| 1 | CDT1, GMNN
|
| Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication.
|
| Ballabeni A, Zamponi R, Moore JK, Helin K, Kirschner MW.
|
| Proc Natl Acad Sci U S A 110(30):E2848-53. doi: 10.1073/pnas.1310677110. Epub 2013 Jul 8.
2013
|
| 2 | CDT1, GMNN
|
| Cell cycle-dependent subcellular translocation of the human DNA licensing inhibitor geminin.
|
| Dimaki M, Xouri G, Symeonidou IE, Sirinian C, Nishitani H, Taraviras S, Lygerou Z.
|
| J Biol Chem 288(33):23953-63. doi: 10.1074/jbc.M113.453092. Epub 2013 Jun 29.
2013
|
| 3 | ATR, CDT1, DTL
|
| Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.
|
| Sakaguchi H, Takami T, Yasutani Y, Maeda T, Morino M, Ishii T, Shiomi Y, Nishitani H.
|
| PLoS One 7(9):e46480. doi: 10.1371/journal.pone.0046480. Epub 2012 Sep 28.
2012
|
| 4 | CDC6, CDT1, GMNN
|
| Cdt1 and geminin in DNA replication initiation.
|
| Caillat C, Perrakis A.
|
| Subcell Biochem 62:71-87. doi: 10.1007/978-94-007-4572-8_5. Review.
2012
|
| 5 | CDT1, FOXO3
|
| Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1.
|
| Zhang Y, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW, You H.
|
| Proc Natl Acad Sci U S A 109(15):5717-22. doi: 10.1073/pnas.1203210109. Epub 2012 Mar 26.
2012
|
| 6 | CDC6, CDT1, EPSS, MGORS3, MGORS4, MGORS5, ORC4, ORC6
|
| Mutations in the pre-replication complex cause Meier-Gorlin syndrome.
|
| Bicknell LS, Bongers EM, Leitch A, Brown S, Schoots J, Harley ME, Aftimos S, Al-Aama JY, Bober M, Brown PA, van Bokhoven H, Dean J, Edrees AY, Feingold M, Fryer A, Hoefsloot LH, Kau N, Knoers NV, Mackenzie J, Opitz JM, Sarda P, Ross A, Temple IK, Toutain A, Wise CA, Wright M, Jackson AP.
|
| Nat Genet 43(4):356-9.
2011
|
| 7 | CDT1, DTL, PCNA
|
| A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.
|
| Raman M, Havens CG, Walter JC, Harper JW.
|
| Mol Cell 44(1):72-84. doi: 10.1016/j.molcel.2011.06.036.
2011
|
| 8 | CDT1, KAT7
|
| JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.
|
| Miotto B, Struhl K.
|
| Mol Cell 44(1):62-71. doi: 10.1016/j.molcel.2011.06.021.
2011
|
| 9 | CDT1, MCM6
|
| Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6.
|
| Wei Z, Liu C, Wu X, Xu N, Zhou B, Liang C, Zhu G.
|
| J Biol Chem Biol Chem. 2010 Mar 4. [Epub ahead of print]PMID: 20202939 2010
|
| 10 | CDC45, CDC7, CDT1
|
| Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase.
|
| Ballabeni A, Zamponi R, Caprara G, Melixetian M, Bossi S, Masiero L, Helin K.
|
| J Biol Chem 284(5):3028-36. Epub 2008 Dec 3.
2009
|
| 11 | CDT1, DTL, PCNA
|
| Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2.
|
| Havens CG, Walter JC.
|
| Mol Cell 35(1):93-104. doi: 10.1016/j.molcel.2009.05.012.
2009
|
| 12 | CDT1, KAT7
|
| HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1.
|
| Miotto B, Struhl K.
|
| Genes Dev 22(19):2633-8. 2008
|
| 13 | CDT1, MCM9
|
| MCM9 binds Cdt1 and is required for the assembly of prereplication complexes.
|
| Lutzmann M, Méchali M.
|
| Mol Cell 31(2):190-200.
2008
|
| 14 | CDT1, GMNN
|
| Cdt1 and Geminin in cancer: markers or triggers of malignant transformation?
|
| Petropoulou C, Kotantaki P, Karamitros D, Taraviras S.
|
| Front Biosci 13:4485-94. Review.
2008
|
| 15 | CDT1
|
| Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
|
| Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa-Saito M, Matsukage A, Kiyono T, Fujita M.
|
| Mol Biol Cell 19(3):1007-21. Epub 2007 Dec 27.
2008
|
| 16 | CDC6, CDT1
|
| Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.
|
| Hall JR, Lee HO, Bunker BD, Dorn ES, Rogers GC, Duronio RJ, Cook JG.
|
| J Biol Chem 283(37):25356-63. Epub 2008 Jul 10.
2008
|
| 17 | CDT1, MCM6
|
| Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.
|
| You Z, Masai H.
|
| J Biol Chem 283(36):24469-77. Epub 2008 Jul 7.PMID: 18606811 2008
|
| 18 | CDT1
|
| Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
|
| Liontos M, Koutsami M, Sideridou M, Evangelou K, Kletsas D, Levy B, Kotsinas A, Nahum O, Zoumpourlis V, Kouloukoussa M, Lygerou Z, Taraviras S, Kittas C, Bartkova J, Papavassiliou AG, Bartek J, Halazonetis TD, Gorgoulis VG.
|
| Cancer Res 67(22):10899-909.
2007
|
| 19 | CDT1
|
| Cdt1 interactions in the licensing process: a model for dynamic spatiotemporal control of licensing.
|
| Xouri G, Dimaki M, Bastiaens PI, Lygerou Z.
|
| Cell Cycle 6(13):1549-52. Epub 2007 May 22. Review.
2007
|
| 20 | CDT1, ORC1, ORC2, ORC3, ORC4, ORC5, ORC6
|
| Interaction between ORC and Cdt1p of Saccharomyces cerevisiae.
|
| Asano T, Makise M, Takehara M, Mizushima T.
|
| FEMS Yeast Res 7(8):1256-62. Epub 2007 Sep 6.PMID: 17825064 2007
|
| 21 | CDT1, CUL4A, CUL4B
|
| PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.
|
| Senga T, Sivaprasad U, Zhu W, Park JH, Arias EE, Walter JC, Dutta A.
|
| J Biol Chem 281(10):6246-52. Epub 2006 Jan 9. 2006
|
| 22 | CDT1, DDB1
|
| DDB1 maintains genome integrity through regulation of Cdt1.
|
| Lovejoy CA, Lock K, Yenamandra A, Cortez D.
|
| Mol Cell Biol 26(21):7977-90. Epub 2006 Aug 28.
2006
|
| 23 | CDT1, CDT2, DDB1
|
| L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.
|
| Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H.
|
| Cell Cycle 5(15):1675-80. Epub 2006 Aug 1.
2006
|
| 24 | CDT1, PCNA
|
| PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.
|
| Senga T, Sivaprasad U, Zhu W, Park JH, Arias EE, Walter JC, Dutta A.
|
| J Biol Chem 281(10):6246-52. Epub 2006 Jan 9.
2006
|
| 25 | CDT1, DTL
|
| DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.
|
| Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA.
|
| Genes Dev 20(22):3117-29. Epub 2006 Nov 3.
2006
|
| 26 | CDT1
|
| Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.
|
| Sugimoto N, Tatsumi Y, Tsurumi T, Matsukage A, Kiyono T, Nishitani H, Fujita M.
|
| J Biol Chem 279(19):19691-7. Epub 2004 Mar 1. 2004
|
| 27 | CDT1
|
| Essential role of human CDT1 in DNA replication and chromatin licensing.
|
| Rialland M, Sola F, Santocanale C.
|
| J Cell Sci 115(Pt 7):1435-40. 2002
|
| 28 | CDT1
|
| The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase.
|
| Nishitani H, Taraviras S, Lygerou Z, Nishimoto T.
|
| J Biol Chem 276(48):44905-11. Epub 2001 Sep 12. 2001
|