J Biol Chem 280(15):14507-13. Epub 2005 Feb 8. 2005
|
| 39 | CFLAR, FOXO3
|
| The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP.
|
| Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, Walsh K.
|
| J Biol Chem 279(2):1513-25. Epub 2003 Oct 8. 2004
|
| 40 | CFLAR
|
| Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro.
|
| Abedini MR, Qiu Q, Yan X, Tsang BK.
|
| Oncogene 23(42):6997-7004. 2004
|
| 41 | CFLAR, TNFSF10
|
| cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes.
|
| Wachter T, Sprick M, Hausmann D, Kerstan A, McPherson K, Stassi G, Brocker EB, Walczak H, Leverkus M.
|
| J Biol Chem 279(51):52824-34. Epub 2004 Sep 30. 2004
|
| 42 | CFLAR
|
| Identification of genes upregulated in the inflamed colonic lesions of Crohn's disease.
|
| Hagiwara K, Yamaguchi A, Tsuchiya N, Kitamura S, Iwadare J, Sahara R, Yamamoto K, Tokunaga K.
|
| Biochem Biophys Res Commun 283(1):130-5. 2001
|
| 43 | ABI2, AOX1, BMPR2, CASP10, CASP8, CD28, CFLAR, CLK1, CTLA4, DAZAP2, MAGI2, ORC2, PPH1, PSMA2, SATB2, SUMO1, TRAK2
|
| A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension.
|
| Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC.
|
| Genomics 68(2):220-8. 2000
|
| 44 | CFLAR
|
| Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.
|
| Yeh WC, Itie A, Elia AJ, Ng M, Shu HB, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel DV, Mak TW.
|
| Immunity 12(6):633-42. 2000
|
| 45 | ABI2, ALS2, CFLAR, NRP2
|
| A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34.
|
| Hadano S, et al.
|
| Genomics 55 : 106-112. 1999
|
| 46 | CASP9, CFLAR
|
| Genomic organization of the human caspase-9 gene on Chromosome 1p36. 1-p36.3.
|
| Hadano S, et al.
|
| Mamm Genome 10(7):757-60. No abstract available 1999
|
| 47 | CFLAR
|
| Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex.
|
| Rasper DM, Vaillancourt JP, Hadano S, Houtzager VM, Seiden I, Keen SL, Tawa P, Xanthoudakis S, Nasir J, Martindale D, Koop BF, Peterson EP, Thornberry NA, Huang J, MacPherson DP, Black SC, Hornung F, Lenardo MJ, Hayden MR, Roy S, Nicholson DW.
|
| Cell Death Differ 5(4):271-88. 1998
|
| 48 | CASP10, CASP8, CFLAR
|
| FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.
|
| Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES.
|
| J Biol Chem 272(30):18542-5. 1997
|
| 49 | CFLAR
|
| CASH, a novel caspase homologue with death effector domains.
|
| Goltsev YV, Kovalenko AV, Arnold E, Varfolomeev EE, Brodianskii VM, Wallach D.
|
| J Biol Chem 272(32):19641-4. 1997
|
| 50 | CFLAR
|
| MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.
|
| Han DK, Chaudhary PM, Wright ME, Friedman C, Trask BJ, Riedel RT, Baskin DG, Schwartz SM, Hood L.
|
| Proc Natl Acad Sci U S A 94(21):11333-8. 1997
|
| 51 | CFLAR
|
| Inhibition of death receptor signals by cellular FLIP.
|
| Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J.
|
| Nature 388(6638):190-5. 1997
|
| 52 | CFLAR
|
| I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis.
|
| Hu S, Vincenz C, Ni J, Gentz R, Dixit VM.
|
| J Biol Chem 272(28):17255-7. 1997
|
| 53 | CFLAR
|
| CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.
|
| Inohara N, Koseki T, Hu Y, Chen S, Nunez G.
|
| Proc Natl Acad Sci U S A 94(20):10717-22. 1997
|
| 54 | CFLAR, FADD
|
| Casper is a FADD- and caspase-related inducer of apoptosis.
|
| Shu HB, Halpin DR, Goeddel DV.
|
| Immunity. 6(6):751-63. 1997
|