1 | CEBPG, CERS6
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| CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation
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| Shi H, Niimi A, Takeuchi T, Shiogama K, Mizutani Y, Kajino T, Inada K, Hase T, Hatta T, Shibata H, Fukui T, Chen-Yoshikawa TF, Nagano K, Murate T, Kawamoto Y, Tomida S, Takahashi T, Suzuki M.
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| Cancer Sci. Jul;112(7):2770-2780. doi: 10.1111/cas.14928. Epub 2021 May 4. PMID: 33934437 2021
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2 | CERS6
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| CERS6 required for cell migration and metastasis in lung cancer
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| Suzuki M, Cao K, Kato S, Mizutani N, Tanaka K, Arima C, Tai MC, Nakatani N, Yanagisawa K, Takeuchi T, Shi H, Mizutani Y, Niimi A, Taniguchi T, Fukui T, Yokoi K, Wakahara K, Hasegawa Y, Mizutani Y, Iwaki S, Fujii S, Satou A, Tamiya-Koizumi K, Murate T, Kyogashima M, Tomida S, Takahashi T.
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| J Cell Mol Med. Oct;24(20):11949-11959. doi: 10.1111/jcmm.15817. Epub 2020 Sep 9. 2020
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3 | CERS6
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| Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution
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| Holmes RS, Barron KA, Krupenko NI.
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| Biomolecules Oct 8;8(4):111. doi: 10.3390/biom8040111. 2018
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4 | CERS6
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| Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway
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| Uen YH, Fang CL, Lin CC, Hseu YC, Hung ST, Sun DP, Lin KY.
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| Mol Carcinog. Dec;57(12):1675-1689. doi: 10.1002/mc.22888. Epub 2018 Aug 29. 2018
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5 | CERS6, FAS
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| Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia
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| Verlekar D, Wei SJ, Cho H, Yang S, Kang MH.
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| Cell Death Dis. Sep 11;9(9):925. doi: 10.1038/s41419-018-0964-4. 2018
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6 | CERS2, CERS3, CERS4, CERS5, CERS6
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| Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region
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| Sassa T, Hirayama T, Kihara A.
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| J Biol Chem. Apr 1;291(14):7477-87. doi: 10.1074/jbc.M115.695858. Epub 2016 Feb 17. 2016
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7 | CERS2, CERS4, CERS6
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| The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS
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| Hartmann D, Wegner MS, Wanger RA, Ferreirós N, Schreiber Y, Lucks J, Schiffmann S, Geisslinger G, Grösch S.
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| Int J Biochem Cell Biol. Jul;45(7):1195-203. doi: 10.1016/j.biocel.2013.03.012. Epub 2013 Mar 26. 2013
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8 | CERS2, CERS5, CERS6
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| Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.
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| Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R.
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| Cell Signal 22(9):1300-7. Epub 2010 Apr 18.
2010
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9 | CERS2, CERS5, CERS6
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| Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.
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| Erez-Roman R, Pienik R, Futerman AH.
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| Biochem Biophys Res Commun 391(1):219-23. Epub 2009 Nov 11.
2010
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10 | CERS6
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| Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.
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| Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B.
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| FASEB J 24(1):296-308. Epub 2009 Sep 1.
2010
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11 | CERS1, CERS2, CERS3, CERS4, CERS5, CERS6, MAPK10
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| JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction.
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| Yu J, Novgorodov SA, Chudakova D, Zhu H, Bielawska A, Bielawski J, Obeid LM, Kindy MS, Gudz TI.
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| J Biol Chem 282(35):25940-9. Epub 2007 Jul 3. 2007
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12 | CERS6
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| LASS6, an additional member of the longevity assurance gene family.
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| Weinmann A, Galle PR, Teufel A.
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| Int J Mol Med 16(5):905-10. 2005
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13 | CERS6
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| Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
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| Mizutani Y, Kihara A, Igarashi Y.
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| Biochem J 390(Pt 1):263-71. 2005
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14 | CERS6, CXorf30, EFL1, EIF2C4, GAGE12B, GAGE12E, MRPL53, SPATA1, ZIC4
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| Creation of genome-wide protein expression libraries using random activation of gene expression.
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| Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S,Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D,McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K,Lo K, Offenbacher J, Danzig J, Ducar M.
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| Nat Biotechnol 19(5):440-5. 2001
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