1 | CDKN1C
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| Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development. 2020
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| Laukoter S, Beattie R, Pauler FM, Amberg N, Nakayama KI, Hippenmeyer S.
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| Nat Commun. Jan 10;11(1):195. doi: 10.1038/s41467-019-14077-2 2020
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2 | CDKN1C, SRS6
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| Novel mutation points to a hot spot in CDKN1C causing Silver-Russell syndrome.
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| Binder G, Ziegler J, Schweizer R, Habhab W, Haack TB, Heinrich T, Eggermann T.
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| Clin Epigenetics. Oct 19;12(1):152. doi: 10.1186/s13148-020-00945-y. 2020
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3 | CDKN1C, IGF2, PHLDA2
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| Abundances of placental imprinted genes CDKN1C, PHLDA2 and IGF-2 are related to low birth weight and early catch-up growth in full-term infants born small for gestational age
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| Xing Y, Liu H, Cui Y, Wang X, Tong X.
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| PLoS One. Jun 13;14(6):e0218278. doi: 10.1371/journal.pone.0218278 2019
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4 | CDKN1C
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| Methylation of Cdkn1c may be involved in the regulation of tooth development through cell cycle inhibition. 2018
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| Li Q, Guo Y, Yao M, Li J, Chen Y, Liu Q, Chen Y, Zeng Y, Ji B, Feng Y.
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| J Mol Histol. Oct;49(5):459-469. doi: 10.1007/s10735-018-9785-0. Epub 2018 Jul 16 2018
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5 | CDKN1C
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| Loss of Imprinting of Cdkn1c Protects against Age and Diet-Induced Obesity.
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| Van de Pette M, Tunster SJ, John RM.
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| Int J Mol Sci. Sep 12;19(9):2734. doi: 10.3390/ijms19092734. 2018
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6 | CDKN1C
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| Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells.
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| Mademtzoglou D, Asakura Y, Borok MJ, Alonso-Martin S, Mourikis P, Kodaka Y, Mohan A, Asakura A, Relaix F.
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| Elife. Oct 4;7:e33337. doi: 10.7554/eLife.33337. 2018
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7 | CDKN1C, IMAS, SRS6
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| IMAGe and Related Undergrowth Syndromes: The Complex Spectrum of Gain-of-Function CDKN1C Mutations
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| Cabrera-Salcedo C, Kumar P, Hwa V, Dauber A.
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| Pediatr Endocrinol Rev. Mar;14(3):289-297. doi: 10.17458/per.vol14.2017.SKHD.imageandrelatedundergrowth. 2017
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8 | CDKN1C, KCNQ1OT1
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| A cross-talk between DNA methylation and H3 lysine 9 dimethylation at the KvDMR1 region controls the induction of Cdkn1c in muscle cells.
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| Andresini O, Ciotti A, Rossi MN, Battistelli C, Carbone M, Maione R.
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| Epigenetics. Nov;11(11):791-803. doi: 10.1080/15592294.2016.1230576. Epub 2016 Sep 9. 2016
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9 | CDKN1C, LHX6, LHX8
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| Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2
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| Cesario JM, Landin Malt A, Deacon LJ, Sandberg M, Vogt D, Tang Z, Zhao Y, Brown S, Rubenstein JL, Jeong J
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| Hum Mol Genet. Sep 1;24(17):5024-39. doi: 10.1093/hmg/ddv223. Epub 2015 Jun 12 2015
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10 | CDKN1C, IMAS
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| Mutations in the PCNA-binding site of CDKN1C inhibit cell proliferation by impairing the entry into S phase .
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| Borges KS, Arboleda VA, Vilain E
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| Cell Div. Mar 28;10:2. doi: 10.1186/s13008-015-0008-8. 2015
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11 | BWS, CDKN1C, IMAS
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| Beckwith-Wiedemann and IMAGe syndromes: two very different diseases caused by mutations on the same gene.
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| Milani D, Pezzani L, Tabano S, Miozzo M.
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| Appl Clin Genet. Sep 16;7:169-75. doi: 10.2147/TACG.S35474. eCollection 2014 2014
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12 | BWS, CDKN1C
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| A novel mutation in CDKN1C in sibs with Beckwith-Wiedemann syndrome and cleft palate, sensorineural hearing loss, and supernumerary flexion creases.
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| Kantaputra PN, Sittiwangkul R, Sonsuwan N, Romanelli V, Tenorio J, Lapunzina P.
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| Am J Med Genet A 161(1):192-7. doi: 10.1002/ajmg.a.35663. Epub 2012 Nov 29.
2013
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13 | CDKN1C, SRS6
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| CDKN1C mutation affecting the PCNA-binding domain as a cause of familial Russell Silver syndrome
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| Brioude F, Oliver-Petit I, Blaise A, Praz F, Rossignol S, Le Jule M, Thibaud N, Faussat AM, Tauber M, Le Bouc Y, Netchine I.
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| J Med Genet. Dec;50(12):823-30. doi: 10.1136/jmedgenet-2013-101691. Epub 2013 Sep 24. 2013
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14 | CDKN1C
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| p57kip2 regulates glial fate decision in adult neural stem cells.
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| Jadasz JJ, Rivera FJ, Taubert A, Kandasamy M, Sandner B, Weidner N, Aktas O, Hartung HP, Aigner L, Küry P.
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| Development 139(18):3306-15. doi: 10.1242/dev.074518. Epub 2012 Aug 8.
2012
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15 | AHI1, CDKN1C
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| The role of AHI1 and CDKN1C in cutaneous T-cell lymphoma progression.
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| Litvinov IV, Kupper TS, Sasseville D.
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| Exp Dermatol 21(12):964-6. doi: 10.1111/exd.12039.
2012
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16 | CDKN1C
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| Cell cycle regulator Cdkn1c (p57/KIP2) shows distinct expression in epidermal differentiation.
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| Hildebrand J, Spörl F, Korge S, Gallinat S, Wenck H, Deppert W, Knott A, Blatt T.
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| Eur J Dermatol 22(5):694-6. doi: 10.1684/ejd.2012.1828. No abstract available.
2012
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17 | CDKN1C, HES1
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| CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma.
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| Giovannini C, Gramantieri L, Minguzzi M, Fornari F, Chieco P, Grazi GL, Bolondi L.
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| Am J Pathol 181(2):413-22. doi: 10.1016/j.ajpath.2012.04.019. Epub 2012 Jun 15.
2012
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18 | CDKN1C, LIMK1
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| p57(KIP2) control of actin cytoskeleton dynamics is responsible for its mitochondrial pro-apoptotic effect.
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| Kavanagh E, Vlachos P, Emourgeon V, Rodhe J, Joseph B.
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| Cell Death Dis 3:e311. doi: 10.1038/cddis.2012.51.
2012
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19 | CDKN1C
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| The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress.
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| Joaquin M, Gubern A, González-Nuńez D, Josué Ruiz E, Ferreiro I, de Nadal E, Nebreda AR, Posas F.
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| EMBO J 31(13):2952-64. doi: 10.1038/emboj.2012.122.
2012
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20 | CDKN1B, CDKN1C
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| p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex.
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| Mairet-Coello G, Tury A, Van Buskirk E, Robinson K, Genestine M, DiCicco-Bloom E.
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| Development 139(3):475-87. doi: 10.1242/dev.067314.
2012
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21 | CDKN1C
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| Gain of function in CDKN1C.
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| Riccio A, Cubellis MV.
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| Nat Genet 44(7):737-8. doi: 10.1038/ng.2336. No abstract available.
2012
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22 | CDKN1C, IMAS
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| Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome.
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| Arboleda VA, Lee H, Parnaik R, Fleming A, Banerjee A, Ferraz-de-Souza B, Délot EC, Rodriguez-Fernandez IA, Braslavsky D, Bergadá I, Dell'Angelica EC, Nelson SF, Martinez-Agosto JA, Achermann JC, Vilain E.
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| Nat Genet 44(7):788-92. doi: 10.1038/ng.2275.
2012
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23 | CDKN1B, CDKN1C, HSPA8
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| p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.
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| Zou P, Yoshihara H, Hosokawa K, Tai I, Shinmyozu K, Tsukahara F, Maru Y, Nakayama K, Nakayama KI, Suda T.
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| Cell Stem Cell 9(3):247-61.
2011
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24 | CDKN1C
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| The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursors.
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| Tury A, Mairet-Coello G, DiCicco-Bloom E.
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| Cereb Cortex 21(8):1840-56. doi: 10.1093/cercor/bhq254. Epub 2011 Jan 18.
2011
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25 | CDKN1C, EZH2
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| EZH2 regulates expression of p57 and contributes to progression of ovarian cancer in vitro and in vivo.
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| Guo J, Cai J, Yu L, Tang H, Chen C, Wang Z.
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| Cancer Sci 102(3):530-9. doi: 10.1111/j.1349-7006.2010.01836.x. Epub 2011 Jan 18.
2011
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26 | CDKN1C, MYOD1
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| Cdkn1c drives muscle differentiation through a positive feedback loop with Myod.
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| Osborn DP, Li K, Hinits Y, Hughes SM.
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| Dev Biol 350(2):464-75. doi: 10.1016/j.ydbio.2010.12.010. Epub 2010 Dec 11.
2011
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27 | CDKN1B, CDKN1C, E2F1
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| CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner.
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| Ma Y, Chen L, Wright GM, Pillai SR, Chellappan SP, Cress WD.
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| J Biol Chem 285(13):9813-22. Epub 2010 Jan 27.PMID: 20106982 2010
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28 | CDKN1C
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| CDKN1C (p57KIP2) mRNA expression in human retinoblastomas.
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| Madhavan J, Mallikarjuna K, Vikas K, George R, Bremner R, Kumaramanickavel G.
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| Ophthalmic Genet 31(3):141-6. doi: 10.3109/13816810.2010.490544.
2010
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29 | BWS, CDKN1C
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| CDKN1C (p57(Kip2)) analysis in Beckwith-Wiedemann syndrome (BWS) patients: Genotype-phenotype correlations, novel mutations, and polymorphisms.
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| Romanelli V, Belinchón A, Benito-Sanz S, Martínez-Glez V, Gracia-Bouthelier R, Heath KE, Campos-Barros A, García-Mińaur S, Fernandez L, Meneses H, López-Siguero JP, Guillén-Navarro E, Gómez-Puertas P, Wesselink JJ, Mercado G, Esteban-Marfil V, Palomo R, Mena R, Sánchez A, Del Campo M, Lapunzina P.
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| Am J Med Genet A 152A(6):1390-7. doi: 10.1002/ajmg.a.33453. Review.
2010
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30 | CDKN1C, LIMK1
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| p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation.
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| Kremer D, Heinen A, Jadasz J, Göttle P, Zimmermann K, Zickler P, Jander S, Hartung HP, Küry P.
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| Proc Natl Acad Sci U S A 106(22):9087-92. Epub 2009 May 19.
2009
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31 | BWS, CDKN1C, IGF2, SRS11
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| Phenotypic discordance upon paternal or maternal transmission of duplications of the 11p15 imprinted regions.
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| Bliek J, Snijder S, Maas SM, Polstra A, van der Lip K, Alders M, Knegt AC, Mannens MM.
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| Eur J Med Genet 52(6):404-8. Epub 2009 Sep 6.
2009
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32 | CDKN1C, LIMK1
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| The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics.
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| Vlachos P, Joseph B.
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| Oncogene 28(47):4175-88. doi: 10.1038/onc.2009.269. Epub 2009 Sep 7.
2009
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33 | CDKN1C
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| The cyclin-dependent kinase inhibitor p57kip2 is a negative regulator of Schwann cell differentiation and in vitro myelination.
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| Heinen A, Kremer D, Gttle P, Kruse F, Hasse B, Lehmann H, Hartung HP, Kry P.
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| Proc Natl Acad Sci U S A 105(25):8748-53. Epub 2008 Jun 11. 2008
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34 | CDKN1C
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| Significance of p57(Kip2) down-regulation in oncogenesis of bladder carcinoma: an immunohistochemical study.
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| Bozdođan O, Atasoy P, Batislam E, Baţar MM, Baţar H.
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| Tumori 94(4):556-62.
2008
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35 | PAX3, FOXO1, CDKN1C
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| PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1.
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| Roeb W, Boyer A, Cavenee WK, Arden KC.
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| Proc Natl Acad Sci U S A 104(46):18085-90. Epub 2007 Nov 6. 2007
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36 | BMP2, BMP6, CDKN1C
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| BMP2 and BMP6 control p57(Kip2) expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes.
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| Gosselet FP, Magnaldo T, Culerrier RM, Sarasin A, Ehrhart JC.
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| Cell Signal 19(4):731-9. Epub 2006 Oct 4.
2007
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37 | CDKN1C
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| P57kip2 immunohistochemical expression and ultrastructural findings of gestational trophoblastic disease and related disorders.
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| Soma H, Osawa H, Oguro T, Yoshihama I, Fujita K, Mineo S, Kudo M, Tanaka K, Akita M, Urabe S, Kudo Y.
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| Med Mol Morphol 40(2):95-102. Epub 2007 Jun 18.
2007
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38 | CDKN1C
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| The cell cycle inhibitor p57(Kip2) promotes cell death via the mitochondrial apoptotic pathway.
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| Vlachos P, Nyman U, Hajji N, Joseph B.
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| Cell Death Differ 14(8):1497-507. Epub 2007 Apr 27.
2007
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39 | BCL11B, CDKN1C
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| CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene.
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| Topark-Ngarm A, Golonzhka O, Peterson VJ, Barrett B Jr, Martinez B, Crofoot K, Filtz TM, Leid M.
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| J Biol Chem 281(43):32272-83. Epub 2006 Sep 1.
2006
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40 | CDKN1C, KCNQ1OT1, BWS
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| Alternative mechanisms associated with silencing of CDKN1C in Beckwith-Wiedemann syndrome.
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| Diaz-Meyer N, Yang Y, Sait SN, Maher ER, Higgins MJ.
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| J Med Genet 42(8):648-55. 2005
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41 | KCNQ1OT1, PLAGL1, CDKN1C
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| ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome.
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| Arima T, Kamikihara T, Hayashida T, Kato K, Inoue T, Shirayoshi Y, Oshimura M, Soejima H, Mukai T, Wake N.
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| Nucleic Acids Res 33(8):2650-60. Print 2005. 2005
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42 | CDKN1C
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| Downregulation of cyclin-dependent kinase inhibitor; p57(kip2), is involved in the cell cycle progression of vascular smooth muscle cells.
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| Nakano N, Urasawa K, Takagi Y, Saito T, Kaneta S, Ishikawa S, Higashi H, Tsutsui H, Hatakeyama M, Kitabatake A.
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| Biochem Biophys Res Commun 338(3):1661-7. Epub 2005 Oct 25. 2005
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43 | CDKN1B, CDKN1C, RNF123
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| Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase.
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| Kotoshiba S, Kamura T, Hara T, Ishida N, Nakayama KI.
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| J Biol Chem 280(18):17694-700. Epub 2005 Mar 3.
2005
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44 | CDKN1C
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| CDKN1C mutation in Wiedemann-Beckwith syndrome patients reduces RNA splicing efficiency and identifies a splicing enhancer.
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| Lew JM, Fei YL, Aleck K, Blencowe BJ, Weksberg R, Sadowski PD.
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| Am J Med Genet 127A(3):268-76. 2004
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45 | CDKN1C
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| Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer.
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| Soejima H, Nakagawachi T, Zhao W, Higashimoto K, Urano T, Matsukura S, Kitajima Y, Takeuchi M, Nakayama M, Oshimura M, Miyazaki K, Joh K, Mukai T.
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| Oncogene 23(25):4380-8. 2004
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46 | CDKN1C, H19, IGF2, KCNQ1OT1, SLC22A18, PHLDA2, BWS
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| Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development.
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| Weksberg R, Smith AC, Squire J, Sadowski P.
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| Hum Mol Genet 12 Spec No 1:R61-8. 2003
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47 | CDKN1C, H19, KCNQ1OT1, BWS
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| Insulator and silencer sequences in the imprinted region of human chromosome 11p15.5.
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| Du M, Beatty LG, Zhou W, Lew J, Schoenherr C, Weksberg R, Sadowski PD.
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| Hum Mol Genet 12(15):1927-39. 2003
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48 | KCNQ1OT1, CDKN1C, BWS
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| Silencing of CDKN1C (p57KIP2) is associated with hypomethylation at KvDMR1 in Beckwith-Wiedemann syndrome.
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| Diaz-Meyer N, Day CD, Khatod K, Maher ER, Cooper W, Reik W, Junien C, Graham G, Algar E, Der Kaloustian VM, Higgins MJ.
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| J Med Genet 40(11):797-801. 2003
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49 | CDKN1C, OSBPL5
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| Characterization and Imprinting Status of OBPH1/Obph1 Gene: Implications for an Extended Imprinting Domain in Human and Mouse.
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| Higashimoto K, Soejima H, Yatsuki H, Joh K, Uchiyama M, Obata Y, Ono R, Wang Y, Xin Z, Zhu X, Masuko S, Ishino F, Hatada I, Jinno Y, Iwasaka T, Katsuki T, Mukai T.
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| Genomics 80(6):575-84. 2002
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50 | KCNQ1OT1, CDKN1C, BWS
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| Renal abnormalities in beckwith-wiedemann syndrome are associated with 11p15.5 uniparental disomy.
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| Goldman M, Smith A, Shuman C, Caluseriu O, Wei C, Steele L, Ray P, Sadowski P, Squire J, Weksberg R, Rosenblum ND.
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| J Am Soc Nephrol 13(8):2077-84. 2002
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51 | CDKN1C
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| Expression of second class of KIP protein p57KIP2 in human colorectal carcinoma.
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| Noura S, Yamamoto H, Sekimoto M, Takemasa I, Miyake Y, Ikenaga M, Matsuura N, Monden M.
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| Int J Oncol 19(1):39-47. 2001
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52 | BWS, CDKN1C
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| Analysis of CDKN1C in Beckwith Wiedemann syndrome.
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| Algar E, Brickell S, Deeble G, Amor D, Smith P.
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| Hum Mutat 15(6):497-508. 2000
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53 | BWS, CDKN1C, H19, IGF2, NAP1L4
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| Mutation analysis of H19 and NAP1L4 (hNAP2) candidate genes and IGF2 DMR2 in Beckwith-Wiedemann syndrome.
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| Catchpoole D, Smallwood AV, Joyce JA, Murrell A, Lam W, Tang T, Munroe D, Reik W, Schofield PN, Maher ER.
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| J Med Genet 37(3):212-5. No abstract available. 2000
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54 | CDKN1C
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| P57 (KIP2) polymorphisms and breast cancer risk.
|
| Li Y, et al.
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| Hum Genet 104 : 83-88. 1999
|
55 | CDKN1A, CDKN1C
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| p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
|
| Zhang P, et al.
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| Genes Dev 13(2):213-24. 1999
|
56 | BWS, CDKN1C
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| Functional analysis of the p57KIP2 gene mutation in Beckwith-Wiedemann syndrome.
|
| Bhuiyan ZA, et al.
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| Hum Genet 104(3):205-10. 1999
|
57 | CDKN1C
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| CDKN1C expression in Beckwith-Wiedemann syndrome patients with allele imbalance.
|
| Algar EM, et al.
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| J Med Genet 36(7):524-31. 1999
|
58 | CDKN1C
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| Analysis of germline CDKN1C (p57KIP2) mutations in familial and sporadic Beckwith-Wiedemann syndrome (BWS) provides a novel genotype-phenotype correlation.
|
| Lam WW, et al.
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| J Med Genet 36(7):518-23. 1999
|
59 | CDKN1C, IGF2
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| Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.
|
| Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, Tilghman SM.
|
| Genes Dev 13(23):3115-24. 1999
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60 | CDKN1B, CDKN1C
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| Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development.
|
| Zhang P, Wong C, DePinho RA, Harper JW, Elledge SJ.
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| Genes Dev 12 : 3162-3167. 1998
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61 | CDKN1C
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| Human p57KIP2 defines a new imprinted domain on chromosome 11p but is not a tumour suppressor gene in Wilms tumour.
|
| Taniguchi T, et al.
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| Oncogene 14 : 1201-1206. 1997
|
62 | BWS, CDKN1C
|
| Coding mutations in p57KIP2 are present in some cases of Beckwith-Wiedemann syndrome but are rare or absent in Wilms tumors.
|
| O'Keefe D, Dao D, Zhao L, Sanderson R, Warburton D, Weiss L, Anyane-Yeboa K, Tycko B.
|
| Am J Hum Genet 61(2):295-303. 1997
|
63 | BWS, CDKN1C
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| Low frequency of p57KIP2 mutation in Beckwith-Wiedemann syndrome.
|
| Lee MP, DeBaun M, Randhawa G, Reichard BA, Elledge SJ, Feinberg AP.
|
| Am J Hum Genet 61(2):304-9. 1997
|
64 | ASCL2, BWS, CDKN1C, PHLDA2, KCNQ1, TSSC2, CD81, ST5, TSSC1
|
| A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes.
|
| Hu RJ, Lee MP, Connors TD, Johnson LA, Burn TC, Su K, Landes GM, Feinberg AP.
|
| Genomics 46(1):9-17. 1997
|
65 | CDKN1C
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| Genomic organization of the human p57KIP2 gene and its analysis in the G401 Wilms'tumor assay.
|
| Reid LH, et al.
|
| Cancer Res 56 : 1214-1218. 1996
|
66 | CDKN1C, H19
|
| Chromosome 11p15.5 regional imprinting : comparative analysis of KIP2 and H19 in human tissues and Wilms' tumors.
|
| Chung MY, et al.
|
| Hum Mol Genet 5 : 1101-1108. 1996
|
67 | CDKN1C, BWS
|
| An Imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome.
|
| Hatada I, et al.
|
| Nat Genet 14 : 171-173. 1996
|