| 1 | CEBPA, MEST, PPARG, SOX6
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| The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis.
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| Leow SC, Poschmann J, Too PG, Yin J, Joseph R, McFarlane C, Dogra S, Shabbir A, Ingham PW, Prabhakar S, Leow MK, Lee YS, Ng KL, Chong YS, Gluckman PD, Stünkel W.
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| Development Mar 15;143(6):950-61. doi: 10.1242/dev.131573. Epub 2016 Feb 18 2016
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| 2 | CEBPA, CEBPB, CEBPD, JMJD6, PPARG
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| Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.
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| Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN.
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| Nucleic Acids Res 43(16):7790-804. doi: 10.1093/nar/gkv645. Epub 2015 Jun 27.
2015
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| 3 | CEBPA
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| C/EBPα regulates macrophage activation and systemic metabolism.
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| Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J.
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| Am J Physiol Endocrinol Metab 306(10):E1144-54. doi: 10.1152/ajpendo.00002.2014. Epub 2014 Apr 1.
2014
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| 4 | CEBPA, VCAM1
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| C/EBP-α, involvement of a novel transcription factor in leptin-induced VCAM-1 production in mouse chondrocytes.
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| Kang X, Xie QY, Zhou JS, Zhang B, Liao DF, Wu HH, Zheng W, Pan XM, Quan Y.
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| FEBS Lett 588(7):1122-7. doi: 10.1016/j.febslet.2014.02.032. Epub 2014 Feb 25.
2014
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| 5 | AGT, CEBPA
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| Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene.
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| Wang F, Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y.
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| Hypertension 63(2):281-8. doi: 10.1161/HYPERTENSIONAHA.113.02303. Epub 2013 Nov 4.
2014
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| 6 | CEBPA, RARA, ZBTB16
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| RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells.
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| Girard N, Tremblay M, Humbert M, Grondin B, Haman A, Labrecque J, Chen B, Chen Z, Chen SJ, Hoang T.
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| Proc Natl Acad Sci U S A 110(33):13522-7. doi: 10.1073/pnas.1310067110. Epub 2013 Jul 29. 2013
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| 7 | CEBPA, MBD2
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| Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2.
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| Stefanska B, Suderman M, Machnes Z, Bhattacharyya B, Hallett M, Szyf M.
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| Carcinogenesis 34(12):2738-49. doi: 10.1093/carcin/bgt273. Epub 2013 Aug 16.
2013
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| 8 | CEBPA, GNAI2
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| Dual role of C/EBPα as an activator and repressor of Gαi2 gene transcription.
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| Xu J, Kawai Y, Arinze IJ.
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| Genes Cells 18(12):1082-94. doi: 10.1111/gtc.12102. Epub 2013 Nov 7.
2013
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| 9 | CEBPA
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| Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.
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| Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Di Ruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG.
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| Cancer Cell 24(5):575-88. doi: 10.1016/j.ccr.2013.09.018. Epub 2013 Oct 31. Erratum in: Cancer Cell. 2014 Feb 10;25(2):257. Diruscio, Annali 2013
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| 10 | CEBPA, FCAR, GABPA
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| Identification of the C/EBPα C-terminal tail residues involved in the protein interaction with GABP and their potency in myeloid differentiation of K562 cells.
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| Shimokawa T, Nunomura S, Fujisawa D, Ra C.
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| Biochim Biophys Acta 1829(11):1207-17. doi: 10.1016/j.bbagrm.2013.09.004. Epub 2013 Sep 27. 2013
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| 11 | CEBPA, IKZF1
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| Ikaros limits basophil development by suppressing C/EBP-α expression.
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| Rao KN, Smuda C, Gregory GD, Min B, Brown MA.
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| Blood 122(15):2572-81. doi: 10.1182/blood-2013-04-494625. Epub 2013 Aug 29.
2013
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| 12 | CEBPA, UBE3A
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| E3 ubiquitin ligase E6AP negatively regulates adipogenesis by downregulating proadipogenic factor C/EBPalpha.
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| Pal P, Lochab S, Kanaujiya JK, Kapoor I, Sanyal S, Behre G, Trivedi AK.
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| PLoS One 8(6):e65330. doi: 10.1371/journal.pone.0065330. Print 2013.
2013
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| 13 | CEBPA
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| C/EBPα regulates osteoclast lineage commitment.
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| Chen W, Zhu G, Hao L, Wu M, Ci H, Li YP.
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| Proc Natl Acad Sci U S A 110(18):7294-9. doi: 10.1073/pnas.1211383110. Epub 2013 Apr 11.
2013
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| 14 | CEBPA, DDIT3, PPARA, SREBF1
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| C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver.
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| Chikka MR, McCabe DD, Tyra HM, Rutkowski DT.
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| J Biol Chem 288(6):4405-15. doi: 10.1074/jbc.M112.432344. Epub 2012 Dec 31.
2013
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| 15 | ATF3, CEBPA
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| ATF3 inhibits adipocyte differentiation of 3T3-L1 cells.
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| Jang MK, Kim CH, Seong JK, Jung MH.
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| Biochem Biophys Res Commun 421(1):38-43. doi: 10.1016/j.bbrc.2012.03.104. Epub 2012 Mar 27.
2012
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| 16 | CEBPA, QKI
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| The RNA-binding protein QKI5 is a direct target of C/EBPα and delays macrophage differentiation.
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| Fu H, Yang G, Wei M, Liu L, Jin L, Lu X, Wang L, Shen L, Zhang J, Lu H, Yao L, Lu Z.
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| Mol Biol Cell 23(9):1628-35. doi: 10.1091/mbc.E11-05-0412. Epub 2012 Mar 7.
2012
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| 17 | CEBPA, DICER1, PPARG
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| Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells.
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| Fujimoto Y, Nakagawa Y, Shingyouchi A, Tokushige N, Nakanishi N, Satoh A, Matsuzaka T, Ishii KA, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yahagi N, Urayama O, Yamada N, Shimano H.
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| Biochem Biophys Res Commun 420(4):931-6. doi: 10.1016/j.bbrc.2012.03.110. Epub 2012 Mar 26.
2012
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| 18 | CEBPA, CEBPB, GATA1, ZFPM1
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| FOG-1 and GATA-1 act sequentially to specify definitive megakaryocytic and erythroid progenitors.
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| Mancini E, Sanjuan-Pla A, Luciani L, Moore S, Grover A, Zay A, Rasmussen KD, Luc S, Bilbao D, O'Carroll D, Jacobsen SE, Nerlov C.
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| EMBO J 31(2):351-65. doi: 10.1038/emboj.2011.390. Epub 2011 Nov 8.
2012
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| 19 | CEBPA, DACH1, GATA1, GATA1, HOXA9, PBX2
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| Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPα and GATA-1 in myeloid leukemia with MLL-AF9.
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| Lee JW, Kim HS, Hwang J, Kim YH, Lim GY, Sohn WJ, Yoon SR, Kim JY, Park TS, Oh SH, Park KM, Choi SU, Ryoo ZY, Lee S.
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| Biochem Biophys Res Commun 426(3):299-305. doi: 10.1016/j.bbrc.2012.08.048.
2012
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| 20 | CEBPA, FABP1, FOXA2
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| Human liver fatty acid binding protein (hFABP1) gene is regulated by liver-enriched transcription factors HNF3β and C/EBPα.
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| Wu YL, Peng XE, Wang D, Chen WN, Lin X.
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| Biochimie 94(2):384-92. doi: 10.1016/j.biochi.2011.08.006. Epub 2011 Aug 16.
2012
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| 21 | CEBPA, DEK
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| C/EBPα and DEK coordinately regulate myeloid differentiation.
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| Koleva RI, Ficarro SB, Radomska HS, Carrasco-Alfonso MJ, Alberta JA, Webber JT, Luckey CJ, Marcucci G, Tenen DG, Marto JA.
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| Blood 119(21):4878-88. doi: 10.1182/blood-2011-10-383083. Epub 2012 Apr 3.
2012
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| 22 | CEBPA, EP300, HDAC9, USF1
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| Histone deacetylase 9 is a negative regulator of adipogenic differentiation.
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| Chatterjee TK, Idelman G, Blanco V, Blomkalns AL, Piegore MG Jr, Weintraub DS, Kumar S, Rajsheker S, Manka D, Rudich SM, Tang Y, Hui DY, Bassel-Duby R, Olson EN, Lingrel JB, Ho SM, Weintraub NL.
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| J Biol Chem 286(31):27836-47. Epub 2011 Jun 16.
2011
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| 23 | CEBPA, PTPN11
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| SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis.
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| Zhang L, Friedman AD.
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| Blood 118(8):2266-74. doi: 10.1182/blood-2011-01-331157. Epub 2011 Jul 1.
2011
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| 24 | CEBPA, FBXW7
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| The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation.
|
| Bengoechea-Alonso MT, Ericsson J.
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| Proc Natl Acad Sci U S A 107(26):11817-22. Epub 2010 Jun 1.PMID: 20534483 2010
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| 25 | CEBPA, CTNNA1, PTEN
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| An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation.
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| Fu CT, Zhu KY, Mi JQ, Liu YF, Murray ST, Fu YF, Ren CG, Dong ZW, Liu YJ, Dong M, Jin Y, Chen Y, Deng M, Zhang W, Chen B, Breslin P, Chen SJ, Chen Z, Becker MW, Zhu J, Zhang JW, Liu TX.
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| Blood 115(23):4715-24. Epub 2010 Apr 6.
2010
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| 26 | CEBPA, TCERG1
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| Nuclear redistribution of TCERG1 is required for its ability to inhibit the transcriptional and anti-proliferative activities of C/EBPalpha.
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| Banman SL, McFie PJ, Wilson HL, Roesler WJ.
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| J Cell Biochem 109(1):140-51. doi: 10.1002/jcb.22391.
2010
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| 27 | CEBPA, FCAR, GABPA
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| Amino acid residues in the beta3 strand and subsequent loop of the conserved ETS domain that mediate basic leucine zipper (bZIP) recruitment and potentially distinguish functional attributes of Ets proteins.
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| Shimokawa T, Nunomura S, Enomoto Y, Ra C.
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| Biochem J 430(1):129-39. doi: 10.1042/BJ20091742.
2010
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| 28 | CEBPA, ZBTB16
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| PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
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| Doulatov S, Notta F, Rice KL, Howell L, Zelent A, Licht JD, Dick JE.
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| Genes Dev 23(17):2076-87.PMID: 19723763 2009
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| 29 | CDX1, CEBPA, PPARG
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| Homeodomain transcription factor CDX1 is required for the transcriptional induction of PPARgamma in intestinal cell differentiation.
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| Park MJ, Kim HY, Kim K, Cheong J.
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| FEBS Lett 583(1):29-35. Epub 2008 Dec 4.
2009
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| 30 | CEBPA
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| Nature of frequent deletions in CEBPA.
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| Fuchs O, Kostecka A, Provaznikova D, Krasna B, Brezinova J, Filkukova J, Kotlin R, Kouba M, Kobylka P, Neuwirtova R, Jonasova A, Caniga M, Schwarz J, Markova J, Maaloufova J, Sponerova D, Novakova L, Cermak J.
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| Blood Cells Mol Dis 43(3):260-3. Epub 2009 Aug 3.PMID: 19651529 2009
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| 31 | CEBPA, MN1
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| Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.
|
| Kandilci A, Grosveld GC.
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| Blood 114(8):1596-606. Epub 2009 Jun 26.PMID: 19561324 2009
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| 32 | CEBPA
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| Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group.
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| Ho PA, Alonzo TA, Gerbing RB, Pollard J, Stirewalt DL, Hurwitz C, Heerema NA, Hirsch B, Raimondi SC, Lange B, Franklin JL, Radich JP, Meshinchi S.
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| Blood 113(26):6558-66. Epub 2009 Mar 20.PMID: 19304957 2009
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| 33 | CEBPA, CEBPB, CEBPE, CEBPG
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| Inflammatory cytokine production by human neutrophils involves C/EBP transcription factors.
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| Cloutier A, Guindi C, Larivée P, Dubois CM, Amrani A, McDonald PP.
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| J Immunol 182(1):563-71.PMID: 19109189 2009
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| 34 | CEBPA, KLF3
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| Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.
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| Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Molero-Navajas JC, Perkins A, Fujiwara Y, Orkin SH, Bell-Anderson K, Crossley M.
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| Mol Cell Biol 28(12):3967-78. Epub 2008 Apr 7.PMID: 18391014 2008
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| 35 | CEBPA, CITED2, TFAP2C
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| Cited2 is required for fetal lung maturation.
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| Xu B, Qu X, Gu S, Doughman YQ, Watanabe M, Dunwoodie SL, Yang YC.
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| Dev Biol 317(1):95-105. Epub 2008 Feb 26.PMID: 18358466 2008
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| 36 | AFP, CEBPA
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| Identification of CCAAT enhancer binding protein alpha binding sites on the human alpha-fetoprotein gene.
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| Li HM, Ikeda H, Nakabayashi H, Nishi S, Sakai M.
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| Gene 389(2):128-35. Epub 2006 Nov 11. 2007
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| 37 | CEBPA, CEBPE, ATF4
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| ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha.
|
| Gombart AF, Grewal J, Koeffler HP.
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| J Leukoc Biol 81(6):1535-47. Epub 2007 Mar 8. 2007
|
| 38 | CEBPA, NOTCH1
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| Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
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| Wouters BJ, Jordŕ MA, Keeshan K, Louwers I, Erpelinck-Verschueren CA, Tielemans D, Langerak AW, He Y, Yashiro-Ohtani Y, Zhang P, Hetherington CJ, Verhaak RG, Valk PJ, Löwenberg B, Tenen DG, Pear WS, Delwel R.
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| Blood 110(10):3706-14. Epub 2007 Aug 1.PMID: 17671232 2007
|
| 39 | CEBPA, ID1
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| Absence of the transcription factor CCAAT enhancer binding protein {alpha} results in loss of myeloid identity in bcr/abl-induced malignancy.
|
| Wagner K, Zhang P, Rosenbauer F, Drescher B, Kobayashi S, Radomska HS, Kutok JL, Gilliland DG, Krauter J, Tenen DG.
|
| Proc Natl Acad Sci U S A 103(16):6338-43. Epub 2006 Apr 10. 2006
|
| 40 | CEBPA, MDS1, MECOM, RUNX1
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| The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin.
|
| Helbling D, Mueller BU, Timchenko NA, Hagemeijer A, Jotterand M, Meyer-Monard S, Lister A, Rowley JD, Huegli B, Fey MF, Pabst T.
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| Proc Natl Acad Sci U S A 101(36):13312-7. Epub 2004 Aug 23. 2004
|
| 41 | CEBPA
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| Mutation of CEBPA in familial acute myeloid leukemia.
|
| Smith ML, Cavenagh JD, Lister TA, Fitzgibbon J.
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| N Engl J Med 351(23):2403-7. 2004
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| 42 | CEBPA
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| Phosphorylation of C/EBPalpha inhibits granulopoiesis.
|
| Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, Wright WS, Schaufele F, Tenen DG, MacDougald OA.
|
| Mol Cell Biol 24(2):675-86. 2004
|
| 43 | DDIT3, CEBPA, CEBPB
|
| CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation.
|
| Pereira RC, Delany AM, Canalis E.
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| Endocrinology 145(4):1952-60. Epub 2003 Dec 18. 2004
|
| 44 | CEBPA
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| Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2.
|
| Snaddon J, Smith ML, Neat M, Cambal-Parrales M, Dixon-McIver A, Arch R, Amess JA, Rohatiner AZ, Lister TA, Fitzgibbon J.
|
| Genes Chromosomes Cancer 37(1):72-8. 2003
|
| 45 | CEBPA, ADD1, SREBF1, RETN
|
| Functional characterization of the human resistin promoter with adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-alpha.
|
| Seo JB, Noh MJ, Yoo EJ, Park SY, Park J, Lee IK, Park SD, Kim JB.
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| Mol Endocrinol 17(8):1522-33. Epub 2003 May 1. 2003
|
| 46 | CEBPA, PCBP2
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| BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.
|
| Perrotti D, Cesi V, Trotta R, Guerzoni C, Santilli G, Campbell K, Iervolino A, Condorelli F, Gambacorti-Passerini C, Caligiuri MA, Calabretta B.
|
| Nat Genet 30(1):48-58. 2002
|
| 47 | CEBPA, SPI1
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| Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions.
|
| Reddy VA, Iwama A, Iotzova G, Schulz M, Elsasser A, Vangala RK, Tenen DG, Hiddemann W, Behre G.
|
| Blood 100(2):483-90. 2002
|
| 48 | CEBPA, CEBPB
|
| Organization of the promoter region of the human NF-IL6 gene.
|
| Yang Y, Pares-Matos EI, Tesmer VM, Dai C, Ashworth S, Huai J, Bina M.
|
| Biochim Biophys Acta 1577(1):102-8. 2002
|
| 49 | CEBPA
|
| Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.
|
| Pabst T, Mueller BU, Zhang P, Radomska HS, Narravula S, Schnittger S, Behre G, Hiddemann W, Tenen DG.
|
| Nat Genet 27(3):263-70. 2001
|
| 50 | ALB, CAD, CCNA2, CDC25A, CDK1, CEBPA, COL1A1, COL1A2, COL3A1, COL6A3, DHFR, DMTF1, GADD45A, JUN, LDHA, MXI1, MYC, ODC1, RCC1, SERPINE1, TERT, TK1, TK2, TP53
|
| c-Myc target genes involved in cell growth, apoptosis, and metabolism.
|
| Dang CV.
|
| Mol Cell Biol 19(1):1-11. Review. No abstract available 1999
|
| 51 | CEBPA, CEBPB, CEBPD, DIDAN
|
| PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function.
|
| Lowell BB.
|
| Cell 99(3):239-42. Review. No abstract available 1999
|
| 52 | CEBPA, CEBPB, STAR
|
| CCAAT/enhancer-binding proteins regulate expression of the human steroidogenic acute regulatory protein (StAR) gene.
|
| Christenson LK, Johnson PF, McAllister JM, Strauss JF 3rd.
|
| J Biol Chem 274(37):26591-8 1999
|
| 53 | CEBPA, STGD3
|
| CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors.
|
| Radomska HS, Huettner CS, Zhang P, Cheng T, Scadden DT, Tenen DG.
|
| Mol Cell Biol 18(7):4301-14. 1998
|
| 54 | CEBPA
|
| Transcription factor C/EBPalpha: novel sites of expression and cloning of the human gene.
|
| Swart GW, van Groningen JJ, van Ruissen F, Bergers M, Schalkwijk J.
|
| Biol Chem 378(5):373-9. 1997
|
| 55 | CEBPA
|
| Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBPalpha).
|
| Antonson P, et al.
|
| Biochem Biophys Res Commun 215 : 106-113. 1995
|
| 56 | CEBPA, CEBPB
|
| CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.
|
| Ossipow V, Descombes P, Schibler U.
|
| Proc Natl Acad Sci U S A 90(17):8219-23. 1993
|
| 57 | CEBPA
|
| Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF).
|
| Szpirer C, et al.
|
| Genomics 13 : 293-300. 1992
|
| 58 | CEBPA
|
| The CCAAT/enhancer binding protein (C/EBPalpha) gene (CEBPA) maps to human chromosome 19q13.1 and the related nuclear factor NF-IL6 (C/EBPbeta) gene (CEBPB) maps to human chromosome 20q13.1.
|
| Hendricks-Taylor LR, et al.
|
| Genomics 14 : 12-17. 1992
|