Citations for
1CEBPG, CERS6
CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation
Shi H, Niimi A, Takeuchi T, Shiogama K, Mizutani Y, Kajino T, Inada K, Hase T, Hatta T, Shibata H, Fukui T, Chen-Yoshikawa TF, Nagano K, Murate T, Kawamoto Y, Tomida S, Takahashi T, Suzuki M.
Cancer Sci. Jul;112(7):2770-2780. doi: 10.1111/cas.14928. Epub 2021 May 4. PMID: 33934437 2021
2CERS6
CERS6 required for cell migration and metastasis in lung cancer
Suzuki M, Cao K, Kato S, Mizutani N, Tanaka K, Arima C, Tai MC, Nakatani N, Yanagisawa K, Takeuchi T, Shi H, Mizutani Y, Niimi A, Taniguchi T, Fukui T, Yokoi K, Wakahara K, Hasegawa Y, Mizutani Y, Iwaki S, Fujii S, Satou A, Tamiya-Koizumi K, Murate T, Kyogashima M, Tomida S, Takahashi T.
J Cell Mol Med. Oct;24(20):11949-11959. doi: 10.1111/jcmm.15817. Epub 2020 Sep 9. 2020
3CERS6
Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution
Holmes RS, Barron KA, Krupenko NI.
Biomolecules Oct 8;8(4):111. doi: 10.3390/biom8040111. 2018
4CERS6
Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway
Uen YH, Fang CL, Lin CC, Hseu YC, Hung ST, Sun DP, Lin KY.
Mol Carcinog. Dec;57(12):1675-1689. doi: 10.1002/mc.22888. Epub 2018 Aug 29. 2018
5CERS6, FAS
Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia
Verlekar D, Wei SJ, Cho H, Yang S, Kang MH.
Cell Death Dis. Sep 11;9(9):925. doi: 10.1038/s41419-018-0964-4. 2018
6CERS2, CERS3, CERS4, CERS5, CERS6
Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region
Sassa T, Hirayama T, Kihara A.
J Biol Chem. Apr 1;291(14):7477-87. doi: 10.1074/jbc.M115.695858. Epub 2016 Feb 17. 2016
7CERS2, CERS4, CERS6
The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS
Hartmann D, Wegner MS, Wanger RA, Ferreirós N, Schreiber Y, Lucks J, Schiffmann S, Geisslinger G, Grösch S.
Int J Biochem Cell Biol. Jul;45(7):1195-203. doi: 10.1016/j.biocel.2013.03.012. Epub 2013 Mar 26. 2013
8CERS2, CERS5, CERS6
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.
Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R.
Cell Signal 22(9):1300-7. Epub 2010 Apr 18. 2010
9CERS2, CERS5, CERS6
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.
Erez-Roman R, Pienik R, Futerman AH.
Biochem Biophys Res Commun 391(1):219-23. Epub 2009 Nov 11. 2010
10CERS6
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.
Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B.
FASEB J 24(1):296-308. Epub 2009 Sep 1. 2010
11CERS1, CERS2, CERS3, CERS4, CERS5, CERS6, MAPK10
JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction.
Yu J, Novgorodov SA, Chudakova D, Zhu H, Bielawska A, Bielawski J, Obeid LM, Kindy MS, Gudz TI.
J Biol Chem 282(35):25940-9. Epub 2007 Jul 3. 2007
12CERS6
LASS6, an additional member of the longevity assurance gene family.
Weinmann A, Galle PR, Teufel A.
Int J Mol Med 16(5):905-10. 2005
13CERS6
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.
Mizutani Y, Kihara A, Igarashi Y.
Biochem J 390(Pt 1):263-71. 2005
14CERS6, CXorf30, EFL1, EIF2C4, GAGE12B, GAGE12E, MRPL53, SPATA1, ZIC4
Creation of genome-wide protein expression libraries using random activation of gene expression.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S,Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D,McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K,Lo K, Offenbacher J, Danzig J, Ducar M.
Nat Biotechnol 19(5):440-5. 2001